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Protein

Cytochrome P450 2S1

Gene

Cyp2s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a potential importance for extrahepatic xenobiotic metabolism.By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi441Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211958 Miscellaneous substrates
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2S1 (EC:1.14.14.1)
Alternative name(s):
CYPIIS1
Gene namesi
Name:Cyp2s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921384 Cyp2s1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517811 – 501Cytochrome P450 2S1Add BLAST501

Proteomic databases

MaxQBiQ9DBX6
PaxDbiQ9DBX6
PeptideAtlasiQ9DBX6
PRIDEiQ9DBX6

PTM databases

iPTMnetiQ9DBX6
PhosphoSitePlusiQ9DBX6

Expressioni

Gene expression databases

BgeeiENSMUSG00000040703
ExpressionAtlasiQ9DBX6 baseline and differential
GenevisibleiQ9DBX6 MM

Interactioni

Protein-protein interaction databases

IntActiQ9DBX6, 1 interactor
MINTiQ9DBX6
STRINGi10090.ENSMUSP00000041175

Structurei

3D structure databases

ProteinModelPortaliQ9DBX6
SMRiQ9DBX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00900000140831
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiQ9DBX6
KOiK07420
OMAiQLRKFTM
OrthoDBiEOG091G0BT8
PhylomeDBiQ9DBX6
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR002401 Cyt_P450_E_grp-I
IPR008067 Cyt_P450_E_grp-I_CYP2A-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01684 EP450ICYP2A
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAASTWALL LALLLLLLLL SLTLFRTPAR GYLPPGPTPL PLLGNLLQLR
60 70 80 90 100
PGALYSGLLR LSKKYGPVFT VYLGPWRRVV VLVGHDAVRE ALGGQAEEFS
110 120 130 140 150
GRGTLATLDK TFDGHGVFFA NGERWKQLRK FTLLALRDLG MGKREGEELI
160 170 180 190 200
QAEVQSLVEA FQKTEGRPFN PSMLLAQATS NVVCSLVFGI RLPYDDKEFQ
210 220 230 240 250
AVIQAASGTL LGISSPWGQA YEMFSWLLQP LPGPHTQLQH HLGTLAAFTI
260 270 280 290 300
QQVQKHQGRF QTSGPARDVV DAFLLKMAQE KQDPGTEFTE KNLLMTVTYL
310 320 330 340 350
LFAGTMTIGA TIRYALLLLL RYPQVQQRVR EELIQELGPG RAPSLSDRVR
360 370 380 390 400
LPYTDAVLHE AQRLLALVPM GMPHTITRTT CFRGYTLPKG TEVFPLIGSI
410 420 430 440 450
LHDPAVFQNP GEFHPGRFLD EDGRLRKHEA FLPYSLGKRV CLGEGLARAE
460 470 480 490 500
LWLFFTSILQ AFSLETPCPP GDLSLKPAIS GLFNIPPDFQ LRVWPTGDQS

R
Length:501
Mass (Da):55,632
Last modified:June 1, 2001 - v1
Checksum:iD12575F3F8D7B019
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004699 mRNA Translation: BAB23484.1
AK087069 mRNA Translation: BAC39794.1
BC064733 mRNA Translation: AAH64733.1
CCDSiCCDS20997.1
RefSeqiNP_083051.1, NM_028775.3
UniGeneiMm.275188

Genome annotation databases

EnsembliENSMUST00000043314; ENSMUSP00000041175; ENSMUSG00000040703
GeneIDi74134
KEGGimmu:74134
UCSCiuc009fub.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP2S1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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