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Q9DCP9

- DAZP2_MOUSE

UniProt

Q9DCP9 - DAZP2_MOUSE

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Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Proline-rich protein expressed in brain
Gene namesi
Name:Dazap2
Synonyms:Prtb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1344344. Dazap2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168DAZ-associated protein 2PRO_0000079789Add
BLAST

Post-translational modificationi

Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ9DCP9.

PTM databases

PhosphoSiteiQ9DCP9.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in brain.2 Publications

Developmental stagei

Between E11.5 and E12.5 it is specifically expressed in the developing heart. From E13.5, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes.1 Publication

Inductioni

By serum stimulation.1 Publication

Gene expression databases

BgeeiQ9DCP9.
CleanExiMM_DAZAP2.
GenevestigatoriQ9DCP9.

Interactioni

Subunit structurei

Interacts with DAZ and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity). Interacts with SOX6.By similarity1 Publication

Protein-protein interaction databases

BioGridi204844. 3 interactions.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 134127Pro-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG43279.
GeneTreeiENSGT00390000000685.
HOGENOMiHOG000007683.
HOVERGENiHBG051300.
InParanoidiQ9DCP9.
OMAiMNNKGSY.
OrthoDBiEOG77HDG0.
PhylomeDBiQ9DCP9.
TreeFamiTF329672.

Family and domain databases

InterProiIPR022730. DAZ_assoc-2.
[Graphical view]
PfamiPF11029. DAZAP2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCP9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF
60 70 80 90 100
VHPGAATVPT MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP
110 120 130 140 150
GSAVLVEGGY DAGARFGAGA TAGNIPPPPP GCPPNAAQLA VMQGANVLVT
160
QRKGNFFMGG SDGGYTIW
Length:168
Mass (Da):17,289
Last modified:June 1, 2001 - v1
Checksum:i49EDDAA29D8E3AAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621D → N in AAC34594. (PubMed:10373015)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085348 mRNA. Translation: AAC34594.1.
AK002595 mRNA. Translation: BAB22216.1.
AK050159 mRNA. Translation: BAC34100.1.
AK088916 mRNA. Translation: BAC40651.1.
AK132139 mRNA. Translation: BAE20995.1.
AK137246 mRNA. Translation: BAE23285.1.
AK146970 mRNA. Translation: BAE27575.1.
BC014808 mRNA. Translation: AAH14808.1.
BC083347 mRNA. Translation: AAH83347.1.
CCDSiCCDS27841.1.
RefSeqiNP_036003.2. NM_011873.2.
UniGeneiMm.486175.

Genome annotation databases

EnsembliENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346.
GeneIDi23994.
KEGGimmu:23994.
UCSCiuc007xrt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085348 mRNA. Translation: AAC34594.1 .
AK002595 mRNA. Translation: BAB22216.1 .
AK050159 mRNA. Translation: BAC34100.1 .
AK088916 mRNA. Translation: BAC40651.1 .
AK132139 mRNA. Translation: BAE20995.1 .
AK137246 mRNA. Translation: BAE23285.1 .
AK146970 mRNA. Translation: BAE27575.1 .
BC014808 mRNA. Translation: AAH14808.1 .
BC083347 mRNA. Translation: AAH83347.1 .
CCDSi CCDS27841.1.
RefSeqi NP_036003.2. NM_011873.2.
UniGenei Mm.486175.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204844. 3 interactions.

PTM databases

PhosphoSitei Q9DCP9.

Proteomic databases

PRIDEi Q9DCP9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000356 ; ENSMUSP00000000356 ; ENSMUSG00000000346 .
GeneIDi 23994.
KEGGi mmu:23994.
UCSCi uc007xrt.1. mouse.

Organism-specific databases

CTDi 9802.
MGIi MGI:1344344. Dazap2.

Phylogenomic databases

eggNOGi NOG43279.
GeneTreei ENSGT00390000000685.
HOGENOMi HOG000007683.
HOVERGENi HBG051300.
InParanoidi Q9DCP9.
OMAi MNNKGSY.
OrthoDBi EOG77HDG0.
PhylomeDBi Q9DCP9.
TreeFami TF329672.

Miscellaneous databases

ChiTaRSi DAZAP2. mouse.
NextBioi 303905.
PROi Q9DCP9.
SOURCEi Search...

Gene expression databases

Bgeei Q9DCP9.
CleanExi MM_DAZAP2.
Genevestigatori Q9DCP9.

Family and domain databases

InterProi IPR022730. DAZ_assoc-2.
[Graphical view ]
Pfami PF11029. DAZAP2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain."
    Yang W., Mansour S.L.
    Dev. Dyn. 215:108-116(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Head, Heart, Kidney, Liver, Thymus and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Eye.
  4. "Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion."
    Sommerfeldt D.W., Zhi J., Rubin C.T., Hadjiargyrou M.
    J. Cell. Biochem. 84:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  5. Cited for: TISSUE SPECIFICITY, INTERACTION WITH SOX6.

Entry informationi

Entry nameiDAZP2_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP9
Secondary accession number(s): O88675, Q3UVI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3