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Protein

EP300-interacting inhibitor of differentiation 1

Gene

Eid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.1 Publication

GO - Molecular functioni

  • histone acetyltransferase binding Source: UniProtKB
  • histone acetyltransferase regulator activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 1
Alternative name(s):
CREBBP/EP300 inhibitory protein 1
E1A-like inhibitor of differentiation 1
Short name:
EID-1
Gene namesi
Name:Eid1Imported
Synonyms:Cri1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1889651. Eid1.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: May shuttle between nucleus and cytoplasm.1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169EP300-interacting inhibitor of differentiation 1PRO_0000289157Add
BLAST

Proteomic databases

MaxQBiQ9DCR4.
PaxDbiQ9DCR4.
PRIDEiQ9DCR4.

PTM databases

iPTMnetiQ9DCR4.
PhosphoSiteiQ9DCR4.

Expressioni

Tissue specificityi

Expressed in all adult tissues examined and during embryogenesis.1 Publication

Gene expression databases

BgeeiQ9DCR4.
CleanExiMM_EID1.
GenevisibleiQ9DCR4. MM.

Interactioni

Subunit structurei

Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208425. 3 interactions.
IntActiQ9DCR4. 1 interaction.
STRINGi10090.ENSMUSP00000129413.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi94 – 1018Combined sources
Helixi102 – 1054Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NUFX-ray2.80P91-106[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 12067Interaction with NR0B21 PublicationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi150 – 1545LXCXE motif

Phylogenomic databases

eggNOGiENOG410J09N. Eukaryota.
ENOG41118MI. LUCA.
GeneTreeiENSGT00500000045230.
HOGENOMiHOG000054219.
HOVERGENiHBG107840.
InParanoidiQ9DCR4.
OMAiMAEPQGE.
OrthoDBiEOG7SXW53.
PhylomeDBiQ9DCR4.
TreeFamiTF337633.

Family and domain databases

InterProiIPR033258. EID.
IPR033255. EID-1.
[Graphical view]
PANTHERiPTHR15556. PTHR15556. 1 hit.
PTHR15556:SF5. PTHR15556:SF5. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9DCR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEMAELCEL YEESNELQMD VLPGEGYMEV GRGARGPAPE EGPMEEEAGP
60 70 80 90 100
AAARAQRGLF PEAGADLEGD EFDDWEDDYE FPEEERWSGA MHRVSAALEE
110 120 130 140 150
ANKVFLRTAR AGDALDGGFQ ARCEKSPFDQ LAFIEELFSL MVVNRLTEEL
160
GCDEIIDREL MLTREEETT
Note: No experimental confirmation available.Curated
Length:169
Mass (Da):18,921
Last modified:May 29, 2007 - v2
Checksum:iDA9C99F5509073E8
GO
Isoform 21 Publication (identifier: Q9DCR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-169: Missing.

Show »
Length:159
Mass (Da):17,716
Checksum:iD67B10F8A95E8F34
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131E → K in BAB30797 (PubMed:16141072).Curated
Sequence conflicti36 – 361G → W in BAB22187 (PubMed:16141072).Curated
Sequence conflicti37 – 371P → Q in BAC37261 (PubMed:16141072).Curated
Sequence conflicti160 – 1601L → S in BAB30797 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei160 – 16910Missing in isoform 2. 2 PublicationsVSP_052455

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509968 mRNA. Translation: AAM34760.1.
AK002559 mRNA. Translation: BAB22187.1.
AK005258 mRNA. Translation: BAB23911.1.
AK011293 mRNA. Translation: BAB27521.1.
AK014440 mRNA. Translation: BAB29352.1.
AK017543 mRNA. Translation: BAB30797.1.
AK077783 mRNA. Translation: BAC37007.1.
AK078402 mRNA. Translation: BAC37257.1.
AK078409 mRNA. Translation: BAC37261.1.
AK078826 mRNA. Translation: BAC37412.1.
AK148555 mRNA. Translation: BAE28618.1.
AK169604 mRNA. Translation: BAE41254.1.
AK172612 mRNA. Translation: BAE43093.1.
AL929166 Genomic DNA. Translation: CAM20858.1.
CCDSiCCDS50696.1. [Q9DCR4-2]
RefSeqiNP_079889.2. NM_025613.3. [Q9DCR4-2]
UniGeneiMm.425101.
Mm.490315.

Genome annotation databases

EnsembliENSMUST00000164756; ENSMUSP00000129413; ENSMUSG00000091337. [Q9DCR4-2]
GeneIDi58521.
KEGGimmu:58521.
UCSCiuc008mcx.1. mouse. [Q9DCR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509968 mRNA. Translation: AAM34760.1.
AK002559 mRNA. Translation: BAB22187.1.
AK005258 mRNA. Translation: BAB23911.1.
AK011293 mRNA. Translation: BAB27521.1.
AK014440 mRNA. Translation: BAB29352.1.
AK017543 mRNA. Translation: BAB30797.1.
AK077783 mRNA. Translation: BAC37007.1.
AK078402 mRNA. Translation: BAC37257.1.
AK078409 mRNA. Translation: BAC37261.1.
AK078826 mRNA. Translation: BAC37412.1.
AK148555 mRNA. Translation: BAE28618.1.
AK169604 mRNA. Translation: BAE41254.1.
AK172612 mRNA. Translation: BAE43093.1.
AL929166 Genomic DNA. Translation: CAM20858.1.
CCDSiCCDS50696.1. [Q9DCR4-2]
RefSeqiNP_079889.2. NM_025613.3. [Q9DCR4-2]
UniGeneiMm.425101.
Mm.490315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NUFX-ray2.80P91-106[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208425. 3 interactions.
IntActiQ9DCR4. 1 interaction.
STRINGi10090.ENSMUSP00000129413.

PTM databases

iPTMnetiQ9DCR4.
PhosphoSiteiQ9DCR4.

Proteomic databases

MaxQBiQ9DCR4.
PaxDbiQ9DCR4.
PRIDEiQ9DCR4.

Protocols and materials databases

DNASUi58521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164756; ENSMUSP00000129413; ENSMUSG00000091337. [Q9DCR4-2]
GeneIDi58521.
KEGGimmu:58521.
UCSCiuc008mcx.1. mouse. [Q9DCR4-1]

Organism-specific databases

CTDi23741.
MGIiMGI:1889651. Eid1.

Phylogenomic databases

eggNOGiENOG410J09N. Eukaryota.
ENOG41118MI. LUCA.
GeneTreeiENSGT00500000045230.
HOGENOMiHOG000054219.
HOVERGENiHBG107840.
InParanoidiQ9DCR4.
OMAiMAEPQGE.
OrthoDBiEOG7SXW53.
PhylomeDBiQ9DCR4.
TreeFamiTF337633.

Miscellaneous databases

NextBioi314334.
PROiQ9DCR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCR4.
CleanExiMM_EID1.
GenevisibleiQ9DCR4. MM.

Family and domain databases

InterProiIPR033258. EID.
IPR033255. EID-1.
[Graphical view]
PANTHERiPTHR15556. PTHR15556. 1 hit.
PTHR15556:SF5. PTHR15556:SF5. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP."
    Bavner A., Johansson L., Toresson G., Gustafsson J.-A., Treuter E.
    EMBO Rep. 3:478-484(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH NR0B2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Swiss Webster / NIHImported.
    Tissue: EmbryoImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported and NODImported.
    Tissue: CerebellumImported, EmbryoImported, Embryonic lungImported, KidneyImported, SpleenImported, Sympathetic ganglionImported, ThymusImported and Wolffian ductImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
    Strain: C57BL/6J.

Entry informationi

Entry nameiEID1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCR4
Secondary accession number(s): Q3T9D1
, Q8BP25, Q9CQ17, Q9CYM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 11, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.