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Q9DC29 (ABCB6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Gene names
Name:Abcb6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. Ref.4

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane By similarity. Mitochondrion outer membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum By similarity. Golgi apparatus By similarity. Endosome. Note: localized to the endosome-like compartement and dendrite tips. Ref.4 Ref.5

Developmental stage

Highly expressed in embryonic liver. Ref.4

Induction

Up-regulated during erythroid differentiation and heme biosynthesis. Up-regulated by cellular porphyrins (at protein level). Ref.4

Sequence similarities

Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

Sequence caution

The sequence BAE30168.1 differs from that shown. Reason: Frameshift at position 60.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus
Membrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from electronic annotation. Source: Ensembl

cadmium ion transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

detoxification of cadmium ion

Inferred from Biological aspect of Ancestor. Source: RefGenome

porphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: Ensembl

skin development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

endoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

endosome

Inferred from direct assay Ref.5. Source: UniProtKB

integral component of membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

integral component of mitochondrial outer membrane

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 18614015. Source: MGI

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

vacuolar membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity, coupled to transmembrane movement of substances

Inferred from Biological aspect of Ancestor. Source: RefGenome

efflux transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

heme binding

Inferred from electronic annotation. Source: Ensembl

heme-transporting ATPase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 842842ATP-binding cassette sub-family B member 6, mitochondrial
PRO_0000268678

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane292 – 31221Helical; Potential
Transmembrane376 – 39621Helical; Potential
Transmembrane409 – 43123Helical; Potential
Transmembrane500 – 52021Helical; Potential
Transmembrane530 – 55021Helical; Potential
Domain265 – 556292ABC transmembrane type-1
Domain590 – 824235ABC transporter
Nucleotide binding623 – 63412ATP By similarity

Sites

Binding site5991ATP By similarity

Experimental info

Mutagenesis1701S → G: Results in retention of the protein in the Golgi apparatus. Ref.5
Mutagenesis3561L → P: Results in retention of the protein in the Golgi apparatus. Ref.5
Mutagenesis5791G → E: Results in retention of the protein in the Golgi apparatus. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9DC29 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 5B8E1653011A4C0D

FASTA84293,770
        10         20         30         40         50         60 
MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR RRREVPAGPE 

        70         80         90        100        110        120 
ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG VRLPGYLLLA SVLESLASVC 

       130        140        150        160        170        180 
GLWLLVVERS QARQSLAMGV WMKFRHSLGL LLLWTVTFAA ENLALVSWNS PQWWWARADL 

       190        200        210        220        230        240 
GQQVQFGLWV LRYVTSGGLF ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR 

       250        260        270        280        290        300 
DLGRKLRLLS SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS 

       310        320        330        340        350        360 
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF SHLHELSLRW 

       370        380        390        400        410        420 
HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII GIIYFSMFFN AWFGLIVFLC 

       430        440        450        460        470        480 
MSLYLILTIV VTEWRAKFRR DMNTQENATR ARAVDSLLNF ETVKYYGAEG YEVDRYREAI 

       490        500        510        520        530        540 
LKFQGLEWKS TASLVVLNQT QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL 

       550        560        570        580        590        600 
YMPLNWFGTY YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA 

       610        620        630        640        650        660 
DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID GQDISQVTQI 

       670        680        690        700        710        720 
SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA QAAGIHDAIL SFPEGYETQV 

       730        740        750        760        770        780 
GERGLKLSGG EKQRVAIART ILKAPDIILL DEATSALDTS NERAIQASLA KVCTNRTTIV 

       790        800        810        820        830        840 
IAHRLSTVVN ADQILVIKDG CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD 


TA 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow, Kidney and Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 764-771, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[4]"Identification of a mammalian mitochondrial porphyrin transporter."
Krishnamurthy P.C., Du G., Fukuda Y., Sun D., Sampath J., Mercer K.E., Wang J., Sosa-Pineda B., Murti K.G., Schuetz J.D.
Nature 443:586-589(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, SUBCELLULAR LOCATION.
[5]"Mutations in ABCB6 cause dyschromatosis universalis hereditaria."
Zhang C., Li D., Zhang J., Chen X., Huang M., Archacki S., Tian Y., Ren W., Mei A., Zhang Q., Fang M., Su Z., Yin Y., Liu D., Chen Y., Cui X., Li C., Yang H. expand/collapse author list , Wang Q., Wang J., Liu M., Deng Y.
J. Invest. Dermatol. 133:2221-2228(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF SER-170; LEU-356 AND GLY-579.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004605 mRNA. Translation: BAB23404.1.
AK150853 mRNA. Translation: BAE29909.1.
AK151165 mRNA. Translation: BAE30168.1. Frameshift.
AK152584 mRNA. Translation: BAE31334.1.
AK168642 mRNA. Translation: BAE40501.1.
BC006634 mRNA. Translation: AAH06634.1.
CCDSCCDS15065.1.
RefSeqNP_076221.1. NM_023732.2.
UniGeneMm.28663.

3D structure databases

ProteinModelPortalQ9DC29.
SMRQ9DC29. Positions 235-836.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9DC29.

Proteomic databases

PaxDbQ9DC29.
PRIDEQ9DC29.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198.
GeneID74104.
KEGGmmu:74104.
UCSCuc007bnx.1. mouse.

Organism-specific databases

CTD10058.
MGIMGI:1921354. Abcb6.

Phylogenomic databases

eggNOGCOG5265.
GeneTreeENSGT00440000033373.
HOVERGENHBG080810.
InParanoidQ9DC29.
KOK05661.
OMAFLWIRIQ.
OrthoDBEOG7Z69BT.
PhylomeDBQ9DC29.
TreeFamTF105194.

Gene expression databases

ArrayExpressQ9DC29.
BgeeQ9DC29.
GenevestigatorQ9DC29.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio339782.
PROQ9DC29.
SOURCESearch...

Entry information

Entry nameABCB6_MOUSE
AccessionPrimary (citable) accession number: Q9DC29
Secondary accession number(s): Q3U7N5, Q3UAZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot