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Reviewed, UniProtKB/Swiss-Prot Q9DCD6 (GBRAP_MOUSE)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
    GABA(A) receptor-associated protein
Gene names
Name: Gabarap
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length117 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton By similarity.

Subunit structure

Interacts with GABRG2, TUBA1, ULK1 and NSF By similarity. Interacts with beta-tubulin and GPHN.

Subcellular location

Endomembrane system By similarity. Cytoplasm › cytoskeleton By similarity. Golgi apparatus membrane By similarity. Note: Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules By similarity.

Sequence similarities

Belongs to the MAP1 LC3 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 117117Gamma-aminobutyric acid receptor-associated protein
PRO_0000212364

Regions

Region1 – 2222Interaction with beta-tubulin
Region36 – 11782Interaction with GPHN
Region36 – 6833Interaction with GABRG2 Potential

Experimental info

Sequence conflict121E → D in BAB22426. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q9DCD6-1 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: BC0B84B8A51C1E32

FASTA11713,918
        10         20         30         40         50         60 
MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 

        70         80         90        100        110 
YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

« Hide

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References

« Hide 'large scale' references
[1]"Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction."
Wang H., Olsen R.W.
J. Neurochem. 75:644-655(2000) [PubMed: 10899939] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH BETA-TUBULIN.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Kidney.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver and Mammary tumor.
[4]"The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse."
Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H.
Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000) [PubMed: 10900017] [Abstract]
Cited for: INTERACTION WITH GPHN.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF161587 mRNA. Translation: AAD47642.1.
AK002879 mRNA. Translation: BAB22426.1.
AK011731 mRNA. Translation: BAB27806.1.
BC002126 mRNA. Translation: AAH02126.1.
BC024621 mRNA. Translation: AAH24621.1.
BC030350 mRNA. Translation: AAH30350.1.
IPIIPI00120754.
RefSeqNP_062723.1.
UniGeneMm.272460

3D structure databases

SMRQ9DCD6. Positions 1-117.
ModBaseSearch...

PTM databases

PhosphoSiteQ9DCD6.

Proteomic databases

PRIDEQ9DCD6.

Genome annotation databases

EnsemblENSMUSG00000018567. Mus musculus. [Contig view]
GeneID56486.
KEGGmmu:56486.

Organism-specific databases

MGIMGI:1861742. Gabarap.

Phylogenomic databases

HOGENOMQ9DCD6.
HOVERGENQ9DCD6.
OMAQ9DCD6. TTMGQLY.

Gene expression databases

ArrayExpressQ9DCD6.
BgeeQ9DCD6.
GermOnlineENSMUSG00000018567. Mus musculus.

Family and domain databases

InterProIPR004241. MAP1_LC3.
[Graphical view]
PANTHERPTHR10969. MAP1_LC3. 1 hit.
PfamPF02991. MAP1_LC3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio312758.
SOURCESearch...

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Entry information

Entry nameGBRAP_MOUSE
AccessionPrimary (citable) accession number: Q9DCD6
Secondary accession number(s): Q9QUI7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents