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Q9DCK3 (TSN4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-4

Short name=Tspan-4
Alternative name(s):
Transmembrane 4 superfamily member 7
Gene names
Name:Tspan4
Synonyms:Tm4sf7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Forms a complex with integrins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 238238Tetraspanin-4
PRO_0000219242

Regions

Topological domain1 – 1313Cytoplasmic Potential
Transmembrane14 – 3421Helical; Potential
Topological domain35 – 5521Extracellular Potential
Transmembrane56 – 7621Helical; Potential
Topological domain77 – 859Cytoplasmic Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 20195Extracellular Potential
Transmembrane202 – 22221Helical; Potential
Topological domain223 – 23816Cytoplasmic Potential

Amino acid modifications

Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9DCK3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AA916EF6078777FA

FASTA23826,054
        10         20         30         40         50         60 
MARGCLQGVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGN FATLSSSFPS LSAANLLIVT 

        70         80         90        100        110        120 
GTFVMAIGFV GCIGALKENK CLLLTFFVLL LLVFLLEATI AVLFFAYSDK IDSYAQQDLK 

       130        140        150        160        170        180 
KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV SNYTDWFEVY NATRVPDSCC LEFSDSCGLH 

       190        200        210        220        230 
EPGTWWKSPC YETVKAWLQE NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002709 mRNA. Translation: BAB22301.1.
BC003482 mRNA. Translation: AAH03482.1.
BC083070 mRNA. Translation: AAH83070.1.
RefSeqNP_001239517.1. NM_001252588.1.
NP_444312.1. NM_053082.3.
UniGeneMm.489619.

3D structure databases

ProteinModelPortalQ9DCK3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9DCK3. 1 interaction.
MINTMINT-217510.

Proteomic databases

PaxDbQ9DCK3.
PRIDEQ9DCK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511.
ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511.
GeneID64540.
KEGGmmu:64540.
UCSCuc009kln.2. mouse.

Organism-specific databases

CTD7106.
MGIMGI:1928097. Tspan4.

Phylogenomic databases

eggNOGNOG290117.
GeneTreeENSGT00740000115399.
HOGENOMHOG000230651.
HOVERGENHBG002324.
InParanoidQ9DCK3.
KOK17294.
OMAMARGCLQ.
OrthoDBEOG7PGDRZ.
PhylomeDBQ9DCK3.
TreeFamTF352892.

Gene expression databases

ArrayExpressQ9DCK3.
BgeeQ9DCK3.
CleanExMM_TSPAN4.
GenevestigatorQ9DCK3.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
SUPFAMSSF48652. SSF48652. 1 hit.
PROSITEPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTSPAN4. mouse.
NextBio320115.
PROQ9DCK3.
SOURCESearch...

Entry information

Entry nameTSN4_MOUSE
AccessionPrimary (citable) accession number: Q9DCK3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot