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Protein

Regulator of cell cycle RGCC

Gene

Rgcc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of cell cycle RGCC
Alternative name(s):
Response gene to complement 32 protein
Short name:
RGC-32
Gene namesi
Name:Rgcc
Synonyms:Rgc32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913464 Rgcc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002747021 – 137Regulator of cell cycle RGCCAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67PhosphoserineCombined sources1
Modified residuei69PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei91PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei111PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DBX1
MaxQBiQ9DBX1
PaxDbiQ9DBX1
PeptideAtlasiQ9DBX1
PRIDEiQ9DBX1

PTM databases

iPTMnetiQ9DBX1
PhosphoSitePlusiQ9DBX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000022018
CleanExiMM_1190002H23RIK
GenevisibleiQ9DBX1 MM

Interactioni

Subunit structurei

Interacts with CDK1 and PLK1 (By similarity). Interacts with SMAD3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022595

Structurei

3D structure databases

ProteinModelPortaliQ9DBX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 26Ala-richAdd BLAST16
Compositional biasi64 – 108Ser/Thr-richAdd BLAST45

Phylogenomic databases

eggNOGiENOG410J12H Eukaryota
ENOG4111Y7V LUCA
GeneTreeiENSGT00390000011709
HOGENOMiHOG000294092
HOVERGENiHBG060999
InParanoidiQ9DBX1
OMAiFRYDEHL
OrthoDBiEOG091G1849
PhylomeDBiQ9DBX1
TreeFamiTF336312

Family and domain databases

InterProiView protein in InterPro
IPR029252 RGCC
PANTHERiPTHR32193 PTHR32193, 1 hit
PfamiView protein in Pfam
PF15151 RGCC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DBX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPSAQSSP AAVAAAAPAM DSAAAADLTD VLCEFDAVLA DFASPFHERH
60 70 80 90 100
FHYEEHLERM KRRSSASVSD SSGFSDSESA DSVYRDSFTF SDEKLNSPTN
110 120 130
SSPALLPSAV TPRKAKLGDT KELEDFIADL DRTLASM
Length:137
Mass (Da):14,717
Last modified:June 1, 2001 - v1
Checksum:i01646F247F8B284A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68V → I in BAB23310 (PubMed:16141072).Curated1
Sequence conflicti70D → N in BAB23310 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276981 mRNA Translation: AAK69442.1
AK004451 mRNA Translation: BAB23310.1
AK004705 mRNA Translation: BAB23490.1
CT010403 mRNA Translation: CAJ18609.1
BC049580 mRNA Translation: AAH49580.1
BC050935 mRNA Translation: AAH50935.1
CCDSiCCDS49552.1
RefSeqiNP_079703.2, NM_025427.2
UniGeneiMm.29811

Genome annotation databases

EnsembliENSMUST00000022595; ENSMUSP00000022595; ENSMUSG00000022018
GeneIDi66214
KEGGimmu:66214
UCSCiuc007ust.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRGCC_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX1
Secondary accession number(s): Q9D0U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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