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Protein

Tetraspanin-4

Gene

Tspan4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: MGI
  2. integrin binding Source: MGI

GO - Biological processi

  1. protein complex assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-4
Short name:
Tspan-4
Alternative name(s):
Transmembrane 4 superfamily member 7
Gene namesi
Name:Tspan4
Synonyms:Tm4sf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928097. Tspan4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Topological domaini35 – 5521ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 859CytoplasmicSequence Analysis
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 20195ExtracellularSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Topological domaini223 – 23816CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. focal adhesion Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
  4. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Tetraspanin-4PRO_0000219242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9DCK3.
PRIDEiQ9DCK3.

Expressioni

Gene expression databases

BgeeiQ9DCK3.
CleanExiMM_TSPAN4.
ExpressionAtlasiQ9DCK3. baseline and differential.
GenevestigatoriQ9DCK3.

Interactioni

Subunit structurei

Forms a complex with integrins.By similarity

Protein-protein interaction databases

IntActiQ9DCK3. 1 interaction.
MINTiMINT-217510.

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG290117.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ9DCK3.
KOiK17294.
OMAiMARGCLQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ9DCK3.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLQGVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGN FATLSSSFPS
60 70 80 90 100
LSAANLLIVT GTFVMAIGFV GCIGALKENK CLLLTFFVLL LLVFLLEATI
110 120 130 140 150
AVLFFAYSDK IDSYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV
160 170 180 190 200
SNYTDWFEVY NATRVPDSCC LEFSDSCGLH EPGTWWKSPC YETVKAWLQE
210 220 230
NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA
Length:238
Mass (Da):26,054
Last modified:June 1, 2001 - v1
Checksum:iAA916EF6078777FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002709 mRNA. Translation: BAB22301.1.
BC003482 mRNA. Translation: AAH03482.1.
BC083070 mRNA. Translation: AAH83070.1.
CCDSiCCDS22018.1.
RefSeqiNP_001239517.1. NM_001252588.1.
NP_444312.1. NM_053082.3.
UniGeneiMm.489619.

Genome annotation databases

EnsembliENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511.
ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511.
GeneIDi64540.
KEGGimmu:64540.
UCSCiuc009kln.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002709 mRNA. Translation: BAB22301.1.
BC003482 mRNA. Translation: AAH03482.1.
BC083070 mRNA. Translation: AAH83070.1.
CCDSiCCDS22018.1.
RefSeqiNP_001239517.1. NM_001252588.1.
NP_444312.1. NM_053082.3.
UniGeneiMm.489619.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DCK3. 1 interaction.
MINTiMINT-217510.

Proteomic databases

PaxDbiQ9DCK3.
PRIDEiQ9DCK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511.
ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511.
GeneIDi64540.
KEGGimmu:64540.
UCSCiuc009kln.2. mouse.

Organism-specific databases

CTDi7106.
MGIiMGI:1928097. Tspan4.

Phylogenomic databases

eggNOGiNOG290117.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ9DCK3.
KOiK17294.
OMAiMARGCLQ.
OrthoDBiEOG7PGDRZ.
PhylomeDBiQ9DCK3.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTspan4. mouse.
NextBioi320115.
PROiQ9DCK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCK3.
CleanExiMM_TSPAN4.
ExpressionAtlasiQ9DCK3. baseline and differential.
GenevestigatoriQ9DCK3.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiTSN4_MOUSE
AccessioniPrimary (citable) accession number: Q9DCK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.