Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9DCA7

- CALY_MOUSE

UniProt

Q9DCA7 - CALY_MOUSE

Protein

Neuron-specific vesicular protein calcyon

Gene

Caly

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.By similarity

    GO - Molecular functioni

    1. clathrin light chain binding Source: UniProtKB

    GO - Biological processi

    1. clathrin coat assembly Source: UniProtKB
    2. dopamine receptor signaling pathway Source: InterPro
    3. endocytosis Source: UniProtKB-KW
    4. positive regulation of endocytosis Source: UniProtKB

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuron-specific vesicular protein calcyon
    Gene namesi
    Name:Caly
    Synonyms:Drd1ip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1915816. Caly.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: UniProtKB
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice display impaired clathrin assembly and clathrin-mediated endocytosis. Transgenic mice with up-regulated forebrain expression of Caly display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety and/or impaired harm avoidance.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226Neuron-specific vesicular protein calcyonPRO_0000164369Add
    BLAST

    Proteomic databases

    PaxDbiQ9DCA7.
    PRIDEiQ9DCA7.

    PTM databases

    PhosphoSiteiQ9DCA7.

    Expressioni

    Tissue specificityi

    Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart.1 Publication

    Gene expression databases

    BgeeiQ9DCA7.
    CleanExiMM_CALY.
    GenevestigatoriQ9DCA7.

    Interactioni

    Subunit structurei

    Interacts with CLTA.By similarity

    Protein-protein interaction databases

    BioGridi212931. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DCA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8888ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini110 – 226117CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi190 – 1967Poly-Ala

    Sequence similaritiesi

    Belongs to the NSG family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43575.
    GeneTreeiENSGT00390000000483.
    HOGENOMiHOG000030909.
    HOVERGENiHBG012403.
    InParanoidiQ9DCA7.
    KOiK15493.
    OMAiDQFSCPD.
    OrthoDBiEOG71CFNC.
    PhylomeDBiQ9DCA7.
    TreeFamiTF332232.

    Family and domain databases

    InterProiIPR009431. Calcyon_neuron-sp.
    [Graphical view]
    PfamiPF06387. Calcyon. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002383. Calcyon. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9DCA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLGCSFSG KPGKEAGDQD GAAMDSVPLI SPLDVSQLQP SFSDQVVINT    50
    QTEYQLTSAD QPKKFADLEG QRLACSHSEE GRRLPTARMI AFAMALLGCV 100
    LIMYKAIWYD QFTCPDGFLL RHKICTPLTL EMYYTEMDPE RHRSILAAIG 150
    AYPLSRKHGT EMPAVWGNNY RTAKEEHKGT TPAAMAVSTA AAAAAAEGTE 200
    PSGKSLDTRE KEDPQKAEGV PSQPPK 226
    Length:226
    Mass (Da):24,580
    Last modified:June 1, 2001 - v1
    Checksum:iAFF880F4292ADC98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002979 mRNA. Translation: BAB22492.1.
    AK003400 mRNA. Translation: BAB22765.2.
    BC049663 mRNA. Translation: AAH49663.1.
    CCDSiCCDS21962.1.
    RefSeqiNP_001177314.1. NM_001190385.1.
    NP_001177315.1. NM_001190386.1.
    NP_081045.2. NM_026769.5.
    XP_006536300.1. XM_006536237.1.
    UniGeneiMm.44241.

    Genome annotation databases

    EnsembliENSMUST00000026541; ENSMUSP00000026541; ENSMUSG00000025468.
    ENSMUST00000166758; ENSMUSP00000130779; ENSMUSG00000025468.
    GeneIDi68566.
    KEGGimmu:68566.
    UCSCiuc009kgr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002979 mRNA. Translation: BAB22492.1 .
    AK003400 mRNA. Translation: BAB22765.2 .
    BC049663 mRNA. Translation: AAH49663.1 .
    CCDSi CCDS21962.1.
    RefSeqi NP_001177314.1. NM_001190385.1.
    NP_001177315.1. NM_001190386.1.
    NP_081045.2. NM_026769.5.
    XP_006536300.1. XM_006536237.1.
    UniGenei Mm.44241.

    3D structure databases

    ProteinModelPortali Q9DCA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212931. 1 interaction.

    PTM databases

    PhosphoSitei Q9DCA7.

    Proteomic databases

    PaxDbi Q9DCA7.
    PRIDEi Q9DCA7.

    Protocols and materials databases

    DNASUi 68566.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026541 ; ENSMUSP00000026541 ; ENSMUSG00000025468 .
    ENSMUST00000166758 ; ENSMUSP00000130779 ; ENSMUSG00000025468 .
    GeneIDi 68566.
    KEGGi mmu:68566.
    UCSCi uc009kgr.1. mouse.

    Organism-specific databases

    CTDi 50632.
    MGIi MGI:1915816. Caly.

    Phylogenomic databases

    eggNOGi NOG43575.
    GeneTreei ENSGT00390000000483.
    HOGENOMi HOG000030909.
    HOVERGENi HBG012403.
    InParanoidi Q9DCA7.
    KOi K15493.
    OMAi DQFSCPD.
    OrthoDBi EOG71CFNC.
    PhylomeDBi Q9DCA7.
    TreeFami TF332232.

    Miscellaneous databases

    NextBioi 327470.
    PROi Q9DCA7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9DCA7.
    CleanExi MM_CALY.
    Genevestigatori Q9DCA7.

    Family and domain databases

    InterProi IPR009431. Calcyon_neuron-sp.
    [Graphical view ]
    Pfami PF06387. Calcyon. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002383. Calcyon. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the murine calcyon gene."
      Dai R., Bergson C.
      Gene 311:111-117(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain and Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis."
      Xiao J., Dai R., Negyessy L., Bergson C.
      J. Biol. Chem. 281:15182-15193(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    5. "Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice."
      Trantham-Davidson H., Vazdarjanova A., Dai R., Terry A., Bergson C.
      Behav. Brain Res. 189:244-249(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TRANSGENIC MICE.

    Entry informationi

    Entry nameiCALY_MOUSE
    AccessioniPrimary (citable) accession number: Q9DCA7
    Secondary accession number(s): Q9D1K9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3