Reviewed,
UniProtKB/Swiss-Prot Q9DCC4 (P5CR3_MOUSE)
Last modified
June 16, 2009.
Version 46.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Pyrroline-5-carboxylate reductase 3 Short name=P5C reductase 3 Short name=P5CR 3 EC=1.5.1.2 Alternative name(s): Pyrroline-5-carboxylate reductase-like protein | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 274 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. |
| Pathway | |
| Subunit structure | Homodecamer; composed of 5 homodimers By similarity. |
| Sequence similarities | Belongs to the pyrroline-5-carboxylate reductase family. |
| Sequence caution | The sequence BAB23252.1 differs from that shown. Reason: Frameshift at positions 231 and 242. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Proline biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | identical protein binding Inferred from physical interaction. Source: MGI pyrroline-5-carboxylate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 274 | 274 | Pyrroline-5-carboxylate reductase 3 | PRO_0000324563 | |||||
Experimental info | |||||||||
| Sequence conflict | 59 | 1 | T → N in BAB23252. Ref.1 | ||||||
| Sequence conflict | 68 | 1 | N → S in BAB22451. Ref.1 | ||||||
| Sequence conflict | 92 – 93 | 2 | VT → IN in BAB23252. Ref.1 | ||||||
| Sequence conflict | 107 – 110 | 4 | LSTM → HGTK in BAB23252. Ref.1 | ||||||
| Sequence conflict | 120 | 1 | V → A in BAB23252. Ref.1 | ||||||
| Sequence conflict | 128 | 1 | P → T in BAB23252. Ref.1 | ||||||
| Sequence conflict | 152 | 1 | L → I in BAB23252. Ref.1 | ||||||
| Sequence conflict | 164 | 1 | E → K in BAB23252. Ref.1 | ||||||
| Sequence conflict | 190 | 1 | A → G in BAB23252. Ref.1 | ||||||
| Sequence conflict | 198 | 1 | M → I in BAB23252. Ref.1 | ||||||
| Sequence conflict | 268 | 1 | A → V in BAB23252. Ref.1 | ||||||
Sequences
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References
| [1] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Kidney. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK002912 mRNA. Translation: BAB22451.1. AK004291 mRNA. Translation: BAB23252.1. Frameshift. BC026536 mRNA. Translation: AAH26536.1. | |
| IPI | IPI00153234. |
| RefSeq | NP_079688.2. |
| UniGene | Mm.250599 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9DCC4. 1 interaction. |
Proteomic databases | |
| PRIDE | Q9DCC4. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000022571. Mus musculus. [Contig view] |
| GeneID | 66194. |
| KEGG | mmu:66194. |
Organism-specific databases | |
| MGI | MGI:1913444. Pycrl. |
Phylogenomic databases | |
| HOVERGEN | Q9DCC4. |
| OMA | Q9DCC4. RVSPNLP. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.2. 244. |
Gene expression databases | |
| ArrayExpress | Q9DCC4. |
| Bgee | Q9DCC4. |
| CleanEx | MM_PYCRL. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11645. P5CR. 1 hit. |
| Pfam | PF03807. F420_oxidored. 1 hit. [Graphical view] |
| PIRSF | PIRSF000193. Pyrrol-5-carb_rd. 1 hit. |
| TIGRFAMs | TIGR00112. proC. 1 hit. |
| PROSITE | PS00521. P5CR. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 320915. |
| SOURCE | Search... |
Entry information
| Entry name | P5CR3_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9DCC4 Secondary accession number(s): Q8R0P9, Q9D0X2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
