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Q9DCP2

- S38A3_MOUSE

UniProt

Q9DCP2 - S38A3_MOUSE

Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW
    2. L-asparagine transmembrane transporter activity Source: Ensembl
    3. L-glutamine transmembrane transporter activity Source: MGI
    4. L-histidine transmembrane transporter activity Source: MGI
    5. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. glutamine transport Source: MGI
    2. histidine transport Source: MGI
    3. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.18.6.2. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 3
    Alternative name(s):
    N-system amino acid transporter 1
    Na(+)-coupled neutral amino acid transporter 3
    Solute carrier family 38 member 3
    Short name:
    mNAT
    System N amino acid transporter 1
    Gene namesi
    Name:Slc38a3Imported
    Synonyms:Sn1, Snat3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1923507. Slc38a3.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Sodium-coupled neutral amino acid transporter 3PRO_0000093829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9DCP2.
    PaxDbiQ9DCP2.
    PRIDEiQ9DCP2.

    PTM databases

    PhosphoSiteiQ9DCP2.

    Expressioni

    Tissue specificityi

    Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis.1 Publication

    Gene expression databases

    BgeeiQ9DCP2.
    CleanExiMM_SLC38A3.
    GenevestigatoriQ9DCP2.

    Interactioni

    Protein-protein interaction databases

    BioGridi218051. 1 interaction.
    IntActiQ9DCP2. 2 interactions.
    MINTiMINT-1837264.
    STRINGi10090.ENSMUSP00000010208.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei105 – 12521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei186 – 20621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei325 – 34521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei367 – 38721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei409 – 42921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    GeneTreeiENSGT00650000093166.
    HOGENOMiHOG000013088.
    HOVERGENiHBG059571.
    InParanoidiQ9DCP2.
    KOiK13576.
    OMAiIGHSATH.
    OrthoDBiEOG7WHH9J.
    PhylomeDBiQ9DCP2.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DCP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK    50
    SPSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF 100
    LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL 150
    QNIGAMSSYL YIIKSELPLV IQTFLNLEKP ASVWYMDGNY LVILVSVTII 200
    LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLANATG 250
    NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC 300
    HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE 350
    SELLHTYSKV DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN 400
    QEFSWLRHVL IATGLLTCIN LLVIFAPNIL GIFGIIGATS APCLIFIFPA 450
    IFYFRIMPTD KEPARSTPKI LALCFAAVGF LLMTMSLSFI IIDWVSGTSQ 500
    HGGNH 505
    Length:505
    Mass (Da):55,592
    Last modified:June 1, 2001 - v1
    Checksum:i368DBB87F1BB248A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti110 – 1101S → N in BAC28963. (PubMed:16141072)Curated
    Sequence conflicti130 – 1301Q → R in BAC28963. (PubMed:16141072)Curated
    Sequence conflicti270 – 2701T → A in AAF61849. (PubMed:10716701)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159856 mRNA. Translation: AAF61849.1.
    AK002607 mRNA. Translation: BAB22226.1.
    AK035155 mRNA. Translation: BAC28963.1.
    BC054846 mRNA. Translation: AAH54846.1.
    BC055339 mRNA. Translation: AAH55339.1.
    CCDSiCCDS23503.1.
    RefSeqiNP_001186146.1. NM_001199217.1.
    NP_001186147.1. NM_001199218.1.
    NP_076294.2. NM_023805.3.
    XP_006511909.1. XM_006511846.1.
    UniGeneiMm.296560.

    Genome annotation databases

    EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064.
    ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064.
    ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064.
    GeneIDi76257.
    KEGGimmu:76257.
    UCSCiuc009rmn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF159856 mRNA. Translation: AAF61849.1 .
    AK002607 mRNA. Translation: BAB22226.1 .
    AK035155 mRNA. Translation: BAC28963.1 .
    BC054846 mRNA. Translation: AAH54846.1 .
    BC055339 mRNA. Translation: AAH55339.1 .
    CCDSi CCDS23503.1.
    RefSeqi NP_001186146.1. NM_001199217.1.
    NP_001186147.1. NM_001199218.1.
    NP_076294.2. NM_023805.3.
    XP_006511909.1. XM_006511846.1.
    UniGenei Mm.296560.

    3D structure databases

    ProteinModelPortali Q9DCP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218051. 1 interaction.
    IntActi Q9DCP2. 2 interactions.
    MINTi MINT-1837264.
    STRINGi 10090.ENSMUSP00000010208.

    Protein family/group databases

    TCDBi 2.A.18.6.2. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q9DCP2.

    Proteomic databases

    MaxQBi Q9DCP2.
    PaxDbi Q9DCP2.
    PRIDEi Q9DCP2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000010208 ; ENSMUSP00000010208 ; ENSMUSG00000010064 .
    ENSMUST00000167868 ; ENSMUSP00000130414 ; ENSMUSG00000010064 .
    ENSMUST00000177567 ; ENSMUSP00000137561 ; ENSMUSG00000010064 .
    GeneIDi 76257.
    KEGGi mmu:76257.
    UCSCi uc009rmn.1. mouse.

    Organism-specific databases

    CTDi 10991.
    MGIi MGI:1923507. Slc38a3.

    Phylogenomic databases

    eggNOGi COG0814.
    GeneTreei ENSGT00650000093166.
    HOGENOMi HOG000013088.
    HOVERGENi HBG059571.
    InParanoidi Q9DCP2.
    KOi K13576.
    OMAi IGHSATH.
    OrthoDBi EOG7WHH9J.
    PhylomeDBi Q9DCP2.
    TreeFami TF328787.

    Miscellaneous databases

    ChiTaRSi SLC38A3. mouse.
    NextBioi 344865.
    PROi Q9DCP2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCP2.
    CleanExi MM_SLC38A3.
    Genevestigatori Q9DCP2.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of an amino acid transporter expressed differentially in liver."
      Gu S., Roderick H.L., Camacho P., Jiang J.X.
      Proc. Natl. Acad. Sci. U.S.A. 97:3230-3235(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain1 Publication, Kidney1 Publication and LiverImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported and RetinaImported.

    Entry informationi

    Entry nameiS38A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCP2
    Secondary accession number(s): Q8BS53, Q9JLL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3