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Protein

p21-activated protein kinase-interacting protein 1

Gene

Pak1ip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.By similarity

GO - Biological processi

  • cell proliferation Source: MGI
  • negative regulation of signal transduction Source: UniProtKB-KW
  • palate development Source: MGI
  • regulation of signal transduction by p53 class mediator Source: UniProtKB
  • ribosomal large subunit biogenesis Source: UniProtKB

Keywordsi

Molecular functionSignal transduction inhibitor
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
p21-activated protein kinase-interacting protein 1
Alternative name(s):
PAK1-interacting protein 1
Putative PAK inhibitor Skb15
Gene namesi
Name:Pak1ip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1915333 Pak1ip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511261 – 382p21-activated protein kinase-interacting protein 1Add BLAST382

Proteomic databases

EPDiQ9DCE5
MaxQBiQ9DCE5
PaxDbiQ9DCE5
PRIDEiQ9DCE5

PTM databases

iPTMnetiQ9DCE5
PhosphoSitePlusiQ9DCE5

Expressioni

Gene expression databases

BgeeiENSMUSG00000038683
CleanExiMM_PAK1IP1
GenevisibleiQ9DCE5 MM

Interactioni

Subunit structurei

Interacts with PAK1.By similarity

Protein-protein interaction databases

BioGridi2126471 interactor.
STRINGi10090.ENSMUSP00000040846

Structurei

3D structure databases

ProteinModelPortaliQ9DCE5
SMRiQ9DCE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati37 – 77WD 1Add BLAST41
Repeati80 – 120WD 2Add BLAST41
Repeati122 – 160WD 3Add BLAST39
Repeati202 – 240WD 4Add BLAST39
Repeati243 – 284WD 5Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0294 Eukaryota
ENOG410XRDQ LUCA
GeneTreeiENSGT00390000001263
HOGENOMiHOG000007618
HOVERGENiHBG082144
InParanoidiQ9DCE5
KOiK14830
OMAiSYEHNLL
OrthoDBiEOG091G0JNV
PhylomeDBiQ9DCE5
TreeFamiTF326684

Family and domain databases

Gene3Di2.130.10.102 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q9DCE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVAGSYEQ VLFGFTVQRG PAKSGHQETW TPVADFTHHS HTASLSVLAS
60 70 80 90 100
NSRYVVSGSK DETIHIYDMK RKVEHGALVH HAGTVTCLKF HGNQHLISGA
110 120 130 140 150
EDGHICIWDV KRWKCLKTFK AHRGHVTFLS IHPSGKLALS VGTDKTLRTW
160 170 180 190 200
NLIEGRSAFI KNIKENAHIV EWSPSGGKYI VVVQNKVDVY RLGTASVSGT
210 220 230 240 250
ITNGKRISSV TFLSDSVLAV AGDEEVVRIF DCDSLECLCE FRAHENRVKD
260 270 280 290 300
MVSFEVPDHH VLVTASNDGF IKMWTLPQDK KVPPSLLCEA KTGARLTCLT
310 320 330 340 350
VWLDRAANGM ASLPPAAEPC PDQPKTIEKE SGDTVQEETS EPNSEKSDVS
360 370 380
GDSKQPTKGN SPVTAKKRKM ATMSEKKRKK KM
Length:382
Mass (Da):42,116
Last modified:July 19, 2005 - v2
Checksum:i7EA5788A4B7EF2D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176G → R in AAK51599 (PubMed:11389855).Curated1
Sequence conflicti382M → MSLTWQIPDFSSLSECPFDG ILHVPVRRKYLLP (Ref. 2) Curated1
Sequence conflicti382M → MSLTWQIPDFSSLSECPFDG ILHVPVRRKYLLP in BAB22407 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY030406 mRNA Translation: AAK51599.1
AF386076 mRNA Translation: AAL40652.1
AK002852 mRNA Translation: BAB22407.1
AK077941 mRNA Translation: BAC37076.1
AK150747 mRNA Translation: BAE29818.1
AK150919 mRNA Translation: BAE29957.1
BC051498 mRNA Translation: AAH51498.1
CCDSiCCDS36638.1
RefSeqiNP_080826.2, NM_026550.3
UniGeneiMm.24789

Genome annotation databases

EnsembliENSMUST00000046951; ENSMUSP00000040846; ENSMUSG00000038683
GeneIDi68083
KEGGimmu:68083
UCSCiuc007qer.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPK1IP_MOUSE
AccessioniPrimary (citable) accession number: Q9DCE5
Secondary accession number(s): Q3UBK7
, Q80UT4, Q8C5N6, Q923K2, Q9D3E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome