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Q9DCP9

- DAZP2_MOUSE

UniProt

Q9DCP9 - DAZP2_MOUSE

Protein

DAZ-associated protein 2

Gene

Dazap2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DAZ-associated protein 2
    Alternative name(s):
    Deleted in azoospermia-associated protein 2
    Proline-rich protein expressed in brain
    Gene namesi
    Name:Dazap2
    Synonyms:Prtb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1344344. Dazap2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168DAZ-associated protein 2PRO_0000079789Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by SMURF2, leading to proteasomal degradation.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ9DCP9.

    PTM databases

    PhosphoSiteiQ9DCP9.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in brain.2 Publications

    Developmental stagei

    Between E11.5 and E12.5 it is specifically expressed in the developing heart. From E13.5, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes.1 Publication

    Inductioni

    By serum stimulation.1 Publication

    Gene expression databases

    BgeeiQ9DCP9.
    CleanExiMM_DAZAP2.
    GenevestigatoriQ9DCP9.

    Interactioni

    Subunit structurei

    Interacts with DAZ and DAZL By similarity. Interacts with IL17RB By similarity. May interact with FAM168B By similarity. Interacts with SOX6.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi204844. 3 interactions.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 134127Pro-richAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG43279.
    GeneTreeiENSGT00390000000685.
    HOGENOMiHOG000007683.
    HOVERGENiHBG051300.
    InParanoidiQ9DCP9.
    OMAiMNNKGSY.
    OrthoDBiEOG77HDG0.
    PhylomeDBiQ9DCP9.
    TreeFamiTF329672.

    Family and domain databases

    InterProiIPR022730. DAZ_assoc-2.
    [Graphical view]
    PfamiPF11029. DAZAP2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DCP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSKGQYPTQ PTYPVQPPGN PVYPQTLHLP QAPPYTDAPP AYSELYRPSF    50
    VHPGAATVPT MSAAFPGASL YLPMAQSVAV GPLGSTIPMA YYPVGPIYPP 100
    GSAVLVEGGY DAGARFGAGA TAGNIPPPPP GCPPNAAQLA VMQGANVLVT 150
    QRKGNFFMGG SDGGYTIW 168
    Length:168
    Mass (Da):17,289
    Last modified:June 1, 2001 - v1
    Checksum:i49EDDAA29D8E3AAC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti162 – 1621D → N in AAC34594. (PubMed:10373015)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085348 mRNA. Translation: AAC34594.1.
    AK002595 mRNA. Translation: BAB22216.1.
    AK050159 mRNA. Translation: BAC34100.1.
    AK088916 mRNA. Translation: BAC40651.1.
    AK132139 mRNA. Translation: BAE20995.1.
    AK137246 mRNA. Translation: BAE23285.1.
    AK146970 mRNA. Translation: BAE27575.1.
    BC014808 mRNA. Translation: AAH14808.1.
    BC083347 mRNA. Translation: AAH83347.1.
    CCDSiCCDS27841.1.
    RefSeqiNP_036003.2. NM_011873.2.
    UniGeneiMm.486175.

    Genome annotation databases

    EnsembliENSMUST00000000356; ENSMUSP00000000356; ENSMUSG00000000346.
    GeneIDi23994.
    KEGGimmu:23994.
    UCSCiuc007xrt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085348 mRNA. Translation: AAC34594.1 .
    AK002595 mRNA. Translation: BAB22216.1 .
    AK050159 mRNA. Translation: BAC34100.1 .
    AK088916 mRNA. Translation: BAC40651.1 .
    AK132139 mRNA. Translation: BAE20995.1 .
    AK137246 mRNA. Translation: BAE23285.1 .
    AK146970 mRNA. Translation: BAE27575.1 .
    BC014808 mRNA. Translation: AAH14808.1 .
    BC083347 mRNA. Translation: AAH83347.1 .
    CCDSi CCDS27841.1.
    RefSeqi NP_036003.2. NM_011873.2.
    UniGenei Mm.486175.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204844. 3 interactions.

    PTM databases

    PhosphoSitei Q9DCP9.

    Proteomic databases

    PRIDEi Q9DCP9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000356 ; ENSMUSP00000000356 ; ENSMUSG00000000346 .
    GeneIDi 23994.
    KEGGi mmu:23994.
    UCSCi uc007xrt.1. mouse.

    Organism-specific databases

    CTDi 9802.
    MGIi MGI:1344344. Dazap2.

    Phylogenomic databases

    eggNOGi NOG43279.
    GeneTreei ENSGT00390000000685.
    HOGENOMi HOG000007683.
    HOVERGENi HBG051300.
    InParanoidi Q9DCP9.
    OMAi MNNKGSY.
    OrthoDBi EOG77HDG0.
    PhylomeDBi Q9DCP9.
    TreeFami TF329672.

    Miscellaneous databases

    ChiTaRSi DAZAP2. mouse.
    NextBioi 303905.
    PROi Q9DCP9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCP9.
    CleanExi MM_DAZAP2.
    Genevestigatori Q9DCP9.

    Family and domain databases

    InterProi IPR022730. DAZ_assoc-2.
    [Graphical view ]
    Pfami PF11029. DAZAP2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and genetic analysis of prtb, a gene that encodes a highly conserved proline-rich protein expressed in the brain."
      Yang W., Mansour S.L.
      Dev. Dyn. 215:108-116(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: CD-1.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head, Heart, Kidney, Liver, Thymus and Urinary bladder.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    4. "Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion."
      Sommerfeldt D.W., Zhi J., Rubin C.T., Hadjiargyrou M.
      J. Cell. Biochem. 84:301-308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    5. Cited for: TISSUE SPECIFICITY, INTERACTION WITH SOX6.

    Entry informationi

    Entry nameiDAZP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCP9
    Secondary accession number(s): O88675, Q3UVI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3