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Protein

AN1-type zinc finger protein 6

Gene

Zfand6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri161 – 204AN1-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

  • DNA binding Source: InterPro
  • polyubiquitin binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 6
Alternative name(s):
Associated with PRK1 protein
Zinc finger A20 domain-containing protein 3
Gene namesi
Name:Zfand6
Synonyms:Awp1, Za20d3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1929510. Zfand6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi30C → S: Abolishes interaction with PEX6 and ubiquitin. Impairs interaction with PEX5. 1 Publication1
Mutagenesisi180C → S: Impairs interaction with PEX6. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452361 – 223AN1-type zinc finger protein 6Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1
Modified residuei219N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DCH6.
MaxQBiQ9DCH6.
PaxDbiQ9DCH6.
PeptideAtlasiQ9DCH6.
PRIDEiQ9DCH6.

PTM databases

iPTMnetiQ9DCH6.
PhosphoSitePlusiQ9DCH6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030629.
CleanExiMM_ZFAND6.
ExpressionAtlasiQ9DCH6. baseline and differential.
GenevisibleiQ9DCH6. MM.

Interactioni

Subunit structurei

Interacts with PKN1. Interacts with TRAF2 (By similarity). Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated).By similarity2 Publications

GO - Molecular functioni

  • polyubiquitin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi211125. 1 interactor.
STRINGi10090.ENSMUSP00000069228.

Structurei

3D structure databases

ProteinModelPortaliQ9DCH6.
SMRiQ9DCH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.By similarity
The AN1-type zinc finger domain mediates association with TRAF2.By similarity

Sequence similaritiesi

Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 AN1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri161 – 204AN1-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00510000046525.
HOGENOMiHOG000238229.
HOVERGENiHBG053349.
InParanoidiQ9DCH6.
OMAiNVPEAQS.
OrthoDBiEOG091G0M53.
PhylomeDBiQ9DCH6.
TreeFamiTF313612.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQETNHSQA PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP
60 70 80 90 100
PAASVSSLSE SLPVQCADGS VPDAQSALDS TSSSMQPGPV SNQSLLSESV
110 120 130 140 150
APSQVDSTSV DKAVSETEDL QGPRAEGLVP LECDPPSSVS DTTQQPSEEQ
160 170 180 190 200
SKSLEKPKQK KNRCFMCRKK VGLTGFECRC GNVYCGVHRY SDVHNCSYNY
210 220
KADAAEKIRK ENPVVVGEKI QKI
Length:223
Mass (Da):24,001
Last modified:June 1, 2001 - v1
Checksum:iFFBF1A09EEC39901
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti99S → P in CAC14886 (PubMed:11054541).Curated1
Sequence conflicti190Y → S in CAC14886 (PubMed:11054541).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251508 mRNA. Translation: CAC14886.1.
AK002775 mRNA. Translation: BAB22349.1.
AK144902 mRNA. Translation: BAE26124.1.
BC010683 mRNA. Translation: AAH10683.1.
CCDSiCCDS21419.1.
RefSeqiNP_075361.2. NM_022985.6.
XP_006508168.1. XM_006508105.2.
XP_006508169.1. XM_006508106.2.
XP_006508170.1. XM_006508107.3.
XP_006508171.1. XM_006508108.1.
UniGeneiMm.209349.
Mm.397115.

Genome annotation databases

EnsembliENSMUST00000069537; ENSMUSP00000069228; ENSMUSG00000030629.
ENSMUST00000178385; ENSMUSP00000135968; ENSMUSG00000030629.
ENSMUST00000209117; ENSMUSP00000146518; ENSMUSG00000030629.
GeneIDi65098.
KEGGimmu:65098.
UCSCiuc009iek.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251508 mRNA. Translation: CAC14886.1.
AK002775 mRNA. Translation: BAB22349.1.
AK144902 mRNA. Translation: BAE26124.1.
BC010683 mRNA. Translation: AAH10683.1.
CCDSiCCDS21419.1.
RefSeqiNP_075361.2. NM_022985.6.
XP_006508168.1. XM_006508105.2.
XP_006508169.1. XM_006508106.2.
XP_006508170.1. XM_006508107.3.
XP_006508171.1. XM_006508108.1.
UniGeneiMm.209349.
Mm.397115.

3D structure databases

ProteinModelPortaliQ9DCH6.
SMRiQ9DCH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211125. 1 interactor.
STRINGi10090.ENSMUSP00000069228.

PTM databases

iPTMnetiQ9DCH6.
PhosphoSitePlusiQ9DCH6.

Proteomic databases

EPDiQ9DCH6.
MaxQBiQ9DCH6.
PaxDbiQ9DCH6.
PeptideAtlasiQ9DCH6.
PRIDEiQ9DCH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069537; ENSMUSP00000069228; ENSMUSG00000030629.
ENSMUST00000178385; ENSMUSP00000135968; ENSMUSG00000030629.
ENSMUST00000209117; ENSMUSP00000146518; ENSMUSG00000030629.
GeneIDi65098.
KEGGimmu:65098.
UCSCiuc009iek.1. mouse.

Organism-specific databases

CTDi54469.
MGIiMGI:1929510. Zfand6.

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00510000046525.
HOGENOMiHOG000238229.
HOVERGENiHBG053349.
InParanoidiQ9DCH6.
OMAiNVPEAQS.
OrthoDBiEOG091G0M53.
PhylomeDBiQ9DCH6.
TreeFamiTF313612.

Miscellaneous databases

ChiTaRSiZfand6. mouse.
PROiQ9DCH6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030629.
CleanExiMM_ZFAND6.
ExpressionAtlasiQ9DCH6. baseline and differential.
GenevisibleiQ9DCH6. MM.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFAN6_MOUSE
AccessioniPrimary (citable) accession number: Q9DCH6
Secondary accession number(s): Q9ER79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.