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Q9DCT2

- NDUS3_MOUSE

UniProt

Q9DCT2 - NDUS3_MOUSE

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

Ndufs3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    2. NADH dehydrogenase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of cell growth Source: UniProtKB
    2. negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    3. reactive oxygen species metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-30kD
    Short name:
    CI-30kD
    NADH-ubiquinone oxidoreductase 30 kDa subunit
    Gene namesi
    Name:Ndufs3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1915599. Ndufs3.

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Matrix and cytoplasmic side of the mitochondrial inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial membrane Source: UniProtKB
    3. mitochondrial respiratory chain complex I Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535MitochondrionBy similarityAdd
    BLAST
    Chaini36 – 263228NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialPRO_0000019999Add
    BLAST

    Proteomic databases

    MaxQBiQ9DCT2.
    PaxDbiQ9DCT2.
    PRIDEiQ9DCT2.

    2D gel databases

    World-2DPAGE0004:Q9DCT2.

    PTM databases

    PhosphoSiteiQ9DCT2.

    Expressioni

    Gene expression databases

    BgeeiQ9DCT2.
    CleanExiMM_NDUFS3.
    GenevestigatoriQ9DCT2.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Interacts with NDUFAF3.By similarity

    Protein-protein interaction databases

    BioGridi212816. 3 interactions.
    DIPiDIP-32378N.
    IntActiQ9DCT2. 6 interactions.
    MINTiMINT-4112498.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCT2.
    SMRiQ9DCT2. Positions 47-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0852.
    GeneTreeiENSGT00390000017480.
    HOGENOMiHOG000009797.
    HOVERGENiHBG000450.
    InParanoidiQ9DCT2.
    KOiK03936.
    OMAiAECLPKY.
    OrthoDBiEOG7R56TC.
    PhylomeDBiQ9DCT2.
    TreeFamiTF314794.

    Family and domain databases

    HAMAPiMF_01357. NDH1_NuoC.
    InterProiIPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]
    ProDomiPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR01961. NuoC_fam. 1 hit.
    PROSITEiPS00542. COMPLEX1_30K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DCT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAARVWC RGLLGAASVG RGAGRPSVLW QHVRRESAAA DKRPTVRPRS    50
    DVTHKQLSAF GEYVAEILPK YVQQVQVSCL DELEICIHPD GVIPTLTFLR 100
    DHTNAQFKSL ADLTAVDVPT RQNRFEIVYN LLSLRFNSRI RVKTYADELT 150
    PIDSIVSVHI AANWYEREVW DMFGVFFFNH PDLRRILTDY GFEGHPFRKD 200
    FPLTGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA FPAYRQPPES 250
    LKLEAGDKKP ETK 263
    Length:263
    Mass (Da):30,149
    Last modified:May 1, 2007 - v2
    Checksum:i482F6C4D5E991B7F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201G → D in BAB22149. (PubMed:16141072)Curated
    Sequence conflicti23 – 231A → P in AAH27270. (PubMed:15489334)Curated
    Sequence conflicti49 – 491R → W in AAH27270. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002501 mRNA. Translation: BAB22149.1.
    AK088337 mRNA. Translation: BAC40291.1.
    AL672241 Genomic DNA. Translation: CAM15313.1.
    BC027270 mRNA. Translation: AAH27270.1.
    BC119267 mRNA. Translation: AAI19268.1.
    BC119269 mRNA. Translation: AAI19270.1.
    CCDSiCCDS16418.1.
    RefSeqiNP_080964.1. NM_026688.2.
    UniGeneiMm.30113.

    Genome annotation databases

    EnsembliENSMUST00000005647; ENSMUSP00000005647; ENSMUSG00000005510.
    GeneIDi68349.
    KEGGimmu:68349.
    UCSCiuc008ktr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002501 mRNA. Translation: BAB22149.1 .
    AK088337 mRNA. Translation: BAC40291.1 .
    AL672241 Genomic DNA. Translation: CAM15313.1 .
    BC027270 mRNA. Translation: AAH27270.1 .
    BC119267 mRNA. Translation: AAI19268.1 .
    BC119269 mRNA. Translation: AAI19270.1 .
    CCDSi CCDS16418.1.
    RefSeqi NP_080964.1. NM_026688.2.
    UniGenei Mm.30113.

    3D structure databases

    ProteinModelPortali Q9DCT2.
    SMRi Q9DCT2. Positions 47-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212816. 3 interactions.
    DIPi DIP-32378N.
    IntActi Q9DCT2. 6 interactions.
    MINTi MINT-4112498.

    PTM databases

    PhosphoSitei Q9DCT2.

    2D gel databases

    World-2DPAGE 0004:Q9DCT2.

    Proteomic databases

    MaxQBi Q9DCT2.
    PaxDbi Q9DCT2.
    PRIDEi Q9DCT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005647 ; ENSMUSP00000005647 ; ENSMUSG00000005510 .
    GeneIDi 68349.
    KEGGi mmu:68349.
    UCSCi uc008ktr.1. mouse.

    Organism-specific databases

    CTDi 4722.
    MGIi MGI:1915599. Ndufs3.

    Phylogenomic databases

    eggNOGi COG0852.
    GeneTreei ENSGT00390000017480.
    HOGENOMi HOG000009797.
    HOVERGENi HBG000450.
    InParanoidi Q9DCT2.
    KOi K03936.
    OMAi AECLPKY.
    OrthoDBi EOG7R56TC.
    PhylomeDBi Q9DCT2.
    TreeFami TF314794.

    Miscellaneous databases

    NextBioi 327045.
    PROi Q9DCT2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCT2.
    CleanExi MM_NDUFS3.
    Genevestigatori Q9DCT2.

    Family and domain databases

    HAMAPi MF_01357. NDH1_NuoC.
    InterProi IPR010218. NADH_DH_suC.
    IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    IPR020396. NADH_UbQ_OxRdtase_CS.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProDomi PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR01961. NuoC_fam. 1 hit.
    PROSITEi PS00542. COMPLEX1_30K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Kidney and Thymus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 109-121; 125-135; 186-198; 200-210 AND 218-245, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiNDUS3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCT2
    Secondary accession number(s): Q8BTZ3, Q8R073
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3