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Q9DC28

- KC1D_MOUSE

UniProt

Q9DC28 - KC1D_MOUSE

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Protein

Casein kinase I isoform delta

Gene

Csnk1d

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.9 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication
ATP + [tau protein] = ADP + [tau protein] phosphate.1 Publication

Enzyme regulationi

Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATPPROSITE-ProRule annotation
Active sitei128 – 1281Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. peptide binding Source: Ensembl
  3. protein kinase activity Source: UniProtKB
  4. protein serine/threonine kinase activity Source: UniProtKB-KW
  5. tau-protein kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. circadian regulation of gene expression Source: UniProtKB
  2. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  3. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  4. positive regulation of protein phosphorylation Source: Ensembl
  5. protein phosphorylation Source: UniProtKB
  6. regulation of circadian rhythm Source: UniProtKB
  7. spindle assembly Source: Ensembl
  8. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Biological rhythms, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_241925. Circadian Clock.
REACT_243078. Loss of Nlp from mitotic centrosomes.
REACT_244487. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_245720. Recruitment of mitotic centrosome proteins and complexes.
REACT_24972. Circadian Clock.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform delta (EC:2.7.11.1)
Short name:
CKI-delta
Short name:
CKId
Alternative name(s):
Tau-protein kinase CSNK1D (EC:2.7.11.26)
Gene namesi
Name:Csnk1d
Synonyms:Hckid
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1355272. Csnk1d.

Subcellular locationi

Cytoplasm By similarity. Nucleus 3 Publications. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmperinuclear region By similarity. Cell membrane By similarity. Cytoplasmcytoskeletonspindle By similarity. Golgi apparatus By similarity
Note: Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytosol Source: Reactome
  3. Golgi apparatus Source: UniProtKB-KW
  4. nucleoplasm Source: Reactome
  5. nucleus Source: UniProtKB
  6. perinuclear region of cytoplasm Source: Ensembl
  7. plasma membrane Source: UniProtKB-KW
  8. spindle microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Lethal. There are fewer embryos than expected at late stages of gestation; they weigh about 30% less than control animals, but appear otherwise normal. Mice die shortly after birth. Tissue-specific disruption increases the half-life of PER2 protein and alters circadian protein expression dynamics.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi44 – 441T → A: Increases pain sensitivity; reduces threshold for induction of cortical spreading depression; increases arterial dilation during cortical spreading depression and increases spontaneous and evoked calcium signaling in astrocytes. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Casein kinase I isoform deltaPRO_0000192834Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311PhosphoserineBy similarity
Modified residuei370 – 3701PhosphoserineBy similarity
Modified residuei382 – 3821Phosphoserine1 Publication
Modified residuei383 – 3831PhosphoserineBy similarity
Modified residuei384 – 3841PhosphoserineBy similarity
Modified residuei411 – 4111PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DC28.
PaxDbiQ9DC28.
PRIDEiQ9DC28.

PTM databases

PhosphoSiteiQ9DC28.

Expressioni

Tissue specificityi

Expressed ubiquitously. However, kinase activity is not uniform, with highest kinase activity in splenocytes.1 Publication

Gene expression databases

BgeeiQ9DC28.
CleanExiMM_CSNK1D.
ExpressionAtlasiQ9DC28. baseline and differential.
GenevestigatoriQ9DC28.

Interactioni

Subunit structurei

Binds to MAP1A. Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts with MAPT/TAU, DBNDD2, AIB1/NCOA3 and ESR1. AKAP9/AKAP450 binding promotes centrosomal subcellular location. Binds to tubulins in mitotic cells upon DNA damage. Binds to SNAPIN and DNMT1.2 Publications

Protein-protein interaction databases

BioGridi222545. 4 interactions.
DIPiDIP-47809N.
IntActiQ9DC28. 3 interactions.
STRINGi10090.ENSMUSP00000094305.

Structurei

Secondary structure

1
415
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni6 – 83Combined sources
Beta strandi9 – 179Combined sources
Beta strandi19 – 2810Combined sources
Turni29 – 324Combined sources
Beta strandi33 – 419Combined sources
Helixi49 – 5911Combined sources
Beta strandi68 – 747Combined sources
Beta strandi77 – 837Combined sources
Helixi89 – 957Combined sources
Turni96 – 983Combined sources
Helixi102 – 12120Combined sources
Helixi131 – 1333Combined sources
Beta strandi134 – 1363Combined sources
Helixi139 – 1413Combined sources
Beta strandi145 – 1473Combined sources
Turni159 – 1613Combined sources
Turni177 – 1793Combined sources
Helixi182 – 1854Combined sources
Helixi192 – 20817Combined sources
Helixi224 – 23411Combined sources
Helixi237 – 2404Combined sources
Turni241 – 2433Combined sources
Helixi246 – 25712Combined sources
Helixi266 – 27914Combined sources
Helixi289 – 2924Combined sources
Beta strandi295 – 2973Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JJRX-ray2.41A/B1-299[»]
ProteinModelPortaliQ9DC28.
SMRiQ9DC28. Positions 3-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 277269Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 36487Centrosomal localization signal (CLS)By similarityAdd
BLAST
Regioni317 – 34226AutoinhibitoryBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182055.
HOVERGENiHBG000176.
InParanoidiQ9DC28.
KOiK08959.
OMAiRIGQKIG.
OrthoDBiEOG7CZK5W.
TreeFamiTF300544.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9DC28-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH
60 70 80 90 100
IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
110 120 130 140 150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
160 170 180 190 200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
210 220 230 240 250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
260 270 280 290 300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA
310 320 330 340 350
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS
360 370 380 390 400
HTANTSPRPV SGMERERKVS MRLHRGAPVN VSSSDLTGRQ DTSRMSTSQI
410
PGRVASSGLQ SVVHR
Length:415
Mass (Da):47,316
Last modified:May 10, 2004 - v2
Checksum:iB97F04AF9EB466D2
GO
Isoform 2 (identifier: Q9DC28-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-415: IPGRVASSGLQSVVHR → NSIPFEHHGK

Note: Contains a phosphoserine at position 401.By similarity

Show »
Length:409
Mass (Da):46,818
Checksum:i970B55B1B19AB9DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131E → G in BAB23405. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei400 – 41516IPGRV…SVVHR → NSIPFEHHGK in isoform 2. 1 PublicationVSP_010254Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004606 mRNA. Translation: BAB23405.1.
AK088642 mRNA. Translation: BAC40472.1.
AK152721 mRNA. Translation: BAE31444.1.
AK157812 mRNA. Translation: BAE34206.1.
BC004604 mRNA. Translation: AAH04604.1.
CCDSiCCDS25762.1. [Q9DC28-1]
CCDS25763.1. [Q9DC28-2]
PIRiS47616.
RefSeqiNP_620690.1. NM_139059.2. [Q9DC28-1]
UniGeneiMm.216227.

Genome annotation databases

EnsembliENSMUST00000018274; ENSMUSP00000018274; ENSMUSG00000025162. [Q9DC28-1]
ENSMUST00000070575; ENSMUSP00000070721; ENSMUSG00000025162. [Q9DC28-2]
GeneIDi104318.
KEGGimmu:104318.
UCSCiuc007mvb.1. mouse. [Q9DC28-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004606 mRNA. Translation: BAB23405.1 .
AK088642 mRNA. Translation: BAC40472.1 .
AK152721 mRNA. Translation: BAE31444.1 .
AK157812 mRNA. Translation: BAE34206.1 .
BC004604 mRNA. Translation: AAH04604.1 .
CCDSi CCDS25762.1. [Q9DC28-1 ]
CCDS25763.1. [Q9DC28-2 ]
PIRi S47616.
RefSeqi NP_620690.1. NM_139059.2. [Q9DC28-1 ]
UniGenei Mm.216227.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JJR X-ray 2.41 A/B 1-299 [» ]
ProteinModelPortali Q9DC28.
SMRi Q9DC28. Positions 3-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 222545. 4 interactions.
DIPi DIP-47809N.
IntActi Q9DC28. 3 interactions.
STRINGi 10090.ENSMUSP00000094305.

Chemistry

BindingDBi Q9DC28.

PTM databases

PhosphoSitei Q9DC28.

Proteomic databases

MaxQBi Q9DC28.
PaxDbi Q9DC28.
PRIDEi Q9DC28.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000018274 ; ENSMUSP00000018274 ; ENSMUSG00000025162 . [Q9DC28-1 ]
ENSMUST00000070575 ; ENSMUSP00000070721 ; ENSMUSG00000025162 . [Q9DC28-2 ]
GeneIDi 104318.
KEGGi mmu:104318.
UCSCi uc007mvb.1. mouse. [Q9DC28-1 ]

Organism-specific databases

CTDi 1453.
MGIi MGI:1355272. Csnk1d.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119040.
HOGENOMi HOG000182055.
HOVERGENi HBG000176.
InParanoidi Q9DC28.
KOi K08959.
OMAi RIGQKIG.
OrthoDBi EOG7CZK5W.
TreeFami TF300544.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
REACT_241925. Circadian Clock.
REACT_243078. Loss of Nlp from mitotic centrosomes.
REACT_244487. Loss of proteins required for interphase microtubule organization from the centrosome.
REACT_245720. Recruitment of mitotic centrosome proteins and complexes.
REACT_24972. Circadian Clock.

Miscellaneous databases

ChiTaRSi Csnk1d. mouse.
NextBioi 356922.
PROi Q9DC28.
SOURCEi Search...

Gene expression databases

Bgeei Q9DC28.
CleanExi MM_CSNK1D.
ExpressionAtlasi Q9DC28. baseline and differential.
Genevestigatori Q9DC28.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Lung and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon."
    Vielhaber E., Eide E., Rivers A., Gao Z.-H., Virshup D.M.
    Mol. Cell. Biol. 20:4888-4899(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS PER1 KINASE, SUBCELLULAR LOCATION.
  4. "Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology."
    Maritzen T., Loehler J., Deppert W., Knippschild U.
    Eur. J. Cell Biol. 82:369-378(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Physiological role for casein kinase 1 in glutamatergic synaptic transmission."
    Chergui K., Svenningsson P., Greengard P.
    J. Neurosci. 25:6601-6609(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SYNAPTIC TRANSMISSION.
  6. "Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin."
    Wolff S., Stoeter M., Giamas G., Piesche M., Henne-Bruns D., Banting G., Knippschild U.
    FEBS Lett. 580:6477-6484(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS SNAPIN KINASE, SUBCELLULAR LOCATION, INTERACTION WITH SNAPIN.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. Cited for: FUNCTION IN CIRCADIAN CLOCK, DISRUPTION PHENOTYPE, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  9. "Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock."
    Lee H., Chen R., Lee Y., Yoo S., Lee C.
    Proc. Natl. Acad. Sci. U.S.A. 106:21359-21364(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN CLOCK, DISRUPTION PHENOTYPE.
  10. "The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon."
    Sugiyama Y., Hatano N., Sueyoshi N., Suetake I., Tajima S., Kinoshita E., Kinoshita-Kikuta E., Koike T., Kameshita I.
    Biochem. J. 427:489-497(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS DNMT1 KINASE, INTERACTION WITH DNMT1.
  11. "Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro."
    Etchegaray J.-P., Yu E.A., Indic P., Dallmann R., Weaver D.R.
    PLoS ONE 5:E10303-E10303(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN CLOCK.
  12. "Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD."
    Zhou M., Rebholz H., Brocia C., Warner-Schmidt J.L., Fienberg A.A., Nairn A.C., Greengard P., Flajolet M.
    Proc. Natl. Acad. Sci. U.S.A. 107:4401-4406(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DOPAMINE RECEPTORS.
  13. "The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1."
    Lee H.M., Chen R., Kim H., Etchegaray J.P., Weaver D.R., Lee C.
    Proc. Natl. Acad. Sci. U.S.A. 108:16451-16456(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CIRCADIAN CLOCK, DEPHOSPHORYLATION.
  14. Cited for: MUTAGENESIS OF THR-44.

Entry informationi

Entry nameiKC1D_MOUSE
AccessioniPrimary (citable) accession number: Q9DC28
Secondary accession number(s): Q3TZK2, Q99KK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 26, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3