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Protein

Copine-8

Gene

Cpne8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Copine-8Curated
Alternative name(s):
Copine VIIIImported
Gene namesi
Name:Cpne8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914121. Cpne8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 577577Copine-8PRO_0000144850Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DC53.
MaxQBiQ9DC53.
PaxDbiQ9DC53.
PeptideAtlasiQ9DC53.
PRIDEiQ9DC53.

PTM databases

iPTMnetiQ9DC53.
PhosphoSiteiQ9DC53.

Expressioni

Gene expression databases

BgeeiQ9DC53.
CleanExiMM_CPNE8.
ExpressionAtlasiQ9DC53. baseline and differential.
GenevisibleiQ9DC53. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DC53. 1 interaction.
MINTiMINT-4998135.
STRINGi10090.ENSMUSP00000067774.

Structurei

3D structure databases

ProteinModelPortaliQ9DC53.
SMRiQ9DC53. Positions 9-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 130108C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 262106C2 2PROSITE-ProRule annotationAdd
BLAST
Domaini322 – 523202VWFAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the copine family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9DC53.
OMAiFLSYMRV.
OrthoDBiEOG77DJ57.
PhylomeDBiQ9DC53.
TreeFamiTF316419.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWARDKCSVP QLEMDSRYTS ATGIGDLNQL SAAIPATRVE VSVSCRNLLD
60 70 80 90 100
RDTFSKSDPI CVLYTQAVGN KEWREFGRTE VIDNTLNPDF VRKFILDYFF
110 120 130 140 150
EERENLRFDL YDVDSKSPNL SKHDFLGQVF CTLGEIVGSQ GSRLEKPIVG
160 170 180 190 200
IPGRKCGTII LTAEELNCCR DAVLMQFCAN KLDKKDFFGK SDPFLVFYRS
210 220 230 240 250
NEDGSFTICH KTEVVKNTLN PVWQAFKISV RALCNGDYDR TIKVEVYDWD
260 270 280 290 300
RDGSHDFIGE FTTSYRELAR GQSQFNVYEV VNPKKKGKKK KYTNSGTVTL
310 320 330 340 350
LSFLVETEVS FLDYIKGGTQ INFTVAIDFT ASNGNPAQPT SLHYMNPYQL
360 370 380 390 400
NAYGMALKAV GEIVQDYDSD KMFPALGFGA KLPPDGRISH EFALNGNPQN
410 420 430 440 450
PYCDGIEGVM EAYYRSLKSV QLYGPTNFAP VINHVARYAS SVKDGSQYFV
460 470 480 490 500
LLIVTDGVIS DMAQTKESIV NASKLPMSII IVGVGPAEFD AMVELDGDDV
510 520 530 540 550
RVSSRGKYAE RDIVQFVPFR DYIDRSGNHI LSMARLAKDV LAEIPEQFLS
560 570
YMRARGIKPS PAPPPYTPPT HVLQTQI
Length:577
Mass (Da):64,667
Last modified:September 18, 2013 - v3
Checksum:i6287BF291AA0A0F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004559 mRNA. Translation: BAB23372.1.
AK010227 mRNA. Translation: BAB26781.1.
AC099572 Genomic DNA. No translation available.
AC113493 Genomic DNA. No translation available.
AC116812 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04322.1.
BC138745 mRNA. Translation: AAI38746.1.
BC138746 mRNA. Translation: AAI38747.1.
CCDSiCCDS27758.1.
RefSeqiNP_080091.1. NM_025815.2.
UniGeneiMm.290991.

Genome annotation databases

EnsembliENSMUST00000064391; ENSMUSP00000067774; ENSMUSG00000052560.
GeneIDi66871.
KEGGimmu:66871.
UCSCiuc007xhn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004559 mRNA. Translation: BAB23372.1.
AK010227 mRNA. Translation: BAB26781.1.
AC099572 Genomic DNA. No translation available.
AC113493 Genomic DNA. No translation available.
AC116812 Genomic DNA. No translation available.
CH466550 Genomic DNA. Translation: EDL04322.1.
BC138745 mRNA. Translation: AAI38746.1.
BC138746 mRNA. Translation: AAI38747.1.
CCDSiCCDS27758.1.
RefSeqiNP_080091.1. NM_025815.2.
UniGeneiMm.290991.

3D structure databases

ProteinModelPortaliQ9DC53.
SMRiQ9DC53. Positions 9-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC53. 1 interaction.
MINTiMINT-4998135.
STRINGi10090.ENSMUSP00000067774.

PTM databases

iPTMnetiQ9DC53.
PhosphoSiteiQ9DC53.

Proteomic databases

EPDiQ9DC53.
MaxQBiQ9DC53.
PaxDbiQ9DC53.
PeptideAtlasiQ9DC53.
PRIDEiQ9DC53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064391; ENSMUSP00000067774; ENSMUSG00000052560.
GeneIDi66871.
KEGGimmu:66871.
UCSCiuc007xhn.1. mouse.

Organism-specific databases

CTDi144402.
MGIiMGI:1914121. Cpne8.

Phylogenomic databases

eggNOGiKOG1327. Eukaryota.
ENOG410XPC8. LUCA.
GeneTreeiENSGT00760000119085.
HOGENOMiHOG000220898.
HOVERGENiHBG066841.
InParanoidiQ9DC53.
OMAiFLSYMRV.
OrthoDBiEOG77DJ57.
PhylomeDBiQ9DC53.
TreeFamiTF316419.

Miscellaneous databases

PROiQ9DC53.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DC53.
CleanExiMM_CPNE8.
ExpressionAtlasiQ9DC53. baseline and differential.
GenevisibleiQ9DC53. MM.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR010734. Copine.
IPR002035. VWF_A.
[Graphical view]
PfamiPF00168. C2. 2 hits.
PF07002. Copine. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF53300. SSF53300. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Tongue.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCPNE8_MOUSE
AccessioniPrimary (citable) accession number: Q9DC53
Secondary accession number(s): B2RS65, Q9CUZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: September 18, 2013
Last modified: July 6, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.