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Protein

Inhibitor of nuclear factor kappa-B kinase-interacting protein

Gene

Ikbip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Target of p53/TP53 with pro-apoptotic function.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of nuclear factor kappa-B kinase-interacting protein
Short name:
I kappa-B kinase-interacting protein
Short name:
IKBKB-interacting protein
Short name:
IKK-interacting protein
Gene namesi
Name:Ikbip
Synonyms:Ikip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914704. Ikbip.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 5917HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: HGNC
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Inhibitor of nuclear factor kappa-B kinase-interacting proteinPRO_0000342262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated at Asn-151.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9DBZ1.
MaxQBiQ9DBZ1.
PaxDbiQ9DBZ1.
PRIDEiQ9DBZ1.

PTM databases

iPTMnetiQ9DBZ1.
PhosphoSiteiQ9DBZ1.

Expressioni

Gene expression databases

BgeeiQ9DBZ1.
ExpressionAtlasiQ9DBZ1. baseline and differential.
GenevisibleiQ9DBZ1. MM.

Interactioni

Protein-protein interaction databases

BioGridi212198. 7 interactions.
IntActiQ9DBZ1. 8 interactions.
STRINGi10090.ENSMUSP00000020149.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili86 – 257172Sequence analysisAdd
BLAST
Coiled coili285 – 32440Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJN2. Eukaryota.
ENOG410YFQ8. LUCA.
GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG108000.
InParanoidiQ9DBZ1.
OrthoDBiEOG7673B1.
PhylomeDBiQ9DBZ1.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBZ1-1) [UniParc]FASTAAdd to basket

Also known as: Ikip1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVKSRKKP GPKVAAPEPE KRSDGRKNPE ARGDAGWADP RTGLSLLSLA
60 70 80 90 100
MTLGLAWLVF QQSEKFAKVE KQYRLLQTES SEFQGLQSKI SLISSKLEST
110 120 130 140 150
ENTLQEATSS ISLMTQFEQE VSGLQRSIRD IETSEEMLTQ KMQNLNEKFQ
160 170 180 190 200
NITDFWKRTL AEMIDDTAVF KSEVKDTHSE VTLKINSADQ EIKSLTERLK
210 220 230 240 250
DLEDSTLRNI RTVSRQEEED LLRVEAQLSS DTKAVKKLEE EQHTLLARDE
260 270 280 290 300
DLTNKLSSYE PKVEECKAHF PTIENAVHSV LRVSQDLIGT ERKMEELTMQ
310 320 330 340 350
MFNMEDDMLR AVSEIMEMQK TLEGIQYDNS LLKMQNELVV LKGKVHDFIA
360 370
YSSAREKGTL GEYSLGNKGT DEY
Length:373
Mass (Da):42,532
Last modified:July 1, 2008 - v2
Checksum:i9F42D944855ADA8A
GO
Isoform 2 (identifier: Q9DBZ1-2) [UniParc]FASTAAdd to basket

Also known as: Ikip2

The sequence of this isoform differs from the canonical sequence as follows:
     97-373: LESTENTLQE...SLGNKGTDEY → YQECEALVEQ...IKDEITHISD

Show »
Length:345
Mass (Da):38,476
Checksum:i036240DB900625BE
GO

Sequence cautioni

The sequence BAB23459.1 differs from that shown. Reason: Frameshift at positions 5 and 9. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171P → H in BAB23459 (PubMed:16141072).Curated
Sequence conflicti51 – 511M → T in AAH55834 (PubMed:15489334).Curated
Sequence conflicti111 – 1111I → M in AAH55834 (PubMed:15489334).Curated
Sequence conflicti164 – 1641I → S in AAH55834 (PubMed:15489334).Curated
Sequence conflicti169 – 1691V → I in AAH55834 (PubMed:15489334).Curated
Sequence conflicti189 – 1891D → E in AAH55834 (PubMed:15489334).Curated
Sequence conflicti270 – 2701F → L in AAH55834 (PubMed:15489334).Curated
Sequence conflicti354 – 3541A → T in AAH55834 (PubMed:15489334).Curated
Isoform 2 (identifier: Q9DBZ1-2)
Sequence conflicti197 – 1971G → E in AAH34890 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei97 – 373277LESTE…GTDEY → YQECEALVEQLKAFQIAAHL KLLQEEIHEMKTWSNRITER QGTLNNTLTRLSEDIIKVDQ GTASMAKDMGLKITSVKTDV RRISGLVTEVESLTDAVQAL GNKVKKVETATVENIGDLLS SSIDRTSALRKTASENAKRI DSVAQRLAELQGDFDEHTDR FLSLESDRAKVLKAVSFAND LKPKVSNLKKDFSRLEPLVD DLTLRIGRLGSDLMQREKEI AFLKEKISNLTVVQAAIKDI KDEITHISD in isoform 2. 2 PublicationsVSP_034411Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004670 mRNA. Translation: BAB23459.1. Frameshift.
AK006283 mRNA. Translation: BAB24502.1.
BC034890 mRNA. Translation: AAH34890.1.
BC055834 mRNA. Translation: AAH55834.1.
CCDSiCCDS24119.1. [Q9DBZ1-2]
CCDS36031.1. [Q9DBZ1-1]
RefSeqiNP_081354.1. NM_027078.2. [Q9DBZ1-2]
UniGeneiMm.252843.

Genome annotation databases

EnsembliENSMUST00000020150; ENSMUSP00000020150; ENSMUSG00000019975. [Q9DBZ1-2]
GeneIDi67454.
KEGGimmu:67454.
UCSCiuc007gtm.1. mouse. [Q9DBZ1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004670 mRNA. Translation: BAB23459.1. Frameshift.
AK006283 mRNA. Translation: BAB24502.1.
BC034890 mRNA. Translation: AAH34890.1.
BC055834 mRNA. Translation: AAH55834.1.
CCDSiCCDS24119.1. [Q9DBZ1-2]
CCDS36031.1. [Q9DBZ1-1]
RefSeqiNP_081354.1. NM_027078.2. [Q9DBZ1-2]
UniGeneiMm.252843.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212198. 7 interactions.
IntActiQ9DBZ1. 8 interactions.
STRINGi10090.ENSMUSP00000020149.

PTM databases

iPTMnetiQ9DBZ1.
PhosphoSiteiQ9DBZ1.

Proteomic databases

EPDiQ9DBZ1.
MaxQBiQ9DBZ1.
PaxDbiQ9DBZ1.
PRIDEiQ9DBZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020150; ENSMUSP00000020150; ENSMUSG00000019975. [Q9DBZ1-2]
GeneIDi67454.
KEGGimmu:67454.
UCSCiuc007gtm.1. mouse. [Q9DBZ1-2]

Organism-specific databases

CTDi121457.
MGIiMGI:1914704. Ikbip.

Phylogenomic databases

eggNOGiENOG410IJN2. Eukaryota.
ENOG410YFQ8. LUCA.
GeneTreeiENSGT00500000045001.
HOGENOMiHOG000113024.
HOVERGENiHBG108000.
InParanoidiQ9DBZ1.
OrthoDBiEOG7673B1.
PhylomeDBiQ9DBZ1.

Miscellaneous databases

PROiQ9DBZ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBZ1.
ExpressionAtlasiQ9DBZ1. baseline and differential.
GenevisibleiQ9DBZ1. MM.

Family and domain databases

InterProiIPR024152. Inh_kappa-B_kinase-int.
[Graphical view]
PANTHERiPTHR21734. PTHR21734. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiIKIP_MOUSE
AccessioniPrimary (citable) accession number: Q9DBZ1
Secondary accession number(s): Q7TMH1, Q8K1Z4, Q9DA09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shares a common promoter with APAF1 from which the 2 genes are transcribed in opposite directions.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.