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Q9DCG2

- CD302_MOUSE

UniProt

Q9DCG2 - CD302_MOUSE

Protein

CD302 antigen

Gene

Cd302

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.By similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. phagocytosis Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD302 antigen
    Alternative name(s):
    C-type lectin domain family 13 member A
    Type I transmembrane C-type lectin receptor DCL-1
    CD_antigen: CD302
    Gene namesi
    Name:Cd302
    Synonyms:Clec13a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1913455. Cd302.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Cell projectionfilopodium By similarity. Cytoplasmcell cortex By similarity. Cell projectionmicrovillus By similarity
    Note: Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.By similarity

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB-SubCell
    2. filopodium Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. microvillus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 228208CD302 antigenPRO_0000252333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi125 ↔ 140PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9DCG2.
    PRIDEiQ9DCG2.

    PTM databases

    PhosphoSiteiQ9DCG2.

    Expressioni

    Gene expression databases

    BgeeiQ9DCG2.
    CleanExiMM_CD302.
    GenevestigatoriQ9DCG2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000074188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCG2.
    SMRiQ9DCG2. Positions 22-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 165145ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini187 – 22842CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 149120C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288401.
    GeneTreeiENSGT00680000100098.
    HOGENOMiHOG000232049.
    HOVERGENiHBG080529.
    InParanoidiA2AW85.
    KOiK06722.
    OMAiHINKSIN.
    OrthoDBiEOG7MSMQG.
    PhylomeDBiQ9DCG2.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9DCG2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV    50
    RKQCTDHGAD MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF 100
    KWYDHSNMTF DKWADQDGED LVDTCGFLYT KTGEWRKGDC EISSVEGTLC 150
    KAAIPYDKKY LSDNHILIST LVIASTVTLA VLGAIIWFLY RRNARSGFTS 200
    FSPAPLSPYS DGCALVVAEE DEYAVQLD 228
    Length:228
    Mass (Da):25,423
    Last modified:July 5, 2004 - v2
    Checksum:i7482F9DB7DC9FD10
    GO
    Isoform 2 (identifier: Q9DCG2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         154-163: IPYDKKYLSD → N

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):24,313
    Checksum:iED4CB80C62704F7C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei154 – 16310IPYDKKYLSD → N in isoform 2. 1 PublicationVSP_020910

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002812 mRNA. Translation: BAB22377.2.
    AK004267 mRNA. Translation: BAB23242.2.
    AL935326 Genomic DNA. Translation: CAM13633.1.
    AL935326 Genomic DNA. Translation: CAM13634.1.
    CH466519 Genomic DNA. Translation: EDL26959.1.
    CH466519 Genomic DNA. Translation: EDL26960.1.
    BC005501 mRNA. Translation: AAH05501.1.
    CCDSiCCDS16058.1. [Q9DCG2-2]
    CCDS71058.1. [Q9DCG2-1]
    RefSeqiNP_001277589.1. NM_001290660.1. [Q9DCG2-1]
    NP_079698.2. NM_025422.4. [Q9DCG2-2]
    UniGeneiMm.227281.

    Genome annotation databases

    EnsembliENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
    ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
    GeneIDi66205.
    KEGGimmu:66205.
    UCSCiuc008jub.1. mouse. [Q9DCG2-2]
    uc008juc.1. mouse. [Q9DCG2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002812 mRNA. Translation: BAB22377.2 .
    AK004267 mRNA. Translation: BAB23242.2 .
    AL935326 Genomic DNA. Translation: CAM13633.1 .
    AL935326 Genomic DNA. Translation: CAM13634.1 .
    CH466519 Genomic DNA. Translation: EDL26959.1 .
    CH466519 Genomic DNA. Translation: EDL26960.1 .
    BC005501 mRNA. Translation: AAH05501.1 .
    CCDSi CCDS16058.1. [Q9DCG2-2 ]
    CCDS71058.1. [Q9DCG2-1 ]
    RefSeqi NP_001277589.1. NM_001290660.1. [Q9DCG2-1 ]
    NP_079698.2. NM_025422.4. [Q9DCG2-2 ]
    UniGenei Mm.227281.

    3D structure databases

    ProteinModelPortali Q9DCG2.
    SMRi Q9DCG2. Positions 22-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000074188.

    PTM databases

    PhosphoSitei Q9DCG2.

    Proteomic databases

    PaxDbi Q9DCG2.
    PRIDEi Q9DCG2.

    Protocols and materials databases

    DNASUi 66205.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028356 ; ENSMUSP00000028356 ; ENSMUSG00000060703 . [Q9DCG2-2 ]
    ENSMUST00000074606 ; ENSMUSP00000074188 ; ENSMUSG00000060703 . [Q9DCG2-1 ]
    GeneIDi 66205.
    KEGGi mmu:66205.
    UCSCi uc008jub.1. mouse. [Q9DCG2-2 ]
    uc008juc.1. mouse. [Q9DCG2-1 ]

    Organism-specific databases

    CTDi 9936.
    MGIi MGI:1913455. Cd302.

    Phylogenomic databases

    eggNOGi NOG288401.
    GeneTreei ENSGT00680000100098.
    HOGENOMi HOG000232049.
    HOVERGENi HBG080529.
    InParanoidi A2AW85.
    KOi K06722.
    OMAi HINKSIN.
    OrthoDBi EOG7MSMQG.
    PhylomeDBi Q9DCG2.

    Miscellaneous databases

    NextBioi 320959.
    PROi Q9DCG2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCG2.
    CleanExi MM_CD302.
    Genevestigatori Q9DCG2.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Embryo and Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-228 (ISOFORM 1).
      Strain: C57BL/6J and FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiCD302_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCG2
    Secondary accession number(s): A2AW84
    , A2AW85, Q78KD8, Q9D0X7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3