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Protein

Trans-2-enoyl-CoA reductase, mitochondrial

Gene

Mecr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis (By similarity).By similarity

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167NADPBy similarity1
Binding sitei368NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 196NADPBy similarity4
Nucleotide bindingi216 – 218NADPBy similarity3
Nucleotide bindingi285 – 288NADPBy similarity4
Nucleotide bindingi310 – 312NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:Mecr
Synonyms:Nrbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1349441. Mecr.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53MitochondrionSequence analysisAdd BLAST53
ChainiPRO_000000088954 – 373Trans-2-enoyl-CoA reductase, mitochondrialAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-acetyllysine; alternateCombined sources1
Modified residuei61N6-succinyllysine; alternateCombined sources1
Modified residuei252N6-acetyllysine; alternateCombined sources1
Modified residuei252N6-succinyllysine; alternateCombined sources1
Modified residuei267N6-acetyllysine; alternateCombined sources1
Modified residuei267N6-succinyllysine; alternateCombined sources1
Modified residuei316N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DCS3.
MaxQBiQ9DCS3.
PaxDbiQ9DCS3.
PeptideAtlasiQ9DCS3.
PRIDEiQ9DCS3.

PTM databases

iPTMnetiQ9DCS3.
PhosphoSitePlusiQ9DCS3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028910.
CleanExiMM_MECR.
ExpressionAtlasiQ9DCS3. baseline and differential.
GenevisibleiQ9DCS3. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DCS3. 2 interactors.
MINTiMINT-4128719.
STRINGi10090.ENSMUSP00000030742.

Structurei

3D structure databases

ProteinModelPortaliQ9DCS3.
SMRiQ9DCS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ9DCS3.
KOiK07512.
OMAiHQLCRAW.
OrthoDBiEOG091G0BAE.
PhylomeDBiQ9DCS3.
TreeFamiTF312886.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSQRVTGA RARAPQLAGL LEAWYRHGRT TSSYSALSEP SRVRALVYGN
60 70 80 90 100
HGDPAKVVQL KNLELTAVEG SDVHVRMLAA PINPSDINMI QGNYGLLPKL
110 120 130 140 150
PAVGGNEGVG QVIAVGSSVS ALKPGDWVIP ANAGLGTWRT EAVFSEEALI
160 170 180 190 200
GIPKDIPLQS AATLGVNPCT AYRMLVDFEQ LQPGDSVIQN ASNSGVGQAV
210 220 230 240 250
IQIASALRLK TINVVRDRPD IKKLTDRLKD LGADYVLTEE ELRMPETKTI
260 270 280 290 300
FKDLPLPRLA LNCVGGKSST ELLRHLAPGG TMVTYGGMAK QPVTASVSLL
310 320 330 340 350
IFKDLKLRGF WLSQWKKNHS PDEFKELILT LCNLIRQGRL TAPSCSEVPL
360 370
QGYQQALEAS MKPFVSSKQI LTM
Length:373
Mass (Da):40,343
Last modified:April 26, 2005 - v2
Checksum:iEBA9A61A46386AEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69E → K in BAB22169 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002533 mRNA. Translation: BAB22169.1.
BC003864 mRNA. Translation: AAH03864.1.
CCDSiCCDS18715.1.
RefSeqiNP_079573.2. NM_025297.2.
UniGeneiMm.192706.

Genome annotation databases

EnsembliENSMUST00000030742; ENSMUSP00000030742; ENSMUSG00000028910.
GeneIDi26922.
KEGGimmu:26922.
UCSCiuc008vae.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002533 mRNA. Translation: BAB22169.1.
BC003864 mRNA. Translation: AAH03864.1.
CCDSiCCDS18715.1.
RefSeqiNP_079573.2. NM_025297.2.
UniGeneiMm.192706.

3D structure databases

ProteinModelPortaliQ9DCS3.
SMRiQ9DCS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DCS3. 2 interactors.
MINTiMINT-4128719.
STRINGi10090.ENSMUSP00000030742.

PTM databases

iPTMnetiQ9DCS3.
PhosphoSitePlusiQ9DCS3.

Proteomic databases

EPDiQ9DCS3.
MaxQBiQ9DCS3.
PaxDbiQ9DCS3.
PeptideAtlasiQ9DCS3.
PRIDEiQ9DCS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030742; ENSMUSP00000030742; ENSMUSG00000028910.
GeneIDi26922.
KEGGimmu:26922.
UCSCiuc008vae.2. mouse.

Organism-specific databases

CTDi51102.
MGIiMGI:1349441. Mecr.

Phylogenomic databases

eggNOGiKOG0025. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294683.
HOVERGENiHBG052446.
InParanoidiQ9DCS3.
KOiK07512.
OMAiHQLCRAW.
OrthoDBiEOG091G0BAE.
PhylomeDBiQ9DCS3.
TreeFamiTF312886.

Miscellaneous databases

PROiQ9DCS3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028910.
CleanExiMM_MECR.
ExpressionAtlasiQ9DCS3. baseline and differential.
GenevisibleiQ9DCS3. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMECR_MOUSE
AccessioniPrimary (citable) accession number: Q9DCS3
Secondary accession number(s): Q99L39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.