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Protein

AP-3 complex subunit sigma-1

Gene

Ap3s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.1 Publication

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • intracellular protein transport Source: MGI
  • vesicle-mediated transport Source: MGI

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma-1
Alternative name(s):
AP-3 complex subunit sigma-3A
Adaptor-related protein complex 3 subunit sigma-1
Sigma-3A-adaptin
Short name:
Sigma3A-adaptin
Sigma-adaptin 3a
Gene namesi
Name:Ap3s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1337062 Ap3s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938161 – 193AP-3 complex subunit sigma-1Add BLAST193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DCR2
MaxQBiQ9DCR2
PaxDbiQ9DCR2
PRIDEiQ9DCR2

PTM databases

iPTMnetiQ9DCR2
PhosphoSitePlusiQ9DCR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000024480
ExpressionAtlasiQ9DCR2 baseline and differential
GenevisibleiQ9DCR2 MM

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2) (By similarity). AP-3 associates with the BLOC-1 complex. Interacts with AGAP1.By similarity1 Publication

Protein-protein interaction databases

BioGridi198135, 1 interactor
IntActiQ9DCR2, 2 interactors
MINTiQ9DCR2
STRINGi10090.ENSMUSP00000025357

Structurei

3D structure databases

ProteinModelPortaliQ9DCR2
SMRiQ9DCR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0936 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00550000074761
HOGENOMiHOG000185228
HOVERGENiHBG050517
InParanoidiQ9DCR2
KOiK12399
OMAiVDAQNKM
OrthoDBiEOG091G0QZV
PhylomeDBiQ9DCR2
TreeFamiTF300189

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL
60 70 80 90 100
EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS
160 170 180 190
EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
Length:193
Mass (Da):21,732
Last modified:July 19, 2003 - v2
Checksum:i1EF17F375881288D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → P in BAB22191 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF084575 mRNA Translation: AAC72819.1
AK002565 mRNA Translation: BAB22191.1
BC012656 mRNA Translation: AAH12656.1
CCDSiCCDS29236.1
RefSeqiNP_033811.1, NM_009681.5
UniGeneiMm.312536

Genome annotation databases

EnsembliENSMUST00000025357; ENSMUSP00000025357; ENSMUSG00000024480
GeneIDi11777
KEGGimmu:11777
UCSCiuc008evv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAP3S1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCR2
Secondary accession number(s): O88670
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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