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Protein

Pre-mRNA-processing factor 17

Gene

Cdc40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72187. mRNA 3'-end processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 17
Alternative name(s):
Cell division cycle 40 homolog
PRP17 homolog
Gene namesi
Name:Cdc40
Synonyms:Prp17, Prpf17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918963. Cdc40.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000511431 – 579Pre-mRNA-processing factor 17Add BLAST579

Proteomic databases

EPDiQ9DC48.
MaxQBiQ9DC48.
PaxDbiQ9DC48.
PeptideAtlasiQ9DC48.
PRIDEiQ9DC48.

PTM databases

PhosphoSitePlusiQ9DC48.

Expressioni

Gene expression databases

BgeeiENSMUSG00000038446.
CleanExiMM_CDC40.
GenevisibleiQ9DC48. MM.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.By similarity

Protein-protein interaction databases

BioGridi214875. 2 interactors.
IntActiQ9DC48. 1 interactor.
MINTiMINT-4108664.
STRINGi10090.ENSMUSP00000044305.

Structurei

3D structure databases

ProteinModelPortaliQ9DC48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati286 – 326WD 1Add BLAST41
Repeati330 – 369WD 2Add BLAST40
Repeati371 – 413WD 3Add BLAST43
Repeati416 – 455WD 4Add BLAST40
Repeati459 – 498WD 5Add BLAST40
Repeati504 – 545WD 6Add BLAST42
Repeati548 – 578WD 7Add BLAST31

Sequence similaritiesi

Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0282. Eukaryota.
ENOG410XP87. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000214672.
HOVERGENiHBG053695.
InParanoidiQ9DC48.
KOiK12816.
OMAiHTYRGHN.
OrthoDBiEOG091G03TK.
PhylomeDBiQ9DC48.
TreeFamiTF101064.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR032847. PRPF17.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22847:SF474. PTHR22847:SF474. 1 hit.
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAIAALAA SYGSGSGSES DSDSEGSRCP LPAADSLMHL TKSPSAKLSL
60 70 80 90 100
TVAVDSAPEV AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR
110 120 130 140 150
TQQMAAPRNM LSGYAEPAHI NDFMFEQQRR TFATYGYALD PSLDNHQVSA
160 170 180 190 200
KYIGSVEEAE KNQGLTVFET GQKKTEKRKK FKENDASNID GFLGPWAKYV
210 220 230 240 250
DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI LHVKEMYDYQ
260 270 280 290 300
GRSYLHIPQD VGVNLRSSVP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS
310 320 330 340 350
GHLLLSCSMD CKIKLWEVYG DRRCLRTFIG HSKAVRDICF NTAGTQFLSA
360 370 380 390 400
AYDRYLKLWD TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI
410 420 430 440 450
VQWDIRSGEI VQEYDRHLGA VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP
460 470 480 490 500
VDFKYIAEPS MHSMPAVTLS PNGKWLACQS MDNQILIFGA QNRFRLNKKK
510 520 530 540 550
IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT KLYSRFKAHD
560 570
KVCIGAVWHP HETSKVITCG WDGLIKLWD
Length:579
Mass (Da):65,461
Last modified:June 1, 2001 - v1
Checksum:i422A5FEB8D9CE2C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004569 mRNA. Translation: BAB23380.1.
BC147503 mRNA. Translation: AAI47504.1.
BC158078 mRNA. Translation: AAI58079.1.
CCDSiCCDS48546.1.
RefSeqiNP_082155.1. NM_027879.2.
UniGeneiMm.46063.

Genome annotation databases

EnsembliENSMUST00000044166; ENSMUSP00000044305; ENSMUSG00000038446.
GeneIDi71713.
KEGGimmu:71713.
UCSCiuc007exe.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004569 mRNA. Translation: BAB23380.1.
BC147503 mRNA. Translation: AAI47504.1.
BC158078 mRNA. Translation: AAI58079.1.
CCDSiCCDS48546.1.
RefSeqiNP_082155.1. NM_027879.2.
UniGeneiMm.46063.

3D structure databases

ProteinModelPortaliQ9DC48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214875. 2 interactors.
IntActiQ9DC48. 1 interactor.
MINTiMINT-4108664.
STRINGi10090.ENSMUSP00000044305.

PTM databases

PhosphoSitePlusiQ9DC48.

Proteomic databases

EPDiQ9DC48.
MaxQBiQ9DC48.
PaxDbiQ9DC48.
PeptideAtlasiQ9DC48.
PRIDEiQ9DC48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044166; ENSMUSP00000044305; ENSMUSG00000038446.
GeneIDi71713.
KEGGimmu:71713.
UCSCiuc007exe.3. mouse.

Organism-specific databases

CTDi51362.
MGIiMGI:1918963. Cdc40.

Phylogenomic databases

eggNOGiKOG0282. Eukaryota.
ENOG410XP87. LUCA.
GeneTreeiENSGT00530000063583.
HOGENOMiHOG000214672.
HOVERGENiHBG053695.
InParanoidiQ9DC48.
KOiK12816.
OMAiHTYRGHN.
OrthoDBiEOG091G03TK.
PhylomeDBiQ9DC48.
TreeFamiTF101064.

Enzyme and pathway databases

ReactomeiR-MMU-109688. Cleavage of Growing Transcript in the Termination Region.
R-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72187. mRNA 3'-end processing.

Miscellaneous databases

ChiTaRSiCdc40. mouse.
PROiQ9DC48.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038446.
CleanExiMM_CDC40.
GenevisibleiQ9DC48. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR032847. PRPF17.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22847:SF474. PTHR22847:SF474. 1 hit.
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRP17_MOUSE
AccessioniPrimary (citable) accession number: Q9DC48
Secondary accession number(s): B2RY33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.