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Protein

ATP-binding cassette sub-family B member 6, mitochondrial

Gene

Abcb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi623 – 634ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369007. Mitochondrial ABC transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 6, mitochondrial
Gene namesi
Name:Abcb6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921354. Abcb6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei73 – 93HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei148 – 168HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei186 – 206HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei264 – 284HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei292 – 312HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei376 – 396HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei409 – 431HelicalPROSITE-ProRule annotationAdd BLAST23
Transmembranei500 – 520HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei530 – 550HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi170S → G: Results in retention of the protein in the Golgi apparatus. 1 Publication1
Mutagenesisi356L → P: Results in retention of the protein in the Golgi apparatus. 1 Publication1
Mutagenesisi579G → E: Results in retention of the protein in the Golgi apparatus. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686781 – 842ATP-binding cassette sub-family B member 6, mitochondrialAdd BLAST842

Proteomic databases

EPDiQ9DC29.
MaxQBiQ9DC29.
PaxDbiQ9DC29.
PeptideAtlasiQ9DC29.
PRIDEiQ9DC29.

PTM databases

iPTMnetiQ9DC29.
PhosphoSitePlusiQ9DC29.

Expressioni

Developmental stagei

Highly expressed in embryonic liver.1 Publication

Inductioni

Up-regulated during erythroid differentiation and heme biosynthesis. Up-regulated by cellular porphyrins (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026198.
ExpressionAtlasiQ9DC29. baseline and differential.
GenevisibleiQ9DC29. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027396.

Structurei

3D structure databases

ProteinModelPortaliQ9DC29.
SMRiQ9DC29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini265 – 556ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST292
Domaini590 – 824ABC transporterPROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080810.
InParanoidiQ9DC29.
KOiK05661.
OMAiRYQEAII.
OrthoDBiEOG091G02G4.
PhylomeDBiQ9DC29.
TreeFamiTF105194.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR032410. MTABC_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF16185. MTABC_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTVGNYCET EGPAGPAWTQ NGLSPCFFFT LVPSTLLTLG VLALVLVLPR
60 70 80 90 100
RRREVPAGPE ELSWAAGPRV APYVLQLFLA TLQMALPLAG LAGRVGTARG
110 120 130 140 150
VRLPGYLLLA SVLESLASVC GLWLLVVERS QARQSLAMGV WMKFRHSLGL
160 170 180 190 200
LLLWTVTFAA ENLALVSWNS PQWWWARADL GQQVQFGLWV LRYVTSGGLF
210 220 230 240 250
ILGLWAPGLR PQSYTLHVHE EDQDVGGNQG RSTDRRSTWR DLGRKLRLLS
260 270 280 290 300
SYLWPRGSPS LQLIVLICLG LMGLERALNV LVPIFYRDIV NLLTAKAPWS
310 320 330 340 350
SLAWTVTTYV FLKFLQGGGT GSTGFVSNLR TFLWIRVQQF TSRGVELRLF
360 370 380 390 400
SHLHELSLRW HLGRRTGEVL RIVDRGTSSV TGLLSYLVFS IIPTLADIII
410 420 430 440 450
GIIYFSMFFN AWFGLIVFLC MSLYLILTIV VTEWRAKFRR DMNTQENATR
460 470 480 490 500
ARAVDSLLNF ETVKYYGAEG YEVDRYREAI LKFQGLEWKS TASLVVLNQT
510 520 530 540 550
QNLVIGLGLL AGSLLCAYFV SEQKLQVGDF VLFGTYITQL YMPLNWFGTY
560 570 580 590 600
YRMIQTNFID MENMFDLLKE ETEVKDVPGA GPLRFHKGRI EFENVHFSYA
610 620 630 640 650
DGQETLQDVS FTVMPGQTVA LVGPSGAGKS TILRLLFRFY DISSGCIRID
660 670 680 690 700
GQDISQVTQI SLRSHIGVVP QDTVLFNDTI ANNIRYGRVT AGDSEVEAAA
710 720 730 740 750
QAAGIHDAIL SFPEGYETQV GERGLKLSGG EKQRVAIART ILKAPDIILL
760 770 780 790 800
DEATSALDTS NERAIQASLA KVCTNRTTIV IAHRLSTVVN ADQILVIKDG
810 820 830 840
CIIERGRHEA LLSRGGVYAE MWQLQQQGQE TVPEESKPQD TA
Length:842
Mass (Da):93,770
Last modified:June 1, 2001 - v1
Checksum:i5B8E1653011A4C0D
GO

Sequence cautioni

The sequence BAE30168 differs from that shown. Reason: Frameshift at position 60.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004605 mRNA. Translation: BAB23404.1.
AK150853 mRNA. Translation: BAE29909.1.
AK151165 mRNA. Translation: BAE30168.1. Frameshift.
AK152584 mRNA. Translation: BAE31334.1.
AK168642 mRNA. Translation: BAE40501.1.
BC006634 mRNA. Translation: AAH06634.1.
CCDSiCCDS15065.1.
RefSeqiNP_076221.1. NM_023732.3.
UniGeneiMm.28663.

Genome annotation databases

EnsembliENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198.
GeneIDi74104.
KEGGimmu:74104.
UCSCiuc007bnx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004605 mRNA. Translation: BAB23404.1.
AK150853 mRNA. Translation: BAE29909.1.
AK151165 mRNA. Translation: BAE30168.1. Frameshift.
AK152584 mRNA. Translation: BAE31334.1.
AK168642 mRNA. Translation: BAE40501.1.
BC006634 mRNA. Translation: AAH06634.1.
CCDSiCCDS15065.1.
RefSeqiNP_076221.1. NM_023732.3.
UniGeneiMm.28663.

3D structure databases

ProteinModelPortaliQ9DC29.
SMRiQ9DC29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027396.

PTM databases

iPTMnetiQ9DC29.
PhosphoSitePlusiQ9DC29.

Proteomic databases

EPDiQ9DC29.
MaxQBiQ9DC29.
PaxDbiQ9DC29.
PeptideAtlasiQ9DC29.
PRIDEiQ9DC29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027396; ENSMUSP00000027396; ENSMUSG00000026198.
GeneIDi74104.
KEGGimmu:74104.
UCSCiuc007bnx.1. mouse.

Organism-specific databases

CTDi10058.
MGIiMGI:1921354. Abcb6.

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
GeneTreeiENSGT00440000033373.
HOVERGENiHBG080810.
InParanoidiQ9DC29.
KOiK05661.
OMAiRYQEAII.
OrthoDBiEOG091G02G4.
PhylomeDBiQ9DC29.
TreeFamiTF105194.

Enzyme and pathway databases

ReactomeiR-MMU-1369007. Mitochondrial ABC transporters.

Miscellaneous databases

PROiQ9DC29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026198.
ExpressionAtlasiQ9DC29. baseline and differential.
GenevisibleiQ9DC29. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR032410. MTABC_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
PF16185. MTABC_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCB6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC29
Secondary accession number(s): Q3U7N5, Q3UAZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.