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Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. WW domain binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Proline-rich protein expressed in brain
Gene namesi
Name:Dazap2
Synonyms:Prtb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1344344. Dazap2.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Nucleus By similarity

  3. Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168DAZ-associated protein 2PRO_0000079789Add
BLAST

Post-translational modificationi

Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9DCP9.

PTM databases

PhosphoSiteiQ9DCP9.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain.2 Publications

Developmental stagei

Between E11.5 and E12.5 it is specifically expressed in the developing heart. From E13.5, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes.1 Publication

Inductioni

By serum stimulation.1 Publication

Gene expression databases

BgeeiQ9DCP9.
CleanExiMM_DAZAP2.
GenevestigatoriQ9DCP9.

Interactioni

Subunit structurei

Interacts with DAZ and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity). Interacts with SOX6.By similarity1 Publication

Protein-protein interaction databases

BioGridi204844. 3 interactions.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 134127Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiQ9DCP9.
OMAiAYSEIYQ.
OrthoDBiEOG77HDG0.
PhylomeDBiQ9DCP9.
TreeFamiTF329672.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF
60 70 80 90 100
VHPGAATVPT MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP
110 120 130 140 150
GSAVLVEGGY DAGARFGAGA TAGNIPPPPP GCPPNAAQLA VMQGANVLVT
160
QRKGNFFMGG SDGGYTIW
Length:168
Mass (Da):17,289
Last modified:June 1, 2001 - v1
Checksum:i49EDDAA29D8E3AAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621D → N in AAC34594 (PubMed:10373015).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085348 mRNA. Translation: AAC34594.1.
AK002595 mRNA. Translation: BAB22216.1.
AK050159 mRNA. Translation: BAC34100.1.
AK088916 mRNA. Translation: BAC40651.1.
AK132139 mRNA. Translation: BAE20995.1.
AK137246 mRNA. Translation: BAE23285.1.
AK146970 mRNA. Translation: BAE27575.1.
BC014808 mRNA. Translation: AAH14808.1.
BC083347 mRNA. Translation: AAH83347.1.
CCDSiCCDS27841.1.
RefSeqiNP_036003.2. NM_011873.2.
UniGeneiMm.486175.

Genome annotation databases

EnsembliENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346.
GeneIDi23994.
KEGGimmu:23994.
UCSCiuc007xrt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085348 mRNA. Translation: AAC34594.1.
AK002595 mRNA. Translation: BAB22216.1.
AK050159 mRNA. Translation: BAC34100.1.
AK088916 mRNA. Translation: BAC40651.1.
AK132139 mRNA. Translation: BAE20995.1.
AK137246 mRNA. Translation: BAE23285.1.
AK146970 mRNA. Translation: BAE27575.1.
BC014808 mRNA. Translation: AAH14808.1.
BC083347 mRNA. Translation: AAH83347.1.
CCDSiCCDS27841.1.
RefSeqiNP_036003.2. NM_011873.2.
UniGeneiMm.486175.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204844. 3 interactions.

PTM databases

PhosphoSiteiQ9DCP9.

Proteomic databases

PRIDEiQ9DCP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346.
GeneIDi23994.
KEGGimmu:23994.
UCSCiuc007xrt.1. mouse.

Organism-specific databases

CTDi9802.
MGIiMGI:1344344. Dazap2.

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiQ9DCP9.
OMAiAYSEIYQ.
OrthoDBiEOG77HDG0.
PhylomeDBiQ9DCP9.
TreeFamiTF329672.

Miscellaneous databases

ChiTaRSiDazap2. mouse.
NextBioi303905.
PROiQ9DCP9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCP9.
CleanExiMM_DAZAP2.
GenevestigatoriQ9DCP9.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain."
    Yang W., Mansour S.L.
    Dev. Dyn. 215:108-116(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Heart, Kidney, Liver, Thymus and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  4. "Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion."
    Sommerfeldt D.W., Zhi J., Rubin C.T., Hadjiargyrou M.
    J. Cell. Biochem. 84:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: TISSUE SPECIFICITY, INTERACTION WITH SOX6.

Entry informationi

Entry nameiDAZP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP9
Secondary accession number(s): O88675, Q3UVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.