Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Gene

Ndufs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi100Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi164Iron-sulfur (4Fe-4S)Sequence analysis1
Metal bindingi194Iron-sulfur (4Fe-4S)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport
R-MMU-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-20kD
Short name:
CI-20kD
NADH-ubiquinone oxidoreductase 20 kDa subunit
Gene namesi
Name:Ndufs7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1922656 Ndufs7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000002002836 – 224NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei39PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1

Post-translational modificationi

Hydroxylated ar Arg-111 by NDUFAF5 early in the pathway of assembly of complex I, before the formation of the juncture between peripheral and membrane arms.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DC70
MaxQBiQ9DC70
PaxDbiQ9DC70
PeptideAtlasiQ9DC70
PRIDEiQ9DC70

PTM databases

iPTMnetiQ9DC70
PhosphoSitePlusiQ9DC70
SwissPalmiQ9DC70

Expressioni

Gene expression databases

BgeeiENSMUSG00000020153
CleanExiMM_NDUFS7
GenevisibleiQ9DC70 MM

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi217459, 1 interactor
CORUMiQ9DC70
IntActiQ9DC70, 1 interactor
STRINGi10090.ENSMUSP00000020361

Structurei

3D structure databases

ProteinModelPortaliQ9DC70
SMRiQ9DC70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 20 kDa subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1687 Eukaryota
COG0377 LUCA
GeneTreeiENSGT00390000006565
HOGENOMiHOG000228249
HOVERGENiHBG001576
InParanoidiQ9DC70
KOiK03940
OMAiEMMTTGA
OrthoDBiEOG091G0ST7
PhylomeDBiQ9DC70
TreeFamiTF312859

Family and domain databases

HAMAPiMF_01356 NDH1_NuoB, 1 hit
InterProiView protein in InterPro
IPR006137 NADH_UbQ_OxRdtase-like_20kDa
IPR006138 NADH_UQ_OxRdtase_20Kd_su
PfamiView protein in Pfam
PF01058 Oxidored_q6, 1 hit
TIGRFAMsiTIGR01957 nuoB_fam, 1 hit
PROSITEiView protein in PROSITE
PS01150 COMPLEX1_20K, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DC70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAAPGLL SVRILGLRTA QVQLRRVHQS VATEGPSPSP SPSLSSTQSA
60 70 80 90 100
VSKAGAGAVV PKLSHLPRSR AEYVVTKLDD LINWARRSSL WPMTFGLACC
110 120 130 140 150
AVEMMHMAAP RYDMDRFGVV FRASPRQADV MIVAGTLTNK MAPALRKVYD
160 170 180 190 200
QMPEPRYVVS MGSCANGGGY YHYSYSVVRG CDRIVPVDIY VPGCPPTAEA
210 220
LLYGILQLQR KIKREQKLKI WYRR
Length:224
Mass (Da):24,683
Last modified:June 1, 2001 - v1
Checksum:i234F3FF0ABC36A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003132 mRNA Translation: BAB22592.1
BC013503 mRNA Translation: AAH13503.1
CCDSiCCDS24015.1
RefSeqiNP_083548.1, NM_029272.3
UniGeneiMm.28712

Genome annotation databases

EnsembliENSMUST00000020361; ENSMUSP00000020361; ENSMUSG00000020153
ENSMUST00000105364; ENSMUSP00000101003; ENSMUSG00000020153
GeneIDi75406
KEGGimmu:75406
UCSCiuc007gci.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNDUS7_MOUSE
AccessioniPrimary (citable) accession number: Q9DC70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health