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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. L-alanine transmembrane transporter activity Source: MGI
  3. L-asparagine transmembrane transporter activity Source: MGI
  4. L-glutamine transmembrane transporter activity Source: MGI
  5. L-histidine transmembrane transporter activity Source: MGI
  6. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transmembrane transport Source: GO_Central
  2. asparagine transport Source: MGI
  3. cellular response to potassium ion starvation Source: MGI
  4. glutamine transport Source: MGI
  5. histidine transport Source: MGI
  6. L-alanine transport Source: MGI
  7. L-histidine transmembrane transport Source: GOC
  8. positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Source: MGI
  9. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
Short name:
mNAT
System N amino acid transporter 1
Gene namesi
Name:Slc38a3Imported
Synonyms:Sn1, Snat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1923507. Slc38a3.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence AnalysisAdd
BLAST
Transmembranei143 – 16321HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Transmembranei367 – 38721HelicalSequence AnalysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST
Transmembranei472 – 49221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
  2. membrane Source: MGI
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Sodium-coupled neutral amino acid transporter 3PRO_0000093829Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DCP2.
PaxDbiQ9DCP2.
PRIDEiQ9DCP2.

PTM databases

PhosphoSiteiQ9DCP2.

Expressioni

Tissue specificityi

Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis.1 Publication

Gene expression databases

BgeeiQ9DCP2.
CleanExiMM_SLC38A3.
GenevestigatoriQ9DCP2.

Interactioni

Protein-protein interaction databases

BioGridi218051. 1 interaction.
IntActiQ9DCP2. 2 interactions.
MINTiMINT-1837264.
STRINGi10090.ENSMUSP00000010208.

Structurei

3D structure databases

ProteinModelPortaliQ9DCP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9DCP2.
KOiK13576.
OMAiLCTPSYF.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ9DCP2.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK
60 70 80 90 100
SPSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP ASVWYMDGNY LVILVSVTII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLANATG
260 270 280 290 300
NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC
310 320 330 340 350
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE
360 370 380 390 400
SELLHTYSKV DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN
410 420 430 440 450
QEFSWLRHVL IATGLLTCIN LLVIFAPNIL GIFGIIGATS APCLIFIFPA
460 470 480 490 500
IFYFRIMPTD KEPARSTPKI LALCFAAVGF LLMTMSLSFI IIDWVSGTSQ

HGGNH
Length:505
Mass (Da):55,592
Last modified:June 1, 2001 - v1
Checksum:i368DBB87F1BB248A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101S → N in BAC28963. (PubMed:16141072)Curated
Sequence conflicti130 – 1301Q → R in BAC28963. (PubMed:16141072)Curated
Sequence conflicti270 – 2701T → A in AAF61849. (PubMed:10716701)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159856 mRNA. Translation: AAF61849.1.
AK002607 mRNA. Translation: BAB22226.1.
AK035155 mRNA. Translation: BAC28963.1.
BC054846 mRNA. Translation: AAH54846.1.
BC055339 mRNA. Translation: AAH55339.1.
CCDSiCCDS23503.1.
RefSeqiNP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_006511909.1. XM_006511846.1.
UniGeneiMm.296560.

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064.
GeneIDi76257.
KEGGimmu:76257.
UCSCiuc009rmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159856 mRNA. Translation: AAF61849.1.
AK002607 mRNA. Translation: BAB22226.1.
AK035155 mRNA. Translation: BAC28963.1.
BC054846 mRNA. Translation: AAH54846.1.
BC055339 mRNA. Translation: AAH55339.1.
CCDSiCCDS23503.1.
RefSeqiNP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_006511909.1. XM_006511846.1.
UniGeneiMm.296560.

3D structure databases

ProteinModelPortaliQ9DCP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218051. 1 interaction.
IntActiQ9DCP2. 2 interactions.
MINTiMINT-1837264.
STRINGi10090.ENSMUSP00000010208.

Protein family/group databases

TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteiQ9DCP2.

Proteomic databases

MaxQBiQ9DCP2.
PaxDbiQ9DCP2.
PRIDEiQ9DCP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064.
GeneIDi76257.
KEGGimmu:76257.
UCSCiuc009rmn.1. mouse.

Organism-specific databases

CTDi10991.
MGIiMGI:1923507. Slc38a3.

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9DCP2.
KOiK13576.
OMAiLCTPSYF.
OrthoDBiEOG7WHH9J.
PhylomeDBiQ9DCP2.
TreeFamiTF328787.

Miscellaneous databases

NextBioi344865.
PROiQ9DCP2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCP2.
CleanExiMM_SLC38A3.
GenevestigatoriQ9DCP2.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of an amino acid transporter expressed differentially in liver."
    Gu S., Roderick H.L., Camacho P., Jiang J.X.
    Proc. Natl. Acad. Sci. U.S.A. 97:3230-3235(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain1 Publication, Kidney1 Publication and LiverImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported and RetinaImported.

Entry informationi

Entry nameiS38A3_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP2
Secondary accession number(s): Q8BS53, Q9JLL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.