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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Gene

Ndufa9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Alternative name(s):
Complex I-39kD
Short name:
CI-39kD
NADH-ubiquinone oxidoreductase 39 kDa subunit
Gene namesi
Name:Ndufa9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913358. Ndufa9.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: MGI
  • mitochondrial matrix Source: MGI
  • mitochondrial membrane Source: MGI
  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535MitochondrionBy similarityAdd
BLAST
Chaini36 – 377342NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialPRO_0000019993Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei175 – 1751N6-succinyllysineCombined sources
Modified residuei189 – 1891N6-acetyllysineCombined sources
Modified residuei370 – 3701N6-acetyllysineCombined sources

Post-translational modificationi

Acetylated on lysine residues. BLOC1S1 is required for acetylation (By similarity).By similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DC69.
MaxQBiQ9DC69.
PaxDbiQ9DC69.
PeptideAtlasiQ9DC69.
PRIDEiQ9DC69.
TopDownProteomicsiQ9DC69.

PTM databases

iPTMnetiQ9DC69.
PhosphoSiteiQ9DC69.
SwissPalmiQ9DC69.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000399.
GenevisibleiQ9DC69. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (By similarity). Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211219. 4 interactions.
IntActiQ9DC69. 7 interactions.
MINTiMINT-1860990.
STRINGi10090.ENSMUSP00000085523.

Structurei

3D structure databases

ProteinModelPortaliQ9DC69.
SMRiQ9DC69. Positions 54-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA9 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2865. Eukaryota.
COG0702. LUCA.
GeneTreeiENSGT00390000006865.
HOGENOMiHOG000168008.
HOVERGENiHBG006546.
InParanoidiQ9DC69.
KOiK03953.
OMAiYVFAMAH.
OrthoDBiEOG091G07EJ.
TreeFamiTF105961.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF13460. NAD_binding_10. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVRFRVV RALPMSRPAI TAAATSVFCG SSHRQLHHAV IPHGKGGRSS
60 70 80 90 100
VSGVVATVFG ATGFLGRYVV NHLGRMGSQV IIPYRCDVYD IMHLRLMGDL
110 120 130 140 150
GQLTFLEWDA RDKDSIRKAV QHSNVVINLI GREWETRNFD FEDVFVNIPR
160 170 180 190 200
AIAQASKEAG VERFIHVSHL NASMKSSSKS LRSKAVGEKE VRSVFPEAII
210 220 230 240 250
IRPSDIFGRE DRFLNHFANY RWFLAVPLVS LGFKTVKQPV YVADVSKGIV
260 270 280 290 300
NATKDPDAVG KTFAFTGPNR YLLFHLVKYI FGMTHRTFIP YPLPLFVYSW
310 320 330 340 350
IGKLFGLSPF EPWTTKDKVE RIHISDVMPT DLPGLEDLGV QPTPLELKSI
360 370
EVLRRHRTYR WLSSEIEETK PAKTVNY
Length:377
Mass (Da):42,525
Last modified:July 27, 2011 - v2
Checksum:i473FA5F2F018AC78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001L → P in BAB22596 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003137 mRNA. Translation: BAB22596.1.
CH466523 Genomic DNA. Translation: EDK99844.1.
BC005760 mRNA. Translation: AAH05760.1.
BC058378 mRNA. Translation: AAH58378.1.
CCDSiCCDS20557.1.
RefSeqiNP_079634.2. NM_025358.3.
UniGeneiMm.29939.

Genome annotation databases

EnsembliENSMUST00000205002; ENSMUSP00000144904; ENSMUSG00000000399.
GeneIDi66108.
KEGGimmu:66108.
UCSCiuc009dve.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003137 mRNA. Translation: BAB22596.1.
CH466523 Genomic DNA. Translation: EDK99844.1.
BC005760 mRNA. Translation: AAH05760.1.
BC058378 mRNA. Translation: AAH58378.1.
CCDSiCCDS20557.1.
RefSeqiNP_079634.2. NM_025358.3.
UniGeneiMm.29939.

3D structure databases

ProteinModelPortaliQ9DC69.
SMRiQ9DC69. Positions 54-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211219. 4 interactions.
IntActiQ9DC69. 7 interactions.
MINTiMINT-1860990.
STRINGi10090.ENSMUSP00000085523.

PTM databases

iPTMnetiQ9DC69.
PhosphoSiteiQ9DC69.
SwissPalmiQ9DC69.

Proteomic databases

EPDiQ9DC69.
MaxQBiQ9DC69.
PaxDbiQ9DC69.
PeptideAtlasiQ9DC69.
PRIDEiQ9DC69.
TopDownProteomicsiQ9DC69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000205002; ENSMUSP00000144904; ENSMUSG00000000399.
GeneIDi66108.
KEGGimmu:66108.
UCSCiuc009dve.2. mouse.

Organism-specific databases

CTDi4704.
MGIiMGI:1913358. Ndufa9.

Phylogenomic databases

eggNOGiKOG2865. Eukaryota.
COG0702. LUCA.
GeneTreeiENSGT00390000006865.
HOGENOMiHOG000168008.
HOVERGENiHBG006546.
InParanoidiQ9DC69.
KOiK03953.
OMAiYVFAMAH.
OrthoDBiEOG091G07EJ.
TreeFamiTF105961.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ9DC69.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000399.
GenevisibleiQ9DC69. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF13460. NAD_binding_10. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUA9_MOUSE
AccessioniPrimary (citable) accession number: Q9DC69
Secondary accession number(s): Q6GTD3, Q99JP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.