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Q9DBY8

- NVL_MOUSE

UniProt

Q9DBY8 - NVL_MOUSE

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Protein
Nuclear valosin-containing protein-like
Gene
Nvl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi304 – 3118ATP Reviewed prediction
Nucleotide bindingi621 – 6288ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear valosin-containing protein-like
Short name:
NVLp
Short name:
Nuclear VCP-like protein
Gene namesi
Name:Nvl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914709. Nvl.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Nuclear valosin-containing protein-like
PRO_0000084589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701N6-acetyllysine1 Publication
Modified residuei133 – 1331Phosphoserine By similarity
Modified residuei137 – 1371Phosphothreonine By similarity
Modified residuei155 – 1551N6-acetyllysine1 Publication
Modified residuei190 – 1901Phosphoserine2 Publications
Modified residuei210 – 2101Phosphoserine By similarity
Modified residuei214 – 2141Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9DBY8.
PaxDbiQ9DBY8.
PRIDEiQ9DBY8.

PTM databases

PhosphoSiteiQ9DBY8.

Expressioni

Gene expression databases

ArrayExpressiQ9DBY8.
BgeeiQ9DBY8.
CleanExiMM_NVL.
GenevestigatoriQ9DBY8.

Interactioni

Subunit structurei

Interacts with NCL/nucleolin.1 Publication

Protein-protein interaction databases

BioGridi212203. 2 interactions.
IntActiQ9DBY8. 1 interaction.
MINTiMINT-4104517.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2313
Beta strandi27 – 293
Helixi32 – 4211
Turni43 – 475
Helixi52 – 6918

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RRENMR-A1-74[»]
ProteinModelPortaliQ9DBY8.
SMRiQ9DBY8. Positions 1-74, 250-853.

Miscellaneous databases

EvolutionaryTraceiQ9DBY8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi49 – 524Nucleolar localization signal

Sequence similaritiesi

Belongs to the AAA ATPase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00570000079239.
HOGENOMiHOG000223225.
HOVERGENiHBG001226.
InParanoidiQ9DBY8.
KOiK14571.
OMAiELHMCIV.
OrthoDBiEOG72VH5H.
PhylomeDBiQ9DBY8.
TreeFamiTF314681.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBY8-1 [UniParc]FASTAAdd to Basket

« Hide

MKPRPGVFVD RKLKQRVIQY LSSNRCGKYV DTGILASDLQ RLYSVDYGRR    50
KRNAFRIQVE KVFSIISSEK ELKNLKELED GHLAKRARQD EEDEYTESYS 100
DDDSNMEDYP DPQSANPMNS SLLSLYRRGN SESVSTTPKW GQREATTSTP 150
LLTSKTGSVP LKTPARESEG GWFIDKTPGG KKESLPLDLS DDQSNSKKQD 200
SEIQILKDSS LLESDKKRKG RAKGKGNKRK TENLQEVDGE IEALLQKKAK 250
ARSTELQISN VKFEDVGGND ATLKEVCKML IHMRHPEVYQ HLGVVPPRGV 300
LLHGPPGCGK TLLAHAIAGE LDLPILKVAA PEIVSGVSGE SEQKLRELFD 350
QAVSNAPCIV FIDEIDAITP KREVASKDME RRIVAQLLTC MDDLNNVAAT 400
ARVLVIGATN RPDSLDPALR RAGRFDREVC LGIPDEAARE RILQTLCRKL 450
RLPETFNFCH LAHLTPGFVG ADLMALCREA AMCAVNRVLM KQQAQQKKKP 500
EIEGLPSEGD QEERLGAEPT SETQDELQRL LGLLRDQDPL SEEQMQGLCI 550
ELNDFIVALA EVQPSAKREG FVTVPNVTWA DIGALEDIRD ELIMAILAPV 600
RNPDQFRTLG LGTPAGILLA GPPGCGKTLL AKAVANESGL NFISVKGPEL 650
LNMYVGESER AVRQVFQRAK NSAPCVIFFD EVDALCPRRS DRETGASVRV 700
VNQLLTEMDG LETRQQVFIL AATNRPDIID PAILRPGRLD KTLFVGLPPP 750
ADRVAILKTI TKNGTKPPLD EDVNLETIAN DLRCNCYTGA DLTALVREAS 800
LCALRQEITA QKNGVGAGEL KVSHKHFEDA FKKVKPSISI KDQVMYEALQ 850
RSLSQ 855
Length:855
Mass (Da):94,476
Last modified:June 1, 2001 - v1
Checksum:iF69A173AB40E0AE9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti513 – 5131E → K in AAH31847. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004676 mRNA. Translation: BAB23464.1.
AK054502 mRNA. Translation: BAC35806.1.
AK140509 mRNA. Translation: BAE24409.1.
BC031847 mRNA. Translation: AAH31847.1.
CCDSiCCDS15581.1.
RefSeqiNP_080447.1. NM_026171.1.
UniGeneiMm.263464.

Genome annotation databases

EnsembliENSMUST00000027797; ENSMUSP00000027797; ENSMUSG00000026516.
GeneIDi67459.
KEGGimmu:67459.
UCSCiuc007dxb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004676 mRNA. Translation: BAB23464.1 .
AK054502 mRNA. Translation: BAC35806.1 .
AK140509 mRNA. Translation: BAE24409.1 .
BC031847 mRNA. Translation: AAH31847.1 .
CCDSi CCDS15581.1.
RefSeqi NP_080447.1. NM_026171.1.
UniGenei Mm.263464.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RRE NMR - A 1-74 [» ]
ProteinModelPortali Q9DBY8.
SMRi Q9DBY8. Positions 1-74, 250-853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212203. 2 interactions.
IntActi Q9DBY8. 1 interaction.
MINTi MINT-4104517.

PTM databases

PhosphoSitei Q9DBY8.

Proteomic databases

MaxQBi Q9DBY8.
PaxDbi Q9DBY8.
PRIDEi Q9DBY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027797 ; ENSMUSP00000027797 ; ENSMUSG00000026516 .
GeneIDi 67459.
KEGGi mmu:67459.
UCSCi uc007dxb.1. mouse.

Organism-specific databases

CTDi 4931.
MGIi MGI:1914709. Nvl.

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00570000079239.
HOGENOMi HOG000223225.
HOVERGENi HBG001226.
InParanoidi Q9DBY8.
KOi K14571.
OMAi ELHMCIV.
OrthoDBi EOG72VH5H.
PhylomeDBi Q9DBY8.
TreeFami TF314681.

Miscellaneous databases

EvolutionaryTracei Q9DBY8.
NextBioi 324638.
PROi Q9DBY8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DBY8.
Bgeei Q9DBY8.
CleanExi MM_NVL.
Genevestigatori Q9DBY8.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Lung and Ovary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  6. "Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal."
    Fujiwara Y., Fujiwara K., Goda N., Iwaya N., Tenno T., Shirakawa M., Hiroaki H.
    J. Biol. Chem. 286:21732-21741(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-74, SUBCELLULAR LOCATION, INTERACTION WITH NCL/NUCLEOLIN, NUCLEOLAR LOCALIZATION SIGNAL.

Entry informationi

Entry nameiNVL_MOUSE
AccessioniPrimary (citable) accession number: Q9DBY8
Secondary accession number(s): Q3USC4, Q8BW27, Q8K2B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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