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Protein

Telomere length regulation protein TEL2 homolog

Gene

Telo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).By similarity

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI
  • protein complex binding Source: MGI
  • protein complex scaffold Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere length regulation protein TEL2 homolog
Gene namesi
Name:Telo2
Synonyms:Kiaa0683
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1918968. Telo2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Membrane, Nucleus, Telomere

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi395L → Q: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with E-407 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with E-407 and R-424. 1 Publication1
Mutagenesisi407M → E: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or R-424. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and R-424. 1 Publication1
Mutagenesisi424L → R: Does not inhibit interaction with TTI1 or TTI2. Inhibits weakly interaction with TTI1 or TTI2; when associated with Q-395 or E-407. Inhibits interaction with TTI1 or TTI2; when associated with Q-395 and E-407. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185161 – 840Telomere length regulation protein TEL2 homologAdd BLAST840

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei374HydroxyprolineBy similarity1
Modified residuei419HydroxyprolineBy similarity1
Modified residuei422HydroxyprolineBy similarity1
Modified residuei457PhosphoserineCombined sources1
Modified residuei486Phosphoserine; by CK2By similarity1
Modified residuei488PhosphoserineBy similarity1
Modified residuei492PhosphoserineBy similarity1
Modified residuei837PhosphoserineBy similarity1

Post-translational modificationi

Hydroxylation by PHD3 is required for a proper interaction with ATR, and activation of the ATR/CHK1/p53 pathway following DNA damage.By similarity
Phosphorylated at Ser-486 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein (By similarity).By similarity
Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9DC40.
PaxDbiQ9DC40.
PeptideAtlasiQ9DC40.
PRIDEiQ9DC40.

PTM databases

iPTMnetiQ9DC40.
PhosphoSitePlusiQ9DC40.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024170.
GenevisibleiQ9DC40. MM.

Interactioni

Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2. Interacts with ATM, ATR, MTOR, PRKDC, RUVBL2, TTI1, TTI2, SMG1 and TRRAP. Component of the mTORC1 and mTORC2 complexes. Interacts (phosphorylated form) with PIH1D1 (PubMed:24794838). Interaction with PIH1D1 mediates interaction of TELO2 with the R2TP complex composed of RUVBL1, RUVBL2, PIH1D1, and RPAP3 (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei491Interaction with PIH1D11 Publication1
Sitei492Interaction with PIH1D11 Publication1
Sitei493Interaction with PIH1D11 Publication1

GO - Molecular functioni

  • Hsp90 protein binding Source: MGI
  • protein complex binding Source: MGI
  • protein complex scaffold Source: MGI
  • protein kinase binding Source: MGI

Protein-protein interaction databases

BioGridi214877. 3 interactors.
DIPiDIP-60997N.
IntActiQ9DC40. 2 interactors.
STRINGi10090.ENSMUSP00000024987.

Structurei

Secondary structure

1840
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi492 – 494Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CKTX-ray3.00C/D489-496[»]
4CSEX-ray3.30C/D488-496[»]
ProteinModelPortaliQ9DC40.
SMRiQ9DC40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TEL2 family.Curated

Phylogenomic databases

eggNOGiKOG4346. Eukaryota.
ENOG410XR2X. LUCA.
GeneTreeiENSGT00390000006698.
HOVERGENiHBG108557.
InParanoidiQ9DC40.
KOiK11137.
OMAiELWDSFF.
OrthoDBiEOG091G058H.
PhylomeDBiQ9DC40.
TreeFamiTF313925.

Family and domain databases

InterProiIPR019337. Telomere_length_regulation_dom.
[Graphical view]
PfamiPF10193. Telomere_reg-2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DC40-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPALSAVRL TVQEAIHILS SSEDAGHILS TLGTLKRYLG GTEDPVLPEE
60 70 80 90 100
KEEFATVHFS AVLRCLVSKL SPGWLELSPG GQLERLWESF FLDGPPDQAF
110 120 130 140 150
LVLMEAIEST AGPSFRLMKM AQLLDTFLST GRVAALMEEQ CRPQTKPSFP
160 170 180 190 200
LFQETLLSKV VGLPDLLGNC LQRDNLTQFF PQNYFPLLGQ EVVQALKAVV
210 220 230 240 250
NFLQDGLDCS VSFVSRVLGK VCIQGRKREI LSVLVPQLTV LTQDSCLWQR
260 270 280 290 300
VCWRLVEQVP DRAVEAVLTG LVEAAPRPEV LSRLLGNLVV KNKKARFVVT
310 320 330 340 350
RKLLLLQYQH TTPMVQSLLG YLALDSQRRP LLIQVLKELL ETWGCSSAVR
360 370 380 390 400
HTPLEQQCYI SKAILVCLAH LGEPELQDIR DELLASMMAG VKCRLDSSLP
410 420 430 440 450
PVRRLGMIVA EVISSRIHPE GPLLKFQYED DEMSRELLAL ATPEPAGDCS
460 470 480 490 500
SVSRGPSPAP VDTESPVEMP EKAVESDVPP TQPQGSDSEL DSDDEFIPYD
510 520 530 540 550
MSGDRELKSS KEPLYIRDCV EALTTSEDME RWEASLKGLE GLVYRSPTAT
560 570 580 590 600
REVSVELAKV LLHLEEKTCV AEFEQLRQSA LVAVTVTDPE QVAKYLTSQF
610 620 630 640 650
YGLNYSLRQR MDILDVLVLA AQALSRPKSL QRRSQHGPPV PGTMCSPALA
660 670 680 690 700
VSQTGNVAAP DWQVVVEERI RSKTRRFSKG CPQRELSGVP NEFSSVAGYF
710 720 730 740 750
FFPLLQHFDR PLVTFDLLGD DQLVLGRLTH TLASLMYLAV NTTVAVPMGK
760 770 780 790 800
ALLEFVWALR FHVDIYVRRG LLSAVSSVLL SVPTERLLGD LPDELLEARS
810 820 830 840
WLADVAEKDV DEDCRELAVR ALLLLERLKD KLLSSSSPQP
Length:840
Mass (Da):93,313
Last modified:February 5, 2008 - v2
Checksum:iC3ADB9DCE1724EAC
GO
Isoform 2 (identifier: Q9DC40-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     680-690: GCPQRELSGVP → VTGLCSDPMLS
     691-840: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,494
Checksum:i1C17E24740BEC671
GO

Sequence cautioni

The sequence BAE25556 differs from that shown. Reason: Erroneous termination at position 771. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18I → T in AAS21644 (Ref. 2) Curated1
Sequence conflicti18I → T in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti106A → T in BAE32791 (PubMed:16141072).Curated1
Sequence conflicti205D → G in AAS21644 (Ref. 2) Curated1
Sequence conflicti205D → G in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti461V → A in AAS21644 (Ref. 2) Curated1
Sequence conflicti461V → A in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti465S → P in AAS21644 (Ref. 2) Curated1
Sequence conflicti465S → P in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti509S → N in AAS21644 (Ref. 2) Curated1
Sequence conflicti509S → N in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti548T → A in AAS21644 (Ref. 2) Curated1
Sequence conflicti548T → A in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti638 – 639PP → SL in AAS21644 (Ref. 2) Curated2
Sequence conflicti638 – 639PP → SL in AAH11077 (PubMed:15489334).Curated2
Sequence conflicti664V → M in AAS21644 (Ref. 2) Curated1
Sequence conflicti664V → M in AAH11077 (PubMed:15489334).Curated1
Sequence conflicti689V → I in BAC26051 (PubMed:16141072).Curated1
Sequence conflicti775V → M in BAB23388 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312071 – 386Missing in isoform 2. 1 PublicationAdd BLAST386
Alternative sequenceiVSP_031208680 – 690GCPQRELSGVP → VTGLCSDPMLS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_031209691 – 840Missing in isoform 2. 1 PublicationAdd BLAST150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004582 mRNA. Translation: BAB23388.1.
AK045321 mRNA. Translation: BAC32309.1.
AK028658 mRNA. Translation: BAC26051.1.
AK143827 mRNA. Translation: BAE25556.1. Sequence problems.
AK146963 mRNA. Translation: BAE27569.1.
AK154727 mRNA. Translation: BAE32791.1.
AY491413 Genomic DNA. Translation: AAS21644.1.
BC011077 mRNA. Translation: AAH11077.1.
CCDSiCCDS28507.1. [Q9DC40-1]
RefSeqiNP_001157133.1. NM_001163661.1. [Q9DC40-1]
NP_082156.2. NM_027880.2. [Q9DC40-1]
UniGeneiMm.288702.

Genome annotation databases

EnsembliENSMUST00000024987; ENSMUSP00000024987; ENSMUSG00000024170. [Q9DC40-1]
ENSMUST00000115181; ENSMUSP00000110835; ENSMUSG00000024170. [Q9DC40-1]
GeneIDi71718.
KEGGimmu:71718.
UCSCiuc008azq.2. mouse. [Q9DC40-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004582 mRNA. Translation: BAB23388.1.
AK045321 mRNA. Translation: BAC32309.1.
AK028658 mRNA. Translation: BAC26051.1.
AK143827 mRNA. Translation: BAE25556.1. Sequence problems.
AK146963 mRNA. Translation: BAE27569.1.
AK154727 mRNA. Translation: BAE32791.1.
AY491413 Genomic DNA. Translation: AAS21644.1.
BC011077 mRNA. Translation: AAH11077.1.
CCDSiCCDS28507.1. [Q9DC40-1]
RefSeqiNP_001157133.1. NM_001163661.1. [Q9DC40-1]
NP_082156.2. NM_027880.2. [Q9DC40-1]
UniGeneiMm.288702.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CKTX-ray3.00C/D489-496[»]
4CSEX-ray3.30C/D488-496[»]
ProteinModelPortaliQ9DC40.
SMRiQ9DC40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214877. 3 interactors.
DIPiDIP-60997N.
IntActiQ9DC40. 2 interactors.
STRINGi10090.ENSMUSP00000024987.

PTM databases

iPTMnetiQ9DC40.
PhosphoSitePlusiQ9DC40.

Proteomic databases

EPDiQ9DC40.
PaxDbiQ9DC40.
PeptideAtlasiQ9DC40.
PRIDEiQ9DC40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024987; ENSMUSP00000024987; ENSMUSG00000024170. [Q9DC40-1]
ENSMUST00000115181; ENSMUSP00000110835; ENSMUSG00000024170. [Q9DC40-1]
GeneIDi71718.
KEGGimmu:71718.
UCSCiuc008azq.2. mouse. [Q9DC40-1]

Organism-specific databases

CTDi9894.
MGIiMGI:1918968. Telo2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4346. Eukaryota.
ENOG410XR2X. LUCA.
GeneTreeiENSGT00390000006698.
HOVERGENiHBG108557.
InParanoidiQ9DC40.
KOiK11137.
OMAiELWDSFF.
OrthoDBiEOG091G058H.
PhylomeDBiQ9DC40.
TreeFamiTF313925.

Miscellaneous databases

PROiQ9DC40.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024170.
GenevisibleiQ9DC40. MM.

Family and domain databases

InterProiIPR019337. Telomere_length_regulation_dom.
[Graphical view]
PfamiPF10193. Telomere_reg-2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTELO2_MOUSE
AccessioniPrimary (citable) accession number: Q9DC40
Secondary accession number(s): Q3U3J5
, Q3UID7, Q3UP41, Q8BN03, Q8C1T3, Q91VQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.