Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial-processing peptidase subunit alpha

Gene

Pmpca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Protein family/group databases

MEROPSiM16.P01

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit alpha (EC:3.4.24.64)
Alternative name(s):
Alpha-MPP
P-55
Gene namesi
Name:Pmpca
Synonyms:Inpp5e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918568 Pmpca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 33MitochondrionBy similarityAdd BLAST33
ChainiPRO_000002676834 – 524Mitochondrial-processing peptidase subunit alphaAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63N6-succinyllysineCombined sources1
Modified residuei298N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DC61
MaxQBiQ9DC61
PaxDbiQ9DC61
PeptideAtlasiQ9DC61
PRIDEiQ9DC61

PTM databases

iPTMnetiQ9DC61
PhosphoSitePlusiQ9DC61
SwissPalmiQ9DC61

Expressioni

Gene expression databases

BgeeiENSMUSG00000026926
CleanExiMM_INPP5E
MM_PMPCA
ExpressionAtlasiQ9DC61 baseline and differential
GenevisibleiQ9DC61 MM

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.By similarity

Protein-protein interaction databases

BioGridi211772, 1 interactor
IntActiQ9DC61, 3 interactors
MINTiQ9DC61
STRINGi10090.ENSMUSP00000075762

Structurei

3D structure databases

ProteinModelPortaliQ9DC61
SMRiQ9DC61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2067 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074666
HOGENOMiHOG000206848
HOVERGENiHBG106890
InParanoidiQ9DC61
KOiK01412
OMAiRESMMYQ
OrthoDBiEOG091G07S9
PhylomeDBiQ9DC61
TreeFamiTF105031

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR001431 Pept_M16_Zn_BS
IPR007863 Peptidase_M16_C
IPR037715 PMPCA
PANTHERiPTHR11851:SF183 PTHR11851:SF183, 1 hit
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits
PROSITEiView protein in PROSITE
PS00143 INSULINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DC61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAVWAAAR LLRGSAVLCA RPRFGSPAHR RFSSGATYPN IPLSSPLPGV
60 70 80 90 100
PKPIFATVDG QEKFETKVTT LDNGLRVASQ NKFGQFCTVG ILINSGSRYE
110 120 130 140 150
AKYLSGIAHF LEKLAFSSTA RFDSKDEILL TLEKHGGICD CQTSRDTTMY
160 170 180 190 200
AVSADSKGLD TVVDLLADVV LHPRLTDEEI EMTRMAVQFE LEDLNMRPDP
210 220 230 240 250
EPLLTEMIHE AAFRENTVGL HRFCPVENIA KIDREVLHSY LKNYYTPDRM
260 270 280 290 300
VLAGVGVEHE HLVECARKYL VGAEPAWGAP GTVDVDRSVA QYTGGIIKVE
310 320 330 340 350
RDMSNVSLGP TPIPELTHIM VGLESCSFLE DDFIPFAVLN MMMGGGGSFS
360 370 380 390 400
AGGPGKGMFS RLYLNVLNRH HWMYNATSYH HSYEDTGLLC IHASADPRQV
410 420 430 440 450
REMVEIITKE FILMGRTVDL VELERAKTQL MSMLMMNLES RPVIFEDVGR
460 470 480 490 500
QVLATHSRKL PHELCTLIRN VKPEDIKRVA SKMLRGKPAV AALGDLTDLP
510 520
TYEHIQAALS SRNGHLPRSY RLFR
Length:524
Mass (Da):58,279
Last modified:June 1, 2001 - v1
Checksum:iAD15AE6C97E95F9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004549 mRNA Translation: BAB23363.1
AK147110 mRNA Translation: BAE27682.1
AK169325 mRNA Translation: BAE41079.1
AK169342 mRNA Translation: BAE41094.1
BC010810 mRNA Translation: AAH10810.1
CCDSiCCDS15804.1
RefSeqiNP_775272.1, NM_173180.3
UniGeneiMm.250359
Mm.330070

Genome annotation databases

EnsembliENSMUST00000076431; ENSMUSP00000075762; ENSMUSG00000026926
GeneIDi66865
KEGGimmu:66865
UCSCiuc008ive.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMPPA_MOUSE
AccessioniPrimary (citable) accession number: Q9DC61
Secondary accession number(s): Q3TF19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health