Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9DBY8 (NVL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear valosin-containing protein-like

Short name=NVLp
Short name=Nuclear VCP-like protein
Gene names
Name:Nvl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length855 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with NCL/nucleolin. Ref.6

Subcellular location

Nucleusnucleolus Ref.6.

Sequence similarities

Belongs to the AAA ATPase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 855855Nuclear valosin-containing protein-like
PRO_0000084589

Regions

Nucleotide binding304 – 3118ATP Potential
Nucleotide binding621 – 6288ATP Potential
Motif49 – 524Nucleolar localization signal

Amino acid modifications

Modified residue701N6-acetyllysine Ref.5
Modified residue1331Phosphoserine By similarity
Modified residue1371Phosphothreonine By similarity
Modified residue1551N6-acetyllysine Ref.5
Modified residue1901Phosphoserine Ref.3 Ref.4
Modified residue2101Phosphoserine By similarity
Modified residue2141Phosphoserine By similarity

Experimental info

Sequence conflict5131E → K in AAH31847. Ref.2

Secondary structure

.......... 855
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9DBY8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F69A173AB40E0AE9

FASTA85594,476
        10         20         30         40         50         60 
MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR KRNAFRIQVE 

        70         80         90        100        110        120 
KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS DDDSNMEDYP DPQSANPMNS 

       130        140        150        160        170        180 
SLLSLYRRGN SESVSTTPKW GQREATTSTP LLTSKTGSVP LKTPARESEG GWFIDKTPGG 

       190        200        210        220        230        240 
KKESLPLDLS DDQSNSKKQD SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE 

       250        260        270        280        290        300 
IEALLQKKAK ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV 

       310        320        330        340        350        360 
LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD QAVSNAPCIV 

       370        380        390        400        410        420 
FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT ARVLVIGATN RPDSLDPALR 

       430        440        450        460        470        480 
RAGRFDREVC LGIPDEAARE RILQTLCRKL RLPETFNFCH LAHLTPGFVG ADLMALCREA 

       490        500        510        520        530        540 
AMCAVNRVLM KQQAQQKKKP EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL 

       550        560        570        580        590        600 
SEEQMQGLCI ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV 

       610        620        630        640        650        660 
RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL LNMYVGESER 

       670        680        690        700        710        720 
AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV VNQLLTEMDG LETRQQVFIL 

       730        740        750        760        770        780 
AATNRPDIID PAILRPGRLD KTLFVGLPPP ADRVAILKTI TKNGTKPPLD EDVNLETIAN 

       790        800        810        820        830        840 
DLRCNCYTGA DLTALVREAS LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI 

       850 
KDQVMYEALQ RSLSQ 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Lung and Ovary.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[6]"Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 1-74, SUBCELLULAR LOCATION, INTERACTION WITH NCL/NUCLEOLIN, NUCLEOLAR LOCALIZATION SIGNAL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004676 mRNA. Translation: BAB23464.1.
AK054502 mRNA. Translation: BAC35806.1.
AK140509 mRNA. Translation: BAE24409.1.
BC031847 mRNA. Translation: AAH31847.1.
CCDSCCDS15581.1.
RefSeqNP_080447.1. NM_026171.1.
UniGeneMm.263464.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RRENMR-A1-74[»]
ProteinModelPortalQ9DBY8.
SMRQ9DBY8. Positions 1-74, 250-853.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212203. 2 interactions.
IntActQ9DBY8. 1 interaction.
MINTMINT-4104517.

PTM databases

PhosphoSiteQ9DBY8.

Proteomic databases

MaxQBQ9DBY8.
PaxDbQ9DBY8.
PRIDEQ9DBY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027797; ENSMUSP00000027797; ENSMUSG00000026516.
GeneID67459.
KEGGmmu:67459.
UCSCuc007dxb.1. mouse.

Organism-specific databases

CTD4931.
MGIMGI:1914709. Nvl.

Phylogenomic databases

eggNOGCOG0464.
GeneTreeENSGT00570000079239.
HOGENOMHOG000223225.
HOVERGENHBG001226.
InParanoidQ9DBY8.
KOK14571.
OMAELHMCIV.
OrthoDBEOG72VH5H.
PhylomeDBQ9DBY8.
TreeFamTF314681.

Gene expression databases

ArrayExpressQ9DBY8.
BgeeQ9DBY8.
CleanExMM_NVL.
GenevestigatorQ9DBY8.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00004. AAA. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9DBY8.
NextBio324638.
PROQ9DBY8.
SOURCESearch...

Entry information

Entry nameNVL_MOUSE
AccessionPrimary (citable) accession number: Q9DBY8
Secondary accession number(s): Q3USC4, Q8BW27, Q8K2B5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot