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Q9DCK3

- TSN4_MOUSE

UniProt

Q9DCK3 - TSN4_MOUSE

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Protein

Tetraspanin-4

Gene
Tspan4, Tm4sf7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-4
Short name:
Tspan-4
Alternative name(s):
Transmembrane 4 superfamily member 7
Gene namesi
Name:Tspan4
Synonyms:Tm4sf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1928097. Tspan4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei14 – 3421Helical; Reviewed predictionAdd
BLAST
Topological domaini35 – 5521Extracellular Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Reviewed predictionAdd
BLAST
Topological domaini77 – 859Cytoplasmic Reviewed prediction
Transmembranei86 – 10621Helical; Reviewed predictionAdd
BLAST
Topological domaini107 – 20195Extracellular Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Reviewed predictionAdd
BLAST
Topological domaini223 – 23816Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Tetraspanin-4PRO_0000219242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi152 – 1521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9DCK3.
PRIDEiQ9DCK3.

Expressioni

Gene expression databases

ArrayExpressiQ9DCK3.
BgeeiQ9DCK3.
CleanExiMM_TSPAN4.
GenevestigatoriQ9DCK3.

Interactioni

Subunit structurei

Forms a complex with integrins By similarity.

Protein-protein interaction databases

IntActiQ9DCK3. 1 interaction.
MINTiMINT-217510.

Structurei

3D structure databases

ProteinModelPortaliQ9DCK3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290117.
GeneTreeiENSGT00740000115399.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ9DCK3.
KOiK17294.
OMAiMARGCLQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ9DCK3.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCK3-1 [UniParc]FASTAAdd to Basket

« Hide

MARGCLQGVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGN FATLSSSFPS    50
LSAANLLIVT GTFVMAIGFV GCIGALKENK CLLLTFFVLL LLVFLLEATI 100
AVLFFAYSDK IDSYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV 150
SNYTDWFEVY NATRVPDSCC LEFSDSCGLH EPGTWWKSPC YETVKAWLQE 200
NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 238
Length:238
Mass (Da):26,054
Last modified:June 1, 2001 - v1
Checksum:iAA916EF6078777FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002709 mRNA. Translation: BAB22301.1.
BC003482 mRNA. Translation: AAH03482.1.
BC083070 mRNA. Translation: AAH83070.1.
CCDSiCCDS22018.1.
RefSeqiNP_001239517.1. NM_001252588.1.
NP_444312.1. NM_053082.3.
UniGeneiMm.489619.

Genome annotation databases

EnsembliENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511.
ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511.
GeneIDi64540.
KEGGimmu:64540.
UCSCiuc009kln.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002709 mRNA. Translation: BAB22301.1 .
BC003482 mRNA. Translation: AAH03482.1 .
BC083070 mRNA. Translation: AAH83070.1 .
CCDSi CCDS22018.1.
RefSeqi NP_001239517.1. NM_001252588.1.
NP_444312.1. NM_053082.3.
UniGenei Mm.489619.

3D structure databases

ProteinModelPortali Q9DCK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9DCK3. 1 interaction.
MINTi MINT-217510.

Proteomic databases

PaxDbi Q9DCK3.
PRIDEi Q9DCK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026585 ; ENSMUSP00000026585 ; ENSMUSG00000025511 .
ENSMUST00000117634 ; ENSMUSP00000113085 ; ENSMUSG00000025511 .
GeneIDi 64540.
KEGGi mmu:64540.
UCSCi uc009kln.2. mouse.

Organism-specific databases

CTDi 7106.
MGIi MGI:1928097. Tspan4.

Phylogenomic databases

eggNOGi NOG290117.
GeneTreei ENSGT00740000115399.
HOGENOMi HOG000230651.
HOVERGENi HBG002324.
InParanoidi Q9DCK3.
KOi K17294.
OMAi MARGCLQ.
OrthoDBi EOG7PGDRZ.
PhylomeDBi Q9DCK3.
TreeFami TF352892.

Miscellaneous databases

ChiTaRSi TSPAN4. mouse.
NextBioi 320115.
PROi Q9DCK3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DCK3.
Bgeei Q9DCK3.
CleanExi MM_TSPAN4.
Genevestigatori Q9DCK3.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiTSN4_MOUSE
AccessioniPrimary (citable) accession number: Q9DCK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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