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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

Ndufs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-30kD
Short name:
CI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene namesi
Name:Ndufs3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915599 Ndufs3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000001999936 – 263NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialAdd BLAST228

Proteomic databases

EPDiQ9DCT2
MaxQBiQ9DCT2
PaxDbiQ9DCT2
PeptideAtlasiQ9DCT2
PRIDEiQ9DCT2
TopDownProteomicsiQ9DCT2

2D gel databases

World-2DPAGEi0004:Q9DCT2

PTM databases

iPTMnetiQ9DCT2
PhosphoSitePlusiQ9DCT2
SwissPalmiQ9DCT2

Expressioni

Gene expression databases

BgeeiENSMUSG00000005510
CleanExiMM_NDUFS3
GenevisibleiQ9DCT2 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Interacts with NDUFAF3.By similarity

Protein-protein interaction databases

BioGridi212816, 4 interactors
CORUMiQ9DCT2
DIPiDIP-32378N
IntActiQ9DCT2, 7 interactors
MINTiQ9DCT2
STRINGi10090.ENSMUSP00000005647

Structurei

3D structure databases

ProteinModelPortaliQ9DCT2
SMRiQ9DCT2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1713 Eukaryota
COG0852 LUCA
GeneTreeiENSGT00390000017480
HOGENOMiHOG000009797
HOVERGENiHBG000450
InParanoidiQ9DCT2
KOiK03936
OMAiAECLPKY
OrthoDBiEOG091G0AFP
PhylomeDBiQ9DCT2
TreeFamiTF314794

Family and domain databases

Gene3Di3.30.460.80, 1 hit
HAMAPiMF_01357 NDH1_NuoC, 1 hit
InterProiView protein in InterPro
IPR010218 NADH_DH_suC
IPR037232 NADH_quin_OxRdtase_su_C/D-like
IPR001268 NADH_UbQ_OxRdtase_30kDa_su
IPR020396 NADH_UbQ_OxRdtase_CS
PfamiView protein in Pfam
PF00329 Complex1_30kDa, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581 NADH_UbQ_OxRdtase_30kDa_su, 1 hit
SUPFAMiSSF143243 SSF143243, 1 hit
TIGRFAMsiTIGR01961 NuoC_fam, 1 hit
PROSITEiView protein in PROSITE
PS00542 COMPLEX1_30K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAARVWC RGLLGAASVG RGAGRPSVLW QHVRRESAAA DKRPTVRPRS
60 70 80 90 100
DVTHKQLSAF GEYVAEILPK YVQQVQVSCL DELEICIHPD GVIPTLTFLR
110 120 130 140 150
DHTNAQFKSL ADLTAVDVPT RQNRFEIVYN LLSLRFNSRI RVKTYADELT
160 170 180 190 200
PIDSIVSVHI AANWYEREVW DMFGVFFFNH PDLRRILTDY GFEGHPFRKD
210 220 230 240 250
FPLTGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA FPAYRQPPES
260
LKLEAGDKKP ETK
Length:263
Mass (Da):30,149
Last modified:May 1, 2007 - v2
Checksum:i482F6C4D5E991B7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20G → D in BAB22149 (PubMed:16141072).Curated1
Sequence conflicti23A → P in AAH27270 (PubMed:15489334).Curated1
Sequence conflicti49R → W in AAH27270 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002501 mRNA Translation: BAB22149.1
AK088337 mRNA Translation: BAC40291.1
AL672241 Genomic DNA Translation: CAM15313.1
BC027270 mRNA Translation: AAH27270.1
BC119267 mRNA Translation: AAI19268.1
BC119269 mRNA Translation: AAI19270.1
CCDSiCCDS16418.1
RefSeqiNP_080964.1, NM_026688.2
UniGeneiMm.30113

Genome annotation databases

EnsembliENSMUST00000005647; ENSMUSP00000005647; ENSMUSG00000005510
ENSMUST00000215399; ENSMUSP00000150956; ENSMUSG00000111727
GeneIDi68349
KEGGimmu:68349
UCSCiuc008ktr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUS3_MOUSE
AccessioniPrimary (citable) accession number: Q9DCT2
Secondary accession number(s): Q8BTZ3, Q8R073
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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