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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

Pgd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase X (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase 2 (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx)
  2. 6-phosphogluconolactonase (Pgls)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103NADPBy similarity1
Binding sitei103SubstrateBy similarity1
Active sitei184Proton acceptorBy similarity1
Active sitei191Proton donorBy similarity1
Binding sitei192SubstrateBy similarity1
Binding sitei261Substrate; via amide nitrogenBy similarity1
Binding sitei288SubstrateBy similarity1
Binding sitei447Substrate; shared with dimeric partnerBy similarity1
Binding sitei453Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADPBy similarity6
Nucleotide bindingi33 – 35NADPBy similarity3
Nucleotide bindingi75 – 77NADPBy similarity3
Nucleotide bindingi478 – 481NADP; shared with dimeric partnerBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiR-MMU-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:Pgd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:97553. Pgd.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000900642 – 4836-phosphogluconate dehydrogenase, decarboxylatingAdd BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-acetyllysineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei59N6-acetyllysineBy similarity1
Modified residuei129PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DCD0.
MaxQBiQ9DCD0.
PaxDbiQ9DCD0.
PRIDEiQ9DCD0.

PTM databases

iPTMnetiQ9DCD0.
PhosphoSitePlusiQ9DCD0.
SwissPalmiQ9DCD0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028961.
CleanExiMM_PGD.
GenevisibleiQ9DCD0. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-1868998.
STRINGi10090.ENSMUSP00000081141.

Structurei

3D structure databases

ProteinModelPortaliQ9DCD0.
SMRiQ9DCD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 131Substrate bindingBy similarity3
Regioni187 – 188Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2653. Eukaryota.
COG0362. LUCA.
GeneTreeiENSGT00390000009023.
HOGENOMiHOG000255147.
HOVERGENiHBG000029.
InParanoidiQ9DCD0.
KOiK00033.
OMAiAFAFEEW.
OrthoDBiEOG091G06XF.
PhylomeDBiQ9DCD0.
TreeFamiTF300386.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DCD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT
60 70 80 90 100
KVVGAQSLKD MVSKLKKPRR VILLVKAGQA VDDFIEKLVP LLDTGDIIID
110 120 130 140 150
GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW
160 170 180 190 200
PHIKAIFQAI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE
210 220 230 240 250
AYHLMKDVLG MRHEEMAQAF EEWNKTELDS FLIEITANIL KYRDTDGKEL
260 270 280 290 300
LPKIRDSAGQ KGTGKWTAIS ALEYGMPVTL IGEAVFARCL SSLKEERVQA
310 320 330 340 350
SQKLKGPKVV QLEGSKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG
360 370 380 390 400
WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF ERNPELQNLL LDDFFKSAVD
410 420 430 440 450
NCQDSWRRVI STGVQAGIPM PCFTTALSFY DGYRHEMLPA NLIQAQRDYF
460 470 480
GAHTYELLTK PGEFIHTNWT GHGGSVSSSS YNA
Length:483
Mass (Da):53,247
Last modified:January 23, 2007 - v3
Checksum:iCD0A3F72EEC2831E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002894 mRNA. Translation: BAB22439.1.
AK145602 mRNA. Translation: BAE26535.1.
AK150210 mRNA. Translation: BAE29381.1.
AK153409 mRNA. Translation: BAE31969.1.
AK155027 mRNA. Translation: BAE32999.1.
AK166733 mRNA. Translation: BAE38978.1.
AK166947 mRNA. Translation: BAE39134.1.
AK167215 mRNA. Translation: BAE39341.1.
AK168251 mRNA. Translation: BAE40201.1.
CCDSiCCDS38974.1.
RefSeqiNP_001074743.1. NM_001081274.1.
UniGeneiMm.252080.

Genome annotation databases

EnsembliENSMUST00000084124; ENSMUSP00000081141; ENSMUSG00000028961.
GeneIDi110208.
KEGGimmu:110208.
UCSCiuc008vvv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002894 mRNA. Translation: BAB22439.1.
AK145602 mRNA. Translation: BAE26535.1.
AK150210 mRNA. Translation: BAE29381.1.
AK153409 mRNA. Translation: BAE31969.1.
AK155027 mRNA. Translation: BAE32999.1.
AK166733 mRNA. Translation: BAE38978.1.
AK166947 mRNA. Translation: BAE39134.1.
AK167215 mRNA. Translation: BAE39341.1.
AK168251 mRNA. Translation: BAE40201.1.
CCDSiCCDS38974.1.
RefSeqiNP_001074743.1. NM_001081274.1.
UniGeneiMm.252080.

3D structure databases

ProteinModelPortaliQ9DCD0.
SMRiQ9DCD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1868998.
STRINGi10090.ENSMUSP00000081141.

PTM databases

iPTMnetiQ9DCD0.
PhosphoSitePlusiQ9DCD0.
SwissPalmiQ9DCD0.

Proteomic databases

EPDiQ9DCD0.
MaxQBiQ9DCD0.
PaxDbiQ9DCD0.
PRIDEiQ9DCD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084124; ENSMUSP00000081141; ENSMUSG00000028961.
GeneIDi110208.
KEGGimmu:110208.
UCSCiuc008vvv.1. mouse.

Organism-specific databases

CTDi5226.
MGIiMGI:97553. Pgd.

Phylogenomic databases

eggNOGiKOG2653. Eukaryota.
COG0362. LUCA.
GeneTreeiENSGT00390000009023.
HOGENOMiHOG000255147.
HOVERGENiHBG000029.
InParanoidiQ9DCD0.
KOiK00033.
OMAiAFAFEEW.
OrthoDBiEOG091G06XF.
PhylomeDBiQ9DCD0.
TreeFamiTF300386.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410.
ReactomeiR-MMU-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

ChiTaRSiPgd. mouse.
PROiQ9DCD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028961.
CleanExiMM_PGD.
GenevisibleiQ9DCD0. MM.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR012284. 6PGD_dom_3.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiSM01350. 6PGD. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei6PGD_MOUSE
AccessioniPrimary (citable) accession number: Q9DCD0
Secondary accession number(s): Q3UD80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.