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Q9DCH2

- POP7_MOUSE

UniProt

Q9DCH2 - POP7_MOUSE

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Protein

Ribonuclease P protein subunit p20

Gene
Pop7, Rpp20
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences By similarity.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p20 (EC:3.1.26.5)
Short name:
RNaseP protein p20
Gene namesi
Name:Pop7
Synonyms:Rpp20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1921347. Pop7.

Subcellular locationi

Nucleusnucleolus By similarity. Cytoplasm By similarity. Cytoplasmic granule By similarity
Note: Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Ribonuclease P protein subunit p20PRO_0000237701Add
BLAST

Proteomic databases

PaxDbiQ9DCH2.
PRIDEiQ9DCH2.

PTM databases

PhosphoSiteiQ9DCH2.

Expressioni

Gene expression databases

BgeeiQ9DCH2.
GenevestigatoriQ9DCH2.

Interactioni

Subunit structurei

Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106664.

Structurei

3D structure databases

ProteinModelPortaliQ9DCH2.
SMRiQ9DCH2. Positions 35-136.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone-like Alba family.

Phylogenomic databases

eggNOGiNOG86230.
GeneTreeiENSGT00510000048483.
HOGENOMiHOG000253010.
HOVERGENiHBG001490.
InParanoidiQ9DCH2.
KOiK14527.
OMAiCTEIYIH.
OrthoDBiEOG7N37FG.
PhylomeDBiQ9DCH2.
TreeFamiTF313948.

Family and domain databases

Gene3Di3.30.110.20. 1 hit.
InterProiIPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view]
PANTHERiPTHR15314. PTHR15314. 1 hit.
PfamiPF01918. Alba. 1 hit.
[Graphical view]
PIRSFiPIRSF036572. RPP20. 1 hit.
SUPFAMiSSF82704. SSF82704. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCH2-1 [UniParc]FASTAAdd to Basket

« Hide

MAENREPRCA IEAELDPVEY TLRKRLPHRL PRRPNDIYVN MKTDFKAQLA    50
RCQKLLDGGT RGQNACTEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA 100
NTSTVELVDE LEPETDSREP LTRVRNNSAI HIRVFRVTPK 140
Length:140
Mass (Da):15,777
Last modified:June 1, 2001 - v1
Checksum:i0F30841C7F50DFA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28826.1.
AK002782 mRNA. Translation: BAB22355.1.
AK158620 mRNA. Translation: BAE34584.1.
AK162268 mRNA. Translation: BAE36826.1.
BC010780 mRNA. Translation: AAH10780.1.
CCDSiCCDS19768.1.
RefSeqiNP_083029.1. NM_028753.2.
UniGeneiMm.290242.

Genome annotation databases

EnsembliENSMUST00000031728; ENSMUSP00000031728; ENSMUSG00000029715.
ENSMUST00000111035; ENSMUSP00000106664; ENSMUSG00000029715.
GeneIDi74097.
KEGGimmu:74097.
UCSCiuc009aco.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF312033 Genomic DNA. Translation: AAK28826.1 .
AK002782 mRNA. Translation: BAB22355.1 .
AK158620 mRNA. Translation: BAE34584.1 .
AK162268 mRNA. Translation: BAE36826.1 .
BC010780 mRNA. Translation: AAH10780.1 .
CCDSi CCDS19768.1.
RefSeqi NP_083029.1. NM_028753.2.
UniGenei Mm.290242.

3D structure databases

ProteinModelPortali Q9DCH2.
SMRi Q9DCH2. Positions 35-136.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000106664.

PTM databases

PhosphoSitei Q9DCH2.

Proteomic databases

PaxDbi Q9DCH2.
PRIDEi Q9DCH2.

Protocols and materials databases

DNASUi 74097.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031728 ; ENSMUSP00000031728 ; ENSMUSG00000029715 .
ENSMUST00000111035 ; ENSMUSP00000106664 ; ENSMUSG00000029715 .
GeneIDi 74097.
KEGGi mmu:74097.
UCSCi uc009aco.1. mouse.

Organism-specific databases

CTDi 10248.
MGIi MGI:1921347. Pop7.

Phylogenomic databases

eggNOGi NOG86230.
GeneTreei ENSGT00510000048483.
HOGENOMi HOG000253010.
HOVERGENi HBG001490.
InParanoidi Q9DCH2.
KOi K14527.
OMAi CTEIYIH.
OrthoDBi EOG7N37FG.
PhylomeDBi Q9DCH2.
TreeFami TF313948.

Miscellaneous databases

NextBioi 339761.
PROi Q9DCH2.
SOURCEi Search...

Gene expression databases

Bgeei Q9DCH2.
Genevestigatori Q9DCH2.

Family and domain databases

Gene3Di 3.30.110.20. 1 hit.
InterProi IPR002775. DNA/RNA-bd_Alba-like.
IPR014612. RNase_P/MRP_p20.
[Graphical view ]
PANTHERi PTHR15314. PTHR15314. 1 hit.
Pfami PF01918. Alba. 1 hit.
[Graphical view ]
PIRSFi PIRSF036572. RPP20. 1 hit.
SUPFAMi SSF82704. SSF82704. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
    Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
    Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg, Kidney and Visual cortex.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiPOP7_MOUSE
AccessioniPrimary (citable) accession number: Q9DCH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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