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Protein

Neuron-specific vesicular protein calcyon

Gene

Caly

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.By similarity

Caution

The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processEndocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuron-specific vesicular protein calcyon
Gene namesi
Name:Caly
Synonyms:Drd1ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1915816 Caly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 88ExtracellularSequence analysisAdd BLAST88
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 226CytoplasmicSequence analysisAdd BLAST117

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice display impaired clathrin assembly and clathrin-mediated endocytosis. Transgenic mice with up-regulated forebrain expression of Caly display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety and/or impaired harm avoidance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643691 – 226Neuron-specific vesicular protein calcyonAdd BLAST226

Proteomic databases

MaxQBiQ9DCA7
PaxDbiQ9DCA7
PRIDEiQ9DCA7

PTM databases

iPTMnetiQ9DCA7
PhosphoSitePlusiQ9DCA7

Expressioni

Tissue specificityi

Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000025468
CleanExiMM_CALY
GenevisibleiQ9DCA7 MM

Interactioni

Subunit structurei

Interacts with CLTA.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212931, 1 interactor
STRINGi10090.ENSMUSP00000026541

Structurei

3D structure databases

ProteinModelPortaliQ9DCA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi190 – 196Poly-Ala7

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKA7 Eukaryota
ENOG41118NY LUCA
GeneTreeiENSGT00390000000483
HOGENOMiHOG000030909
HOVERGENiHBG012403
InParanoidiQ9DCA7
KOiK15493
OMAiPAALEMY
OrthoDBiEOG091G0KES
PhylomeDBiQ9DCA7
TreeFamiTF332232

Family and domain databases

InterProiView protein in InterPro
IPR009431 NSG
PANTHERiPTHR28546 PTHR28546, 1 hit
PfamiView protein in Pfam
PF06387 Calcyon, 1 hit
PIRSFiPIRSF002383 Calcyon, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DCA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLGCSFSG KPGKEAGDQD GAAMDSVPLI SPLDVSQLQP SFSDQVVINT
60 70 80 90 100
QTEYQLTSAD QPKKFADLEG QRLACSHSEE GRRLPTARMI AFAMALLGCV
110 120 130 140 150
LIMYKAIWYD QFTCPDGFLL RHKICTPLTL EMYYTEMDPE RHRSILAAIG
160 170 180 190 200
AYPLSRKHGT EMPAVWGNNY RTAKEEHKGT TPAAMAVSTA AAAAAAEGTE
210 220
PSGKSLDTRE KEDPQKAEGV PSQPPK
Length:226
Mass (Da):24,580
Last modified:June 1, 2001 - v1
Checksum:iAFF880F4292ADC98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002979 mRNA Translation: BAB22492.1
AK003400 mRNA Translation: BAB22765.2
BC049663 mRNA Translation: AAH49663.1
CCDSiCCDS21962.1
RefSeqiNP_001177314.1, NM_001190385.1
NP_001177315.1, NM_001190386.1
NP_081045.2, NM_026769.5
XP_006536300.1, XM_006536237.2
XP_011248155.1, XM_011249853.2
UniGeneiMm.44241

Genome annotation databases

EnsembliENSMUST00000026541; ENSMUSP00000026541; ENSMUSG00000025468
ENSMUST00000166758; ENSMUSP00000130779; ENSMUSG00000025468
ENSMUST00000211044; ENSMUSP00000148159; ENSMUSG00000025468
ENSMUST00000211283; ENSMUSP00000148173; ENSMUSG00000025468
GeneIDi68566
KEGGimmu:68566
UCSCiuc009kgr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCALY_MOUSE
AccessioniPrimary (citable) accession number: Q9DCA7
Secondary accession number(s): Q9D1K9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health