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Q9DBY8

- NVL_MOUSE

UniProt

Q9DBY8 - NVL_MOUSE

Protein

Nuclear valosin-containing protein-like

Gene

Nvl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi304 – 3118ATPSequence Analysis
    Nucleotide bindingi621 – 6288ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear valosin-containing protein-like
    Short name:
    NVLp
    Short name:
    Nuclear VCP-like protein
    Gene namesi
    Name:Nvl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914709. Nvl.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. aggresome Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 855855Nuclear valosin-containing protein-likePRO_0000084589Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701N6-acetyllysine1 Publication
    Modified residuei133 – 1331PhosphoserineBy similarity
    Modified residuei137 – 1371PhosphothreonineBy similarity
    Modified residuei155 – 1551N6-acetyllysine1 Publication
    Modified residuei190 – 1901Phosphoserine2 Publications
    Modified residuei210 – 2101PhosphoserineBy similarity
    Modified residuei214 – 2141PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9DBY8.
    PaxDbiQ9DBY8.
    PRIDEiQ9DBY8.

    PTM databases

    PhosphoSiteiQ9DBY8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9DBY8.
    BgeeiQ9DBY8.
    CleanExiMM_NVL.
    GenevestigatoriQ9DBY8.

    Interactioni

    Subunit structurei

    Interacts with NCL/nucleolin.1 Publication

    Protein-protein interaction databases

    BioGridi212203. 2 interactions.
    IntActiQ9DBY8. 1 interaction.
    MINTiMINT-4104517.

    Structurei

    Secondary structure

    1
    855
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 2313
    Beta strandi27 – 293
    Helixi32 – 4211
    Turni43 – 475
    Helixi52 – 6918

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2RRENMR-A1-74[»]
    ProteinModelPortaliQ9DBY8.
    SMRiQ9DBY8. Positions 1-74, 250-853.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9DBY8.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi49 – 524Nucleolar localization signal

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00570000079239.
    HOGENOMiHOG000223225.
    HOVERGENiHBG001226.
    InParanoidiQ9DBY8.
    KOiK14571.
    OMAiELHMCIV.
    OrthoDBiEOG72VH5H.
    PhylomeDBiQ9DBY8.
    TreeFamiTF314681.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS00674. AAA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9DBY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR    50
    KRNAFRIQVE KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS 100
    DDDSNMEDYP DPQSANPMNS SLLSLYRRGN SESVSTTPKW GQREATTSTP 150
    LLTSKTGSVP LKTPARESEG GWFIDKTPGG KKESLPLDLS DDQSNSKKQD 200
    SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE IEALLQKKAK 250
    ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV 300
    LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD 350
    QAVSNAPCIV FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT 400
    ARVLVIGATN RPDSLDPALR RAGRFDREVC LGIPDEAARE RILQTLCRKL 450
    RLPETFNFCH LAHLTPGFVG ADLMALCREA AMCAVNRVLM KQQAQQKKKP 500
    EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL SEEQMQGLCI 550
    ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV 600
    RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL 650
    LNMYVGESER AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV 700
    VNQLLTEMDG LETRQQVFIL AATNRPDIID PAILRPGRLD KTLFVGLPPP 750
    ADRVAILKTI TKNGTKPPLD EDVNLETIAN DLRCNCYTGA DLTALVREAS 800
    LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI KDQVMYEALQ 850
    RSLSQ 855
    Length:855
    Mass (Da):94,476
    Last modified:June 1, 2001 - v1
    Checksum:iF69A173AB40E0AE9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti513 – 5131E → K in AAH31847. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004676 mRNA. Translation: BAB23464.1.
    AK054502 mRNA. Translation: BAC35806.1.
    AK140509 mRNA. Translation: BAE24409.1.
    BC031847 mRNA. Translation: AAH31847.1.
    CCDSiCCDS15581.1.
    RefSeqiNP_080447.1. NM_026171.1.
    UniGeneiMm.263464.

    Genome annotation databases

    EnsembliENSMUST00000027797; ENSMUSP00000027797; ENSMUSG00000026516.
    GeneIDi67459.
    KEGGimmu:67459.
    UCSCiuc007dxb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004676 mRNA. Translation: BAB23464.1 .
    AK054502 mRNA. Translation: BAC35806.1 .
    AK140509 mRNA. Translation: BAE24409.1 .
    BC031847 mRNA. Translation: AAH31847.1 .
    CCDSi CCDS15581.1.
    RefSeqi NP_080447.1. NM_026171.1.
    UniGenei Mm.263464.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2RRE NMR - A 1-74 [» ]
    ProteinModelPortali Q9DBY8.
    SMRi Q9DBY8. Positions 1-74, 250-853.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212203. 2 interactions.
    IntActi Q9DBY8. 1 interaction.
    MINTi MINT-4104517.

    PTM databases

    PhosphoSitei Q9DBY8.

    Proteomic databases

    MaxQBi Q9DBY8.
    PaxDbi Q9DBY8.
    PRIDEi Q9DBY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027797 ; ENSMUSP00000027797 ; ENSMUSG00000026516 .
    GeneIDi 67459.
    KEGGi mmu:67459.
    UCSCi uc007dxb.1. mouse.

    Organism-specific databases

    CTDi 4931.
    MGIi MGI:1914709. Nvl.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00570000079239.
    HOGENOMi HOG000223225.
    HOVERGENi HBG001226.
    InParanoidi Q9DBY8.
    KOi K14571.
    OMAi ELHMCIV.
    OrthoDBi EOG72VH5H.
    PhylomeDBi Q9DBY8.
    TreeFami TF314681.

    Miscellaneous databases

    EvolutionaryTracei Q9DBY8.
    NextBioi 324638.
    PROi Q9DBY8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DBY8.
    Bgeei Q9DBY8.
    CleanExi MM_NVL.
    Genevestigatori Q9DBY8.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS00674. AAA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Lung and Ovary.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    6. "Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
      Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
      J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-74, SUBCELLULAR LOCATION, INTERACTION WITH NCL/NUCLEOLIN, NUCLEOLAR LOCALIZATION SIGNAL.

    Entry informationi

    Entry nameiNVL_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBY8
    Secondary accession number(s): Q3USC4, Q8BW27, Q8K2B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3