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Protein

Sushi domain-containing protein 2

Gene

Susd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May play a role in breast tumorigenesis (PubMed:23131994).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Sushi domain-containing protein 2
Gene namesi
Name:Susd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1918983. Susd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 782ExtracellularSequence analysisAdd BLAST760
Transmembranei783 – 803HelicalSequence analysisAdd BLAST21
Topological domaini804 – 820CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000024944023 – 820Sushi domain-containing protein 2Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 42AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi29 ↔ 33AlternatePROSITE-ProRule annotation
Disulfide bondi33 ↔ 60AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi40 ↔ 53AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi40 ↔ 42AlternatePROSITE-ProRule annotation
Disulfide bondi46 ↔ 521 Publication
Disulfide bondi53 ↔ 60AlternatePROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...)1 Publication1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi491N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi722 ↔ 762By similarity
Disulfide bondi748 ↔ 775By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9DBX3.
PeptideAtlasiQ9DBX3.
PRIDEiQ9DBX3.

PTM databases

PhosphoSitePlusiQ9DBX3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006342.
CleanExiMM_SUSD2.
GenevisibleiQ9DBX3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DBX3. 3 interactors.
MINTiMINT-4114001.
STRINGi10090.ENSMUSP00000093197.

Structurei

Secondary structure

1820
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 49Combined sources4
Helixi56 – 59Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQWNMR-A16-86[»]
ProteinModelPortaliQ9DBX3.
SMRiQ9DBX3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9DBX3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 64SMBPROSITE-ProRule annotationAdd BLAST40
Domaini282 – 430AMOPPROSITE-ProRule annotationAdd BLAST149
Domaini443 – 674VWFDPROSITE-ProRule annotationAdd BLAST232
Domaini720 – 777SushiPROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 AMOP domain.PROSITE-ProRule annotation
Contains 1 SMB (somatomedin-B) domain.Curated
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4291. Eukaryota.
ENOG410YZ7Z. LUCA.
GeneTreeiENSGT00730000110943.
HOVERGENiHBG069278.
InParanoidiQ9DBX3.
OMAiAKWSYLY.
OrthoDBiEOG091G01S5.
PhylomeDBiQ9DBX3.
TreeFamiTF321438.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR005533. AMOP_dom.
IPR001212. Somatomedin_B_dom.
IPR000436. Sushi_SCR_CCP_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF03782. AMOP. 1 hit.
PF01033. Somatomedin_B. 1 hit.
PF00084. Sushi. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00723. AMOP. 1 hit.
SM00032. CCP. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
SSF90188. SSF90188. 1 hit.
PROSITEiPS50856. AMOP. 1 hit.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50923. SUSHI. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLALLPWIL MLLSTIPGPG FTAGAQGSCS LRCGAQDGLC SCHPTCSGLG
60 70 80 90 100
TCCEDFLDYC LEILPSSGSM MGGKDFVVQH LKWTDPTDGV ICRFKESIQT
110 120 130 140 150
LGYVDDFYQV HCISPLLYES GYIPFTISMD NGRSFPHAGT WLAAHPYKVS
160 170 180 190 200
ESEKSQLVNE THWQYYGTSD TRGNLNLTWD TSALPTPAVT IELWGYEETG
210 220 230 240 250
KPYSGNWTSK WSYLYPLATN IPNTGFFTFT PKPASPQYQR WKVGALRISS
260 270 280 290 300
SRNYPGEKDV RALWTNDHAL AWHLGDDFRA DSVAWARAQC LAWEALEDQL
310 320 330 340 350
PNFLTELPDC PCTLAQARAD SGRFFTDYGC DIEHGSVCTY HPGAVHCVRS
360 370 380 390 400
VQASPRYGSG QQCCYTAAGT QLLTSDSTSG STPDRGHDWG APPYRTPPRV
410 420 430 440 450
PGMSHWLYDV ISFYYCCLWA PECPRYMKRR PSSDCRNYRP PRLASAFGDP
460 470 480 490 500
HFVTFDGTSF SFSGNGEYVL LETTLSDLRV QGRAQPGRMP NGTQARGTGL
510 520 530 540 550
TAVAVQEDNS DVIEVRLAGG SRVLEVLLNQ KVLSFTEQNW MDLKGMFLSV
560 570 580 590 600
AAQDKVSIML SSGAGLEVGV QGPFLSVSIL LPEKFLTHTR GLLGTLNNNP
610 620 630 640 650
RDDFTLRNGQ VLPLNASAQQ VFQFGADWAV SNTSSLFTYD SWLLVYQFVY
660 670 680 690 700
GPKHNPNFKP LFPDETTLSP SQTEDVARLC EGDRFCILDV MSTGSSSVGN
710 720 730 740 750
ATRIAHQLHQ HRLKSLQPVV SCGWLPPPAN GHKEGLRYLE GSVVRFSCNN
760 770 780 790 800
GYSLVGPESS TCQADGKWSM PTPECQPGRS YTVLLSIIFG GLAIVALISI
810 820
IYMMLHRRRK SNMTMWSSQP
Length:820
Mass (Da):90,641
Last modified:June 1, 2001 - v1
Checksum:i72B0847EE9C7A687
GO
Isoform 2 (identifier: Q9DBX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     24-143: Missing.

Show »
Length:700
Mass (Da):77,599
Checksum:i32AD43AE2EC4D0A2
GO
Isoform 3 (identifier: Q9DBX3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-402: Missing.

Show »
Length:418
Mass (Da):46,330
Checksum:iEB4C44CA4B536C48
GO

Sequence cautioni

The sequence BAC29714 differs from that shown. Reason: Frameshift at position 779.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239Q → R in BAC28486 (PubMed:16141072).Curated1
Sequence conflicti284A → G in BAC26135 (PubMed:16141072).Curated1
Sequence conflicti354S → C in BAC26135 (PubMed:16141072).Curated1
Sequence conflicti401P → T in BAC29689 (PubMed:16141072).Curated1
Sequence conflicti612L → Q in BAC31269 (PubMed:16141072).Curated1
Sequence conflicti788I → F in BAC26135 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0204251 – 402Missing in isoform 3. 1 PublicationAdd BLAST402
Alternative sequenceiVSP_02042624 – 143Missing in isoform 2. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038944 mRNA. Translation: BAC30177.1.
AK167155 mRNA. Translation: BAE39296.1.
AK033823 mRNA. Translation: BAC28486.1.
AK037127 mRNA. Translation: BAC29714.1. Frameshift.
AK028817 mRNA. Translation: BAC26135.1.
AK004703 mRNA. Translation: BAB23488.1.
AK037059 mRNA. Translation: BAC29689.1.
AK042469 mRNA. Translation: BAC31269.1.
BC026837 mRNA. Translation: AAH26837.1.
CCDSiCCDS23929.1. [Q9DBX3-1]
CCDS48600.1. [Q9DBX3-2]
RefSeqiNP_001156385.1. NM_001162913.1. [Q9DBX3-2]
NP_082166.3. NM_027890.5. [Q9DBX3-1]
UniGeneiMm.247956.

Genome annotation databases

EnsembliENSMUST00000077610; ENSMUSP00000076802; ENSMUSG00000006342. [Q9DBX3-2]
ENSMUST00000095541; ENSMUSP00000093197; ENSMUSG00000006342. [Q9DBX3-1]
GeneIDi71733.
KEGGimmu:71733.
UCSCiuc007fqt.2. mouse. [Q9DBX3-1]
uc011xgq.1. mouse. [Q9DBX3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK038944 mRNA. Translation: BAC30177.1.
AK167155 mRNA. Translation: BAE39296.1.
AK033823 mRNA. Translation: BAC28486.1.
AK037127 mRNA. Translation: BAC29714.1. Frameshift.
AK028817 mRNA. Translation: BAC26135.1.
AK004703 mRNA. Translation: BAB23488.1.
AK037059 mRNA. Translation: BAC29689.1.
AK042469 mRNA. Translation: BAC31269.1.
BC026837 mRNA. Translation: AAH26837.1.
CCDSiCCDS23929.1. [Q9DBX3-1]
CCDS48600.1. [Q9DBX3-2]
RefSeqiNP_001156385.1. NM_001162913.1. [Q9DBX3-2]
NP_082166.3. NM_027890.5. [Q9DBX3-1]
UniGeneiMm.247956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQWNMR-A16-86[»]
ProteinModelPortaliQ9DBX3.
SMRiQ9DBX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBX3. 3 interactors.
MINTiMINT-4114001.
STRINGi10090.ENSMUSP00000093197.

PTM databases

PhosphoSitePlusiQ9DBX3.

Proteomic databases

PaxDbiQ9DBX3.
PeptideAtlasiQ9DBX3.
PRIDEiQ9DBX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077610; ENSMUSP00000076802; ENSMUSG00000006342. [Q9DBX3-2]
ENSMUST00000095541; ENSMUSP00000093197; ENSMUSG00000006342. [Q9DBX3-1]
GeneIDi71733.
KEGGimmu:71733.
UCSCiuc007fqt.2. mouse. [Q9DBX3-1]
uc011xgq.1. mouse. [Q9DBX3-2]

Organism-specific databases

CTDi56241.
MGIiMGI:1918983. Susd2.

Phylogenomic databases

eggNOGiKOG4291. Eukaryota.
ENOG410YZ7Z. LUCA.
GeneTreeiENSGT00730000110943.
HOVERGENiHBG069278.
InParanoidiQ9DBX3.
OMAiAKWSYLY.
OrthoDBiEOG091G01S5.
PhylomeDBiQ9DBX3.
TreeFamiTF321438.

Miscellaneous databases

EvolutionaryTraceiQ9DBX3.
PROiQ9DBX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006342.
CleanExiMM_SUSD2.
GenevisibleiQ9DBX3. MM.

Family and domain databases

CDDicd00033. CCP. 1 hit.
InterProiIPR005533. AMOP_dom.
IPR001212. Somatomedin_B_dom.
IPR000436. Sushi_SCR_CCP_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF03782. AMOP. 1 hit.
PF01033. Somatomedin_B. 1 hit.
PF00084. Sushi. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM00723. AMOP. 1 hit.
SM00032. CCP. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 1 hit.
SSF90188. SSF90188. 1 hit.
PROSITEiPS50856. AMOP. 1 hit.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.
PS50923. SUSHI. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUSD2_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX3
Secondary accession number(s): Q8BY19
, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.