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Protein

Tetraspanin-4

Gene

Tspan4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-4
Short name:
Tspan-4
Alternative name(s):
Transmembrane 4 superfamily member 7
Gene namesi
Name:Tspan4
Synonyms:Tm4sf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1928097 Tspan4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 55ExtracellularSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 85CytoplasmicSequence analysis9
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 201ExtracellularSequence analysisAdd BLAST95
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192421 – 238Tetraspanin-4Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9DCK3
PaxDbiQ9DCK3
PRIDEiQ9DCK3

PTM databases

SwissPalmiQ9DCK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000025511
CleanExiMM_TSPAN4
ExpressionAtlasiQ9DCK3 baseline and differential
GenevisibleiQ9DCK3 MM

Interactioni

Subunit structurei

Forms a complex with integrins.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9DCK3, 1 interactor
MINTiQ9DCK3
STRINGi10090.ENSMUSP00000026585

Structurei

3D structure databases

ProteinModelPortaliQ9DCK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137858
HOGENOMiHOG000230651
HOVERGENiHBG002324
InParanoidiQ9DCK3
KOiK17294
OMAiHSPGTWW
OrthoDBiEOG091G0CQO
PhylomeDBiQ9DCK3
TreeFamiTF352892

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGCLQGVK YLMFAFNLLF WLGGCGVLGV GIWLAATQGN FATLSSSFPS
60 70 80 90 100
LSAANLLIVT GTFVMAIGFV GCIGALKENK CLLLTFFVLL LLVFLLEATI
110 120 130 140 150
AVLFFAYSDK IDSYAQQDLK KGLHLYGTQG NVGLTNAWSI IQTDFRCCGV
160 170 180 190 200
SNYTDWFEVY NATRVPDSCC LEFSDSCGLH EPGTWWKSPC YETVKAWLQE
210 220 230
NLLAVGIFGL CTALVQILGL TFAMTMYCQV VKADTYCA
Length:238
Mass (Da):26,054
Last modified:June 1, 2001 - v1
Checksum:iAA916EF6078777FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002709 mRNA Translation: BAB22301.1
BC003482 mRNA Translation: AAH03482.1
BC083070 mRNA Translation: AAH83070.1
CCDSiCCDS22018.1
RefSeqiNP_001239517.1, NM_001252588.1
NP_444312.1, NM_053082.3
UniGeneiMm.489619

Genome annotation databases

EnsembliENSMUST00000026585; ENSMUSP00000026585; ENSMUSG00000025511
ENSMUST00000117634; ENSMUSP00000113085; ENSMUSG00000025511
GeneIDi64540
KEGGimmu:64540
UCSCiuc009kln.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTSN4_MOUSE
AccessioniPrimary (citable) accession number: Q9DCK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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