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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

Gene

Ndufa8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Alternative name(s):
Complex I-19kD
Short name:
CI-19kD
Complex I-PGIV
Short name:
CI-PGIV
NADH-ubiquinone oxidoreductase 19 kDa subunit
Gene namesi
Name:Ndufa8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915625 Ndufa8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001187352 – 172NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 66PROSITE-ProRule annotation
Disulfide bondi46 ↔ 56PROSITE-ProRule annotation
Disulfide bondi78 ↔ 110PROSITE-ProRule annotation
Disulfide bondi88 ↔ 100PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ9DCJ5
MaxQBiQ9DCJ5
PaxDbiQ9DCJ5
PeptideAtlasiQ9DCJ5
PRIDEiQ9DCJ5

PTM databases

iPTMnetiQ9DCJ5
PhosphoSitePlusiQ9DCJ5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026895
GenevisibleiQ9DCJ5 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi212827, 5 interactors
CORUMiQ9DCJ5
IntActiQ9DCJ5, 8 interactors
MINTiQ9DCJ5
STRINGi10090.ENSMUSP00000065352

Structurei

3D structure databases

ProteinModelPortaliQ9DCJ5
SMRiQ9DCJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 74CHCH 1PROSITE-ProRule annotationAdd BLAST42
Domaini75 – 118CHCH 2PROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi56 – 66Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11
Motifi78 – 88Cx9C motif 3PROSITE-ProRule annotationAdd BLAST11
Motifi100 – 110Cx9C motif 4PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the complex I NDUFA8 subunit family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3458 Eukaryota
ENOG4111IST LUCA
GeneTreeiENSGT00390000008938
HOGENOMiHOG000090856
HOVERGENiHBG001244
InParanoidiQ9DCJ5
KOiK03952
OMAiNEDFMLC
OrthoDBiEOG091G0M0S
PhylomeDBiQ9DCJ5
TreeFamiTF105633

Family and domain databases

InterProiView protein in InterPro
IPR010625 CHCH
IPR016680 NDUFA8
PfamiView protein in Pfam
PF06747 CHCH, 1 hit
PIRSFiPIRSF017016 NDUA8, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGIVELPTL EELKVEEVKV SSAVLKAAAH HYGAQCDKTN KEFMLCRWEE
60 70 80 90 100
KDPRRCLKEG KLVNGCALNF FRQIKSHCAE PFTEYWTCLD YSNMQLFRHC
110 120 130 140 150
RQQQAKFDQC VLDKLGWVRP DLGQLSKVTK VKTDRPLPEN PYHSRARPEP
160 170
NPVIEGDLKP AKHGTRFFFW TV
Length:172
Mass (Da):19,992
Last modified:January 23, 2007 - v3
Checksum:i7DF62AB86B5BF684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002744 mRNA Translation: BAB22322.1
AL773525 Genomic DNA No translation available.
BC012416 mRNA Translation: AAH12416.1
BC024673 mRNA Translation: AAH24673.1
CCDSiCCDS15967.1
RefSeqiNP_080979.1, NM_026703.2
UniGeneiMm.19834

Genome annotation databases

EnsembliENSMUST00000070112; ENSMUSP00000065352; ENSMUSG00000026895
GeneIDi68375
KEGGimmu:68375
UCSCiuc008jlb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUA8_MOUSE
AccessioniPrimary (citable) accession number: Q9DCJ5
Secondary accession number(s): A2AL45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health