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Q9DCK3

- TSN4_MOUSE

UniProt

Q9DCK3 - TSN4_MOUSE

Protein

Tetraspanin-4

Gene

Tspan4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-4
    Short name:
    Tspan-4
    Alternative name(s):
    Transmembrane 4 superfamily member 7
    Gene namesi
    Name:Tspan4
    Synonyms:Tm4sf7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1928097. Tspan4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Tetraspanin-4PRO_0000219242Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9DCK3.
    PRIDEiQ9DCK3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DCK3.
    BgeeiQ9DCK3.
    CleanExiMM_TSPAN4.
    GenevestigatoriQ9DCK3.

    Interactioni

    Subunit structurei

    Forms a complex with integrins.By similarity

    Protein-protein interaction databases

    IntActiQ9DCK3. 1 interaction.
    MINTiMINT-217510.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini35 – 5521ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 859CytoplasmicSequence Analysis
    Topological domaini107 – 20195ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini223 – 23816CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG290117.
    GeneTreeiENSGT00740000115399.
    HOGENOMiHOG000230651.
    HOVERGENiHBG002324.
    InParanoidiQ9DCK3.
    KOiK17294.
    OMAiMARGCLQ.
    OrthoDBiEOG7PGDRZ.
    PhylomeDBiQ9DCK3.
    TreeFamiTF352892.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DCK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGCLQGVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGN FATLSSSFPS    50
    LSAANLLIVT GTFVMAIGFV GCIGALKENK CLLLTFFVLL LLVFLLEATI 100
    AVLFFAYSDK IDSYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV 150
    SNYTDWFEVY NATRVPDSCC LEFSDSCGLH EPGTWWKSPC YETVKAWLQE 200
    NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 238
    Length:238
    Mass (Da):26,054
    Last modified:June 1, 2001 - v1
    Checksum:iAA916EF6078777FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002709 mRNA. Translation: BAB22301.1.
    BC003482 mRNA. Translation: AAH03482.1.
    BC083070 mRNA. Translation: AAH83070.1.
    CCDSiCCDS22018.1.
    RefSeqiNP_001239517.1. NM_001252588.1.
    NP_444312.1. NM_053082.3.
    UniGeneiMm.489619.

    Genome annotation databases

    EnsembliENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511.
    ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511.
    GeneIDi64540.
    KEGGimmu:64540.
    UCSCiuc009kln.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002709 mRNA. Translation: BAB22301.1 .
    BC003482 mRNA. Translation: AAH03482.1 .
    BC083070 mRNA. Translation: AAH83070.1 .
    CCDSi CCDS22018.1.
    RefSeqi NP_001239517.1. NM_001252588.1.
    NP_444312.1. NM_053082.3.
    UniGenei Mm.489619.

    3D structure databases

    ProteinModelPortali Q9DCK3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9DCK3. 1 interaction.
    MINTi MINT-217510.

    Proteomic databases

    PaxDbi Q9DCK3.
    PRIDEi Q9DCK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026585 ; ENSMUSP00000026585 ; ENSMUSG00000025511 .
    ENSMUST00000117634 ; ENSMUSP00000113085 ; ENSMUSG00000025511 .
    GeneIDi 64540.
    KEGGi mmu:64540.
    UCSCi uc009kln.2. mouse.

    Organism-specific databases

    CTDi 7106.
    MGIi MGI:1928097. Tspan4.

    Phylogenomic databases

    eggNOGi NOG290117.
    GeneTreei ENSGT00740000115399.
    HOGENOMi HOG000230651.
    HOVERGENi HBG002324.
    InParanoidi Q9DCK3.
    KOi K17294.
    OMAi MARGCLQ.
    OrthoDBi EOG7PGDRZ.
    PhylomeDBi Q9DCK3.
    TreeFami TF352892.

    Miscellaneous databases

    ChiTaRSi TSPAN4. mouse.
    NextBioi 320115.
    PROi Q9DCK3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DCK3.
    Bgeei Q9DCK3.
    CleanExi MM_TSPAN4.
    Genevestigatori Q9DCK3.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiTSN4_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3