ID   GBRAP_MOUSE             Reviewed;         117 AA.
AC   Q9DCD6; B1AR49; Q9QUI7;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   03-NOV-2009, entry version 58.
DE   RecName: Full=Gamma-aminobutyric acid receptor-associated protein;
DE   AltName: Full=GABA(A) receptor-associated protein;
GN   Name=Gabarap;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND INTERACTION WITH
RP   BETA-TUBULIN.
RX   PubMed=10899939; DOI=10.1046/j.1471-4159.2000.0750644.x;
RA   Wang H., Olsen R.W.;
RT   "Binding of the GABA(A) receptor-associated protein (GABARAP) to
RT   microtubules and microfilaments suggests involvement of the
RT   cytoskeleton in GABARAPGABA(A) receptor interaction.";
RL   J. Neurochem. 75:644-655(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INTERACTION WITH GPHN.
RX   PubMed=10900017; DOI=10.1073/pnas.97.15.8594;
RA   Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H.,
RA   Olsen R.W., Betz H.;
RT   "The gamma-aminobutyric acid type A receptor (GABAAR)-associated
RT   protein GABARAP interacts with gephyrin but is not involved in
RT   receptor anchoring at the synapse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000).
CC   -!- FUNCTION: May play a role in intracellular transport of GABA(A)
CC       receptors and its interaction with the cytoskeleton (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with GABRG2, TUBA1, ULK1 and NSF (By
CC       similarity). Interacts with beta-tubulin and GPHN.
CC   -!- SUBCELLULAR LOCATION: Endomembrane system (By similarity).
CC       Cytoplasm, cytoskeleton (By similarity). Golgi apparatus membrane
CC       (By similarity). Note=Largely associated with intracellular
CC       membrane structures including the Golgi apparatus and post-
CC       synaptic cisternae. Colocalizes with microtubules (By similarity).
CC   -!- SIMILARITY: Belongs to the MAP1 LC3 family.
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DR   EMBL; AF161587; AAD47642.1; -; mRNA.
DR   EMBL; AK002879; BAB22426.1; -; mRNA.
DR   EMBL; AK011731; BAB27806.1; -; mRNA.
DR   EMBL; AL596185; CAI35162.1; -; Genomic_DNA.
DR   EMBL; BC002126; AAH02126.1; -; mRNA.
DR   EMBL; BC024621; AAH24621.1; -; mRNA.
DR   EMBL; BC030350; AAH30350.1; -; mRNA.
DR   IPI; IPI00120754; -.
DR   RefSeq; NP_062723.1; -.
DR   UniGene; Mm.272460; -.
DR   SMR; Q9DCD6; 1-117.
DR   STRING; Q9DCD6; -.
DR   PRIDE; Q9DCD6; -.
DR   Ensembl; ENSMUST00000018711; ENSMUSP00000018711; ENSMUSG00000018567; Mus musculus.
DR   GeneID; 56486; -.
DR   KEGG; mmu:56486; -.
DR   UCSC; uc007jtg.1; mouse.
DR   CTD; 56486; -.
DR   MGI; MGI:1861742; Gabarap.
DR   HOGENOM; Q9DCD6; -.
DR   HOVERGEN; Q9DCD6; -.
DR   OMA; TTMGQLY; -.
DR   NextBio; 312758; -.
DR   ArrayExpress; Q9DCD6; -.
DR   Bgee; Q9DCD6; -.
DR   Genevestigator; Q9DCD6; -.
DR   GermOnline; ENSMUSG00000018567; Mus musculus.
DR   GO; GO:0015629; C:actin cytoskeleton; IDA:MGI.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IDA:MGI.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005875; C:microtubule associated complex; IDA:MGI.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0008017; F:microtubule binding; IDA:MGI.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IDA:MGI.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004241; MAP1_LC3.
DR   PANTHER; PTHR10969; MAP1_LC3; 1.
DR   Pfam; PF02991; MAP1_LC3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; Microtubule;
KW   Protein transport; Transport.
FT   CHAIN         1    117       Gamma-aminobutyric acid receptor-
FT                                associated protein.
FT                                /FTId=PRO_0000212364.
FT   REGION        1     22       Interaction with beta-tubulin.
FT   REGION       36    117       Interaction with GPHN.
FT   REGION       36     68       Interaction with GABRG2 (Potential).
FT   CONFLICT     12     12       E -> D (in Ref. 2; BAB22426).
SQ   SEQUENCE   117 AA;  13918 MW;  BC0B84B8A51C1E32 CRC64;
     MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF
     YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL
//