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Protein

Neuron-specific vesicular protein calcyon

Gene

Caly

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific vesicular protein calcyon
Gene namesi
Name:Caly
Synonyms:Drd1ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915816. Caly.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8888ExtracellularSequence AnalysisAdd
BLAST
Transmembranei89 – 10921HelicalSequence AnalysisAdd
BLAST
Topological domaini110 – 226117CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display impaired clathrin assembly and clathrin-mediated endocytosis. Transgenic mice with up-regulated forebrain expression of Caly display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety and/or impaired harm avoidance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Neuron-specific vesicular protein calcyonPRO_0000164369Add
BLAST

Proteomic databases

MaxQBiQ9DCA7.
PaxDbiQ9DCA7.
PRIDEiQ9DCA7.

PTM databases

PhosphoSiteiQ9DCA7.

Expressioni

Tissue specificityi

Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart.1 Publication

Gene expression databases

BgeeiQ9DCA7.
CleanExiMM_CALY.
GenevisibleiQ9DCA7. MM.

Interactioni

Subunit structurei

Interacts with CLTA.By similarity

Protein-protein interaction databases

BioGridi212931. 1 interaction.
STRINGi10090.ENSMUSP00000026541.

Structurei

3D structure databases

ProteinModelPortaliQ9DCA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi190 – 1967Poly-Ala

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43575.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiQ9DCA7.
KOiK15493.
OMAiDQFSCPD.
OrthoDBiEOG71CFNC.
PhylomeDBiQ9DCA7.
TreeFamiTF332232.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DCA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLGCSFSG KPGKEAGDQD GAAMDSVPLI SPLDVSQLQP SFSDQVVINT
60 70 80 90 100
QTEYQLTSAD QPKKFADLEG QRLACSHSEE GRRLPTARMI AFAMALLGCV
110 120 130 140 150
LIMYKAIWYD QFTCPDGFLL RHKICTPLTL EMYYTEMDPE RHRSILAAIG
160 170 180 190 200
AYPLSRKHGT EMPAVWGNNY RTAKEEHKGT TPAAMAVSTA AAAAAAEGTE
210 220
PSGKSLDTRE KEDPQKAEGV PSQPPK
Length:226
Mass (Da):24,580
Last modified:June 1, 2001 - v1
Checksum:iAFF880F4292ADC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002979 mRNA. Translation: BAB22492.1.
AK003400 mRNA. Translation: BAB22765.2.
BC049663 mRNA. Translation: AAH49663.1.
CCDSiCCDS21962.1.
RefSeqiNP_001177314.1. NM_001190385.1.
NP_001177315.1. NM_001190386.1.
NP_081045.2. NM_026769.5.
XP_006536300.1. XM_006536237.1.
UniGeneiMm.44241.

Genome annotation databases

EnsembliENSMUST00000026541; ENSMUSP00000026541; ENSMUSG00000025468.
ENSMUST00000166758; ENSMUSP00000130779; ENSMUSG00000025468.
GeneIDi68566.
KEGGimmu:68566.
UCSCiuc009kgr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002979 mRNA. Translation: BAB22492.1.
AK003400 mRNA. Translation: BAB22765.2.
BC049663 mRNA. Translation: AAH49663.1.
CCDSiCCDS21962.1.
RefSeqiNP_001177314.1. NM_001190385.1.
NP_001177315.1. NM_001190386.1.
NP_081045.2. NM_026769.5.
XP_006536300.1. XM_006536237.1.
UniGeneiMm.44241.

3D structure databases

ProteinModelPortaliQ9DCA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212931. 1 interaction.
STRINGi10090.ENSMUSP00000026541.

PTM databases

PhosphoSiteiQ9DCA7.

Proteomic databases

MaxQBiQ9DCA7.
PaxDbiQ9DCA7.
PRIDEiQ9DCA7.

Protocols and materials databases

DNASUi68566.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026541; ENSMUSP00000026541; ENSMUSG00000025468.
ENSMUST00000166758; ENSMUSP00000130779; ENSMUSG00000025468.
GeneIDi68566.
KEGGimmu:68566.
UCSCiuc009kgr.1. mouse.

Organism-specific databases

CTDi50632.
MGIiMGI:1915816. Caly.

Phylogenomic databases

eggNOGiNOG43575.
GeneTreeiENSGT00390000000483.
HOGENOMiHOG000030909.
HOVERGENiHBG012403.
InParanoidiQ9DCA7.
KOiK15493.
OMAiDQFSCPD.
OrthoDBiEOG71CFNC.
PhylomeDBiQ9DCA7.
TreeFamiTF332232.

Miscellaneous databases

NextBioi327470.
PROiQ9DCA7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DCA7.
CleanExiMM_CALY.
GenevisibleiQ9DCA7. MM.

Family and domain databases

InterProiIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamiPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFiPIRSF002383. Calcyon. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the murine calcyon gene."
    Dai R., Bergson C.
    Gene 311:111-117(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis."
    Xiao J., Dai R., Negyessy L., Bergson C.
    J. Biol. Chem. 281:15182-15193(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice."
    Trantham-Davidson H., Vazdarjanova A., Dai R., Terry A., Bergson C.
    Behav. Brain Res. 189:244-249(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANSGENIC MICE.

Entry informationi

Entry nameiCALY_MOUSE
AccessioniPrimary (citable) accession number: Q9DCA7
Secondary accession number(s): Q9D1K9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.