Sodium-coupled neutral amino acid transporter 3

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Q9DCP2 (S38A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 86. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Sodium-coupled neutral amino acid transporter 3

Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
Short name=mNAT
System N amino acid transporter 1

Gene names

Name:	Slc38a3
Synonyms:	Sn1, Snat3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. Ref.1 UniProtKB Q9JHZ9
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Tissue specificity	Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis. Ref.1
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
Biological process	Amino-acid transport Antiport Ion transport Sodium transport Symport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to plasma membrane Inferred from direct assay Ref.1. Source: MGI
Molecular_function	L-asparagine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-glutamine transmembrane transporter activity Inferred from direct assay Ref.1. Source: MGI L-histidine transmembrane transporter activity Inferred from direct assay Ref.1. Source: MGI antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 505

505

Sodium-coupled neutral amino acid transporter 3

PRO_0000093829

Regions

Transmembrane

82 – 102

Helical; Potential

Transmembrane

105 – 125

Helical; Potential

Transmembrane

143 – 163

Helical; Potential

Transmembrane

186 – 206

Helical; Potential

Transmembrane

212 – 232

Helical; Potential

Transmembrane

288 – 308

Helical; Potential

Transmembrane

325 – 345

Helical; Potential

Transmembrane

367 – 387

Helical; Potential

Transmembrane

409 – 429

Helical; Potential

Transmembrane

432 – 452

Helical; Potential

Transmembrane

472 – 492

Helical; Potential

Amino acid modifications

Modified residue

Phosphoserine Ref.4

Modified residue

Phosphoserine Ref.4

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

247

N-linked (GlcNAc...) Potential

Glycosylation

251

N-linked (GlcNAc...) Potential

Glycosylation

324

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

110

S → N in BAC28963. Ref.2

Sequence conflict

130

Q → R in BAC28963. Ref.2

Sequence conflict

270

T → A in AAF61849. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9DCP2 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 368DBB87F1BB248A
Show »

FASTA

505

55,592

        10         20         30         40         50         60 
MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK SPSKEPHFTD 

        70         80         90        100        110        120 
FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF LLTAVALLSS YSIHLLLKSS 

       130        140        150        160        170        180 
GIVGIRAYEQ LGYRAFGTPG KLAAALAITL QNIGAMSSYL YIIKSELPLV IQTFLNLEKP 

       190        200        210        220        230        240 
ASVWYMDGNY LVILVSVTII LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP 

       250        260        270        280        290        300 
LAHNLANATG NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC 

       310        320        330        340        350        360 
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE SELLHTYSKV 

       370        380        390        400        410        420 
DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN QEFSWLRHVL IATGLLTCIN 

       430        440        450        460        470        480 
LLVIFAPNIL GIFGIIGATS APCLIFIFPA IFYFRIMPTD KEPARSTPKI LALCFAAVGF 

       490        500 
LLMTMSLSFI IIDWVSGTSQ HGGNH

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of an amino acid transporter expressed differentially in liver." Gu S., Roderick H.L., Camacho P., Jiang J.X. Proc. Natl. Acad. Sci. U.S.A. 97:3230-3235(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Brain, Kidney and Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain and Retina.
[4]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-53, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF159856 mRNA. Translation: AAF61849.1. AK002607 mRNA. Translation: BAB22226.1. AK035155 mRNA. Translation: BAC28963.1. BC054846 mRNA. Translation: AAH54846.1. BC055339 mRNA. Translation: AAH55339.1.
IPI	IPI00322156.
RefSeq	NP_001186146.1. NM_001199217.1. NP_001186147.1. NM_001199218.1. NP_076294.2. NM_023805.3.
UniGene	Mm.296560.
3D structure databases
ProteinModelPortal	Q9DCP2.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000010208.
Protein family/group databases
TCDB	2.A.18.6.2. amino acid/auxin permease (AAAP) family.
PTM databases
PhosphoSite	Q9DCP2.
Proteomic databases
PaxDb	Q9DCP2.
PRIDE	Q9DCP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064. ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064. ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
GeneID	76257.
KEGG	mmu:76257.
UCSC	uc009rmn.1. mouse.
Organism-specific databases
CTD	10991.
MGI	MGI:1923507. Slc38a3.
Phylogenomic databases
eggNOG	COG0814.
GeneTree	ENSGT00650000093166.
HOGENOM	HOG000013088.
HOVERGEN	HBG059571.
InParanoid	Q9DCP2.
KO	K13576.
OMA	LCTPSYF.
OrthoDB	EOG4DR9C7.
Gene expression databases
Bgee	Q9DCP2.
CleanEx	MM_SLC38A3.
Genevestigator	Q9DCP2.
GermOnline	ENSMUSG00000010064. Mus musculus.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC38A3. mouse.
NextBio	344865.
SOURCE	Search...

Entry information

Entry name

S38A3_MOUSE

Accession

Primary (citable) accession number: Q9DCP2
Secondary accession number(s): Q8BS53, Q9JLL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents