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Q9DCA7 (CALY_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuron-specific vesicular protein calcyon
Gene names
Name:Caly
Synonyms:Drd1ip
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis By similarity.

Subunit structure

Interacts with CLTA By similarity.

Subcellular location

Cytoplasmic vesicle membrane; Single-pass membrane protein By similarity. Cell membrane; Single-pass membrane protein By similarity.

Tissue specificity

Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart. Ref.1

Disruption phenotype

Mice display impaired clathrin assembly and clathrin-mediated endocytosis. Transgenic mice with up-regulated forebrain expression of Caly display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety and/or impaired harm avoidance. Ref.4

Sequence similarities

Belongs to the NSG family.

Caution

The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226Neuron-specific vesicular protein calcyon
PRO_0000164369

Regions

Topological domain1 – 8888Extracellular Potential
Transmembrane89 – 10921Helical; Potential
Topological domain110 – 226117Cytoplasmic Potential
Compositional bias190 – 1967Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q9DCA7 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AFF880F4292ADC98

FASTA22624,580
        10         20         30         40         50         60 
MVKLGCSFSG KPGKEAGDQD GAAMDSVPLI SPLDVSQLQP SFSDQVVINT QTEYQLTSAD 

        70         80         90        100        110        120 
QPKKFADLEG QRLACSHSEE GRRLPTARMI AFAMALLGCV LIMYKAIWYD QFTCPDGFLL 

       130        140        150        160        170        180 
RHKICTPLTL EMYYTEMDPE RHRSILAAIG AYPLSRKHGT EMPAVWGNNY RTAKEEHKGT 

       190        200        210        220 
TPAAMAVSTA AAAAAAEGTE PSGKSLDTRE KEDPQKAEGV PSQPPK 

« Hide

References

« Hide 'large scale' references
[1]"Structure and expression of the murine calcyon gene."
Dai R., Bergson C.
Gene 311:111-117(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain and Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis."
Xiao J., Dai R., Negyessy L., Bergson C.
J. Biol. Chem. 281:15182-15193(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[5]"Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice."
Trantham-Davidson H., Vazdarjanova A., Dai R., Terry A., Bergson C.
Behav. Brain Res. 189:244-249(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TRANSGENIC MICE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002979 mRNA. Translation: BAB22492.1.
AK003400 mRNA. Translation: BAB22765.2.
BC049663 mRNA. Translation: AAH49663.1.
CCDSCCDS21962.1.
RefSeqNP_001177314.1. NM_001190385.1.
NP_001177315.1. NM_001190386.1.
NP_081045.2. NM_026769.5.
XP_006536300.1. XM_006536237.1.
UniGeneMm.44241.

3D structure databases

ProteinModelPortalQ9DCA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212931. 1 interaction.

PTM databases

PhosphoSiteQ9DCA7.

Proteomic databases

PaxDbQ9DCA7.
PRIDEQ9DCA7.

Protocols and materials databases

DNASU68566.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026541; ENSMUSP00000026541; ENSMUSG00000025468.
ENSMUST00000166758; ENSMUSP00000130779; ENSMUSG00000025468.
GeneID68566.
KEGGmmu:68566.
UCSCuc009kgr.1. mouse.

Organism-specific databases

CTD50632.
MGIMGI:1915816. Caly.

Phylogenomic databases

eggNOGNOG43575.
GeneTreeENSGT00390000000483.
HOGENOMHOG000030909.
HOVERGENHBG012403.
InParanoidQ9DCA7.
KOK15493.
OMADQFSCPD.
OrthoDBEOG71CFNC.
PhylomeDBQ9DCA7.
TreeFamTF332232.

Gene expression databases

BgeeQ9DCA7.
CleanExMM_CALY.
GenevestigatorQ9DCA7.

Family and domain databases

InterProIPR009431. Calcyon_neuron-sp.
[Graphical view]
PfamPF06387. Calcyon. 1 hit.
[Graphical view]
PIRSFPIRSF002383. Calcyon. 1 hit.
ProtoNetSearch...

Other

NextBio327470.
PROQ9DCA7.
SOURCESearch...

Entry information

Entry nameCALY_MOUSE
AccessionPrimary (citable) accession number: Q9DCA7
Secondary accession number(s): Q9D1K9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot