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Protein

Sodium-coupled neutral amino acid transporter 3

Gene

Slc38a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAmino-acid transport, Antiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane

Protein family/group databases

TCDBi2.A.18.6.2 the amino acid/auxin permease (aaap) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-coupled neutral amino acid transporter 3
Alternative name(s):
N-system amino acid transporter 1
Na(+)-coupled neutral amino acid transporter 3
Solute carrier family 38 member 3
Short name:
mNAT
System N amino acid transporter 1
Gene namesi
Name:Slc38a3Imported
Synonyms:Sn1, Snat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1923507 Slc38a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei105 – 125HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei288 – 308HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei367 – 387HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938291 – 505Sodium-coupled neutral amino acid transporter 3Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi239 ↔ 276PROSITE-ProRule annotation
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9DCP2
PaxDbiQ9DCP2
PeptideAtlasiQ9DCP2
PRIDEiQ9DCP2

PTM databases

iPTMnetiQ9DCP2
PhosphoSitePlusiQ9DCP2
SwissPalmiQ9DCP2

Expressioni

Tissue specificityi

Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000010064
CleanExiMM_SLC38A3
ExpressionAtlasiQ9DCP2 baseline and differential
GenevisibleiQ9DCP2 MM

Interactioni

Protein-protein interaction databases

BioGridi218051, 1 interactor
IntActiQ9DCP2, 2 interactors
MINTiQ9DCP2
STRINGi10090.ENSMUSP00000010208

Structurei

3D structure databases

ProteinModelPortaliQ9DCP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1305 Eukaryota
COG0814 LUCA
GeneTreeiENSGT00760000119147
HOGENOMiHOG000013088
HOVERGENiHBG059571
InParanoidiQ9DCP2
KOiK13576
OMAiKKKMQHV
OrthoDBiEOG091G0GP8
PhylomeDBiQ9DCP2
TreeFamiTF328787

Family and domain databases

InterProiView protein in InterPro
IPR013057 AA_transpt_TM
PfamiView protein in Pfam
PF01490 Aa_trans, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPRQTEMV ELVPNGKHLE GLLPVGVPTT DTQRTEDTQH CGEGKGFLQK
60 70 80 90 100
SPSKEPHFTD FEGKTSFGMS VFNLSNAIMG SGILGLAYAM ANTGIILFLF
110 120 130 140 150
LLTAVALLSS YSIHLLLKSS GIVGIRAYEQ LGYRAFGTPG KLAAALAITL
160 170 180 190 200
QNIGAMSSYL YIIKSELPLV IQTFLNLEKP ASVWYMDGNY LVILVSVTII
210 220 230 240 250
LPLALMRQLG YLGYSSGFSL SCMVFFLIAV IYKKFQVPCP LAHNLANATG
260 270 280 290 300
NFSHMVVAEE KAQLQGEPDT AAEAFCTPSY FTLNSQTAYT IPIMAFAFVC
310 320 330 340 350
HPEVLPIYTE LKDPSKRKMQ HISNLSIAVM YVMYFLAALF GYLTFYDGVE
360 370 380 390 400
SELLHTYSKV DPFDVLILCV RVAVLIAVTL TVPIVLFPVR RAIQQMLFQN
410 420 430 440 450
QEFSWLRHVL IATGLLTCIN LLVIFAPNIL GIFGIIGATS APCLIFIFPA
460 470 480 490 500
IFYFRIMPTD KEPARSTPKI LALCFAAVGF LLMTMSLSFI IIDWVSGTSQ

HGGNH
Length:505
Mass (Da):55,592
Last modified:June 1, 2001 - v1
Checksum:i368DBB87F1BB248A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110S → N in BAC28963 (PubMed:16141072).Curated1
Sequence conflicti130Q → R in BAC28963 (PubMed:16141072).Curated1
Sequence conflicti270T → A in AAF61849 (PubMed:10716701).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159856 mRNA Translation: AAF61849.1
AK002607 mRNA Translation: BAB22226.1
AK035155 mRNA Translation: BAC28963.1
BC054846 mRNA Translation: AAH54846.1
BC055339 mRNA Translation: AAH55339.1
CCDSiCCDS23503.1
RefSeqiNP_001186146.1, NM_001199217.1
NP_001186147.1, NM_001199218.1
NP_076294.2, NM_023805.3
XP_017169171.1, XM_017313682.1
UniGeneiMm.296560

Genome annotation databases

EnsembliENSMUST00000010208; ENSMUSP00000010208; ENSMUSG00000010064
ENSMUST00000167868; ENSMUSP00000130414; ENSMUSG00000010064
ENSMUST00000177567; ENSMUSP00000137561; ENSMUSG00000010064
ENSMUST00000193932; ENSMUSP00000142087; ENSMUSG00000010064
GeneIDi76257
KEGGimmu:76257
UCSCiuc009rmn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS38A3_MOUSE
AccessioniPrimary (citable) accession number: Q9DCP2
Secondary accession number(s): Q8BS53, Q9JLL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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