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Protein

EP300-interacting inhibitor of differentiation 1

Gene

Eid1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.1 Publication

Miscellaneous

Inhibition of MYOD1 may be partly due to the ability of EID1 to bind and inhibit EP300 histone acetyltransferase activity.By similarity

GO - Molecular functioni

  • histone acetyltransferase binding Source: UniProtKB
  • histone acetyltransferase regulator activity Source: UniProtKB
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processCell cycle, Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
EP300-interacting inhibitor of differentiation 1
Alternative name(s):
CREBBP/EP300 inhibitory protein 1
E1A-like inhibitor of differentiation 1
Short name:
EID-1
Gene namesi
Name:Eid1Imported
Synonyms:Cri1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1889651 Eid1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002891571 – 169EP300-interacting inhibitor of differentiation 1Add BLAST169

Proteomic databases

PaxDbiQ9DCR4
PRIDEiQ9DCR4

PTM databases

iPTMnetiQ9DCR4
PhosphoSitePlusiQ9DCR4

Expressioni

Tissue specificityi

Expressed in all adult tissues examined and during embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000091337
CleanExiMM_EID1
GenevisibleiQ9DCR4 MM

Interactioni

Subunit structurei

Interacts via its LXCXE motif with the entire pocket region of RB1. Interacts with EP300, NR0B2 and TRIM27.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208425, 3 interactors
IntActiQ9DCR4, 1 interactor
STRINGi10090.ENSMUSP00000129413

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi94 – 101Combined sources8
Helixi102 – 105Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NUFX-ray2.80P91-106[»]
SMRiQ9DCR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 120Interaction with NR0B21 PublicationAdd BLAST67

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi150 – 154LXCXE motif5

Phylogenomic databases

eggNOGiENOG410J09N Eukaryota
ENOG41118MI LUCA
GeneTreeiENSGT00500000045230
HOGENOMiHOG000054219
HOVERGENiHBG107840
InParanoidiQ9DCR4
OMAiMAEPQGE
OrthoDBiEOG091G0YVS
PhylomeDBiQ9DCR4
TreeFamiTF337633

Family and domain databases

InterProiView protein in InterPro
IPR033258 EID
IPR033255 EID-1
PANTHERiPTHR15556 PTHR15556, 1 hit
PTHR15556:SF5 PTHR15556:SF5, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9DCR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEMAELCEL YEESNELQMD VLPGEGYMEV GRGARGPAPE EGPMEEEAGP
60 70 80 90 100
AAARAQRGLF PEAGADLEGD EFDDWEDDYE FPEEERWSGA MHRVSAALEE
110 120 130 140 150
ANKVFLRTAR AGDALDGGFQ ARCEKSPFDQ LAFIEELFSL MVVNRLTEEL
160
GCDEIIDREL MLTREEETT
Note: No experimental confirmation available.Curated
Length:169
Mass (Da):18,921
Last modified:May 29, 2007 - v2
Checksum:iDA9C99F5509073E8
GO
Isoform 21 Publication (identifier: Q9DCR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     160-169: Missing.

Show »
Length:159
Mass (Da):17,716
Checksum:iD67B10F8A95E8F34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13E → K in BAB30797 (PubMed:16141072).Curated1
Sequence conflicti36G → W in BAB22187 (PubMed:16141072).Curated1
Sequence conflicti37P → Q in BAC37261 (PubMed:16141072).Curated1
Sequence conflicti160L → S in BAB30797 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052455160 – 169Missing in isoform 2. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509968 mRNA Translation: AAM34760.1
AK002559 mRNA Translation: BAB22187.1
AK005258 mRNA Translation: BAB23911.1
AK011293 mRNA Translation: BAB27521.1
AK014440 mRNA Translation: BAB29352.1
AK017543 mRNA Translation: BAB30797.1
AK077783 mRNA Translation: BAC37007.1
AK078402 mRNA Translation: BAC37257.1
AK078409 mRNA Translation: BAC37261.1
AK078826 mRNA Translation: BAC37412.1
AK148555 mRNA Translation: BAE28618.1
AK169604 mRNA Translation: BAE41254.1
AK172612 mRNA Translation: BAE43093.1
AL929166 Genomic DNA No translation available.
CCDSiCCDS50696.1 [Q9DCR4-2]
RefSeqiNP_079889.2, NM_025613.3 [Q9DCR4-2]
UniGeneiMm.425101
Mm.490315

Genome annotation databases

EnsembliENSMUST00000164756; ENSMUSP00000129413; ENSMUSG00000091337 [Q9DCR4-2]
GeneIDi58521
KEGGimmu:58521
UCSCiuc008mcx.1 mouse [Q9DCR4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEID1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCR4
Secondary accession number(s): Q3T9D1
, Q8BP25, Q9CQ17, Q9CYM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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