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Q9DC29

- ABCB6_MOUSE

UniProt

Q9DC29 - ABCB6_MOUSE

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Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

Abcb6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei599 – 5991ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi623 – 63412ATPPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: UniProtKB-KW
  3. efflux transmembrane transporter activity Source: Ensembl
  4. heme binding Source: Ensembl
  5. heme-transporting ATPase activity Source: Ensembl

GO - Biological processi

  1. brain development Source: Ensembl
  2. porphyrin-containing compound biosynthetic process Source: Ensembl
  3. skin development Source: Ensembl
  4. transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197885. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Gene namesi
Name:Abcb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1921354. Abcb6.

Subcellular locationi

Cell membrane By similarity. Mitochondrion outer membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Endosome 2 Publications
Note: localized to the endosome-like compartement and dendrite tips.

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. endosome Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. Golgi apparatus Source: UniProtKB-KW
  5. integral component of membrane Source: RefGenome
  6. integral component of mitochondrial outer membrane Source: Ensembl
  7. mitochondrion Source: MGI
  8. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi170 – 1701S → G: Results in retention of the protein in the Golgi apparatus. 1 Publication
Mutagenesisi356 – 3561L → P: Results in retention of the protein in the Golgi apparatus. 1 Publication
Mutagenesisi579 – 5791G → E: Results in retention of the protein in the Golgi apparatus. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 842842ATP-binding cassette sub-family B member 6, mitochondrialPRO_0000268678Add
BLAST

Proteomic databases

MaxQBiQ9DC29.
PaxDbiQ9DC29.
PRIDEiQ9DC29.

PTM databases

PhosphoSiteiQ9DC29.

Expressioni

Developmental stagei

Highly expressed in embryonic liver.1 Publication

Inductioni

Up-regulated during erythroid differentiation and heme biosynthesis. Up-regulated by cellular porphyrins (at protein level).1 Publication

Gene expression databases

BgeeiQ9DC29.
ExpressionAtlasiQ9DC29. baseline and differential.
GenevestigatoriQ9DC29.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9DC29.
SMRiQ9DC29. Positions 235-836.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei73 – 9321HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei107 – 12721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei148 – 16821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei264 – 28421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei292 – 31221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei376 – 39621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei409 – 43123HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei500 – 52021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei530 – 55021HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini265 – 556292ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini590 – 824235ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5265.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080810.
InParanoidiQ9DC29.
KOiK05661.
OMAiFLWIRIQ.
OrthoDBiEOG7Z69BT.
PhylomeDBiQ9DC29.
TreeFamiTF105194.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC29-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR
60 70 80 90 100
RRREVPAGPE ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG
110 120 130 140 150
VRLPGYLLLA SVLESLASVC GLWLLVVERS QARQSLAMGV WMKFRHSLGL
160 170 180 190 200
LLLWTVTFAA ENLALVSWNS PQWWWARADL GQQVQFGLWV LRYVTSGGLF
210 220 230 240 250
ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR DLGRKLRLLS
260 270 280 290 300
SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS
310 320 330 340 350
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF
360 370 380 390 400
SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII
410 420 430 440 450
GIIYFSMFFN AWFGLIVFLC MSLYLILTIV VTEWRAKFRR DMNTQENATR
460 470 480 490 500
ARAVDSLLNF ETVKYYGAEG YEVDRYREAI LKFQGLEWKS TASLVVLNQT
510 520 530 540 550
QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL YMPLNWFGTY
560 570 580 590 600
YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA
610 620 630 640 650
DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID
660 670 680 690 700
GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA
710 720 730 740 750
QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL
760 770 780 790 800
DEATSALDTS NERAIQASLA KVCTNRTTIV IAHRLSTVVN ADQILVIKDG
810 820 830 840
CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD TA
Length:842
Mass (Da):93,770
Last modified:June 1, 2001 - v1
Checksum:i5B8E1653011A4C0D
GO

Sequence cautioni

The sequence BAE30168.1 differs from that shown. Reason: Frameshift at position 60.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004605 mRNA. Translation: BAB23404.1.
AK150853 mRNA. Translation: BAE29909.1.
AK151165 mRNA. Translation: BAE30168.1. Frameshift.
AK152584 mRNA. Translation: BAE31334.1.
AK168642 mRNA. Translation: BAE40501.1.
BC006634 mRNA. Translation: AAH06634.1.
CCDSiCCDS15065.1.
RefSeqiNP_076221.1. NM_023732.2.
UniGeneiMm.28663.

Genome annotation databases

EnsembliENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198.
GeneIDi74104.
KEGGimmu:74104.
UCSCiuc007bnx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004605 mRNA. Translation: BAB23404.1 .
AK150853 mRNA. Translation: BAE29909.1 .
AK151165 mRNA. Translation: BAE30168.1 . Frameshift.
AK152584 mRNA. Translation: BAE31334.1 .
AK168642 mRNA. Translation: BAE40501.1 .
BC006634 mRNA. Translation: AAH06634.1 .
CCDSi CCDS15065.1.
RefSeqi NP_076221.1. NM_023732.2.
UniGenei Mm.28663.

3D structure databases

ProteinModelPortali Q9DC29.
SMRi Q9DC29. Positions 235-836.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9DC29.

Proteomic databases

MaxQBi Q9DC29.
PaxDbi Q9DC29.
PRIDEi Q9DC29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027396 ; ENSMUSP00000027396 ; ENSMUSG00000026198 .
GeneIDi 74104.
KEGGi mmu:74104.
UCSCi uc007bnx.1. mouse.

Organism-specific databases

CTDi 10058.
MGIi MGI:1921354. Abcb6.

Phylogenomic databases

eggNOGi COG5265.
GeneTreei ENSGT00440000033373.
HOVERGENi HBG080810.
InParanoidi Q9DC29.
KOi K05661.
OMAi FLWIRIQ.
OrthoDBi EOG7Z69BT.
PhylomeDBi Q9DC29.
TreeFami TF105194.

Enzyme and pathway databases

Reactomei REACT_197885. Mitochondrial ABC transporters.

Miscellaneous databases

NextBioi 339782.
PROi Q9DC29.
SOURCEi Search...

Gene expression databases

Bgeei Q9DC29.
ExpressionAtlasi Q9DC29. baseline and differential.
Genevestigatori Q9DC29.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 764-771, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, SUBCELLULAR LOCATION.
  5. Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-170; LEU-356 AND GLY-579.

Entry informationi

Entry nameiABCB6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC29
Secondary accession number(s): Q3U7N5, Q3UAZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3