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Protein

Chromobox protein homolog 6

Gene

Cbx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).By similarity

GO - Molecular functioni

  • single-stranded RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 6
Gene namesi
Name:Cbx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3512628. Cbx6.

Subcellular locationi

GO - Cellular componenti

  • heterochromatin Source: UniProtKB
  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Chromobox protein homolog 6PRO_0000080211Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei107 – 1071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DBY5.
MaxQBiQ9DBY5.
PaxDbiQ9DBY5.
PeptideAtlasiQ9DBY5.
PRIDEiQ9DBY5.

PTM databases

iPTMnetiQ9DBY5.
PhosphoSiteiQ9DBY5.

Expressioni

Gene expression databases

BgeeiQ9DBY5.
ExpressionAtlasiQ9DBY5. baseline and differential.
GenevisibleiQ9DBY5. MM.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi243462. 3 interactions.
STRINGi10090.ENSMUSP00000105255.

Structurei

3D structure databases

ProteinModelPortaliQ9DBY5.
SMRiQ9DBY5. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6959ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000013217.
HOVERGENiHBG003608.
InParanoidiQ9DBY5.
KOiK11453.
OMAiTIKEFCS.
OrthoDBiEOG77T15B.
PhylomeDBiQ9DBY5.
TreeFamiTF106456.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD
60 70 80 90 100
SRLIAAFEQK ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK
110 120 130 140 150
PSASASSPKL HSSAAVHRLK KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI
160 170 180 190 200
SPFSETVRII NRKVKPREPK RNRIILNLKV IDKGPGGGST AQGTGALARP
210 220 230 240 250
KVPSRNRVIG KSKKFSESML RTQIRHMKFG TFALYKPPPA PLAPSTAGKA
260 270 280 290 300
DVASSGPGLL LATPAAAPFD AHSSSSSGCP SPTLQSSDPD DAPPKLLPET
310 320 330 340 350
LSRSVPNWRE SEVLDLSIPP EAAATGQRVP PDVTGAADQA LHTALEPTGA
360 370 380 390 400
GSSEPEAGDW RPEMSPCSNV VVTDVTSNLL TVTIKEFCSP EDFEKVAAGV
410
AGATGGGGGT GPSK
Length:414
Mass (Da):44,460
Last modified:June 7, 2004 - v2
Checksum:i299347436FC04629
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231Q → P in BAB23467 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004679 mRNA. Translation: BAB23467.1.
AK035250 mRNA. Translation: BAC29001.1.
BC048240 mRNA. Translation: AAH48240.1.
CCDSiCCDS37142.1.
RefSeqiNP_083039.2. NM_028763.3.
UniGeneiMm.38438.

Genome annotation databases

EnsembliENSMUST00000109627; ENSMUSP00000105255; ENSMUSG00000089715.
GeneIDi494448.
KEGGimmu:494448.
UCSCiuc007wuo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004679 mRNA. Translation: BAB23467.1.
AK035250 mRNA. Translation: BAC29001.1.
BC048240 mRNA. Translation: AAH48240.1.
CCDSiCCDS37142.1.
RefSeqiNP_083039.2. NM_028763.3.
UniGeneiMm.38438.

3D structure databases

ProteinModelPortaliQ9DBY5.
SMRiQ9DBY5. Positions 8-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi243462. 3 interactions.
STRINGi10090.ENSMUSP00000105255.

PTM databases

iPTMnetiQ9DBY5.
PhosphoSiteiQ9DBY5.

Proteomic databases

EPDiQ9DBY5.
MaxQBiQ9DBY5.
PaxDbiQ9DBY5.
PeptideAtlasiQ9DBY5.
PRIDEiQ9DBY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109627; ENSMUSP00000105255; ENSMUSG00000089715.
GeneIDi494448.
KEGGimmu:494448.
UCSCiuc007wuo.1. mouse.

Organism-specific databases

CTDi23466.
MGIiMGI:3512628. Cbx6.

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG41122KC. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000013217.
HOVERGENiHBG003608.
InParanoidiQ9DBY5.
KOiK11453.
OMAiTIKEFCS.
OrthoDBiEOG77T15B.
PhylomeDBiQ9DBY5.
TreeFamiTF106456.

Enzyme and pathway databases

ReactomeiR-MMU-2559580. Oxidative Stress Induced Senescence.

Miscellaneous databases

PROiQ9DBY5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBY5.
ExpressionAtlasiQ9DBY5. baseline and differential.
GenevisibleiQ9DBY5. MM.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Urinary bladder.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiCBX6_MOUSE
AccessioniPrimary (citable) accession number: Q9DBY5
Secondary accession number(s): Q8BZH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 7, 2004
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.