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Q9DCN1 (NUD12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal NADH pyrophosphatase NUDT12

EC=3.6.1.22
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 12
Short name=Nudix motif 12
Gene names
Name:Nudt12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle By similarity.

Catalytic activity

NAD+ + H2O = AMP + NMN.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the Nudix hydrolase family. NudC subfamily.

Contains 3 ANK repeats.

Contains 1 nudix hydrolase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9DCN1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9DCN1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     361-367: ETIEDAV → KPILTGF
     368-462: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Peroxisomal NADH pyrophosphatase NUDT12
PRO_0000056957

Regions

Repeat11 – 4030ANK 1
Repeat45 – 7430ANK 2
Repeat78 – 9821ANK 3
Domain319 – 453135Nudix hydrolase
Motif355 – 37622Nudix box
Motif460 – 4623Microbody targeting signal By similarity

Sites

Metal binding3701Magnesium or manganese By similarity
Metal binding3741Magnesium or manganese By similarity

Amino acid modifications

Modified residue101N6-succinyllysine Ref.3
Modified residue1851N6-succinyllysine Ref.3
Modified residue2921N6-succinyllysine Ref.3

Natural variations

Alternative sequence361 – 3677ETIEDAV → KPILTGF in isoform 2.
VSP_014280
Alternative sequence368 – 46295Missing in isoform 2.
VSP_014281

Experimental info

Sequence conflict781A → G in AAH57657. Ref.2
Sequence conflict2901A → V in AAH57657. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 92C2CBB0FAACEA6D

FASTA46251,511
        10         20         30         40         50         60 
MSSVKRNPKK EMISELHSSA AEGNVAKLAG ILSHSPSLLN ETSENGWTAL MYAARNGHPD 

        70         80         90        100        110        120 
VVQFLLEKGC DRSLVNKARQ TALDIAAFWG YRHIANLLAN AKGGKKPWFL TNEVDECENY 

       130        140        150        160        170        180 
FSRTLLDRRS DKRNNSDWLQ AKESHPTTVY LLFSDLNPLV TLGGNKESSQ QPEVRLCQLN 

       190        200        210        220        230        240 
YPDVKGYLAQ PEKITLVFLG VELEMRKGSP AQAGGVPEEE EDGLVAWFAL GIEPGAAEEF 

       250        260        270        280        290        300 
KQRHENCYFL HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGSA TKIEEGGYKR 

       310        320        330        340        350        360 
VCVRETCPSL QGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF TCLAGFIEPG 

       370        380        390        400        410        420 
ETIEDAVRRE VEEESGVKVG HVQYVSCQPW PMPSSLMIGC LAVAVSTEIK VDKNEIEDAR 

       430        440        450        460 
WFTREQVVDV LTKGKQQAFF VPPSRAIAHQ LIKHWVGMNP NL 

« Hide

Isoform 2 [UniParc].

Checksum: 7A0CB8E3A75AA8D1
Show »

FASTA36740,756

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: Czech II.
Tissue: Mammary tumor.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-10; LYS-185 AND LYS-292, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002641 mRNA. Translation: BAB22253.1.
BC057657 mRNA. Translation: AAH57657.1.
CCDSCCDS28933.1. [Q9DCN1-1]
RefSeqNP_080773.1. NM_026497.2. [Q9DCN1-1]
UniGeneMm.36507.

3D structure databases

ProteinModelPortalQ9DCN1.
SMRQ9DCN1. Positions 10-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9DCN1. 1 interaction.
MINTMINT-4128687.

PTM databases

PhosphoSiteQ9DCN1.

Proteomic databases

MaxQBQ9DCN1.
PaxDbQ9DCN1.
PRIDEQ9DCN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025065; ENSMUSP00000025065; ENSMUSG00000024228. [Q9DCN1-1]
ENSMUST00000174122; ENSMUSP00000133678; ENSMUSG00000024228. [Q9DCN1-2]
GeneID67993.
KEGGmmu:67993.
UCSCuc008dfc.1. mouse. [Q9DCN1-1]
uc008dfd.1. mouse. [Q9DCN1-2]

Organism-specific databases

CTD83594.
MGIMGI:1915243. Nudt12.

Phylogenomic databases

eggNOGCOG2816.
GeneTreeENSGT00530000063600.
HOGENOMHOG000247937.
HOVERGENHBG054394.
InParanoidQ9DCN1.
KOK03426.
OMAQPEVRLC.
OrthoDBEOG7N0C55.
PhylomeDBQ9DCN1.
TreeFamTF106352.

Gene expression databases

BgeeQ9DCN1.
GenevestigatorQ9DCN1.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
3.90.79.10. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR015375. NADH_PPase-like_N.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
SSF55811. SSF55811. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326156.
PROQ9DCN1.
SOURCESearch...

Entry information

Entry nameNUD12_MOUSE
AccessionPrimary (citable) accession number: Q9DCN1
Secondary accession number(s): Q6PFA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot