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Protein
Submitted name:

Adhesion G protein-coupled receptor E5

Gene

Adgre5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Adhesion G protein-coupled receptor E5Imported
Gene namesi
Name:Adgre5Imported
Synonyms:Cd97Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1347095. Adgre5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei439 – 458HelicalSequence analysisAdd BLAST20
Transmembranei470 – 487HelicalSequence analysisAdd BLAST18
Transmembranei499 – 531HelicalSequence analysisAdd BLAST33
Transmembranei543 – 560HelicalSequence analysisAdd BLAST18
Transmembranei580 – 604HelicalSequence analysisAdd BLAST25
Transmembranei625 – 648HelicalSequence analysisAdd BLAST24
Transmembranei654 – 677HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501121251122 – 722Sequence analysisAdd BLAST701

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000002885.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 105EGF-likeInterPro annotationAdd BLAST39
Domaini118 – 156EGF-likeInterPro annotationAdd BLAST39
Domaini383 – 428GPSInterPro annotationAdd BLAST46
Domaini433 – 678G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST246

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140800.
HOVERGENiHBG048917.
KOiK08446.

Family and domain databases

InterProiView protein in InterPro
IPR001881. EGF-like_Ca-bd_dom.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR017981. GPCR_2-like.
IPR003056. GPCR_2_CD97.
IPR000832. GPCR_2_secretin-like.
IPR000203. GPS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF07645. EGF_CA. 2 hits.
PF01825. GPS. 1 hit.
PRINTSiPR01278. CD97PROTEIN.
PR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00303. GPS. 1 hit.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
PS50221. GPS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9DC42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGVRCPGLL VVCILLSLSG AGTQKAENCA KWCPINSKCV SNRSCVCKPG
60 70 80 90 100
FSSEKELITN PAESCEDINE CLLPGFSCGD FAMCKNSEGS YTCVCNLGYK
110 120 130 140 150
LLSGAESFVN ESENTCQDVD ECSSGQHQCH NSTVCKNTVG SYKCHCRPGW
160 170 180 190 200
KPTSGSLRGP DTICQEPPFP TWTLLPTAHS QTLLRFSVEV QNLLRDFNPA
210 220 230 240 250
TVNYTIQKLI EAVDKLLEDP METETQQVAA QLLSNLEQSL RTLAQFLPKG
260 270 280 290 300
PFTYTSPSNT ELSLMVKEQD NKDVTTVHHG QTWMELDWAV TAGAKISENG
310 320 330 340 350
SSVAGILSSP NMEKLLGNTP LNLEQRRASL EDFYGSPIPS VSLKLLSNIN
360 370 380 390 400
SVFLTNTNTE KLASNVTFKF DFTSVESIEP RHELICAFWK AHNGNGYWDT
410 420 430 440 450
DGCSMNGTGF CHCNHLTSFA ILMAQYHVQD PRLELITKVG LLLSLICLLL
460 470 480 490 500
CILTFLLVKP IQSSRTMVHL HLCICLFLGS IIFLVGVENE GGEVGLRCRL
510 520 530 540 550
VAVMLHFCFL AAFCWMALEG VELYFLVVRV FQGQGLSTWQ RCLIGYGVPL
560 570 580 590 600
LIVAISMAVV KMDGYGHATY CWLDFRKQGF LWSFSGPVAF IIFCNAAIFV
610 620 630 640 650
ITVWKLTKKF SEINPNMKKL RKARVLTITS IAQLLVLGCT WGFGLFLFNP
660 670 680 690 700
HSTWLSYIFT LLNCLQGLFL YVMLCLLNKK VREEYWKWAC MVTGSKYTEF
710 720
NSSTTGTGTS QTRALRSSES GM
Length:722
Mass (Da):80,203
Last modified:June 1, 2001 - v1
Checksum:iD944563020DE3326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC164432 Genomic DNA. No translation available.
AK004577 mRNA. Translation: BAB23386.1.
RefSeqiNP_001156501.1. NM_001163029.1.
NP_001156502.1. NM_001163030.1.
NP_001156503.1. NM_001163031.1.
NP_036055.2. NM_011925.2.
UniGeneiMm.334648.

Genome annotation databases

EnsembliENSMUST00000166939; ENSMUSP00000128220; ENSMUSG00000002885.
GeneIDi26364.
KEGGimmu:26364.
UCSCiuc009mle.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ9DC42_MOUSE
AccessioniPrimary (citable) accession number: Q9DC42
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: November 22, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported