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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 1

Gene

Ergic1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 1
Alternative name(s):
ER-Golgi intermediate compartment 32 kDa protein
Short name:
ERGIC-32
Gene namesi
Name:Ergic1
Synonyms:Ergic32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914708. Ergic1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence analysisAdd
BLAST
Transmembranei27 – 4721HelicalSequence analysisAdd
BLAST
Topological domaini48 – 254207LumenalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Topological domaini276 – 29015CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Endoplasmic reticulum-Golgi intermediate compartment protein 1PRO_0000087024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9DC16.
MaxQBiQ9DC16.
PaxDbiQ9DC16.
PRIDEiQ9DC16.
TopDownProteomicsiQ9DC16.

PTM databases

iPTMnetiQ9DC16.
PhosphoSiteiQ9DC16.
SwissPalmiQ9DC16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001576.
ExpressionAtlasiQ9DC16. baseline and differential.
GenevisibleiQ9DC16. MM.

Interactioni

Subunit structurei

Interacts with ERGIC3/ERV46.By similarity

Protein-protein interaction databases

IntActiQ9DC16. 3 interactions.
MINTiMINT-4094160.
STRINGi10090.ENSMUSP00000132922.

Structurei

3D structure databases

ProteinModelPortaliQ9DC16.
SMRiQ9DC16. Positions 114-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOVERGENiHBG081479.
InParanoidiQ9DC16.
OMAiHEYILKI.
OrthoDBiEOG091G0DGE.
TreeFamiTF354253.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DC16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFDFRRFDI YRKVPKDLTQ PTYTGAIISI CCCLFILFLF LSELTGFITT
60 70 80 90 100
EVVNELYVDD PDKDSGGKID VSLNISLPNL HCELVGLDIQ DEMGRHEVGH
110 120 130 140 150
IDNSMKIPLN NGAGCRFEGQ FSINKVPGNF HVSTHSATAQ PQNPDMTHTI
160 170 180 190 200
HKLSFGDTLQ VQNVHGAFNA LGGADRLTSN PLASHDYILK IVPTVYEDKS
210 220 230 240 250
GKQRYSYQYT VANKEYVAYS HTGRIIPAIW FRYDLSPITV KYTERRQPLY
260 270 280 290
RFITTICAII GGTFTVAGIL DSCIFTASEA WKKIQLGKIH
Length:290
Mass (Da):32,562
Last modified:June 1, 2001 - v1
Checksum:i9F6507BB1D89D46F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004629 mRNA. Translation: BAB23423.1.
AK084385 mRNA. Translation: BAC39170.1.
AK088157 mRNA. Translation: BAC40179.1.
BC005516 mRNA. Translation: AAH05516.1.
BC083144 mRNA. Translation: AAH83144.1.
CCDSiCCDS28553.1.
RefSeqiNP_080446.1. NM_026170.3.
UniGeneiMm.30496.

Genome annotation databases

EnsembliENSMUST00000167662; ENSMUSP00000132922; ENSMUSG00000001576.
GeneIDi67458.
KEGGimmu:67458.
UCSCiuc008bef.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004629 mRNA. Translation: BAB23423.1.
AK084385 mRNA. Translation: BAC39170.1.
AK088157 mRNA. Translation: BAC40179.1.
BC005516 mRNA. Translation: AAH05516.1.
BC083144 mRNA. Translation: AAH83144.1.
CCDSiCCDS28553.1.
RefSeqiNP_080446.1. NM_026170.3.
UniGeneiMm.30496.

3D structure databases

ProteinModelPortaliQ9DC16.
SMRiQ9DC16. Positions 114-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DC16. 3 interactions.
MINTiMINT-4094160.
STRINGi10090.ENSMUSP00000132922.

PTM databases

iPTMnetiQ9DC16.
PhosphoSiteiQ9DC16.
SwissPalmiQ9DC16.

Proteomic databases

EPDiQ9DC16.
MaxQBiQ9DC16.
PaxDbiQ9DC16.
PRIDEiQ9DC16.
TopDownProteomicsiQ9DC16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167662; ENSMUSP00000132922; ENSMUSG00000001576.
GeneIDi67458.
KEGGimmu:67458.
UCSCiuc008bef.1. mouse.

Organism-specific databases

CTDi57222.
MGIiMGI:1914708. Ergic1.

Phylogenomic databases

eggNOGiKOG2667. Eukaryota.
ENOG410XP7X. LUCA.
GeneTreeiENSGT00530000063113.
HOVERGENiHBG081479.
InParanoidiQ9DC16.
OMAiHEYILKI.
OrthoDBiEOG091G0DGE.
TreeFamiTF354253.

Miscellaneous databases

ChiTaRSiErgic1. mouse.
PROiQ9DC16.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001576.
ExpressionAtlasiQ9DC16. baseline and differential.
GenevisibleiQ9DC16. MM.

Family and domain databases

InterProiIPR012936. Erv_C.
[Graphical view]
PfamiPF07970. COPIIcoated_ERV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERGI1_MOUSE
AccessioniPrimary (citable) accession number: Q9DC16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.