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Protein

Ribosome biogenesis protein BRX1 homolog

Gene

Brix1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BRX1 homolog
Alternative name(s):
Brix domain-containing protein 2
Gene namesi
Name:Brix1
Synonyms:Brix, Bxdc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915082. Brix1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001202311 – 353Ribosome biogenesis protein BRX1 homologAdd BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261PhosphoserineBy similarity1
Modified residuei276N6-acetyllysineBy similarity1
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DCA5.
MaxQBiQ9DCA5.
PaxDbiQ9DCA5.
PeptideAtlasiQ9DCA5.
PRIDEiQ9DCA5.

PTM databases

iPTMnetiQ9DCA5.
PhosphoSitePlusiQ9DCA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022247.
CleanExiMM_BXDC2.
ExpressionAtlasiQ9DCA5. baseline and differential.
GenevisibleiQ9DCA5. MM.

Interactioni

Protein-protein interaction databases

BioGridi212465. 1 interactor.
IntActiQ9DCA5. 2 interactors.
MINTiMINT-4089395.
STRINGi10090.ENSMUSP00000022855.

Structurei

3D structure databases

ProteinModelPortaliQ9DCA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 249BrixPROSITE-ProRule annotationAdd BLAST190

Sequence similaritiesi

Belongs to the BRX1 family.Curated
Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2971. Eukaryota.
COG5154. LUCA.
GeneTreeiENSGT00390000014467.
HOGENOMiHOG000212937.
HOVERGENiHBG039185.
InParanoidiQ9DCA5.
KOiK14820.
OMAiKKPKRNE.
OrthoDBiEOG091G0C4X.
PhylomeDBiQ9DCA5.
TreeFamiTF105766.

Family and domain databases

InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
IPR026532. BRX1.
[Graphical view]
PANTHERiPTHR13634. PTHR13634. 1 hit.
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DCA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATKRKRRG GLEVQAKKPK RSSKDAGQPA KQADVAKEAE EENRDRIPGP
60 70 80 90 100
VCKGKWKNKE RILIFSSRGI NFRTRHLMQD LRMLMPHSKA DTKMDRKDKL
110 120 130 140 150
FVINEVCEMK NCNKCIYFEA KKKQDLYMWL SNSPHGPSAK FLVQNIHTLA
160 170 180 190 200
ELKMTGNCLK GSRPLLSFDP AFDDLPHYAL LKEFLIQIFS TPRYHPKSQP
210 220 230 240 250
FVDHVFTFTI LDNRIWFRNF QIIEEDAALV EIGPRFVLNL IKIFQGSFGG
260 270 280 290 300
PTLYENPHYQ SPNMHRRVIR SITAAKYRER QQVKDVQKLR KKEPKTILPH
310 320 330 340 350
DPTADVFVIP AEEKPVEIQW VKPEPKVDLK ARKRRIYKRH RKLQQKMSRG

SAK
Length:353
Mass (Da):41,241
Last modified:January 9, 2007 - v3
Checksum:i6087F4F9C340692F
GO

Sequence cautioni

The sequence AAH14832 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB22497 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195H → N in BAE40264 (PubMed:16141072).Curated1
Sequence conflicti242K → E in BAB22497 (PubMed:16141072).Curated1
Sequence conflicti265H → Q in BAB22497 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002985 mRNA. Translation: BAB22497.1. Different initiation.
AK168325 mRNA. Translation: BAE40264.1.
BC014832 mRNA. Translation: AAH14832.1. Different initiation.
CCDSiCCDS37042.1.
RefSeqiNP_080672.3. NM_026396.3.
UniGeneiMm.28057.

Genome annotation databases

EnsembliENSMUST00000022855; ENSMUSP00000022855; ENSMUSG00000022247.
GeneIDi67832.
KEGGimmu:67832.
UCSCiuc007vgg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002985 mRNA. Translation: BAB22497.1. Different initiation.
AK168325 mRNA. Translation: BAE40264.1.
BC014832 mRNA. Translation: AAH14832.1. Different initiation.
CCDSiCCDS37042.1.
RefSeqiNP_080672.3. NM_026396.3.
UniGeneiMm.28057.

3D structure databases

ProteinModelPortaliQ9DCA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212465. 1 interactor.
IntActiQ9DCA5. 2 interactors.
MINTiMINT-4089395.
STRINGi10090.ENSMUSP00000022855.

PTM databases

iPTMnetiQ9DCA5.
PhosphoSitePlusiQ9DCA5.

Proteomic databases

EPDiQ9DCA5.
MaxQBiQ9DCA5.
PaxDbiQ9DCA5.
PeptideAtlasiQ9DCA5.
PRIDEiQ9DCA5.

Protocols and materials databases

DNASUi67832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022855; ENSMUSP00000022855; ENSMUSG00000022247.
GeneIDi67832.
KEGGimmu:67832.
UCSCiuc007vgg.1. mouse.

Organism-specific databases

CTDi55299.
MGIiMGI:1915082. Brix1.

Phylogenomic databases

eggNOGiKOG2971. Eukaryota.
COG5154. LUCA.
GeneTreeiENSGT00390000014467.
HOGENOMiHOG000212937.
HOVERGENiHBG039185.
InParanoidiQ9DCA5.
KOiK14820.
OMAiKKPKRNE.
OrthoDBiEOG091G0C4X.
PhylomeDBiQ9DCA5.
TreeFamiTF105766.

Miscellaneous databases

PROiQ9DCA5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022247.
CleanExiMM_BXDC2.
ExpressionAtlasiQ9DCA5. baseline and differential.
GenevisibleiQ9DCA5. MM.

Family and domain databases

InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
IPR026532. BRX1.
[Graphical view]
PANTHERiPTHR13634. PTHR13634. 1 hit.
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRX1_MOUSE
AccessioniPrimary (citable) accession number: Q9DCA5
Secondary accession number(s): Q3THD3, Q91YS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: January 9, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.