Ndufa9

Functionⁱ

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

Cofactorⁱ

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

GO - Molecular functionⁱ

NADH dehydrogenase activity Source: MGI
protein complex binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23209302

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian rhythm Source: UniProtKB
mitochondrial respiratory chain complex I assembly Source: UniProtKB
response to glucose Source: Ensembl
ubiquinone-6 biosynthetic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport
Ligand	FAD, Flavoprotein

Enzyme and pathway databases

Reactomeⁱ	R-MMU-611105. Respiratory electron transport. R-MMU-6799198. Complex I biogenesis.

Reactomeⁱ

R-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial Alternative name(s): Complex I-39kD Short name: CI-39kD NADH-ubiquinone oxidoreductase 39 kDa subunit
Gene namesⁱ	Name:Ndufa9
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 6

Organism-specific databases

MGIⁱ	MGI:1913358. Ndufa9.

Keywords - Cellular componentⁱ

Mitochondrion

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 35	MitochondrionBy similarityAdd BLAST		35
ChainⁱPRO_0000019993	36 – 377	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialAdd BLAST		342

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	175	N6-succinyllysineCombined sources	1
Modified residueⁱ	189	N6-acetyllysineCombined sources	1
Modified residueⁱ	370	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Acetylated on lysine residues. BLOC1S1 is required for acetylation. Acetylated by CLOCK in a circadian manner.By similarity

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9DC69.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9DC69.
PaxDbⁱ	Q9DC69.
PeptideAtlas More...PeptideAtlasⁱ	Q9DC69.
PRIDEⁱ	Q9DC69.
TopDownProteomicsⁱ	Q9DC69.

PTM databases

iPTMnetⁱ	Q9DC69.
PhosphoSitePlusⁱ	Q9DC69.
SwissPalmⁱ	Q9DC69.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000000399.
ExpressionAtlasⁱ	Q9DC69. baseline and differential.
Genevisibleⁱ	Q9DC69. MM.

Interactionⁱ

Subunit structureⁱ

Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction. Interacts with BLOC1S1 (By similarity). Interacts with SLC2A4. Interacts with CLOCK (By similarity).By similarity

GO - Molecular functionⁱ

protein complex binding
Source: MGI
Inferred from sequence orthologyⁱ
- 23209302

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	211219. 4 interactors.
CORUMⁱ	Q9DC69.
IntActⁱ	Q9DC69. 8 interactors.
Molecular INTeraction database More...MINTⁱ	Q9DC69.
STRINGⁱ	10090.ENSMUSP00000085523.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9DC69.
SMRⁱ	Q9DC69.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the complex I NDUFA9 subunit family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG2865. Eukaryota. COG0702. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006865.
HOGENOMⁱ	HOG000168008.
HOVERGENⁱ	HBG006546.
InParanoidⁱ	Q9DC69.
KEGG Orthology (KO) More...KOⁱ	K03953.
OMAⁱ	KFIHVSH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07EJ.
TreeFamⁱ	TF105961.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016040. NAD(P)-bd_dom. IPR036291. NAD(P)-bd_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13460. NAD_binding_10. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9DC69-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAAVRFRVV RALPMSRPAI TAAATSVFCG SSHRQLHHAV IPHGKGGRSS 
        60         70         80         90        100
VSGVVATVFG ATGFLGRYVV NHLGRMGSQV IIPYRCDVYD IMHLRLMGDL 
       110        120        130        140        150
GQLTFLEWDA RDKDSIRKAV QHSNVVINLI GREWETRNFD FEDVFVNIPR 
       160        170        180        190        200
AIAQASKEAG VERFIHVSHL NASMKSSSKS LRSKAVGEKE VRSVFPEAII 
       210        220        230        240        250
IRPSDIFGRE DRFLNHFANY RWFLAVPLVS LGFKTVKQPV YVADVSKGIV 
       260        270        280        290        300
NATKDPDAVG KTFAFTGPNR YLLFHLVKYI FGMTHRTFIP YPLPLFVYSW 
       310        320        330        340        350
IGKLFGLSPF EPWTTKDKVE RIHISDVMPT DLPGLEDLGV QPTPLELKSI 
       360        370 
EVLRRHRTYR WLSSEIEETK PAKTVNY

Length:377

Mass (Da):42,525

Last modified:July 27, 2011 - v2

Checksum:ⁱ473FA5F2F018AC78

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	100	L → P in BAB22596 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003137 mRNA. Translation: BAB22596.1. CH466523 Genomic DNA. Translation: EDK99844.1. BC005760 mRNA. Translation: AAH05760.1. BC058378 mRNA. Translation: AAH58378.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20557.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_079634.2. NM_025358.3.
UniGeneⁱ	Mm.29939.

Genome annotation databases

Ensemblⁱ	ENSMUST00000205002; ENSMUSP00000144904; ENSMUSG00000000399.
GeneIDⁱ	66108.
KEGGⁱ	mmu:66108.
UCSC genome browser More...UCSCⁱ	uc009dve.2. mouse.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9DC69	Q5BK63 UPI000A316BD5 A0A0R3P9C8 UPI0003D0AEF0	Rattus norvegicus (Rat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus musculus (Mouse)	377	UniRef90_Q5BK63	Cluster: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9DC69	Q16795 Q9BTT5 UPI000BA4E636 H2NG64 G3S167 Q0MQB4 K7B3G4 H2Q592 P0CB81 P0CB82 +185	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Pongo pygmaeus (Bornean orangutan) Gorilla gorilla (western gorilla) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Monodelphis domestica (Gray short-tailed opossum) Loxodonta africana (African elephant) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) And more	377	UniRef50_Q16795	Cluster: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	196

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK003137 mRNA. Translation: BAB22596.1. CH466523 Genomic DNA. Translation: EDK99844.1. BC005760 mRNA. Translation: AAH05760.1. BC058378 mRNA. Translation: AAH58378.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20557.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_079634.2. NM_025358.3.
UniGeneⁱ	Mm.29939.

3D structure databases

ProteinModelPortalⁱ	Q9DC69.
SMRⁱ	Q9DC69.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211219. 4 interactors.
CORUMⁱ	Q9DC69.
IntActⁱ	Q9DC69. 8 interactors.
Molecular INTeraction database More...MINTⁱ	Q9DC69.
STRINGⁱ	10090.ENSMUSP00000085523.

PTM databases

iPTMnetⁱ	Q9DC69.
PhosphoSitePlusⁱ	Q9DC69.
SwissPalmⁱ	Q9DC69.

Proteomic databases

EPDⁱ	Q9DC69.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9DC69.
PaxDbⁱ	Q9DC69.
PeptideAtlas More...PeptideAtlasⁱ	Q9DC69.
PRIDEⁱ	Q9DC69.
TopDownProteomicsⁱ	Q9DC69.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000205002; ENSMUSP00000144904; ENSMUSG00000000399.
GeneIDⁱ	66108.
KEGGⁱ	mmu:66108.
UCSC genome browser More...UCSCⁱ	uc009dve.2. mouse.

Organism-specific databases

CTDⁱ	4704.
MGIⁱ	MGI:1913358. Ndufa9.

Phylogenomic databases

eggNOGⁱ	KOG2865. Eukaryota. COG0702. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000006865.
HOGENOMⁱ	HOG000168008.
HOVERGENⁱ	HBG006546.
InParanoidⁱ	Q9DC69.
KEGG Orthology (KO) More...KOⁱ	K03953.
OMAⁱ	KFIHVSH.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07EJ.
TreeFamⁱ	TF105961.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-611105. Respiratory electron transport. R-MMU-6799198. Complex I biogenesis.

Reactomeⁱ

R-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9DC69.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000000399.
ExpressionAtlasⁱ	Q9DC69. baseline and differential.
Genevisibleⁱ	Q9DC69. MM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR016040. NAD(P)-bd_dom. IPR036291. NAD(P)-bd_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13460. NAD_binding_10. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDUA9_MOUSE
Accessionⁱ	Q9DC69Primary (citable) accession number: Q9DC69 Secondary accession number(s): Q6GTD3, Q99JP9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 27, 2003
	Last sequence update:	July 27, 2011
	Last modified:	February 28, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9DC69 (NDUA9_MOUSE)

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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ