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Q9DCP9 (DAZP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DAZ-associated protein 2
Alternative name(s):
Deleted in azoospermia-associated protein 2
Proline-rich protein expressed in brain
Gene names
Name:Dazap2
Synonyms:Prtb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length168 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with DAZ and DAZL By similarity. Interacts with IL17RB By similarity. May interact with FAM168B By similarity. Interacts with SOX6. Ref.5

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm By similarity.

Tissue specificity

Widely expressed. Highly expressed in brain. Ref.1 Ref.5

Developmental stage

Between E11.5 and E12.5 it is specifically expressed in the developing heart. From E13.5, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes. Ref.1

Induction

By serum stimulation. Ref.4

Post-translational modification

Ubiquitinated by SMURF2, leading to proteasomal degradation By similarity.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred by curator Ref.5. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 168168DAZ-associated protein 2
PRO_0000079789

Regions

Compositional bias8 – 134127Pro-rich

Experimental info

Sequence conflict1621D → N in AAC34594. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9DCP9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 49EDDAA29D8E3AAC

FASTA16817,289
        10         20         30         40         50         60 
MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF VHPGAATVPT 

        70         80         90        100        110        120 
MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP GSAVLVEGGY DAGARFGAGA 

       130        140        150        160 
TAGNIPPPPP GCPPNAAQLA VMQGANVLVT QRKGNFFMGG SDGGYTIW 

« Hide

References

« Hide 'large scale' references
[1]"Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain."
Yang W., Mansour S.L.
Dev. Dyn. 215:108-116(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: CD-1.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Head, Heart, Kidney, Liver, Thymus and Urinary bladder.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain and Eye.
[4]"Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion."
Sommerfeldt D.W., Zhi J., Rubin C.T., Hadjiargyrou M.
J. Cell. Biochem. 84:301-308(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[5]"Sox6 regulation of cardiac myocyte development."
Cohen-Barak O., Yi Z., Hagiwara N., Monzen K., Komuro I., Brilliant M.H.
Nucleic Acids Res. 31:5941-5948(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH SOX6.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF085348 mRNA. Translation: AAC34594.1.
AK002595 mRNA. Translation: BAB22216.1.
AK050159 mRNA. Translation: BAC34100.1.
AK088916 mRNA. Translation: BAC40651.1.
AK132139 mRNA. Translation: BAE20995.1.
AK137246 mRNA. Translation: BAE23285.1.
AK146970 mRNA. Translation: BAE27575.1.
BC014808 mRNA. Translation: AAH14808.1.
BC083347 mRNA. Translation: AAH83347.1.
RefSeqNP_036003.2. NM_011873.2.
UniGeneMm.486175.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204844. 3 interactions.

PTM databases

PhosphoSiteQ9DCP9.

Proteomic databases

PRIDEQ9DCP9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346.
GeneID23994.
KEGGmmu:23994.
UCSCuc007xrt.1. mouse.

Organism-specific databases

CTD9802.
MGIMGI:1344344. Dazap2.

Phylogenomic databases

eggNOGNOG43279.
GeneTreeENSGT00390000000685.
HOGENOMHOG000007683.
HOVERGENHBG051300.
InParanoidQ9DCP9.
OMAMNNKGSY.
OrthoDBEOG77HDG0.
PhylomeDBQ9DCP9.
TreeFamTF329672.

Gene expression databases

BgeeQ9DCP9.
CleanExMM_DAZAP2.
GenevestigatorQ9DCP9.

Family and domain databases

InterProIPR022730. DAZ_assoc-2.
[Graphical view]
PfamPF11029. DAZAP2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDAZAP2. mouse.
NextBio303905.
PROQ9DCP9.
SOURCESearch...

Entry information

Entry nameDAZP2_MOUSE
AccessionPrimary (citable) accession number: Q9DCP9
Secondary accession number(s): O88675, Q3UVI4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot