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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Protein family/group databases

TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
Short name:
mNAT
System N amino acid transporter 1
Gene namesi
Name:Slc38a3Imported
Synonyms:Sn1, Snat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923507. Slc38a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • integral component of plasma membrane Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938291 – 505Sodium-coupled neutral amino acid transporter 3Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1
Glycosylationi251N-linked (GlcNAc...)Sequence analysis1
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DCP2.
PaxDbiQ9DCP2.
PeptideAtlasiQ9DCP2.
PRIDEiQ9DCP2.

PTM databases

iPTMnetiQ9DCP2.
PhosphoSitePlusiQ9DCP2.

Expressioni

Tissue specificityi

Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000010064.
CleanExiMM_SLC38A3.
ExpressionAtlasiQ9DCP2. baseline and differential.
GenevisibleiQ9DCP2. MM.

Interactioni

Protein-protein interaction databases

BioGridi218051. 1 interactor.
IntActiQ9DCP2. 2 interactors.
MINTiMINT-1837264.
STRINGi10090.ENSMUSP00000010208.

Structurei

3D structure databases

ProteinModelPortaliQ9DCP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9DCP2.
KOiK13576.
OMAiFSHVEVM.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9DCP2.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK
60 70 80 90 100
SPSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP ASVWYMDGNY LVILVSVTII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLANATG
260 270 280 290 300
NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC
310 320 330 340 350
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE
360 370 380 390 400
SELLHTYSKV DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN
410 420 430 440 450
QEFSWLRHVL IATGLLTCIN LLVIFAPNIL GIFGIIGATS APCLIFIFPA
460 470 480 490 500
IFYFRIMPTD KEPARSTPKI LALCFAAVGF LLMTMSLSFI IIDWVSGTSQ

HGGNH
Length:505
Mass (Da):55,592
Last modified:June 1, 2001 - v1
Checksum:i368DBB87F1BB248A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → N in BAC28963 (PubMed:16141072).Curated1
Sequence conflicti130Q → R in BAC28963 (PubMed:16141072).Curated1
Sequence conflicti270T → A in AAF61849 (PubMed:10716701).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159856 mRNA. Translation: AAF61849.1.
AK002607 mRNA. Translation: BAB22226.1.
AK035155 mRNA. Translation: BAC28963.1.
BC054846 mRNA. Translation: AAH54846.1.
BC055339 mRNA. Translation: AAH55339.1.
CCDSiCCDS23503.1.
RefSeqiNP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_017169171.1. XM_017313682.1.
UniGeneiMm.296560.

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064.
GeneIDi76257.
KEGGimmu:76257.
UCSCiuc009rmn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159856 mRNA. Translation: AAF61849.1.
AK002607 mRNA. Translation: BAB22226.1.
AK035155 mRNA. Translation: BAC28963.1.
BC054846 mRNA. Translation: AAH54846.1.
BC055339 mRNA. Translation: AAH55339.1.
CCDSiCCDS23503.1.
RefSeqiNP_001186146.1. NM_001199217.1.
NP_001186147.1. NM_001199218.1.
NP_076294.2. NM_023805.3.
XP_017169171.1. XM_017313682.1.
UniGeneiMm.296560.

3D structure databases

ProteinModelPortaliQ9DCP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218051. 1 interactor.
IntActiQ9DCP2. 2 interactors.
MINTiMINT-1837264.
STRINGi10090.ENSMUSP00000010208.

Protein family/group databases

TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

PTM databases

iPTMnetiQ9DCP2.
PhosphoSitePlusiQ9DCP2.

Proteomic databases

MaxQBiQ9DCP2.
PaxDbiQ9DCP2.
PeptideAtlasiQ9DCP2.
PRIDEiQ9DCP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064.
GeneIDi76257.
KEGGimmu:76257.
UCSCiuc009rmn.1. mouse.

Organism-specific databases

CTDi10991.
MGIiMGI:1923507. Slc38a3.

Phylogenomic databases

eggNOGiKOG1305. Eukaryota.
COG0814. LUCA.
GeneTreeiENSGT00760000119147.
HOGENOMiHOG000013088.
HOVERGENiHBG059571.
InParanoidiQ9DCP2.
KOiK13576.
OMAiFSHVEVM.
OrthoDBiEOG091G0GP8.
PhylomeDBiQ9DCP2.
TreeFamiTF328787.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.

Miscellaneous databases

PROiQ9DCP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010064.
CleanExiMM_SLC38A3.
ExpressionAtlasiQ9DCP2. baseline and differential.
GenevisibleiQ9DCP2. MM.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS38A3_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP2
Secondary accession number(s): Q8BS53, Q9JLL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.