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Protein

Glutathione S-transferase kappa 1

Gene

Gstk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53GlutathioneBy similarity1
Binding sitei183Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

  • glutathione peroxidase activity Source: MGI
  • glutathione transferase activity Source: MGI
  • protein disulfide oxidoreductase activity Source: InterPro
  • receptor binding Source: MGI

GO - Biological processi

  • epithelial cell differentiation Source: Ensembl
  • glutathione metabolic process Source: MGI

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-MMU-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase kappa 1 (EC:2.5.1.18)
Alternative name(s):
GST 13-13
GST class-kappa
GSTK1-1
Short name:
mGSTK1
Glutathione S-transferase subunit 13
Gene namesi
Name:Gstk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1923513. Gstk1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858921 – 226Glutathione S-transferase kappa 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-succinyllysineCombined sources1
Modified residuei49N6-succinyllysineCombined sources1
Modified residuei68N6-acetyllysine; alternateCombined sources1
Modified residuei68N6-succinyllysine; alternateCombined sources1
Modified residuei74N6-acetyllysine; alternateCombined sources1
Modified residuei74N6-succinyllysine; alternateCombined sources1
Modified residuei85N6-acetyllysineCombined sources1
Modified residuei93N6-acetyllysine; alternateCombined sources1
Modified residuei93N6-succinyllysine; alternateCombined sources1
Modified residuei116N6-acetyllysine; alternateCombined sources1
Modified residuei116N6-succinyllysine; alternateCombined sources1
Modified residuei144N6-succinyllysineCombined sources1
Modified residuei158N6-acetyllysine; alternateCombined sources1
Modified residuei158N6-succinyllysine; alternateCombined sources1
Modified residuei165N6-acetyllysineCombined sources1
Modified residuei167N6-acetyllysine; alternateCombined sources1
Modified residuei167N6-succinyllysine; alternateCombined sources1
Modified residuei177N6-acetyllysine; alternateCombined sources1
Modified residuei177N6-succinyllysine; alternateCombined sources1
Modified residuei193N6-succinyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-93 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DCM2.
MaxQBiQ9DCM2.
PaxDbiQ9DCM2.
PeptideAtlasiQ9DCM2.
PRIDEiQ9DCM2.

PTM databases

iPTMnetiQ9DCM2.
PhosphoSitePlusiQ9DCM2.

Expressioni

Tissue specificityi

Predominantly expressed in heart, kidney, liver and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000029864.
CleanExiMM_GSTK1.
ExpressionAtlasiQ9DCM2. baseline and differential.
GenevisibleiQ9DCM2. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-48623N.
IntActiQ9DCM2. 2 interactors.
MINTiMINT-1860526.
STRINGi10090.ENSMUSP00000031897.

Structurei

3D structure databases

ProteinModelPortaliQ9DCM2.
SMRiQ9DCM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 18Glutathione bindingBy similarity3
Regioni200 – 201Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

eggNOGiENOG410IJK9. Eukaryota.
COG3917. LUCA.
GeneTreeiENSGT00440000033697.
HOGENOMiHOG000219769.
HOVERGENiHBG051852.
InParanoidiQ9DCM2.
KOiK13299.
OMAiETEGFWG.
OrthoDBiEOG091G0LCM.
PhylomeDBiQ9DCM2.
TreeFamiTF105323.

Family and domain databases

InterProiView protein in InterPro
IPR001853. DSBA-like_thioredoxin_dom.
IPR014440. HCCAis_GSTk.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF01323. DSBA. 1 hit.
PIRSFiPIRSF006386. HCCAis_GSTk. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPAPRILEL FYDVLSPYSW LGFEVLCRYQ HLWNIKLQLR PTLIAGIMKD
60 70 80 90 100
SGNQPPAMVP RKGQYIFKEI PLLKQFFQVP LNIPKDFFGE TVKKGSINAM
110 120 130 140 150
RFLTTVSMEQ PEMLEKVSRE IWMRVWSRDE DITEYQSILA AAVKAGMSTA
160 170 180 190 200
QAQHFLEKIS TQQVKNKLIE NTDAACKYGA FGLPTTVAHV DGKTYMLFGS
210 220
DRLELLAYLL GEKWMGPVPP TANARL
Length:226
Mass (Da):25,704
Last modified:January 23, 2007 - v3
Checksum:i480332FD618ABCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002661 mRNA. Translation: BAB22268.1.
AY279096 mRNA. Translation: AAP20655.1.
BC058163 mRNA. Translation: AAH58163.1.
CCDSiCCDS20063.1.
RefSeqiNP_083831.1. NM_029555.2.
UniGeneiMm.267014.

Genome annotation databases

EnsembliENSMUST00000031897; ENSMUSP00000031897; ENSMUSG00000029864.
GeneIDi76263.
KEGGimmu:76263.
UCSCiuc009bqo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiGSTK1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families