Reviewed, UniProtKB/Swiss-Prot Q9DCD6 (GBRAP_MOUSE)

Names and origin

Protein names

Recommended name:
    Gamma-aminobutyric acid receptor-associated protein
Alternative name(s):
    GABA(A) receptor-associated protein

Gene names

Name:

Gabarap

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	117 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton By similarity.
Subunit structure	Interacts with GABRG2, TUBA1, ULK1 and NSF By similarity. Interacts with beta-tubulin and GPHN.
Subcellular location	Intracytoplasmic membraneBy similarity. Cytoplasm › cytoskeletonBy similarity. Golgi apparatus membraneBy similarity. Note= Largely associated with intracellular membrane structures including the Golgi apparatus and post-synaptic cisternae. Colocalizes with microtubules By similarity.
Sequence similarities	Belongs to the MAP1 LC3 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Membrane Microtubule
Gene Ontology (GO)
Biological process	microtubule cytoskeleton organization and biogenesis Ref.1 Inferred from direct assay. Source: MGI
Cellular component	Golgi apparatus Inferred from direct assay. Source: MGI actin cytoskeleton Ref.1 Inferred from direct assay. Source: MGI lysosome Inferred from direct assay. Source: MGI microtubule associated complex Ref.1 Inferred from direct assay. Source: MGI plasma membrane Ref.4 Inferred from direct assay. Source: MGI smooth endoplasmic reticulum Inferred from direct assay. Source: MGI
Molecular function	microtubule binding Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 117	117	Gamma-aminobutyric acid receptor-associated protein
Regions
	Region	1 – 22	22	Interaction with beta-tubulin
	Region	36 – 117	82	Interaction with GPHN
	Region	36 – 68	33	Interaction with GABRG2 Potential
Experimental info
	Sequence conflict	12	1	E → D in BAB22426. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9DCD6-1 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: BC0B84B8A51C1E32	FASTA	117	13,918
	10 20 30 40 50 60 MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF 70 80 90 100 110 YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Binding of the GABA(A) receptor-associated protein (GABARAP) to microtubules and microfilaments suggests involvement of the cytoskeleton in GABARAPGABA(A) receptor interaction." Wang H., Olsen R.W. J. Neurochem. 75:644-655(2000) [PubMed: 10899939] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH BETA-TUBULIN.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Kidney.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver and Mammary tumor.
[4]	"The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse." Kneussel M., Haverkamp S., Fuhrmann J.C., Wang H., Waessle H., Olsen R.W., Betz H. Proc. Natl. Acad. Sci. U.S.A. 97:8594-8599(2000) [PubMed: 10900017] [Abstract] Cited for: INTERACTION WITH GPHN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF161587 mRNA. Translation: AAD47642.1. AK002879 mRNA. Translation: BAB22426.1. AK011731 mRNA. Translation: BAB27806.1. BC002126 mRNA. Translation: AAH02126.1. BC024621 mRNA. Translation: AAH24621.1. BC030350 mRNA. Translation: AAH30350.1.
RefSeq	NP_062723.1.
UniGene	Mm.272460
3D structure databases
SMR	Q9DCD6. Positions 1-117.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000018567. Mus musculus. [Contig view]
GeneID	56486.
KEGG	mmu:56486.
Organism-specific databases
MGI	MGI:1861742. Gabarap.
Phylogenomic databases
HOGENOM	Q9DCD6.
HOVERGEN	Q9DCD6.
Gene expression databases
ArrayExpress	Q9DCD6.
GermOnline	ENSMUSG00000018567. Mus musculus.
Family and domain databases
InterPro	IPR004241. MAP1_LC3. [Graphical view]
PANTHER	PTHR10969. MAP1_LC3. 1 hit.
Pfam	PF02991. MAP1_LC3. 1 hit. [Graphical view]
ProDom	Q9DCD6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

GBRAP_MOUSE

Accession

Primary (citable) accession number: Q9DCD6
Secondary accession number(s): Q9QUI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	September 23, 2008
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)