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Protein

Gamma-aminobutyric acid receptor-associated protein

Gene

Gabarap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Autophagy, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-8854214. TBC/RABGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
GABA(A) receptor-associated protein
Gene namesi
Name:Gabarap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1861742. Gabarap.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002123641 – 116Gamma-aminobutyric acid receptor-associated proteinAdd BLAST116
PropeptideiPRO_0000423066117Removed in mature form1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi116Phosphatidylethanolamine amidated glycineBy similarity1

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei116 – 117Cleavage; by ATG4B2

Keywords - PTMi

Lipoprotein

Proteomic databases

EPDiQ9DCD6.
MaxQBiQ9DCD6.
PaxDbiQ9DCD6.
PeptideAtlasiQ9DCD6.
PRIDEiQ9DCD6.

PTM databases

iPTMnetiQ9DCD6.
PhosphoSitePlusiQ9DCD6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018567.
ExpressionAtlasiQ9DCD6. baseline and differential.
GenevisibleiQ9DCD6. MM.

Interactioni

Subunit structurei

Interacts with GPHN (PubMed:10900017). Interacts with NSF (By similarity). Interacts with ATG7 (PubMed:11890701). Interacts with ATG3 and ATG13 (By similarity). Interacts with alpha-tubulin (By similarity). Interacts with beta-tubulin (PubMed:10899939). Interacts with GABRG2 (By similarity). Interacts with RB1CC1 (By similarity). Interacts with ULK1 (By similarity). Interacts with CALR (By similarity). Interacts with DDX47 (By similarity). Interacts with TP53INP1 and TP53INP2 (By similarity). Interacts with TBC1D5 (By similarity). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1 (By similarity). Interacts with MAPK15 (By similarity). Interacts with TECPR2 (By similarity). Interacts with PCM1 (By similarity). Interacts with TRIM5 and TRIM21 (By similarity). Interacts with MEFV (By similarity). Interacts with KIF21B (By similarity). Interacts with WDFY3; this interaction is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies (By similarity).By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208012. 2 interactors.
ELMiQ9DCD6.
IntActiQ9DCD6. 1 interactor.
STRINGi10090.ENSMUSP00000018711.

Structurei

3D structure databases

ProteinModelPortaliQ9DCD6.
SMRiQ9DCD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 22Interaction with beta-tubulinAdd BLAST22
Regioni36 – 117Interaction with GPHN1 PublicationAdd BLAST82
Regioni36 – 68Interaction with GABRG2Sequence analysisAdd BLAST33

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiKOG1654. Eukaryota.
ENOG4111JAT. LUCA.
GeneTreeiENSGT00390000012937.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9DCD6.
KOiK08341.
OMAiRVPVICE.
OrthoDBiEOG091G10QX.
PhylomeDBiQ9DCD6.
TreeFamiTF314556.

Family and domain databases

CDDicd01611. GABARAP. 1 hit.
InterProiView protein in InterPro
IPR004241. Atg8-like.
IPR029071. Ubiquitin-rel_dom.
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiView protein in Pfam
PF02991. Atg8. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL
60 70 80 90 100
VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE
110
EDFFLYIAYS DESVYGL
Length:117
Mass (Da):13,918
Last modified:March 1, 2004 - v2
Checksum:iBC0B84B8A51C1E32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12E → D in BAB22426 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161587 mRNA. Translation: AAD47642.1.
AK002879 mRNA. Translation: BAB22426.1.
AK011731 mRNA. Translation: BAB27806.1.
AL596185 Genomic DNA. Translation: CAI35162.1.
BC002126 mRNA. Translation: AAH02126.1.
BC024621 mRNA. Translation: AAH24621.1.
BC030350 mRNA. Translation: AAH30350.1.
CCDSiCCDS24928.1.
RefSeqiNP_062723.1. NM_019749.4.
UniGeneiMm.272460.

Genome annotation databases

EnsembliENSMUST00000018711; ENSMUSP00000018711; ENSMUSG00000018567.
GeneIDi56486.
KEGGimmu:56486.
UCSCiuc007jtg.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiGBRAP_MOUSE
AccessioniPrimary (citable) accession number: Q9DCD6
Secondary accession number(s): B1AR49, Q9QUI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: October 25, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families