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Protein

Regulator of cell cycle RGCC

Gene

Rgcc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.1 Publication

GO - Molecular functioni

  1. protein kinase activator activity Source: MGI
  2. protein kinase binding Source: MGI
  3. R-SMAD binding Source: MGI

GO - Biological processi

  1. cellular response to hypoxia Source: MGI
  2. complement activation Source: MGI
  3. fibroblast activation Source: UniProtKB
  4. G1/S transition of mitotic cell cycle Source: MGI
  5. mitotic cell cycle arrest Source: MGI
  6. negative regulation of angiogenesis Source: MGI
  7. negative regulation of blood vessel endothelial cell migration Source: MGI
  8. negative regulation of cell-cell adhesion mediated by cadherin Source: MGI
  9. negative regulation of cell proliferation Source: MGI
  10. negative regulation of cytokine secretion Source: MGI
  11. negative regulation of endothelial cell proliferation Source: MGI
  12. negative regulation of exit from mitosis Source: MGI
  13. negative regulation of fibroblast growth factor production Source: MGI
  14. negative regulation of mitotic cell cycle phase transition Source: MGI
  15. positive regulation of cell cycle arrest Source: MGI
  16. positive regulation of collagen biosynthetic process Source: MGI
  17. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: MGI
  18. positive regulation of cytokine secretion Source: MGI
  19. positive regulation of DNA biosynthetic process Source: Ensembl
  20. positive regulation of endothelial cell apoptotic process Source: MGI
  21. positive regulation of epithelial to mesenchymal transition Source: MGI
  22. positive regulation of extracellular matrix assembly Source: MGI
  23. positive regulation of extracellular matrix constituent secretion Source: MGI
  24. positive regulation of gene expression Source: MGI
  25. positive regulation of mitotic nuclear division Source: MGI
  26. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  27. positive regulation of stress fiber assembly Source: MGI
  28. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of cell cycle RGCC
Alternative name(s):
Response gene to complement 32 protein
Short name:
RGC-32
Gene namesi
Name:Rgcc
Synonyms:Rgc32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913464. Rgcc.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Nucleus By similarity
  3. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity

  4. Note: Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Regulator of cell cycle RGCCPRO_0000274702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei111 – 1111Phosphothreonine; by CDK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBX1.
PaxDbiQ9DBX1.
PRIDEiQ9DBX1.

PTM databases

PhosphoSiteiQ9DBX1.

Expressioni

Gene expression databases

BgeeiQ9DBX1.
CleanExiMM_1190002H23RIK.
GenevestigatoriQ9DBX1.

Interactioni

Subunit structurei

Interacts with CDK1 and PLK1 (By similarity). Interacts with SMAD3.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9DBX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 2616Ala-richAdd
BLAST
Compositional biasi64 – 10845Ser/Thr-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG39648.
GeneTreeiENSGT00390000011709.
HOGENOMiHOG000294092.
HOVERGENiHBG060999.
InParanoidiQ9DBX1.
OMAiFRYDEHL.
OrthoDBiEOG7ZGX5S.
PhylomeDBiQ9DBX1.
TreeFamiTF336312.

Family and domain databases

InterProiIPR029252. RGCC.
[Graphical view]
PfamiPF15151. RGCC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPSAQSSP AAVAAAAPAM DSAAAADLTD VLCEFDAVLA DFASPFHERH
60 70 80 90 100
FHYEEHLERM KRRSSASVSD SSGFSDSESA DSVYRDSFTF SDEKLNSPTN
110 120 130
SSPALLPSAV TPRKAKLGDT KELEDFIADL DRTLASM
Length:137
Mass (Da):14,717
Last modified:June 1, 2001 - v1
Checksum:i01646F247F8B284A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681V → I in BAB23310 (PubMed:16141072).Curated
Sequence conflicti70 – 701D → N in BAB23310 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276981 mRNA. Translation: AAK69442.1.
AK004451 mRNA. Translation: BAB23310.1.
AK004705 mRNA. Translation: BAB23490.1.
CT010403 mRNA. Translation: CAJ18609.1.
BC049580 mRNA. Translation: AAH49580.1.
BC050935 mRNA. Translation: AAH50935.1.
CCDSiCCDS49552.1.
RefSeqiNP_079703.2. NM_025427.2.
UniGeneiMm.29811.

Genome annotation databases

EnsembliENSMUST00000022595; ENSMUSP00000022595; ENSMUSG00000022018.
GeneIDi66214.
KEGGimmu:66214.
UCSCiuc007ust.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276981 mRNA. Translation: AAK69442.1.
AK004451 mRNA. Translation: BAB23310.1.
AK004705 mRNA. Translation: BAB23490.1.
CT010403 mRNA. Translation: CAJ18609.1.
BC049580 mRNA. Translation: AAH49580.1.
BC050935 mRNA. Translation: AAH50935.1.
CCDSiCCDS49552.1.
RefSeqiNP_079703.2. NM_025427.2.
UniGeneiMm.29811.

3D structure databases

ProteinModelPortaliQ9DBX1.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9DBX1.

Proteomic databases

MaxQBiQ9DBX1.
PaxDbiQ9DBX1.
PRIDEiQ9DBX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022595; ENSMUSP00000022595; ENSMUSG00000022018.
GeneIDi66214.
KEGGimmu:66214.
UCSCiuc007ust.1. mouse.

Organism-specific databases

CTDi28984.
MGIiMGI:1913464. Rgcc.

Phylogenomic databases

eggNOGiNOG39648.
GeneTreeiENSGT00390000011709.
HOGENOMiHOG000294092.
HOVERGENiHBG060999.
InParanoidiQ9DBX1.
OMAiFRYDEHL.
OrthoDBiEOG7ZGX5S.
PhylomeDBiQ9DBX1.
TreeFamiTF336312.

Miscellaneous databases

NextBioi320993.
PROiQ9DBX1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBX1.
CleanExiMM_1190002H23RIK.
GenevestigatoriQ9DBX1.

Family and domain databases

InterProiIPR029252. RGCC.
[Graphical view]
PfamiPF15151. RGCC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase."
    Badea T., Niculescu F., Soane L., Fosbrink M., Sorana H., Rus V., Shin M.L., Rus H.
    J. Biol. Chem. 277:502-508(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Lung.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Testis.
  5. "Response gene to complement 32 is essential for fibroblast activation in renal fibrosis."
    Li Z., Xie W.B., Escano C.S., Asico L.D., Xie Q., Jose P.A., Chen S.Y.
    J. Biol. Chem. 286:41323-41330(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMAD3.

Entry informationi

Entry nameiRGCC_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX1
Secondary accession number(s): Q9D0U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.