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Protein

DDB1- and CUL4-associated factor 6

Gene

Dcaf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:Dcaf6
Synonyms:Iqwd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921356. Dcaf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876DDB1- and CUL4-associated factor 6PRO_0000304402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei336 – 3361PhosphoserineCombined sources
Modified residuei665 – 6651PhosphoserineBy similarity
Modified residuei670 – 6701PhosphothreonineCombined sources
Modified residuei673 – 6731PhosphoserineCombined sources
Modified residuei863 – 8631PhosphoserineCombined sources
Modified residuei866 – 8661PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DC22.
PaxDbiQ9DC22.
PRIDEiQ9DC22.

PTM databases

iPTMnetiQ9DC22.
PhosphoSiteiQ9DC22.

Expressioni

Gene expression databases

BgeeiQ9DC22.
CleanExiMM_IQWD1.
ExpressionAtlasiQ9DC22. baseline and differential.
GenevisibleiQ9DC22. MM.

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9DC22. 1 interaction.
STRINGi10090.ENSMUSP00000027856.

Structurei

3D structure databases

ProteinModelPortaliQ9DC22.
SMRiQ9DC22. Positions 42-222, 249-285, 729-804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati49 – 8840WD 1Add
BLAST
Repeati92 – 13342WD 2Add
BLAST
Repeati139 – 17941WD 3Add
BLAST
Repeati189 – 22941WD 4Add
BLAST
Repeati251 – 29040WD 5Add
BLAST
Domaini692 – 72130IQPROSITE-ProRule annotationAdd
BLAST
Repeati734 – 77239WD 6Add
BLAST
Repeati775 – 81440WD 7Add
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ9DC22.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG7P5T0B.
PhylomeDBiQ9DC22.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSGSCPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTDDKQ IVSCSGDGVI FYTNIEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPVPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLS
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRPR PRGGTNQPDV STLPTVPSSP NLEVCETAMD
410 420 430 440 450
VDMPAALLQP STSSTDPVQA QAATAAIESP RSSSLLSCPD SEPRQSVEAS
460 470 480 490 500
GHHAHHQSDN SNERLSPKPG TGEPVLSLHY STEGTTTSTI KLNFTDEWSS
510 520 530 540 550
TASSSRGNGS HCKSEGQEEC LVPPSSVQPP EGDSETRAPE ELSEKGTLPE
560 570 580 590 600
NLTQNQIDTA QLDNFPAEPL DSNSGEKNNP SQDSPCGLPE EGTLSETDRE
610 620 630 640 650
TCEQASTESA TRHASTKPEL PSQTEAIEQA STESATRHTS ANPELPSQTE
660 670 680 690 700
AIAPLAHEDP SARDSALQDT DDSDDDPVLI PGARYRTGPG DRRSAVARIQ
710 720 730 740 750
EFFRRRKERK EMEELDTLNI RRPLVKMVYK GHRNSRTMIK EANFWGANFV
760 770 780 790 800
MSGSDCGHIF IWDRHTAEHL MLLEADNHVV NCLQPHPFDP ILASSGIDYD
810 820 830 840 850
IKIWSPLEES RIFNRKLADE VITRNELMLE ETRNTITVPA SFMLRMLASL
860 870
NHIRADRLEG DRSEGSGQEN ENEDEE
Length:876
Mass (Da):97,588
Last modified:June 1, 2001 - v1
Checksum:i6F7B1A3F8DFBB407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004618 mRNA. Translation: BAB23414.1.
AK077238 mRNA. Translation: BAC36701.1.
CCDSiCCDS48424.1.
RefSeqiNP_083035.1. NM_028759.1.
UniGeneiMm.227605.

Genome annotation databases

EnsembliENSMUST00000027856; ENSMUSP00000027856; ENSMUSG00000026571.
GeneIDi74106.
KEGGimmu:74106.
UCSCiuc007djb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004618 mRNA. Translation: BAB23414.1.
AK077238 mRNA. Translation: BAC36701.1.
CCDSiCCDS48424.1.
RefSeqiNP_083035.1. NM_028759.1.
UniGeneiMm.227605.

3D structure databases

ProteinModelPortaliQ9DC22.
SMRiQ9DC22. Positions 42-222, 249-285, 729-804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC22. 1 interaction.
STRINGi10090.ENSMUSP00000027856.

PTM databases

iPTMnetiQ9DC22.
PhosphoSiteiQ9DC22.

Proteomic databases

MaxQBiQ9DC22.
PaxDbiQ9DC22.
PRIDEiQ9DC22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027856; ENSMUSP00000027856; ENSMUSG00000026571.
GeneIDi74106.
KEGGimmu:74106.
UCSCiuc007djb.2. mouse.

Organism-specific databases

CTDi55827.
MGIiMGI:1921356. Dcaf6.

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ9DC22.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG7P5T0B.
PhylomeDBiQ9DC22.
TreeFamiTF326071.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi339790.
PROiQ9DC22.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DC22.
CleanExiMM_IQWD1.
ExpressionAtlasiQ9DC22. baseline and differential.
GenevisibleiQ9DC22. MM.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung, Ovary and Uterus.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-336; THR-670; SER-673; SER-863 AND SER-866, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiDCAF6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC22
Secondary accession number(s): Q8BK50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.