Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9DCM2

- GSTK1_MOUSE

UniProt

Q9DCM2 - GSTK1_MOUSE

Protein

Glutathione S-transferase kappa 1

Gene

Gstk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531GlutathioneBy similarity
    Binding sitei183 – 1831Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. glutathione peroxidase activity Source: MGI
    2. glutathione transferase activity Source: MGI
    3. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. glutathione metabolic process Source: MGI
    2. oxidation-reduction process Source: GOC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase kappa 1 (EC:2.5.1.18)
    Alternative name(s):
    GST 13-13
    GST class-kappa
    GSTK1-1
    Short name:
    mGSTK1
    Glutathione S-transferase subunit 13
    Gene namesi
    Name:Gstk1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1923513. Gstk1.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial matrix Source: Ensembl
    3. mitochondrion Source: MGI
    4. peroxisome Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 226225Glutathione S-transferase kappa 1PRO_0000185892Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei36 – 361N6-succinyllysine1 Publication
    Modified residuei49 – 491N6-succinyllysine1 Publication
    Modified residuei68 – 681N6-acetyllysine; alternate1 Publication
    Modified residuei68 – 681N6-succinyllysine; alternate1 Publication
    Modified residuei74 – 741N6-acetyllysine; alternate1 Publication
    Modified residuei74 – 741N6-succinyllysine; alternate1 Publication
    Modified residuei85 – 851N6-acetyllysine1 Publication
    Modified residuei93 – 931N6-acetyllysine; alternate1 Publication
    Modified residuei93 – 931N6-succinyllysine; alternate1 Publication
    Modified residuei116 – 1161N6-acetyllysine; alternate1 Publication
    Modified residuei116 – 1161N6-succinyllysine; alternate1 Publication
    Modified residuei144 – 1441N6-succinyllysine1 Publication
    Modified residuei158 – 1581N6-acetyllysine; alternate1 Publication
    Modified residuei158 – 1581N6-succinyllysine; alternate1 Publication
    Modified residuei165 – 1651N6-acetyllysine1 Publication
    Modified residuei167 – 1671N6-acetyllysine; alternate1 Publication
    Modified residuei167 – 1671N6-succinyllysine; alternate1 Publication
    Modified residuei177 – 1771N6-acetyllysine; alternate1 Publication
    Modified residuei177 – 1771N6-succinyllysine; alternate1 Publication
    Modified residuei193 – 1931N6-succinyllysine1 Publication

    Post-translational modificationi

    Acetylation of Lys-93 is observed in liver mitochondria from fasted mice but not from fed mice.1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9DCM2.
    PaxDbiQ9DCM2.
    PRIDEiQ9DCM2.

    PTM databases

    PhosphoSiteiQ9DCM2.

    Expressioni

    Tissue specificityi

    Predominantly expressed in heart, kidney, liver and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiQ9DCM2.
    CleanExiMM_GSTK1.
    GenevestigatoriQ9DCM2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    DIPiDIP-48623N.
    IntActiQ9DCM2. 2 interactions.
    MINTiMINT-1860526.
    STRINGi10090.ENSMUSP00000031897.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCM2.
    SMRiQ9DCM2. Positions 2-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni16 – 183Glutathione bindingBy similarity
    Regioni200 – 2012Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Kappa family.Curated

    Phylogenomic databases

    eggNOGiCOG3917.
    GeneTreeiENSGT00440000033697.
    HOGENOMiHOG000219769.
    HOVERGENiHBG051852.
    InParanoidiQ9DCM2.
    KOiK13299.
    OMAiELWRRIW.
    OrthoDBiEOG793B9B.
    PhylomeDBiQ9DCM2.
    TreeFamiTF105323.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR001853. DSBA-like_thioredoxin_dom.
    IPR014440. HCCAis_GSTk.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF01323. DSBA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
    SUPFAMiSSF52833. SSF52833. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9DCM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPAPRILEL FYDVLSPYSW LGFEVLCRYQ HLWNIKLQLR PTLIAGIMKD    50
    SGNQPPAMVP RKGQYIFKEI PLLKQFFQVP LNIPKDFFGE TVKKGSINAM 100
    RFLTTVSMEQ PEMLEKVSRE IWMRVWSRDE DITEYQSILA AAVKAGMSTA 150
    QAQHFLEKIS TQQVKNKLIE NTDAACKYGA FGLPTTVAHV DGKTYMLFGS 200
    DRLELLAYLL GEKWMGPVPP TANARL 226
    Length:226
    Mass (Da):25,704
    Last modified:January 23, 2007 - v3
    Checksum:i480332FD618ABCDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002661 mRNA. Translation: BAB22268.1.
    AY279096 mRNA. Translation: AAP20655.1.
    BC058163 mRNA. Translation: AAH58163.1.
    CCDSiCCDS20063.1.
    RefSeqiNP_083831.1. NM_029555.2.
    UniGeneiMm.267014.

    Genome annotation databases

    EnsembliENSMUST00000031897; ENSMUSP00000031897; ENSMUSG00000029864.
    GeneIDi76263.
    KEGGimmu:76263.
    UCSCiuc009bqo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002661 mRNA. Translation: BAB22268.1 .
    AY279096 mRNA. Translation: AAP20655.1 .
    BC058163 mRNA. Translation: AAH58163.1 .
    CCDSi CCDS20063.1.
    RefSeqi NP_083831.1. NM_029555.2.
    UniGenei Mm.267014.

    3D structure databases

    ProteinModelPortali Q9DCM2.
    SMRi Q9DCM2. Positions 2-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48623N.
    IntActi Q9DCM2. 2 interactions.
    MINTi MINT-1860526.
    STRINGi 10090.ENSMUSP00000031897.

    PTM databases

    PhosphoSitei Q9DCM2.

    Proteomic databases

    MaxQBi Q9DCM2.
    PaxDbi Q9DCM2.
    PRIDEi Q9DCM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031897 ; ENSMUSP00000031897 ; ENSMUSG00000029864 .
    GeneIDi 76263.
    KEGGi mmu:76263.
    UCSCi uc009bqo.1. mouse.

    Organism-specific databases

    CTDi 373156.
    MGIi MGI:1923513. Gstk1.

    Phylogenomic databases

    eggNOGi COG3917.
    GeneTreei ENSGT00440000033697.
    HOGENOMi HOG000219769.
    HOVERGENi HBG051852.
    InParanoidi Q9DCM2.
    KOi K13299.
    OMAi ELWRRIW.
    OrthoDBi EOG793B9B.
    PhylomeDBi Q9DCM2.
    TreeFami TF105323.

    Miscellaneous databases

    NextBioi 344879.
    PROi Q9DCM2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCM2.
    CleanExi MM_GSTK1.
    Genevestigatori Q9DCM2.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR001853. DSBA-like_thioredoxin_dom.
    IPR014440. HCCAis_GSTk.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF01323. DSBA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006386. HCCAis_GSTk. 1 hit.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase."
      Jowsey I.R., Thomson R.E., Orton T.C., Elcombe C.R., Hayes J.D.
      Biochem. J. 373:559-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: FVB/N.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 203-213, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-36; LYS-49; LYS-68; LYS-74; LYS-93; LYS-116; LYS-144; LYS-158; LYS-167; LYS-177 AND LYS-193, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68; LYS-74; LYS-85; LYS-93; LYS-116; LYS-158; LYS-165; LYS-167 AND LYS-177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGSTK1_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3