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Q9DCG2 (CD302_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD302 antigen
Alternative name(s):
C-type lectin domain family 13 member A
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen=CD302
Gene names
Name:Cd302
Synonyms:Clec13a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential. Cell projectionfilopodium By similarity. Cytoplasmcell cortex By similarity. Cell projectionmicrovillus By similarity. Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface By similarity.

Sequence similarities

Contains 1 C-type lectin domain.

Ontologies

Keywords
   Cellular componentCell projection
Cytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   LigandLectin
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processphagocytosis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell cortex

Inferred from electronic annotation. Source: UniProtKB-SubCell

filopodium

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

microvillus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9DCG2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9DCG2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     154-163: IPYDKKYLSD → N
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 228208CD302 antigen
PRO_0000252333

Regions

Topological domain21 – 165145Extracellular Potential
Transmembrane166 – 18621Helical; Potential
Topological domain187 – 22842Cytoplasmic Potential
Domain30 – 149120C-type lectin

Amino acid modifications

Glycosylation1071N-linked (GlcNAc...) Potential
Disulfide bond125 ↔ 140 By similarity

Natural variations

Alternative sequence154 – 16310IPYDKKYLSD → N in isoform 2.
VSP_020910

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 7482F9DB7DC9FD10

FASTA22825,423
        10         20         30         40         50         60 
MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV RKQCTDHGAD 

        70         80         90        100        110        120 
MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF KWYDHSNMTF DKWADQDGED 

       130        140        150        160        170        180 
LVDTCGFLYT KTGEWRKGDC EISSVEGTLC KAAIPYDKKY LSDNHILIST LVIASTVTLA 

       190        200        210        220 
VLGAIIWFLY RRNARSGFTS FSPAPLSPYS DGCALVVAEE DEYAVQLD 

« Hide

Isoform 2 [UniParc].

Checksum: ED4CB80C62704F7C
Show »

FASTA21924,313

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Embryo and Kidney.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-228 (ISOFORM 1).
Strain: C57BL/6J and FVB/N.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002812 mRNA. Translation: BAB22377.2.
AK004267 mRNA. Translation: BAB23242.2.
AL935326 Genomic DNA. Translation: CAM13633.1.
AL935326 Genomic DNA. Translation: CAM13634.1.
CH466519 Genomic DNA. Translation: EDL26959.1.
CH466519 Genomic DNA. Translation: EDL26960.1.
BC005501 mRNA. Translation: AAH05501.1.
CCDSCCDS16058.1. [Q9DCG2-2]
RefSeqNP_001277589.1. NM_001290660.1. [Q9DCG2-1]
NP_079698.2. NM_025422.4. [Q9DCG2-2]
UniGeneMm.227281.

3D structure databases

ProteinModelPortalQ9DCG2.
SMRQ9DCG2. Positions 22-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000074188.

PTM databases

PhosphoSiteQ9DCG2.

Proteomic databases

PaxDbQ9DCG2.
PRIDEQ9DCG2.

Protocols and materials databases

DNASU66205.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
GeneID66205.
KEGGmmu:66205.
UCSCuc008jub.1. mouse. [Q9DCG2-2]
uc008juc.1. mouse. [Q9DCG2-1]

Organism-specific databases

CTD9936.
MGIMGI:1913455. Cd302.

Phylogenomic databases

eggNOGNOG288401.
GeneTreeENSGT00680000100098.
HOGENOMHOG000232049.
HOVERGENHBG080529.
InParanoidA2AW85.
KOK06722.
OMAHINKSIN.
OrthoDBEOG7MSMQG.
PhylomeDBQ9DCG2.

Gene expression databases

BgeeQ9DCG2.
CleanExMM_CD302.
GenevestigatorQ9DCG2.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio320959.
PROQ9DCG2.
SOURCESearch...

Entry information

Entry nameCD302_MOUSE
AccessionPrimary (citable) accession number: Q9DCG2
Secondary accession number(s): A2AW84 expand/collapse secondary AC list , A2AW85, Q78KD8, Q9D0X7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot