ID   CD302_MOUSE             Reviewed;         228 AA.
AC   Q9DCG2; A2AW84; A2AW85; Q78KD8; Q9D0X7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=CD302 antigen;
DE   AltName: Full=C-type lectin domain family 13 member A;
DE   AltName: Full=Type I transmembrane C-type lectin receptor DCL-1;
DE   AltName: CD_antigen=CD302;
DE   Flags: Precursor;
GN   Name=Cd302; Synonyms=Clec13a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-228 (ISOFORM 1).
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Potential multifunctional C-type lectin receptor that may
CC       play roles in endocytosis and phagocytosis as well as in cell adhesion
CC       and migration. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Cell projection, filopodium
CC       {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection,
CC       microvillus {ECO:0000250}. Note=Colocalizes with F-actin in filopodia,
CC       cellular cortex and microvilli of the apical cell surface.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9DCG2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9DCG2-2; Sequence=VSP_020910;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK002812; BAB22377.2; -; mRNA.
DR   EMBL; AK004267; BAB23242.2; -; mRNA.
DR   EMBL; AL935326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466519; EDL26959.1; -; Genomic_DNA.
DR   EMBL; CH466519; EDL26960.1; -; Genomic_DNA.
DR   EMBL; BC005501; AAH05501.1; -; mRNA.
DR   CCDS; CCDS16058.1; -. [Q9DCG2-2]
DR   CCDS; CCDS71058.1; -. [Q9DCG2-1]
DR   RefSeq; NP_001277589.1; NM_001290660.1. [Q9DCG2-1]
DR   RefSeq; NP_079698.2; NM_025422.4. [Q9DCG2-2]
DR   AlphaFoldDB; Q9DCG2; -.
DR   SMR; Q9DCG2; -.
DR   STRING; 10090.ENSMUSP00000074188; -.
DR   GlyCosmos; Q9DCG2; 1 site, No reported glycans.
DR   GlyGen; Q9DCG2; 1 site.
DR   PhosphoSitePlus; Q9DCG2; -.
DR   SwissPalm; Q9DCG2; -.
DR   jPOST; Q9DCG2; -.
DR   MaxQB; Q9DCG2; -.
DR   PaxDb; 10090-ENSMUSP00000028356; -.
DR   PeptideAtlas; Q9DCG2; -.
DR   ProteomicsDB; 279963; -. [Q9DCG2-1]
DR   ProteomicsDB; 279964; -. [Q9DCG2-2]
DR   Pumba; Q9DCG2; -.
DR   Antibodypedia; 47602; 270 antibodies from 28 providers.
DR   DNASU; 66205; -.
DR   Ensembl; ENSMUST00000028356.9; ENSMUSP00000028356.9; ENSMUSG00000060703.13. [Q9DCG2-2]
DR   Ensembl; ENSMUST00000074606.11; ENSMUSP00000074188.5; ENSMUSG00000060703.13. [Q9DCG2-1]
DR   GeneID; 66205; -.
DR   KEGG; mmu:66205; -.
DR   UCSC; uc008jub.2; mouse. [Q9DCG2-2]
DR   UCSC; uc008juc.2; mouse. [Q9DCG2-1]
DR   AGR; MGI:1913455; -.
DR   CTD; 9936; -.
DR   MGI; MGI:1913455; Cd302.
DR   VEuPathDB; HostDB:ENSMUSG00000060703; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT01050000244842; -.
DR   HOGENOM; CLU_088281_0_0_1; -.
DR   InParanoid; Q9DCG2; -.
DR   OMA; RWENVSC; -.
DR   OrthoDB; 4139174at2759; -.
DR   PhylomeDB; Q9DCG2; -.
DR   BioGRID-ORCS; 66205; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Cd302; mouse.
DR   PRO; PR:Q9DCG2; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q9DCG2; Protein.
DR   Bgee; ENSMUSG00000060703; Expressed in left lobe of liver and 249 other cell types or tissues.
DR   GO; GO:0005938; C:cell cortex; ISO:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0030175; C:filopodium; ISO:MGI.
DR   GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0006909; P:phagocytosis; ISO:MGI.
DR   CDD; cd00037; CLECT; 1.
DR   Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   PANTHER; PTHR22803:SF144; CD302 ANTIGEN; 1.
DR   PANTHER; PTHR22803; MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED; 1.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR   Genevisible; Q9DCG2; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell projection; Cytoplasm; Disulfide bond;
KW   Glycoprotein; Lectin; Membrane; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..228
FT                   /note="CD302 antigen"
FT                   /id="PRO_0000252333"
FT   TOPO_DOM        21..165
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..149
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        125..140
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   VAR_SEQ         154..163
FT                   /note="IPYDKKYLSD -> N (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_020910"
SQ   SEQUENCE   228 AA;  25423 MW;  7482F9DB7DC9FD10 CRC64;
     MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV RKQCTDHGAD
     MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF KWYDHSNMTF DKWADQDGED
     LVDTCGFLYT KTGEWRKGDC EISSVEGTLC KAAIPYDKKY LSDNHILIST LVIASTVTLA
     VLGAIIWFLY RRNARSGFTS FSPAPLSPYS DGCALVVAEE DEYAVQLD
//