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Q9DCG2

- CD302_MOUSE

UniProt

Q9DCG2 - CD302_MOUSE

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Protein

CD302 antigen

Gene

Cd302

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. phagocytosis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin domain family 13 member A
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:Cd302
Synonyms:Clec13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1913455. Cd302.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Cell projectionfilopodium By similarity. Cytoplasmcell cortex By similarity. Cell projectionmicrovillus By similarity
Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 165145ExtracellularSequence AnalysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Topological domaini187 – 22842CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. filopodium Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 228208CD302 antigenPRO_0000252333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi125 ↔ 140PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9DCG2.
PaxDbiQ9DCG2.
PRIDEiQ9DCG2.

PTM databases

PhosphoSiteiQ9DCG2.

Expressioni

Gene expression databases

BgeeiQ9DCG2.
CleanExiMM_CD302.
GenevestigatoriQ9DCG2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074188.

Structurei

3D structure databases

ProteinModelPortaliQ9DCG2.
SMRiQ9DCG2. Positions 22-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 149120C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288401.
GeneTreeiENSGT00680000100098.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
InParanoidiQ9DCG2.
KOiK06722.
OMAiHINKSIN.
OrthoDBiEOG7MSMQG.
PhylomeDBiQ9DCG2.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DCG2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV
60 70 80 90 100
RKQCTDHGAD MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF
110 120 130 140 150
KWYDHSNMTF DKWADQDGED LVDTCGFLYT KTGEWRKGDC EISSVEGTLC
160 170 180 190 200
KAAIPYDKKY LSDNHILIST LVIASTVTLA VLGAIIWFLY RRNARSGFTS
210 220
FSPAPLSPYS DGCALVVAEE DEYAVQLD
Length:228
Mass (Da):25,423
Last modified:July 5, 2004 - v2
Checksum:i7482F9DB7DC9FD10
GO
Isoform 2 (identifier: Q9DCG2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-163: IPYDKKYLSD → N

Note: No experimental confirmation available.

Show »
Length:219
Mass (Da):24,313
Checksum:iED4CB80C62704F7C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 16310IPYDKKYLSD → N in isoform 2. 1 PublicationVSP_020910

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA. Translation: BAB22377.2.
AK004267 mRNA. Translation: BAB23242.2.
AL935326 Genomic DNA. Translation: CAM13633.1.
AL935326 Genomic DNA. Translation: CAM13634.1.
CH466519 Genomic DNA. Translation: EDL26959.1.
CH466519 Genomic DNA. Translation: EDL26960.1.
BC005501 mRNA. Translation: AAH05501.1.
CCDSiCCDS16058.1. [Q9DCG2-2]
CCDS71058.1. [Q9DCG2-1]
RefSeqiNP_001277589.1. NM_001290660.1. [Q9DCG2-1]
NP_079698.2. NM_025422.4. [Q9DCG2-2]
UniGeneiMm.227281.

Genome annotation databases

EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
GeneIDi66205.
KEGGimmu:66205.
UCSCiuc008jub.1. mouse. [Q9DCG2-2]
uc008juc.1. mouse. [Q9DCG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA. Translation: BAB22377.2 .
AK004267 mRNA. Translation: BAB23242.2 .
AL935326 Genomic DNA. Translation: CAM13633.1 .
AL935326 Genomic DNA. Translation: CAM13634.1 .
CH466519 Genomic DNA. Translation: EDL26959.1 .
CH466519 Genomic DNA. Translation: EDL26960.1 .
BC005501 mRNA. Translation: AAH05501.1 .
CCDSi CCDS16058.1. [Q9DCG2-2 ]
CCDS71058.1. [Q9DCG2-1 ]
RefSeqi NP_001277589.1. NM_001290660.1. [Q9DCG2-1 ]
NP_079698.2. NM_025422.4. [Q9DCG2-2 ]
UniGenei Mm.227281.

3D structure databases

ProteinModelPortali Q9DCG2.
SMRi Q9DCG2. Positions 22-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000074188.

PTM databases

PhosphoSitei Q9DCG2.

Proteomic databases

MaxQBi Q9DCG2.
PaxDbi Q9DCG2.
PRIDEi Q9DCG2.

Protocols and materials databases

DNASUi 66205.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028356 ; ENSMUSP00000028356 ; ENSMUSG00000060703 . [Q9DCG2-2 ]
ENSMUST00000074606 ; ENSMUSP00000074188 ; ENSMUSG00000060703 . [Q9DCG2-1 ]
GeneIDi 66205.
KEGGi mmu:66205.
UCSCi uc008jub.1. mouse. [Q9DCG2-2 ]
uc008juc.1. mouse. [Q9DCG2-1 ]

Organism-specific databases

CTDi 9936.
MGIi MGI:1913455. Cd302.

Phylogenomic databases

eggNOGi NOG288401.
GeneTreei ENSGT00680000100098.
HOGENOMi HOG000232049.
HOVERGENi HBG080529.
InParanoidi Q9DCG2.
KOi K06722.
OMAi HINKSIN.
OrthoDBi EOG7MSMQG.
PhylomeDBi Q9DCG2.

Miscellaneous databases

NextBioi 320959.
PROi Q9DCG2.
SOURCEi Search...

Gene expression databases

Bgeei Q9DCG2.
CleanExi MM_CD302.
Genevestigatori Q9DCG2.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Embryo and Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-228 (ISOFORM 1).
    Strain: C57BL/6J and FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCD302_MOUSE
AccessioniPrimary (citable) accession number: Q9DCG2
Secondary accession number(s): A2AW84
, A2AW85, Q78KD8, Q9D0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3