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Protein

CD302 antigen

Gene

Cd302

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
CD302 antigen
Alternative name(s):
C-type lectin domain family 13 member A
Type I transmembrane C-type lectin receptor DCL-1
CD_antigen: CD302
Gene namesi
Name:Cd302
Synonyms:Clec13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913455. Cd302.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 165ExtracellularSequence analysisAdd BLAST145
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 228CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000025233321 – 228CD302 antigenAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi125 ↔ 140PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DCG2.
PeptideAtlasiQ9DCG2.
PRIDEiQ9DCG2.

PTM databases

PhosphoSitePlusiQ9DCG2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060703.
CleanExiMM_CD302.
GenevisibleiQ9DCG2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028356.

Structurei

3D structure databases

ProteinModelPortaliQ9DCG2.
SMRiQ9DCG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 149C-type lectinPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS40. Eukaryota.
ENOG41126J3. LUCA.
GeneTreeiENSGT00680000100098.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
InParanoidiQ9DCG2.
KOiK06722.
OMAiTAFEYHP.
OrthoDBiEOG091G0PMQ.
PhylomeDBiQ9DCG2.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DCG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV
60 70 80 90 100
RKQCTDHGAD MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF
110 120 130 140 150
KWYDHSNMTF DKWADQDGED LVDTCGFLYT KTGEWRKGDC EISSVEGTLC
160 170 180 190 200
KAAIPYDKKY LSDNHILIST LVIASTVTLA VLGAIIWFLY RRNARSGFTS
210 220
FSPAPLSPYS DGCALVVAEE DEYAVQLD
Length:228
Mass (Da):25,423
Last modified:July 5, 2004 - v2
Checksum:i7482F9DB7DC9FD10
GO
Isoform 2 (identifier: Q9DCG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-163: IPYDKKYLSD → N

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):24,313
Checksum:iED4CB80C62704F7C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020910154 – 163IPYDKKYLSD → N in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA. Translation: BAB22377.2.
AK004267 mRNA. Translation: BAB23242.2.
AL935326 Genomic DNA. Translation: CAM13633.1.
AL935326 Genomic DNA. Translation: CAM13634.1.
CH466519 Genomic DNA. Translation: EDL26959.1.
CH466519 Genomic DNA. Translation: EDL26960.1.
BC005501 mRNA. Translation: AAH05501.1.
CCDSiCCDS16058.1. [Q9DCG2-2]
CCDS71058.1. [Q9DCG2-1]
RefSeqiNP_001277589.1. NM_001290660.1. [Q9DCG2-1]
NP_079698.2. NM_025422.4. [Q9DCG2-2]
UniGeneiMm.227281.

Genome annotation databases

EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
GeneIDi66205.
KEGGimmu:66205.
UCSCiuc008jub.2. mouse. [Q9DCG2-2]
uc008juc.2. mouse. [Q9DCG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002812 mRNA. Translation: BAB22377.2.
AK004267 mRNA. Translation: BAB23242.2.
AL935326 Genomic DNA. Translation: CAM13633.1.
AL935326 Genomic DNA. Translation: CAM13634.1.
CH466519 Genomic DNA. Translation: EDL26959.1.
CH466519 Genomic DNA. Translation: EDL26960.1.
BC005501 mRNA. Translation: AAH05501.1.
CCDSiCCDS16058.1. [Q9DCG2-2]
CCDS71058.1. [Q9DCG2-1]
RefSeqiNP_001277589.1. NM_001290660.1. [Q9DCG2-1]
NP_079698.2. NM_025422.4. [Q9DCG2-2]
UniGeneiMm.227281.

3D structure databases

ProteinModelPortaliQ9DCG2.
SMRiQ9DCG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028356.

PTM databases

PhosphoSitePlusiQ9DCG2.

Proteomic databases

PaxDbiQ9DCG2.
PeptideAtlasiQ9DCG2.
PRIDEiQ9DCG2.

Protocols and materials databases

DNASUi66205.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
GeneIDi66205.
KEGGimmu:66205.
UCSCiuc008jub.2. mouse. [Q9DCG2-2]
uc008juc.2. mouse. [Q9DCG2-1]

Organism-specific databases

CTDi9936.
MGIiMGI:1913455. Cd302.

Phylogenomic databases

eggNOGiENOG410IS40. Eukaryota.
ENOG41126J3. LUCA.
GeneTreeiENSGT00680000100098.
HOGENOMiHOG000232049.
HOVERGENiHBG080529.
InParanoidiQ9DCG2.
KOiK06722.
OMAiTAFEYHP.
OrthoDBiEOG091G0PMQ.
PhylomeDBiQ9DCG2.

Miscellaneous databases

PROiQ9DCG2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060703.
CleanExiMM_CD302.
GenevisibleiQ9DCG2. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD302_MOUSE
AccessioniPrimary (citable) accession number: Q9DCG2
Secondary accession number(s): A2AW84
, A2AW85, Q78KD8, Q9D0X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.