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Q9DCH2

- POP7_MOUSE

UniProt

Q9DCH2 - POP7_MOUSE

Protein

Ribonuclease P protein subunit p20

Gene

Pop7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences By similarity.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p20 (EC:3.1.26.5)
    Short name:
    RNaseP protein p20
    Gene namesi
    Name:Pop7
    Synonyms:Rpp20
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1921347. Pop7.

    Subcellular locationi

    Nucleusnucleolus By similarity. Cytoplasm By similarity. Cytoplasmic granule By similarity
    Note: Under stress conditions colocalizes with SMN1 in punctuated cytoplasmic granules.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Ribonuclease P protein subunit p20PRO_0000237701Add
    BLAST

    Proteomic databases

    PaxDbiQ9DCH2.
    PRIDEiQ9DCH2.

    PTM databases

    PhosphoSiteiQ9DCH2.

    Expressioni

    Gene expression databases

    BgeeiQ9DCH2.
    GenevestigatoriQ9DCH2.

    Interactioni

    Subunit structurei

    Component of nuclear RNase P and RNase MRP complexes. RNase P consists of an RNA moiety and at least 8 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38 and RPP40. RNase MRP consists of an RNA moiety and at least 9 protein subunits; POP1, RPP14, RPP20/POP7, RPP25, RPP29/POP4, RPP30, RPP38, RPP40, POP5 and RPP21. Interacts with RPP25 and SMN1. RPP20/POP7 is probably a dimer By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000106664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCH2.
    SMRiQ9DCH2. Positions 35-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone-like Alba family.Curated

    Phylogenomic databases

    eggNOGiNOG86230.
    GeneTreeiENSGT00510000048483.
    HOGENOMiHOG000253010.
    HOVERGENiHBG001490.
    InParanoidiQ9DCH2.
    KOiK14527.
    OMAiCTEIYIH.
    OrthoDBiEOG7N37FG.
    PhylomeDBiQ9DCH2.
    TreeFamiTF313948.

    Family and domain databases

    Gene3Di3.30.110.20. 1 hit.
    InterProiIPR002775. DNA/RNA-bd_Alba-like.
    IPR014612. RNase_P/MRP_p20.
    [Graphical view]
    PANTHERiPTHR15314. PTHR15314. 1 hit.
    PfamiPF01918. Alba. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036572. RPP20. 1 hit.
    SUPFAMiSSF82704. SSF82704. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DCH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENREPRCA IEAELDPVEY TLRKRLPHRL PRRPNDIYVN MKTDFKAQLA    50
    RCQKLLDGGT RGQNACTEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA 100
    NTSTVELVDE LEPETDSREP LTRVRNNSAI HIRVFRVTPK 140
    Length:140
    Mass (Da):15,777
    Last modified:June 1, 2001 - v1
    Checksum:i0F30841C7F50DFA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312033 Genomic DNA. Translation: AAK28826.1.
    AK002782 mRNA. Translation: BAB22355.1.
    AK158620 mRNA. Translation: BAE34584.1.
    AK162268 mRNA. Translation: BAE36826.1.
    BC010780 mRNA. Translation: AAH10780.1.
    CCDSiCCDS19768.1.
    RefSeqiNP_083029.1. NM_028753.2.
    UniGeneiMm.290242.

    Genome annotation databases

    EnsembliENSMUST00000031728; ENSMUSP00000031728; ENSMUSG00000029715.
    ENSMUST00000111035; ENSMUSP00000106664; ENSMUSG00000029715.
    GeneIDi74097.
    KEGGimmu:74097.
    UCSCiuc009aco.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312033 Genomic DNA. Translation: AAK28826.1 .
    AK002782 mRNA. Translation: BAB22355.1 .
    AK158620 mRNA. Translation: BAE34584.1 .
    AK162268 mRNA. Translation: BAE36826.1 .
    BC010780 mRNA. Translation: AAH10780.1 .
    CCDSi CCDS19768.1.
    RefSeqi NP_083029.1. NM_028753.2.
    UniGenei Mm.290242.

    3D structure databases

    ProteinModelPortali Q9DCH2.
    SMRi Q9DCH2. Positions 35-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000106664.

    PTM databases

    PhosphoSitei Q9DCH2.

    Proteomic databases

    PaxDbi Q9DCH2.
    PRIDEi Q9DCH2.

    Protocols and materials databases

    DNASUi 74097.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031728 ; ENSMUSP00000031728 ; ENSMUSG00000029715 .
    ENSMUST00000111035 ; ENSMUSP00000106664 ; ENSMUSG00000029715 .
    GeneIDi 74097.
    KEGGi mmu:74097.
    UCSCi uc009aco.1. mouse.

    Organism-specific databases

    CTDi 10248.
    MGIi MGI:1921347. Pop7.

    Phylogenomic databases

    eggNOGi NOG86230.
    GeneTreei ENSGT00510000048483.
    HOGENOMi HOG000253010.
    HOVERGENi HBG001490.
    InParanoidi Q9DCH2.
    KOi K14527.
    OMAi CTEIYIH.
    OrthoDBi EOG7N37FG.
    PhylomeDBi Q9DCH2.
    TreeFami TF313948.

    Miscellaneous databases

    NextBioi 339761.
    PROi Q9DCH2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCH2.
    Genevestigatori Q9DCH2.

    Family and domain databases

    Gene3Di 3.30.110.20. 1 hit.
    InterProi IPR002775. DNA/RNA-bd_Alba-like.
    IPR014612. RNase_P/MRP_p20.
    [Graphical view ]
    PANTHERi PTHR15314. PTHR15314. 1 hit.
    Pfami PF01918. Alba. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036572. RPP20. 1 hit.
    SUPFAMi SSF82704. SSF82704. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D., Riemer C., Martindale D.W., Schnupf P., Boright A.P., Cheung T.L., Hardy D.M., Schwartz S., Scherer S.W., Tsui L.-C., Miller W., Koop B.F.
      Nucleic Acids Res. 29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg, Kidney and Visual cortex.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiPOP7_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3