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Q9DBY0

- FOXP4_MOUSE

UniProt

Q9DBY0 - FOXP4_MOUSE

Protein

Forkhead box protein P4

Gene

Foxp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that represses lung-specific expression.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri312 – 33726C2H2-typeSequence AnalysisAdd
    BLAST
    DNA bindingi459 – 54991Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. protein heterodimerization activity Source: MGI
    4. protein homodimerization activity Source: MGI
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. embryonic foregut morphogenesis Source: MGI
    2. heart development Source: MGI
    3. lung secretory cell differentiation Source: MGI
    4. negative regulation of lung goblet cell differentiation Source: MGI
    5. negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    6. regulation of lung goblet cell differentiation Source: MGI

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein P4
    Alternative name(s):
    Fork head-related protein-like A
    Short name:
    mFKHLA
    Gene namesi
    Name:Foxp4Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1921373. Foxp4.

    Subcellular locationi

    Nucleus CuratedSequence Analysis

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi366 – 3661Missing: Loss of dimerization. Almost complete loss of DNA-binding. Reduced transcriptional repression activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 795795Forkhead box protein P4PRO_0000247653Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei98 – 981PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9DBY0.
    PRIDEiQ9DBY0.

    PTM databases

    PhosphoSiteiQ9DBY0.

    Expressioni

    Tissue specificityi

    Expressed in the adult heart, brain, spleen lung, liver, kidney and testes.2 Publications

    Developmental stagei

    Expressed predominantly in the lung and brain during embryogenesis. Expressed in the lung epithelium and the mesenchyme immediately adjacent to the epithelium from 10.5 dpc. At 9.5 dpc, expressed in the foregut endoderm but not in the heart. At 16.5 and 18.5 dpc, expressed in both the proximal and distal airway epithelium. Also expressed in the developing gut. In the hindgut, primarily expressed in epithelial cells of the intestine and stomach. Expressed in the brain in a dynamic pattern. At 14.5 dpc, expressed at high levels in the intermediate zone of the neopallial cortex with lower levels in the surrounding cells. By 16.5 dpc, no longer expressed in the intermediate zone, but still present in the surrounding cells of the neopallial cortex.2 Publications

    Gene expression databases

    ArrayExpressiQ9DBY0.
    BgeeiQ9DBY0.
    CleanExiMM_FOXP4.
    GenevestigatoriQ9DBY0.

    Interactioni

    Subunit structurei

    Forms homodimers and heterodimers with FOXP1 and FOXP2. Dimerization is required for DNA-binding.1 Publication

    Protein-protein interaction databases

    BioGridi216509. 2 interactions.
    IntActiQ9DBY0. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9DBY0.
    SMRiQ9DBY0. Positions 317-375, 458-539.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni354 – 37522Leucine-zipperAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi71 – 225155Gln-richSequence AnalysisAdd
    BLAST
    Compositional biasi603 – 724122Pro-richSequence AnalysisAdd
    BLAST

    Domaini

    The leucine-zipper is required for dimerization and transcriptional repression.1 Publication

    Sequence similaritiesi

    Contains 1 C2H2-type zinc finger.Sequence Analysis
    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri312 – 33726C2H2-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5025.
    GeneTreeiENSGT00750000117475.
    HOGENOMiHOG000092089.
    HOVERGENiHBG051657.
    InParanoidiQ9DBY0.
    KOiK09409.
    OrthoDBiEOG7M6D7G.
    PhylomeDBiQ9DBY0.
    TreeFamiTF326978.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q9DBY0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE    50
    AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ 100
    SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE 150
    YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL 200
    LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG 250
    RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE 300
    ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ 350
    MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPVT VSADPFPDGL 400
    VHPPTSAAAP VTPLRPPGLG SASLHSGGPA RRRSNDKFCS PISSELAQNH 450
    EFYKNADVRP PFTYASLIRQ AILETPDRQL TLNEIYNWFT RMFAYFRRNT 500
    ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEREYQKRRP PKMTGSPTLV 550
    KNMISGLSYG ALNASYQAAL AESSFPLLSN PGMLNPGSAS SLLPLSQEDL 600
    GVPGEPLPSN GSSSPPRLSP PQYSHQIQVK EEPAEAEEDR RPGPPLGAPN 650
    PSTVGPPEDR DLEEDLGGED MPSQPCPLIP GWKPSLLHLS YCVKPKFTVS 700
    VGSKTPSSPL PPPPRVQGSY SLPPCSYLAY GDMRGQNPAP SPGLLSGVGG 750
    GLFRCLHRTK SPSLPGVWIL AAELETMRFH RPPMGDPQPK TADWV 795

    Note: No experimental confirmation available.Curated

    Length:795
    Mass (Da):85,981
    Last modified:June 1, 2001 - v1
    Checksum:i860AE60AAD3742CE
    GO
    Isoform 21 Publication (identifier: Q9DBY0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         672-672: P → S
         673-795: Missing.

    Show »
    Length:672
    Mass (Da):72,759
    Checksum:i8B89F59EF85FC768
    GO
    Isoform 31 Publication (identifier: Q9DBY0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         388-388: P → PLNPVPGSSSFSK
         672-672: P → S
         673-795: Missing.

    Show »
    Length:684
    Mass (Da):73,960
    Checksum:iA7CFBE31E1C09A09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti226 – 2261A → AA in AAN08624. 1 PublicationCurated
    Sequence conflicti226 – 2261A → AA in AAH43702. (PubMed:15489334)Curated
    Sequence conflicti226 – 2261A → AA in AAH52407. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei388 – 3881P → PLNPVPGSSSFSK in isoform 3. 2 PublicationsVSP_052129
    Alternative sequencei672 – 6721P → S in isoform 2 and isoform 3. 3 PublicationsVSP_052130
    Alternative sequencei673 – 795123Missing in isoform 2 and isoform 3. 3 PublicationsVSP_052131Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135029 mRNA. Translation: AAN08624.1.
    AB052766 mRNA. Translation: BAC53799.1.
    AK004693 mRNA. Translation: BAB23479.1.
    BC043702 mRNA. Translation: AAH43702.1.
    BC052407 mRNA. Translation: AAH52407.1.
    BC057110 mRNA. Translation: AAH57110.1.
    CCDSiCCDS50135.1. [Q9DBY0-2]
    RefSeqiNP_001104294.1. NM_001110824.1.
    NP_001104295.1. NM_001110825.1.
    NP_083043.2. NM_028767.2. [Q9DBY0-2]
    XP_006525079.1. XM_006525016.1.
    XP_006525080.1. XM_006525017.1. [Q9DBY0-3]
    UniGeneiMm.240062.

    Genome annotation databases

    EnsembliENSMUST00000097311; ENSMUSP00000094916; ENSMUSG00000023991.
    ENSMUST00000113262; ENSMUSP00000108887; ENSMUSG00000023991.
    ENSMUST00000113265; ENSMUSP00000108890; ENSMUSG00000023991. [Q9DBY0-2]
    GeneIDi74123.
    KEGGimmu:74123.
    UCSCiuc008cwm.2. mouse. [Q9DBY0-3]
    uc008cwn.2. mouse. [Q9DBY0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY135029 mRNA. Translation: AAN08624.1 .
    AB052766 mRNA. Translation: BAC53799.1 .
    AK004693 mRNA. Translation: BAB23479.1 .
    BC043702 mRNA. Translation: AAH43702.1 .
    BC052407 mRNA. Translation: AAH52407.1 .
    BC057110 mRNA. Translation: AAH57110.1 .
    CCDSi CCDS50135.1. [Q9DBY0-2 ]
    RefSeqi NP_001104294.1. NM_001110824.1.
    NP_001104295.1. NM_001110825.1.
    NP_083043.2. NM_028767.2. [Q9DBY0-2 ]
    XP_006525079.1. XM_006525016.1.
    XP_006525080.1. XM_006525017.1. [Q9DBY0-3 ]
    UniGenei Mm.240062.

    3D structure databases

    ProteinModelPortali Q9DBY0.
    SMRi Q9DBY0. Positions 317-375, 458-539.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216509. 2 interactions.
    IntActi Q9DBY0. 1 interaction.

    PTM databases

    PhosphoSitei Q9DBY0.

    Proteomic databases

    MaxQBi Q9DBY0.
    PRIDEi Q9DBY0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097311 ; ENSMUSP00000094916 ; ENSMUSG00000023991 .
    ENSMUST00000113262 ; ENSMUSP00000108887 ; ENSMUSG00000023991 .
    ENSMUST00000113265 ; ENSMUSP00000108890 ; ENSMUSG00000023991 . [Q9DBY0-2 ]
    GeneIDi 74123.
    KEGGi mmu:74123.
    UCSCi uc008cwm.2. mouse. [Q9DBY0-3 ]
    uc008cwn.2. mouse. [Q9DBY0-2 ]

    Organism-specific databases

    CTDi 116113.
    MGIi MGI:1921373. Foxp4.

    Phylogenomic databases

    eggNOGi COG5025.
    GeneTreei ENSGT00750000117475.
    HOGENOMi HOG000092089.
    HOVERGENi HBG051657.
    InParanoidi Q9DBY0.
    KOi K09409.
    OrthoDBi EOG7M6D7G.
    PhylomeDBi Q9DBY0.
    TreeFami TF326978.

    Miscellaneous databases

    ChiTaRSi FOXP4. mouse.
    NextBioi 339838.
    PROi Q9DBY0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9DBY0.
    Bgeei Q9DBY0.
    CleanExi MM_FOXP4.
    Genevestigatori Q9DBY0.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues."
      Lu M.M., Li S., Yang H., Morrisey E.E.
      Mech. Dev. 119:S197-S202(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6Imported.
      Tissue: Lung1 Publication.
    2. "Isolation and characterization of novel human and mouse genes, which are expressed in the digestive tract."
      Daigo Y., Takayama I., Fujino M.A.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6JImported.
      Tissue: LungImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: C57BL/6Imported and FVB/NImported.
      Tissue: BrainImported and Mammary gland1 Publication.
    5. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    6. "Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions."
      Li S., Weidenfeld J., Morrisey E.E.
      Mol. Cell. Biol. 24:809-822(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DIMERIZATION, DOMAIN, MUTAGENESIS OF GLU-366.

    Entry informationi

    Entry nameiFOXP4_MOUSE
    AccessioniPrimary (citable) accession number: Q9DBY0
    Secondary accession number(s): Q80V92, Q8CG10, Q8CIS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3