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Protein

Translocon-associated protein subunit gamma

Gene

Ssr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit gamma
Short name:
TRAP-gamma
Alternative name(s):
Signal sequence receptor subunit gamma
Short name:
SSR-gamma
Gene namesi
Name:Ssr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1914687. Ssr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27LumenalSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 54CytoplasmicSequence analysis6
Transmembranei55 – 76HelicalSequence analysisAdd BLAST22
Topological domaini77 – 135LumenalSequence analysisAdd BLAST59
Transmembranei136 – 157HelicalSequence analysisAdd BLAST22
Topological domaini158 – 163CytoplasmicSequence analysis6
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916911 – 185Translocon-associated protein subunit gammaAdd BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9DCF9.
PRIDEiQ9DCF9.

PTM databases

iPTMnetiQ9DCF9.
PhosphoSitePlusiQ9DCF9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027828.
CleanExiMM_SSR3.
ExpressionAtlasiQ9DCF9. baseline and differential.
GenevisibleiQ9DCF9. MM.

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

BioGridi212185. 1 interactor.
IntActiQ9DCF9. 1 interactor.
MINTiMINT-1851910.
STRINGi10090.ENSMUSP00000029414.

Structurei

3D structure databases

ProteinModelPortaliQ9DCF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-gamma family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4490. Eukaryota.
ENOG410XR1X. LUCA.
GeneTreeiENSGT00390000000970.
HOGENOMiHOG000007534.
HOVERGENiHBG012424.
InParanoidiQ9DCF9.
KOiK13251.
OMAiKHKIAVK.
OrthoDBiEOG091G0QS4.
PhylomeDBiQ9DCF9.
TreeFamiTF314998.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DCF9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPKGGSKQQ SEEDLLLQDF SRNLSAKSSA LFFGNAFIVS AIPIWLYWRI
60 70 80 90 100
WHMDLIQSAV LYSVMTLVST YLVAFAYKNV KFVLKHKVAQ KREDAVSKEV
110 120 130 140 150
TRKLSEADNR KMSRKEKDER ILWKKNEVAD YEATTFSIFY NNTLFLVLVI
160 170 180
VASFFILKNF NPTVNYILSI SASSGLIALL STGSK
Length:185
Mass (Da):21,064
Last modified:June 1, 2001 - v1
Checksum:i18E0A54483E45D6E
GO
Isoform 2 (identifier: Q9DCF9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-179: NYILSISASSGLIAL → YPLESFPINSSLLCF
     180-185: Missing.

Show »
Length:179
Mass (Da):20,699
Checksum:i484ECDCB60363FDE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013474165 – 179NYILS…GLIAL → YPLESFPINSSLLCF in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_013475180 – 185Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002818 mRNA. Translation: BAB22381.1.
AK029353 mRNA. Translation: BAC26413.1.
AK076235 mRNA. Translation: BAC36268.1.
AK088555 mRNA. Translation: BAC40420.1.
BC011111 mRNA. Translation: AAH11111.1.
CCDSiCCDS17386.1. [Q9DCF9-1]
RefSeqiNP_080431.1. NM_026155.3. [Q9DCF9-1]
UniGeneiMm.232728.

Genome annotation databases

EnsembliENSMUST00000029414; ENSMUSP00000029414; ENSMUSG00000027828. [Q9DCF9-1]
ENSMUST00000119896; ENSMUSP00000113831; ENSMUSG00000027828. [Q9DCF9-2]
GeneIDi67437.
KEGGimmu:67437.
UCSCiuc008pkn.1. mouse. [Q9DCF9-1]
uc008pko.1. mouse. [Q9DCF9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002818 mRNA. Translation: BAB22381.1.
AK029353 mRNA. Translation: BAC26413.1.
AK076235 mRNA. Translation: BAC36268.1.
AK088555 mRNA. Translation: BAC40420.1.
BC011111 mRNA. Translation: AAH11111.1.
CCDSiCCDS17386.1. [Q9DCF9-1]
RefSeqiNP_080431.1. NM_026155.3. [Q9DCF9-1]
UniGeneiMm.232728.

3D structure databases

ProteinModelPortaliQ9DCF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212185. 1 interactor.
IntActiQ9DCF9. 1 interactor.
MINTiMINT-1851910.
STRINGi10090.ENSMUSP00000029414.

PTM databases

iPTMnetiQ9DCF9.
PhosphoSitePlusiQ9DCF9.

Proteomic databases

PaxDbiQ9DCF9.
PRIDEiQ9DCF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029414; ENSMUSP00000029414; ENSMUSG00000027828. [Q9DCF9-1]
ENSMUST00000119896; ENSMUSP00000113831; ENSMUSG00000027828. [Q9DCF9-2]
GeneIDi67437.
KEGGimmu:67437.
UCSCiuc008pkn.1. mouse. [Q9DCF9-1]
uc008pko.1. mouse. [Q9DCF9-2]

Organism-specific databases

CTDi6747.
MGIiMGI:1914687. Ssr3.

Phylogenomic databases

eggNOGiKOG4490. Eukaryota.
ENOG410XR1X. LUCA.
GeneTreeiENSGT00390000000970.
HOGENOMiHOG000007534.
HOVERGENiHBG012424.
InParanoidiQ9DCF9.
KOiK13251.
OMAiKHKIAVK.
OrthoDBiEOG091G0QS4.
PhylomeDBiQ9DCF9.
TreeFamiTF314998.

Miscellaneous databases

ChiTaRSiSsr3. mouse.
PROiQ9DCF9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027828.
CleanExiMM_SSR3.
ExpressionAtlasiQ9DCF9. baseline and differential.
GenevisibleiQ9DCF9. MM.

Family and domain databases

InterProiIPR009779. SSR3.
[Graphical view]
PANTHERiPTHR13399. PTHR13399. 1 hit.
PfamiPF07074. TRAP-gamma. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSRG_MOUSE
AccessioniPrimary (citable) accession number: Q9DCF9
Secondary accession number(s): Q8C0Z8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.