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Protein

Chromobox protein homolog 6

Gene

Cbx6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion (PubMed:22226355, PubMed:16537902). May have a PRC1-independent function in embryonic stem cells (PubMed:22226355).By similarity2 Publications

GO - Molecular functioni

  • single-stranded RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
R-MMU-8943724 Regulation of PTEN gene transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 6
Gene namesi
Name:Cbx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3512628 Cbx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802111 – 414Chromobox protein homolog 6Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei107PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBY5
PaxDbiQ9DBY5
PeptideAtlasiQ9DBY5
PRIDEiQ9DBY5

PTM databases

iPTMnetiQ9DBY5
PhosphoSitePlusiQ9DBY5

Expressioni

Tissue specificityi

Expressed in mouse embryonic stem cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000089715
ExpressionAtlasiQ9DBY5 baseline and differential
GenevisibleiQ9DBY5 MM

Interactioni

Subunit structurei

Component of a PRC1-like complex. Distinct PRC1-like core complexes are composed of a RING1 subunit (RING1B or RING1A), one of the six PCGF proteins (PCGF1-6), one PHC protein (PHC1-3) and one of the CBX proteins (CBX2, CBX4, CBX6, CBX7 or CBX8). Interacts with PCGF1, PCGF2, PCGF3, BMI1, PCGF5, PCGF6, RING1 and RNF2. May interact with HIST2H3A and HIST1H3A (By similarity). Interacts (via chromodomain) with single-stranded RNA (ssRNA) (PubMed:16537902).By similarity1 Publication

Protein-protein interaction databases

BioGridi243462, 5 interactors
STRINGi10090.ENSMUSP00000105255

Structurei

3D structure databases

ProteinModelPortaliQ9DBY5
SMRiQ9DBY5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiKOG2748 Eukaryota
ENOG41122KC LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000013217
HOVERGENiHBG003608
InParanoidiQ9DBY5
KOiK11453
OMAiETQNASC
OrthoDBiEOG091G0AFX
PhylomeDBiQ9DBY5
TreeFamiTF106456

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAVGERV FAAESIIKRR IRKGRIEYLV KWKGWAIKYS TWEPEENILD
60 70 80 90 100
SRLIAAFEQK ERERELYGPK KRGPKPKTFL LKARAQAEAL RISDVHFSVK
110 120 130 140 150
PSASASSPKL HSSAAVHRLK KDIRRCHRMS RRPLPRPDPQ GGSPGLRPPI
160 170 180 190 200
SPFSETVRII NRKVKPREPK RNRIILNLKV IDKGPGGGST AQGTGALARP
210 220 230 240 250
KVPSRNRVIG KSKKFSESML RTQIRHMKFG TFALYKPPPA PLAPSTAGKA
260 270 280 290 300
DVASSGPGLL LATPAAAPFD AHSSSSSGCP SPTLQSSDPD DAPPKLLPET
310 320 330 340 350
LSRSVPNWRE SEVLDLSIPP EAAATGQRVP PDVTGAADQA LHTALEPTGA
360 370 380 390 400
GSSEPEAGDW RPEMSPCSNV VVTDVTSNLL TVTIKEFCSP EDFEKVAAGV
410
AGATGGGGGT GPSK
Length:414
Mass (Da):44,460
Last modified:June 7, 2004 - v2
Checksum:i299347436FC04629
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223Q → P in BAB23467 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004679 mRNA Translation: BAB23467.1
AK035250 mRNA Translation: BAC29001.1
BC048240 mRNA Translation: AAH48240.1
CCDSiCCDS37142.1
RefSeqiNP_083039.2, NM_028763.3
UniGeneiMm.38438

Genome annotation databases

EnsembliENSMUST00000109627; ENSMUSP00000105255; ENSMUSG00000089715
GeneIDi494448
KEGGimmu:494448
UCSCiuc007wuo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCBX6_MOUSE
AccessioniPrimary (citable) accession number: Q9DBY5
Secondary accession number(s): Q8BZH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health