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Protein

DDB1- and CUL4-associated factor 6

Gene

Dcaf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:Dcaf6
Synonyms:Iqwd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921356 Dcaf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044021 – 876DDB1- and CUL4-associated factor 6Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei665PhosphoserineBy similarity1
Modified residuei670PhosphothreonineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DC22
PaxDbiQ9DC22
PeptideAtlasiQ9DC22
PRIDEiQ9DC22

PTM databases

iPTMnetiQ9DC22
PhosphoSitePlusiQ9DC22

Expressioni

Gene expression databases

BgeeiENSMUSG00000026571
CleanExiMM_IQWD1
ExpressionAtlasiQ9DC22 baseline and differential
GenevisibleiQ9DC22 MM

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B (By similarity).By similarity

Protein-protein interaction databases

BioGridi216497, 1 interactor
IntActiQ9DC22, 2 interactors
STRINGi10090.ENSMUSP00000027856

Structurei

3D structure databases

ProteinModelPortaliQ9DC22
SMRiQ9DC22
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 88WD 1Add BLAST40
Repeati92 – 133WD 2Add BLAST42
Repeati139 – 179WD 3Add BLAST41
Repeati189 – 229WD 4Add BLAST41
Repeati251 – 290WD 5Add BLAST40
Domaini692 – 721IQPROSITE-ProRule annotationAdd BLAST30
Repeati734 – 772WD 6Add BLAST39
Repeati775 – 814WD 7Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310 Eukaryota
KOG1334 Eukaryota
ENOG410XQZP LUCA
GeneTreeiENSGT00530000062951
HOGENOMiHOG000038027
HOVERGENiHBG054871
InParanoidiQ9DC22
KOiK11795
OMAiQTEAIGP
OrthoDBiEOG091G01Z0
PhylomeDBiQ9DC22
TreeFamiTF326071

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q9DC22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSGSCPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTDDKQ IVSCSGDGVI FYTNIEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPVPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLS
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRPR PRGGTNQPDV STLPTVPSSP NLEVCETAMD
410 420 430 440 450
VDMPAALLQP STSSTDPVQA QAATAAIESP RSSSLLSCPD SEPRQSVEAS
460 470 480 490 500
GHHAHHQSDN SNERLSPKPG TGEPVLSLHY STEGTTTSTI KLNFTDEWSS
510 520 530 540 550
TASSSRGNGS HCKSEGQEEC LVPPSSVQPP EGDSETRAPE ELSEKGTLPE
560 570 580 590 600
NLTQNQIDTA QLDNFPAEPL DSNSGEKNNP SQDSPCGLPE EGTLSETDRE
610 620 630 640 650
TCEQASTESA TRHASTKPEL PSQTEAIEQA STESATRHTS ANPELPSQTE
660 670 680 690 700
AIAPLAHEDP SARDSALQDT DDSDDDPVLI PGARYRTGPG DRRSAVARIQ
710 720 730 740 750
EFFRRRKERK EMEELDTLNI RRPLVKMVYK GHRNSRTMIK EANFWGANFV
760 770 780 790 800
MSGSDCGHIF IWDRHTAEHL MLLEADNHVV NCLQPHPFDP ILASSGIDYD
810 820 830 840 850
IKIWSPLEES RIFNRKLADE VITRNELMLE ETRNTITVPA SFMLRMLASL
860 870
NHIRADRLEG DRSEGSGQEN ENEDEE
Length:876
Mass (Da):97,588
Last modified:June 1, 2001 - v1
Checksum:i6F7B1A3F8DFBB407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004618 mRNA Translation: BAB23414.1
AK077238 mRNA Translation: BAC36701.1
CCDSiCCDS48424.1
RefSeqiNP_083035.1, NM_028759.1
UniGeneiMm.227605

Genome annotation databases

EnsembliENSMUST00000027856; ENSMUSP00000027856; ENSMUSG00000026571
GeneIDi74106
KEGGimmu:74106
UCSCiuc007djb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDCAF6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC22
Secondary accession number(s): Q8BK50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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