Q9DBY8 (NVL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear valosin-containing protein-like
Short name=NVLp
Short name=Nuclear VCP-like protein

Gene names

Name:

Nvl

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	855 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with NCL/nucleolin. Ref.3
Subcellular location	Nucleus › nucleolus Ref.3.
Sequence similarities	Belongs to the AAA ATPase family.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	aggresome Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 855

855

Nuclear valosin-containing protein-like

PRO_0000084589

Regions

Nucleotide binding

304 – 311

8

ATP Potential

Nucleotide binding

621 – 628

8

ATP Potential

Motif

49 – 52

4

Nucleolar localization signal

Amino acid modifications

Modified residue

133

1

Phosphoserine By similarity

Modified residue

137

1

Phosphothreonine By similarity

Modified residue

210

1

Phosphoserine By similarity

Modified residue

214

1

Phosphoserine By similarity

Experimental info

Sequence conflict

513

1

E → K in AAH31847. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

855

Helix Strand Turn

Details...

Helix

11 – 23

13

Beta strand

27 – 29

3

Helix

32 – 42

11

Turn

43 – 47

5

Helix

52 – 69

18

Sequences

	Sequence		Length	Mass (Da)
	Q9DBY8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F69A173AB40E0AE9	FASTA	855	94,476
	10 20 30 40 50 60 MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR KRNAFRIQVE 70 80 90 100 110 120 KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS DDDSNMEDYP DPQSANPMNS 130 140 150 160 170 180 SLLSLYRRGN SESVSTTPKW GQREATTSTP LLTSKTGSVP LKTPARESEG GWFIDKTPGG 190 200 210 220 230 240 KKESLPLDLS DDQSNSKKQD SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE 250 260 270 280 290 300 IEALLQKKAK ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV 310 320 330 340 350 360 LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD QAVSNAPCIV 370 380 390 400 410 420 FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT ARVLVIGATN RPDSLDPALR 430 440 450 460 470 480 RAGRFDREVC LGIPDEAARE RILQTLCRKL RLPETFNFCH LAHLTPGFVG ADLMALCREA 490 500 510 520 530 540 AMCAVNRVLM KQQAQQKKKP EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL 550 560 570 580 590 600 SEEQMQGLCI ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV 610 620 630 640 650 660 RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL LNMYVGESER 670 680 690 700 710 720 AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV VNQLLTEMDG LETRQQVFIL 730 740 750 760 770 780 AATNRPDIID PAILRPGRLD KTLFVGLPPP ADRVAILKTI TKNGTKPPLD EDVNLETIAN 790 800 810 820 830 840 DLRCNCYTGA DLTALVREAS LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI 850 KDQVMYEALQ RSLSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Lung and Ovary.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal." Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H. J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 1-74, SUBCELLULAR LOCATION, INTERACTION WITH NCL/NUCLEOLIN, NUCLEOLAR LOCALIZATION SIGNAL.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK004676 mRNA. Translation: BAB23464.1.
AK054502 mRNA. Translation: BAC35806.1.
AK140509 mRNA. Translation: BAE24409.1.
BC031847 mRNA. Translation: AAH31847.1.

IPI

IPI00321884.

RefSeq

NP_080447.1. NM_026171.1.

UniGene

Mm.263464.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2RRE	NMR	-	A	1-74	[»]

ProteinModelPortal

Q9DBY8.

SMR

Q9DBY8. Positions 1-74, 250-853.

ModBase

Search...

PTM databases

PhosphoSite

Q9DBY8.

Proteomic databases

PaxDb

Q9DBY8.

PRIDE

Q9DBY8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000027797; ENSMUSP00000027797; ENSMUSG00000026516.

GeneID

67459.

KEGG

mmu:67459.

UCSC

uc007dxb.1. mouse.

Organism-specific databases

CTD

4931.

MGI

MGI:1914709. Nvl.

Phylogenomic databases

eggNOG

COG0464.

GeneTree

ENSGT00570000079239.

HOGENOM

HOG000223225.

HOVERGEN

HBG001226.

InParanoid

Q9DBY8.

KO

K14571.

OMA

NDMTLKE.

OrthoDB

EOG4ZPDTN.

Gene expression databases

ArrayExpress

Q9DBY8.

Bgee

Q9DBY8.

CleanEx

MM_NVL.

Genevestigator

Q9DBY8.

GermOnline

ENSMUSG00000026516. Mus musculus.

Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
[Graphical view]

Pfam

PF00004. AAA. 2 hits.
[Graphical view]

SMART

SM00382. AAA. 2 hits.
[Graphical view]

PROSITE

PS00674. AAA. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9DBY8.

NextBio

324638.

SOURCE

Search...

Entry information

Entry name

NVL_MOUSE

Accession

Primary (citable) accession number: Q9DBY8
Secondary accession number(s): Q3USC4, Q8BW27, Q8K2B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program