UniProtKB - Q9DC69 (NDUA9_MOUSE)
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Protein
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Gene
Ndufa9
Organism
Mus musculus (Mouse)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity
Cofactori
FADBy similarityNote: Binds 1 FAD per subunit.By similarity
GO - Molecular functioni
- NADH dehydrogenase activity Source: MGI
- protein complex binding Source: MGI
GO - Biological processi
- circadian rhythm Source: UniProtKB
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- response to glucose Source: Ensembl
- ubiquinone-6 biosynthetic process Source: GO_Central
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-MMU-611105. Respiratory electron transport. R-MMU-6799198. Complex I biogenesis. |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialAlternative name(s): Complex I-39kD Short name: CI-39kD NADH-ubiquinone oxidoreductase 39 kDa subunit |
Gene namesi | Name:Ndufa9 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913358. Ndufa9. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionBy similarityAdd BLAST | 35 | |
ChainiPRO_0000019993 | 36 – 377 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialAdd BLAST | 342 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 175 | N6-succinyllysineCombined sources | 1 | |
Modified residuei | 189 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 370 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Acetylated on lysine residues. BLOC1S1 is required for acetylation. Acetylated by CLOCK in a circadian manner.By similarity
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9DC69. |
MaxQBi | Q9DC69. |
PaxDbi | Q9DC69. |
PeptideAtlasi | Q9DC69. |
PRIDEi | Q9DC69. |
TopDownProteomicsi | Q9DC69. |
PTM databases
iPTMneti | Q9DC69. |
PhosphoSitePlusi | Q9DC69. |
SwissPalmi | Q9DC69. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000399. |
ExpressionAtlasi | Q9DC69. baseline and differential. |
Genevisiblei | Q9DC69. MM. |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4. Interacts with CLOCK (By similarity).By similarity
GO - Molecular functioni
- protein complex binding Source: MGI
Protein-protein interaction databases
BioGridi | 211219. 4 interactors. |
CORUMi | Q9DC69. |
IntActi | Q9DC69. 8 interactors. |
MINTi | Q9DC69. |
STRINGi | 10090.ENSMUSP00000085523. |
Structurei
3D structure databases
ProteinModelPortali | Q9DC69. |
SMRi | Q9DC69. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFA9 subunit family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2865. Eukaryota. COG0702. LUCA. |
GeneTreei | ENSGT00390000006865. |
HOGENOMi | HOG000168008. |
HOVERGENi | HBG006546. |
InParanoidi | Q9DC69. |
KOi | K03953. |
OMAi | KFIHVSH. |
OrthoDBi | EOG091G07EJ. |
TreeFami | TF105961. |
Family and domain databases
InterProi | View protein in InterPro IPR016040. NAD(P)-bd_dom. IPR036291. NAD(P)-bd_dom_sf. |
Pfami | View protein in Pfam PF13460. NAD_binding_10. 1 hit. |
SUPFAMi | SSF51735. SSF51735. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9DC69-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAVRFRVV RALPMSRPAI TAAATSVFCG SSHRQLHHAV IPHGKGGRSS
60 70 80 90 100
VSGVVATVFG ATGFLGRYVV NHLGRMGSQV IIPYRCDVYD IMHLRLMGDL
110 120 130 140 150
GQLTFLEWDA RDKDSIRKAV QHSNVVINLI GREWETRNFD FEDVFVNIPR
160 170 180 190 200
AIAQASKEAG VERFIHVSHL NASMKSSSKS LRSKAVGEKE VRSVFPEAII
210 220 230 240 250
IRPSDIFGRE DRFLNHFANY RWFLAVPLVS LGFKTVKQPV YVADVSKGIV
260 270 280 290 300
NATKDPDAVG KTFAFTGPNR YLLFHLVKYI FGMTHRTFIP YPLPLFVYSW
310 320 330 340 350
IGKLFGLSPF EPWTTKDKVE RIHISDVMPT DLPGLEDLGV QPTPLELKSI
360 370
EVLRRHRTYR WLSSEIEETK PAKTVNY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 100 | L → P in BAB22596 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003137 mRNA. Translation: BAB22596.1. CH466523 Genomic DNA. Translation: EDK99844.1. BC005760 mRNA. Translation: AAH05760.1. BC058378 mRNA. Translation: AAH58378.1. |
CCDSi | CCDS20557.1. |
RefSeqi | NP_079634.2. NM_025358.3. |
UniGenei | Mm.29939. |
Genome annotation databases
Ensembli | ENSMUST00000205002; ENSMUSP00000144904; ENSMUSG00000000399. |
GeneIDi | 66108. |
KEGGi | mmu:66108. |
UCSCi | uc009dve.2. mouse. |
Similar proteinsi
Entry informationi
Entry namei | NDUA9_MOUSE | |
Accessioni | Q9DC69Primary (citable) accession number: Q9DC69 Secondary accession number(s): Q6GTD3, Q99JP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2003 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 28, 2018 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |