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Protein

Probable methyltransferase-like protein 15

Gene

Mettl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable S-adenosyl-L-methionine-dependent methyltransferase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191S-adenosyl-L-methionineBy similarity
Binding sitei146 – 1461S-adenosyl-L-methionine; via amide nitrogenBy similarity
Binding sitei169 – 1691S-adenosyl-L-methionineBy similarity
Binding sitei176 – 1761S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable methyltransferase-like protein 15 (EC:2.1.1.-)
Alternative name(s):
Methyltransferase 5 domain-containing protein 1
Gene namesi
Name:Mettl15
Synonyms:Mett5d1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924144. Mettl15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Probable methyltransferase-like protein 15PRO_0000308333Add
BLAST

Proteomic databases

EPDiQ9DCL4.
MaxQBiQ9DCL4.
PaxDbiQ9DCL4.
PRIDEiQ9DCL4.

PTM databases

iPTMnetiQ9DCL4.
PhosphoSiteiQ9DCL4.

Expressioni

Gene expression databases

BgeeiQ9DCL4.
CleanExiMM_METT5D1.
ExpressionAtlasiQ9DCL4. baseline and differential.
GenevisibleiQ9DCL4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080337.

Structurei

3D structure databases

ProteinModelPortaliQ9DCL4.
SMRiQ9DCL4. Positions 72-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni100 – 1023S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2782. Eukaryota.
COG0275. LUCA.
GeneTreeiENSGT00390000014756.
HOVERGENiHBG055013.
InParanoidiQ9DCL4.
OMAiQRPAHIA.
OrthoDBiEOG7PZRX8.
PhylomeDBiQ9DCL4.
TreeFamiTF106425.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 3 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRYPYFYRT YNRLFSHFVD SGASNLDVCP HTIHTAVALH TESKAVEGTA
60 70 80 90 100
LCGPQKVYSS EEKELEAMAK LHIPVMVDQV VHCLAPQKGQ VFLDMTFGSG
110 120 130 140 150
GHTRAILQKE PDVMVYALDR DPVAYAIAEQ LSRLYPTQIQ ALLGQFSQAE
160 170 180 190 200
ALLMKAGVQP GTIDGILMDL GCSSMQLDAP ERGFSLRKDG PLDMRMDGDR
210 220 230 240 250
YPDTPTASDV VNALDQQALA SILRAYGEEK HAKKIASAII QARSTYPISR
260 270 280 290 300
TQQLASIVAG AFPPSAVYAR KDLLQRSTHI ATKTFQALRI FVNNELNELY
310 320 330 340 350
AGLRTAEKFL KTGGRLVALS FHSLEDRIVK RFLLGISMTE RFNLSIRQKV
360 370 380 390 400
KQTSQLDSDQ ETEERHSVRA PLKWELIHKK VLTPEDQDVQ DNPRGRSAKL

RAAIKL
Length:406
Mass (Da):45,282
Last modified:March 1, 2003 - v2
Checksum:i6910C9302AA6BDD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti173 – 1731S → P in AAI06187 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002682 mRNA. Translation: BAB22281.2.
AL691430, BX813309, BX813328 Genomic DNA. Translation: CAM17438.1.
BX813309, AL691430, BX813328 Genomic DNA. Translation: CAM24681.1.
BX813328, AL691430, BX813309 Genomic DNA. Translation: CAM25317.1.
BC106186 mRNA. Translation: AAI06187.1.
BC115926 mRNA. Translation: AAI15927.1.
BC117549 mRNA. Translation: AAI17550.1.
CCDSiCCDS16506.1.
RefSeqiNP_084066.2. NM_029790.3.
XP_006500441.1. XM_006500378.1.
XP_006500442.1. XM_006500379.2.
UniGeneiMm.330451.

Genome annotation databases

EnsembliENSMUST00000081631; ENSMUSP00000080337; ENSMUSG00000057234.
GeneIDi76894.
KEGGimmu:76894.
UCSCiuc008llv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002682 mRNA. Translation: BAB22281.2.
AL691430, BX813309, BX813328 Genomic DNA. Translation: CAM17438.1.
BX813309, AL691430, BX813328 Genomic DNA. Translation: CAM24681.1.
BX813328, AL691430, BX813309 Genomic DNA. Translation: CAM25317.1.
BC106186 mRNA. Translation: AAI06187.1.
BC115926 mRNA. Translation: AAI15927.1.
BC117549 mRNA. Translation: AAI17550.1.
CCDSiCCDS16506.1.
RefSeqiNP_084066.2. NM_029790.3.
XP_006500441.1. XM_006500378.1.
XP_006500442.1. XM_006500379.2.
UniGeneiMm.330451.

3D structure databases

ProteinModelPortaliQ9DCL4.
SMRiQ9DCL4. Positions 72-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080337.

PTM databases

iPTMnetiQ9DCL4.
PhosphoSiteiQ9DCL4.

Proteomic databases

EPDiQ9DCL4.
MaxQBiQ9DCL4.
PaxDbiQ9DCL4.
PRIDEiQ9DCL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081631; ENSMUSP00000080337; ENSMUSG00000057234.
GeneIDi76894.
KEGGimmu:76894.
UCSCiuc008llv.1. mouse.

Organism-specific databases

CTDi196074.
MGIiMGI:1924144. Mettl15.

Phylogenomic databases

eggNOGiKOG2782. Eukaryota.
COG0275. LUCA.
GeneTreeiENSGT00390000014756.
HOVERGENiHBG055013.
InParanoidiQ9DCL4.
OMAiQRPAHIA.
OrthoDBiEOG7PZRX8.
PhylomeDBiQ9DCL4.
TreeFamiTF106425.

Miscellaneous databases

ChiTaRSiMettl15. mouse.
PROiQ9DCL4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCL4.
CleanExiMM_METT5D1.
ExpressionAtlasiQ9DCL4. baseline and differential.
GenevisibleiQ9DCL4. MM.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 3 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiMET15_MOUSE
AccessioniPrimary (citable) accession number: Q9DCL4
Secondary accession number(s): Q3KQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.