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Q9DCN1

- NUD12_MOUSE

UniProt

Q9DCN1 - NUD12_MOUSE

Protein

Peroxisomal NADH pyrophosphatase NUDT12

Gene

Nudt12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle By similarity.By similarity

    Catalytic activityi

    NAD+ + H2O = AMP + NMN.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi370 – 3701Magnesium or manganeseBy similarity
    Metal bindingi374 – 3741Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. NAD+ diphosphatase activity Source: MGI
    3. NADH pyrophosphatase activity Source: MGI

    GO - Biological processi

    1. NAD catabolic process Source: MGI
    2. NADP catabolic process Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal NADH pyrophosphatase NUDT12 (EC:3.6.1.22)
    Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 12
    Short name:
    Nudix motif 12
    Gene namesi
    Name:Nudt12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1915243. Nudt12.

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: Ensembl
    3. peroxisome Source: MGI

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Peroxisomal NADH pyrophosphatase NUDT12PRO_0000056957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101N6-succinyllysine1 Publication
    Modified residuei185 – 1851N6-succinyllysine1 Publication
    Modified residuei292 – 2921N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiQ9DCN1.
    PaxDbiQ9DCN1.
    PRIDEiQ9DCN1.

    PTM databases

    PhosphoSiteiQ9DCN1.

    Expressioni

    Gene expression databases

    BgeeiQ9DCN1.
    GenevestigatoriQ9DCN1.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9DCN1. 1 interaction.
    MINTiMINT-4128687.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCN1.
    SMRiQ9DCN1. Positions 10-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 4030ANK 1Add
    BLAST
    Repeati45 – 7430ANK 2Add
    BLAST
    Repeati78 – 9821ANK 3Add
    BLAST
    Domaini319 – 453135Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi355 – 37622Nudix boxAdd
    BLAST
    Motifi460 – 4623Microbody targeting signalBy similarity

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family. NudC subfamily.Curated
    Contains 3 ANK repeats.PROSITE-ProRule annotation
    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG2816.
    GeneTreeiENSGT00530000063600.
    HOGENOMiHOG000247937.
    HOVERGENiHBG054394.
    InParanoidiQ9DCN1.
    KOiK03426.
    OMAiQPEVRLC.
    OrthoDBiEOG7N0C55.
    PhylomeDBiQ9DCN1.
    TreeFamiTF106352.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    3.90.79.10. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR015375. NADH_PPase-like_N.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR015376. Znr_NADH_PPase.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    PF09296. NUDIX-like. 1 hit.
    PF09297. zf-NADH-PPase. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    SSF55811. SSF55811. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9DCN1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSVKRNPKK EMISELHSSA AEGNVAKLAG ILSHSPSLLN ETSENGWTAL    50
    MYAARNGHPD VVQFLLEKGC DRSLVNKARQ TALDIAAFWG YRHIANLLAN 100
    AKGGKKPWFL TNEVDECENY FSRTLLDRRS DKRNNSDWLQ AKESHPTTVY 150
    LLFSDLNPLV TLGGNKESSQ QPEVRLCQLN YPDVKGYLAQ PEKITLVFLG 200
    VELEMRKGSP AQAGGVPEEE EDGLVAWFAL GIEPGAAEEF KQRHENCYFL 250
    HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGSA TKIEEGGYKR 300
    VCVRETCPSL QGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF 350
    TCLAGFIEPG ETIEDAVRRE VEEESGVKVG HVQYVSCQPW PMPSSLMIGC 400
    LAVAVSTEIK VDKNEIEDAR WFTREQVVDV LTKGKQQAFF VPPSRAIAHQ 450
    LIKHWVGMNP NL 462
    Length:462
    Mass (Da):51,511
    Last modified:June 1, 2001 - v1
    Checksum:i92C2CBB0FAACEA6D
    GO
    Isoform 2 (identifier: Q9DCN1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         361-367: ETIEDAV → KPILTGF
         368-462: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:367
    Mass (Da):40,756
    Checksum:i7A0CB8E3A75AA8D1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781A → G in AAH57657. (PubMed:15489334)Curated
    Sequence conflicti290 – 2901A → V in AAH57657. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei361 – 3677ETIEDAV → KPILTGF in isoform 2. 1 PublicationVSP_014280
    Alternative sequencei368 – 46295Missing in isoform 2. 1 PublicationVSP_014281Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002641 mRNA. Translation: BAB22253.1.
    BC057657 mRNA. Translation: AAH57657.1.
    CCDSiCCDS28933.1. [Q9DCN1-1]
    RefSeqiNP_080773.1. NM_026497.2. [Q9DCN1-1]
    UniGeneiMm.36507.

    Genome annotation databases

    EnsembliENSMUST00000025065; ENSMUSP00000025065; ENSMUSG00000024228. [Q9DCN1-1]
    ENSMUST00000174122; ENSMUSP00000133678; ENSMUSG00000024228. [Q9DCN1-2]
    GeneIDi67993.
    KEGGimmu:67993.
    UCSCiuc008dfc.1. mouse. [Q9DCN1-1]
    uc008dfd.1. mouse. [Q9DCN1-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002641 mRNA. Translation: BAB22253.1 .
    BC057657 mRNA. Translation: AAH57657.1 .
    CCDSi CCDS28933.1. [Q9DCN1-1 ]
    RefSeqi NP_080773.1. NM_026497.2. [Q9DCN1-1 ]
    UniGenei Mm.36507.

    3D structure databases

    ProteinModelPortali Q9DCN1.
    SMRi Q9DCN1. Positions 10-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DCN1. 1 interaction.
    MINTi MINT-4128687.

    PTM databases

    PhosphoSitei Q9DCN1.

    Proteomic databases

    MaxQBi Q9DCN1.
    PaxDbi Q9DCN1.
    PRIDEi Q9DCN1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025065 ; ENSMUSP00000025065 ; ENSMUSG00000024228 . [Q9DCN1-1 ]
    ENSMUST00000174122 ; ENSMUSP00000133678 ; ENSMUSG00000024228 . [Q9DCN1-2 ]
    GeneIDi 67993.
    KEGGi mmu:67993.
    UCSCi uc008dfc.1. mouse. [Q9DCN1-1 ]
    uc008dfd.1. mouse. [Q9DCN1-2 ]

    Organism-specific databases

    CTDi 83594.
    MGIi MGI:1915243. Nudt12.

    Phylogenomic databases

    eggNOGi COG2816.
    GeneTreei ENSGT00530000063600.
    HOGENOMi HOG000247937.
    HOVERGENi HBG054394.
    InParanoidi Q9DCN1.
    KOi K03426.
    OMAi QPEVRLC.
    OrthoDBi EOG7N0C55.
    PhylomeDBi Q9DCN1.
    TreeFami TF106352.

    Miscellaneous databases

    NextBioi 326156.
    PROi Q9DCN1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCN1.
    Genevestigatori Q9DCN1.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    3.90.79.10. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR015375. NADH_PPase-like_N.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR015376. Znr_NADH_PPase.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    PF09296. NUDIX-like. 1 hit.
    PF09297. zf-NADH-PPase. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    SSF55811. SSF55811. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: Czech II.
      Tissue: Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-10; LYS-185 AND LYS-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiNUD12_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCN1
    Secondary accession number(s): Q6PFA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3