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Protein

DDB1- and CUL4-associated factor 6

Gene

Dcaf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 6
Alternative name(s):
IQ motif and WD repeat-containing protein 1
Nuclear receptor interaction protein
Short name:
NRIP
Gene namesi
Name:Dcaf6
Synonyms:Iqwd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921356. Dcaf6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003044021 – 876DDB1- and CUL4-associated factor 6Add BLAST876

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineCombined sources1
Modified residuei665PhosphoserineBy similarity1
Modified residuei670PhosphothreonineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei863PhosphoserineCombined sources1
Modified residuei866PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DC22.
PaxDbiQ9DC22.
PeptideAtlasiQ9DC22.
PRIDEiQ9DC22.

PTM databases

iPTMnetiQ9DC22.
PhosphoSitePlusiQ9DC22.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026571.
CleanExiMM_IQWD1.
ExpressionAtlasiQ9DC22. baseline and differential.
GenevisibleiQ9DC22. MM.

Interactioni

Subunit structurei

Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9DC22. 1 interactor.
STRINGi10090.ENSMUSP00000027856.

Structurei

3D structure databases

ProteinModelPortaliQ9DC22.
SMRiQ9DC22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 88WD 1Add BLAST40
Repeati92 – 133WD 2Add BLAST42
Repeati139 – 179WD 3Add BLAST41
Repeati189 – 229WD 4Add BLAST41
Repeati251 – 290WD 5Add BLAST40
Domaini692 – 721IQPROSITE-ProRule annotationAdd BLAST30
Repeati734 – 772WD 6Add BLAST39
Repeati775 – 814WD 7Add BLAST40

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ9DC22.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG091G01Z0.
PhylomeDBiQ9DC22.
TreeFamiTF326071.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSGSCPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH
60 70 80 90 100
DGCVNTICWN DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA
110 120 130 140 150
KFLPCTDDKQ IVSCSGDGVI FYTNIEQDAE TNRQCQFTCH YGTTYEIMTV
160 170 180 190 200
PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE DCKDDILINC RRAATSVAIC
210 220 230 240 250
PPVPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM VARFIPSHLS
260 270 280 290 300
NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE
310 320 330 340 350
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS
360 370 380 390 400
RWFEEASEVA QSNRGRGRPR PRGGTNQPDV STLPTVPSSP NLEVCETAMD
410 420 430 440 450
VDMPAALLQP STSSTDPVQA QAATAAIESP RSSSLLSCPD SEPRQSVEAS
460 470 480 490 500
GHHAHHQSDN SNERLSPKPG TGEPVLSLHY STEGTTTSTI KLNFTDEWSS
510 520 530 540 550
TASSSRGNGS HCKSEGQEEC LVPPSSVQPP EGDSETRAPE ELSEKGTLPE
560 570 580 590 600
NLTQNQIDTA QLDNFPAEPL DSNSGEKNNP SQDSPCGLPE EGTLSETDRE
610 620 630 640 650
TCEQASTESA TRHASTKPEL PSQTEAIEQA STESATRHTS ANPELPSQTE
660 670 680 690 700
AIAPLAHEDP SARDSALQDT DDSDDDPVLI PGARYRTGPG DRRSAVARIQ
710 720 730 740 750
EFFRRRKERK EMEELDTLNI RRPLVKMVYK GHRNSRTMIK EANFWGANFV
760 770 780 790 800
MSGSDCGHIF IWDRHTAEHL MLLEADNHVV NCLQPHPFDP ILASSGIDYD
810 820 830 840 850
IKIWSPLEES RIFNRKLADE VITRNELMLE ETRNTITVPA SFMLRMLASL
860 870
NHIRADRLEG DRSEGSGQEN ENEDEE
Length:876
Mass (Da):97,588
Last modified:June 1, 2001 - v1
Checksum:i6F7B1A3F8DFBB407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004618 mRNA. Translation: BAB23414.1.
AK077238 mRNA. Translation: BAC36701.1.
CCDSiCCDS48424.1.
RefSeqiNP_083035.1. NM_028759.1.
UniGeneiMm.227605.

Genome annotation databases

EnsembliENSMUST00000027856; ENSMUSP00000027856; ENSMUSG00000026571.
GeneIDi74106.
KEGGimmu:74106.
UCSCiuc007djb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004618 mRNA. Translation: BAB23414.1.
AK077238 mRNA. Translation: BAC36701.1.
CCDSiCCDS48424.1.
RefSeqiNP_083035.1. NM_028759.1.
UniGeneiMm.227605.

3D structure databases

ProteinModelPortaliQ9DC22.
SMRiQ9DC22.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC22. 1 interactor.
STRINGi10090.ENSMUSP00000027856.

PTM databases

iPTMnetiQ9DC22.
PhosphoSitePlusiQ9DC22.

Proteomic databases

MaxQBiQ9DC22.
PaxDbiQ9DC22.
PeptideAtlasiQ9DC22.
PRIDEiQ9DC22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027856; ENSMUSP00000027856; ENSMUSG00000026571.
GeneIDi74106.
KEGGimmu:74106.
UCSCiuc007djb.2. mouse.

Organism-specific databases

CTDi55827.
MGIiMGI:1921356. Dcaf6.

Phylogenomic databases

eggNOGiKOG1310. Eukaryota.
KOG1334. Eukaryota.
ENOG410XQZP. LUCA.
GeneTreeiENSGT00530000062951.
HOGENOMiHOG000038027.
HOVERGENiHBG054871.
InParanoidiQ9DC22.
KOiK11795.
OMAiFWGNNFV.
OrthoDBiEOG091G01Z0.
PhylomeDBiQ9DC22.
TreeFamiTF326071.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9DC22.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026571.
CleanExiMM_IQWD1.
ExpressionAtlasiQ9DC22. baseline and differential.
GenevisibleiQ9DC22. MM.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50096. IQ. 1 hit.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCAF6_MOUSE
AccessioniPrimary (citable) accession number: Q9DC22
Secondary accession number(s): Q8BK50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.