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Protein

Mitochondrial import receptor subunit TOM20 homolog

Gene

Tomm20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5205685 Pink/Parkin Mediated Mitophagy
R-MMU-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor Tom20
Gene namesi
Name:Tomm20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915202 Tomm20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneSequence analysis6
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
Topological domaini25 – 145CytoplasmicSequence analysisAdd BLAST121

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515391 – 145Mitochondrial import receptor subunit TOM20 homologAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DCC8
MaxQBiQ9DCC8
PaxDbiQ9DCC8
PRIDEiQ9DCC8

PTM databases

iPTMnetiQ9DCC8
PhosphoSitePlusiQ9DCC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000093904
ExpressionAtlasiQ9DCC8 baseline and differential
GenevisibleiQ9DCC8 MM

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212562, 2 interactors
DIPiDIP-60017N
IntActiQ9DCC8, 2 interactors
MINTiQ9DCC8
STRINGi10090.ENSMUSP00000136493

Structurei

3D structure databases

ProteinModelPortaliQ9DCC8
SMRiQ9DCC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4056 Eukaryota
ENOG4111NAH LUCA
GeneTreeiENSGT00390000011698
HOGENOMiHOG000006671
HOVERGENiHBG057315
InParanoidiQ9DCC8
KOiK17770
OMAiFVGYCFY
OrthoDBiEOG091G0Z80
PhylomeDBiQ9DCC8
TreeFamiTF106200

Family and domain databases

Gene3Di1.20.960.10, 1 hit
InterProiView protein in InterPro
IPR002056 MAS20
IPR022422 MAS20_rcpt_metazoan
IPR023392 Tom20_dom_sf
PANTHERiPTHR12430 PTHR12430, 1 hit
PfamiView protein in Pfam
PF02064 MAS20, 1 hit
PIRSFiPIRSF037707 MAS20_rcpt, 1 hit
PRINTSiPR01989 EUOM20RECPTR
PR00351 OM20RECEPTOR
SUPFAMiSSF47157 SSF47157, 1 hit
TIGRFAMsiTIGR00985 3a0801s04tom, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE
60 70 80 90 100
RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGDYEKGV DHLTNAIAVC
110 120 130 140
GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE
Length:145
Mass (Da):16,284
Last modified:June 1, 2001 - v1
Checksum:i50E3BD25AD5C9B3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002902 mRNA Translation: BAB22444.1
BC002087 mRNA Translation: AAH02087.1
CCDSiCCDS22786.1
RefSeqiNP_077176.1, NM_024214.2
UniGeneiMm.372086
Mm.489811
Mm.6932

Genome annotation databases

EnsembliENSMUST00000179857; ENSMUSP00000136493; ENSMUSG00000093904
GeneIDi67952
KEGGimmu:67952
UCSCiuc009nza.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTOM20_MOUSE
AccessioniPrimary (citable) accession number: Q9DCC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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