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Protein

Glutathione S-transferase kappa 1

Gene

Gstk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53GlutathioneBy similarity1
Binding sitei183Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: MGI
  • glutathione transferase activity Source: MGI
  • protein disulfide oxidoreductase activity Source: InterPro
  • signaling receptor binding Source: MGI

GO - Biological processi

  • epithelial cell differentiation Source: Ensembl
  • glutathione metabolic process Source: MGI

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590 Glutathione conjugation
R-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase kappa 1 (EC:2.5.1.18)
Alternative name(s):
GST 13-13
GST class-kappa
GSTK1-1
Short name:
mGSTK1
Glutathione S-transferase subunit 13
Gene namesi
Name:Gstk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923513 Gstk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858921 – 226Glutathione S-transferase kappa 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-succinyllysineCombined sources1
Modified residuei49N6-succinyllysineCombined sources1
Modified residuei68N6-acetyllysine; alternateCombined sources1
Modified residuei68N6-succinyllysine; alternateCombined sources1
Modified residuei74N6-acetyllysine; alternateCombined sources1
Modified residuei74N6-succinyllysine; alternateCombined sources1
Modified residuei85N6-acetyllysineCombined sources1
Modified residuei93N6-acetyllysine; alternateCombined sources1
Modified residuei93N6-succinyllysine; alternateCombined sources1
Modified residuei116N6-acetyllysine; alternateCombined sources1
Modified residuei116N6-succinyllysine; alternateCombined sources1
Modified residuei144N6-succinyllysineCombined sources1
Modified residuei158N6-acetyllysine; alternateCombined sources1
Modified residuei158N6-succinyllysine; alternateCombined sources1
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei167N6-acetyllysine; alternateCombined sources1
Modified residuei167N6-succinyllysine; alternateCombined sources1
Modified residuei177N6-acetyllysine; alternateCombined sources1
Modified residuei177N6-succinyllysine; alternateCombined sources1
Modified residuei193N6-succinyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-93 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DCM2
MaxQBiQ9DCM2
PaxDbiQ9DCM2
PeptideAtlasiQ9DCM2
PRIDEiQ9DCM2

PTM databases

iPTMnetiQ9DCM2
PhosphoSitePlusiQ9DCM2
SwissPalmiQ9DCM2

Expressioni

Tissue specificityi

Predominantly expressed in heart, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000029864
CleanExiMM_GSTK1
ExpressionAtlasiQ9DCM2 baseline and differential
GenevisibleiQ9DCM2 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AdipoqQ609943EBI-8369416,EBI-7264589

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48623N
IntActiQ9DCM2, 3 interactors
MINTiQ9DCM2
STRINGi10090.ENSMUSP00000031897

Structurei

3D structure databases

ProteinModelPortaliQ9DCM2
SMRiQ9DCM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 18Glutathione bindingBy similarity3
Regioni200 – 201Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiENOG410IJK9 Eukaryota
COG3917 LUCA
GeneTreeiENSGT00440000033697
HOGENOMiHOG000219769
HOVERGENiHBG051852
InParanoidiQ9DCM2
KOiK13299
OMAiETEGFWG
OrthoDBiEOG091G0LCM
PhylomeDBiQ9DCM2
TreeFamiTF105323

Family and domain databases

InterProiView protein in InterPro
IPR001853 DSBA-like_thioredoxin_dom
IPR014440 HCCAis_GSTk
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF01323 DSBA, 1 hit
PIRSFiPIRSF006386 HCCAis_GSTk, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAPRILEL FYDVLSPYSW LGFEVLCRYQ HLWNIKLQLR PTLIAGIMKD
60 70 80 90 100
SGNQPPAMVP RKGQYIFKEI PLLKQFFQVP LNIPKDFFGE TVKKGSINAM
110 120 130 140 150
RFLTTVSMEQ PEMLEKVSRE IWMRVWSRDE DITEYQSILA AAVKAGMSTA
160 170 180 190 200
QAQHFLEKIS TQQVKNKLIE NTDAACKYGA FGLPTTVAHV DGKTYMLFGS
210 220
DRLELLAYLL GEKWMGPVPP TANARL
Length:226
Mass (Da):25,704
Last modified:January 23, 2007 - v3
Checksum:i480332FD618ABCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002661 mRNA Translation: BAB22268.1
AY279096 mRNA Translation: AAP20655.1
BC058163 mRNA Translation: AAH58163.1
CCDSiCCDS20063.1
RefSeqiNP_083831.1, NM_029555.2
UniGeneiMm.267014

Genome annotation databases

EnsembliENSMUST00000031897; ENSMUSP00000031897; ENSMUSG00000029864
GeneIDi76263
KEGGimmu:76263
UCSCiuc009bqo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGSTK1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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