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Q9DC29

- ABCB6_MOUSE

UniProt

Q9DC29 - ABCB6_MOUSE

Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

Abcb6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei599 – 5991ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi623 – 63412ATPPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
    2. ATP binding Source: UniProtKB-KW
    3. efflux transmembrane transporter activity Source: Ensembl
    4. heme binding Source: Ensembl
    5. heme-transporting ATPase activity Source: Ensembl

    GO - Biological processi

    1. brain development Source: Ensembl
    2. porphyrin-containing compound biosynthetic process Source: Ensembl
    3. skin development Source: Ensembl
    4. transmembrane transport Source: RefGenome

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197885. Mitochondrial ABC transporters.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family B member 6, mitochondrial
    Gene namesi
    Name:Abcb6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1921354. Abcb6.

    Subcellular locationi

    Cell membrane By similarity. Mitochondrion outer membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Endosome 2 Publications
    Note: localized to the endosome-like compartement and dendrite tips.

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell
    2. endosome Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. integral component of membrane Source: RefGenome
    5. integral component of mitochondrial outer membrane Source: Ensembl
    6. mitochondrion Source: MGI
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi170 – 1701S → G: Results in retention of the protein in the Golgi apparatus. 1 Publication
    Mutagenesisi356 – 3561L → P: Results in retention of the protein in the Golgi apparatus. 1 Publication
    Mutagenesisi579 – 5791G → E: Results in retention of the protein in the Golgi apparatus. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842ATP-binding cassette sub-family B member 6, mitochondrialPRO_0000268678Add
    BLAST

    Proteomic databases

    PaxDbiQ9DC29.
    PRIDEiQ9DC29.

    PTM databases

    PhosphoSiteiQ9DC29.

    Expressioni

    Developmental stagei

    Highly expressed in embryonic liver.1 Publication

    Inductioni

    Up-regulated during erythroid differentiation and heme biosynthesis. Up-regulated by cellular porphyrins (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9DC29.
    BgeeiQ9DC29.
    GenevestigatoriQ9DC29.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DC29.
    SMRiQ9DC29. Positions 235-836.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei73 – 9321HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei107 – 12721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei148 – 16821HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei186 – 20621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei264 – 28421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei292 – 31221HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei376 – 39621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei409 – 43123HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei500 – 52021HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei530 – 55021HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini265 – 556292ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini590 – 824235ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5265.
    GeneTreeiENSGT00440000033373.
    HOVERGENiHBG080810.
    InParanoidiQ9DC29.
    KOiK05661.
    OMAiFLWIRIQ.
    OrthoDBiEOG7Z69BT.
    PhylomeDBiQ9DC29.
    TreeFamiTF105194.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DC29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR    50
    RRREVPAGPE ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG 100
    VRLPGYLLLA SVLESLASVC GLWLLVVERS QARQSLAMGV WMKFRHSLGL 150
    LLLWTVTFAA ENLALVSWNS PQWWWARADL GQQVQFGLWV LRYVTSGGLF 200
    ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR DLGRKLRLLS 250
    SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS 300
    SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF 350
    SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII 400
    GIIYFSMFFN AWFGLIVFLC MSLYLILTIV VTEWRAKFRR DMNTQENATR 450
    ARAVDSLLNF ETVKYYGAEG YEVDRYREAI LKFQGLEWKS TASLVVLNQT 500
    QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL YMPLNWFGTY 550
    YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA 600
    DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID 650
    GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA 700
    QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL 750
    DEATSALDTS NERAIQASLA KVCTNRTTIV IAHRLSTVVN ADQILVIKDG 800
    CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD TA 842
    Length:842
    Mass (Da):93,770
    Last modified:June 1, 2001 - v1
    Checksum:i5B8E1653011A4C0D
    GO

    Sequence cautioni

    The sequence BAE30168.1 differs from that shown. Reason: Frameshift at position 60.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004605 mRNA. Translation: BAB23404.1.
    AK150853 mRNA. Translation: BAE29909.1.
    AK151165 mRNA. Translation: BAE30168.1. Frameshift.
    AK152584 mRNA. Translation: BAE31334.1.
    AK168642 mRNA. Translation: BAE40501.1.
    BC006634 mRNA. Translation: AAH06634.1.
    CCDSiCCDS15065.1.
    RefSeqiNP_076221.1. NM_023732.2.
    UniGeneiMm.28663.

    Genome annotation databases

    EnsembliENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198.
    GeneIDi74104.
    KEGGimmu:74104.
    UCSCiuc007bnx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004605 mRNA. Translation: BAB23404.1 .
    AK150853 mRNA. Translation: BAE29909.1 .
    AK151165 mRNA. Translation: BAE30168.1 . Frameshift.
    AK152584 mRNA. Translation: BAE31334.1 .
    AK168642 mRNA. Translation: BAE40501.1 .
    BC006634 mRNA. Translation: AAH06634.1 .
    CCDSi CCDS15065.1.
    RefSeqi NP_076221.1. NM_023732.2.
    UniGenei Mm.28663.

    3D structure databases

    ProteinModelPortali Q9DC29.
    SMRi Q9DC29. Positions 235-836.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9DC29.

    Proteomic databases

    PaxDbi Q9DC29.
    PRIDEi Q9DC29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027396 ; ENSMUSP00000027396 ; ENSMUSG00000026198 .
    GeneIDi 74104.
    KEGGi mmu:74104.
    UCSCi uc007bnx.1. mouse.

    Organism-specific databases

    CTDi 10058.
    MGIi MGI:1921354. Abcb6.

    Phylogenomic databases

    eggNOGi COG5265.
    GeneTreei ENSGT00440000033373.
    HOVERGENi HBG080810.
    InParanoidi Q9DC29.
    KOi K05661.
    OMAi FLWIRIQ.
    OrthoDBi EOG7Z69BT.
    PhylomeDBi Q9DC29.
    TreeFami TF105194.

    Enzyme and pathway databases

    Reactomei REACT_197885. Mitochondrial ABC transporters.

    Miscellaneous databases

    NextBioi 339782.
    PROi Q9DC29.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DC29.
    Bgeei Q9DC29.
    Genevestigatori Q9DC29.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Kidney and Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 764-771, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    4. Cited for: FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, SUBCELLULAR LOCATION.
    5. Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-170; LEU-356 AND GLY-579.

    Entry informationi

    Entry nameiABCB6_MOUSE
    AccessioniPrimary (citable) accession number: Q9DC29
    Secondary accession number(s): Q3U7N5, Q3UAZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3