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Q9DCP2

- S38A3_MOUSE

UniProt

Q9DCP2 - S38A3_MOUSE

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Protein
Sodium-coupled neutral amino acid transporter 3
Gene
Slc38a3, Sn1, Snat3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

  1. L-asparagine transmembrane transporter activity Source: Ensembl
  2. L-glutamine transmembrane transporter activity Source: MGI
  3. L-histidine transmembrane transporter activity Source: MGI
  4. antiporter activity Source: UniProtKB-KW
  5. symporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. glutamine transport Source: MGI
  2. histidine transport Source: MGI
  3. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
Short name:
mNAT
System N amino acid transporter 1
Gene namesi
Name:Slc38a3
Synonyms:Sn1, Snat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1923507. Slc38a3.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Transmembranei105 – 12521Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei212 – 23221Helical; Reviewed prediction
Add
BLAST
Transmembranei288 – 30821Helical; Reviewed prediction
Add
BLAST
Transmembranei325 – 34521Helical; Reviewed prediction
Add
BLAST
Transmembranei367 – 38721Helical; Reviewed prediction
Add
BLAST
Transmembranei409 – 42921Helical; Reviewed prediction
Add
BLAST
Transmembranei432 – 45221Helical; Reviewed prediction
Add
BLAST
Transmembranei472 – 49221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Sodium-coupled neutral amino acid transporter 3
PRO_0000093829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi247 – 2471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi251 – 2511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi324 – 3241N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DCP2.
PaxDbiQ9DCP2.
PRIDEiQ9DCP2.

PTM databases

PhosphoSiteiQ9DCP2.

Expressioni

Tissue specificityi

Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis.1 Publication

Gene expression databases

BgeeiQ9DCP2.
CleanExiMM_SLC38A3.
GenevestigatoriQ9DCP2.

Interactioni

Protein-protein interaction databases

BioGridi218051. 1 interaction.
IntActiQ9DCP2. 2 interactions.
MINTiMINT-1837264.
STRINGi10090.ENSMUSP00000010208.

Structurei

3D structure databases

ProteinModelPortaliQ9DCP2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00650000093166.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9DCP2.
KOiK13576.
OMAiIGHSATH.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ9DCP2.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCP2-1 [UniParc]FASTAAdd to Basket

« Hide

MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK    50
SPSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF 100
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL 150
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP ASVWYMDGNY LVILVSVTII 200
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLANATG 250
NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC 300
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE 350
SELLHTYSKV DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN 400
QEFSWLRHVL IATGLLTCIN LLVIFAPNIL GIFGIIGATS APCLIFIFPA 450
IFYFRIMPTD KEPARSTPKI LALCFAAVGF LLMTMSLSFI IIDWVSGTSQ 500
HGGNH 505
Length:505
Mass (Da):55,592
Last modified:June 1, 2001 - v1
Checksum:i368DBB87F1BB248A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101S → N in BAC28963. 1 Publication
Sequence conflicti130 – 1301Q → R in BAC28963. 1 Publication
Sequence conflicti270 – 2701T → A in AAF61849. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159856 mRNA. Translation: AAF61849.1.
AK002607 mRNA. Translation: BAB22226.1.
AK035155 mRNA. Translation: BAC28963.1.
BC054846 mRNA. Translation: AAH54846.1.
BC055339 mRNA. Translation: AAH55339.1.
CCDSiCCDS23503.1.
RefSeqiNP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_006511909.1. XM_006511846.1.
UniGeneiMm.296560.

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
GeneIDi76257.
KEGGimmu:76257.
UCSCiuc009rmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF159856 mRNA. Translation: AAF61849.1 .
AK002607 mRNA. Translation: BAB22226.1 .
AK035155 mRNA. Translation: BAC28963.1 .
BC054846 mRNA. Translation: AAH54846.1 .
BC055339 mRNA. Translation: AAH55339.1 .
CCDSi CCDS23503.1.
RefSeqi NP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_006511909.1. XM_006511846.1.
UniGenei Mm.296560.

3D structure databases

ProteinModelPortali Q9DCP2.
ModBasei Search...

Protein-protein interaction databases

BioGridi 218051. 1 interaction.
IntActi Q9DCP2. 2 interactions.
MINTi MINT-1837264.
STRINGi 10090.ENSMUSP00000010208.

Protein family/group databases

TCDBi 2.A.18.6.2. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q9DCP2.

Proteomic databases

MaxQBi Q9DCP2.
PaxDbi Q9DCP2.
PRIDEi Q9DCP2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000010208 ; ENSMUSP00000010208 ; ENSMUSG00000010064 .
ENSMUST00000167868 ; ENSMUSP00000130414 ; ENSMUSG00000010064 .
ENSMUST00000177567 ; ENSMUSP00000137561 ; ENSMUSG00000010064 .
GeneIDi 76257.
KEGGi mmu:76257.
UCSCi uc009rmn.1. mouse.

Organism-specific databases

CTDi 10991.
MGIi MGI:1923507. Slc38a3.

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00650000093166.
HOGENOMi HOG000013088.
HOVERGENi HBG059571.
InParanoidi Q9DCP2.
KOi K13576.
OMAi IGHSATH.
OrthoDBi EOG7WHH9J.
PhylomeDBi Q9DCP2.
TreeFami TF328787.

Miscellaneous databases

ChiTaRSi SLC38A3. mouse.
NextBioi 344865.
PROi Q9DCP2.
SOURCEi Search...

Gene expression databases

Bgeei Q9DCP2.
CleanExi MM_SLC38A3.
Genevestigatori Q9DCP2.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of an amino acid transporter expressed differentially in liver."
    Gu S., Roderick H.L., Camacho P., Jiang J.X.
    Proc. Natl. Acad. Sci. U.S.A. 97:3230-3235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain, Kidney and Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Retina.

Entry informationi

Entry nameiS38A3_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP2
Secondary accession number(s): Q8BS53, Q9JLL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi