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Q9DCG9 (TR112_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA methyltransferase 112 homolog
Alternative name(s):
TRM112-like protein
Gene names
Name:Trmt112
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species By similarity.

Subunit structure

Interacts with ALKBH8 and HEMK2/N6AMT1 By similarity.

Sequence similarities

Belongs to the TRM112 family.

Contains 1 TRM112 domain.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 125125tRNA methyltransferase 112 homolog
PRO_0000215798

Regions

Domain2 – 119118TRM112

Experimental info

Sequence conflict851H → Q in BAB22695. Ref.1
Sequence conflict1221Missing in AAH16191. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9DCG9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A749605B3982A6F6

FASTA12514,141
        10         20         30         40         50         60 
MKLLTHNLLS SHVRGVGTRG FPLRLQATEV RINPVEFNPE FVARMIPKVE WAALVQAADT 

        70         80         90        100        110        120 
LNLAEVPKEP TEGYEHDETF LRKMHHVLLE VDVLEGTLQC PESGRLFPIS RGIPNMLLND 


EETET

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK002791 mRNA. Translation: BAB22361.1.
AK003292 mRNA. Translation: BAB22695.1.
BC016191 mRNA. Translation: AAH16191.1.
IPIIPI00120871.
RefSeqNP_001159842.1. NM_001166370.1.
NP_080582.3. NM_026306.3.
XP_003086453.1. XM_003086405.1.
XP_897794.1. XM_892701.4.
UniGeneMm.318804.
Mm.371597.

3D structure databases

ProteinModelPortalQ9DCG9.
SMRQ9DCG9. Positions 1-124.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9DCG9.

PTM databases

PhosphoSiteQ9DCG9.

Proteomic databases

PRIDEQ9DCG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088257; ENSMUSP00000085591; ENSMUSG00000038812.
ENSMUST00000116551; ENSMUSP00000112250; ENSMUSG00000038812.
GeneID100503161.
627985.
67674.
KEGGmmu:100503161.
mmu:627985.
mmu:67674.
UCSCuc008gjd.2. mouse.

Organism-specific databases

CTD51504.
MGIMGI:1914924. Trmt112.

Phylogenomic databases

GeneTreeENSGT00390000009268.
HOGENOMHBG526194.
HOVERGENHBG056590.
InParanoidQ9DCG9.
OMARLLTHNM.
OrthoDBEOG4WQ140.
PhylomeDBQ9DCG9.

Gene expression databases

ArrayExpressQ9DCG9.
BgeeQ9DCG9.
CleanExMM_0610038D11RIK.
GenevestigatorQ9DCG9.
GermOnlineENSMUSG00000038812. Mus musculus.
ENSMUSG00000070572. Mus musculus.

Family and domain databases

InterProIPR005651. UPF0434/Trm112.
[Graphical view]
KOK15448.
PfamPF03966. Trm112p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio420118.
SOURCESearch...

Entry information

Entry nameTR112_MOUSE
AccessionPrimary (citable) accession number: Q9DCG9
Secondary accession number(s): Q91YP8, Q9D1N6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2001
Last modified: November 16, 2011
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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