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Q9DBX1

- RGCC_MOUSE

UniProt

Q9DBX1 - RGCC_MOUSE

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Protein

Regulator of cell cycle RGCC

Gene

Rgcc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.1 Publication

GO - Molecular functioni

  1. protein kinase activator activity Source: MGI

GO - Biological processi

  1. cellular response to hypoxia Source: Ensembl
  2. complement activation Source: Ensembl
  3. fibroblast activation Source: UniProtKB
  4. G1/S transition of mitotic cell cycle Source: MGI
  5. mitotic cell cycle arrest Source: Ensembl
  6. negative regulation of angiogenesis Source: Ensembl
  7. negative regulation of blood vessel endothelial cell migration Source: Ensembl
  8. negative regulation of cell-cell adhesion mediated by cadherin Source: Ensembl
  9. negative regulation of cytokine secretion Source: Ensembl
  10. negative regulation of endothelial cell proliferation Source: Ensembl
  11. negative regulation of exit from mitosis Source: Ensembl
  12. negative regulation of fibroblast growth factor production Source: Ensembl
  13. negative regulation of mitotic cell cycle phase transition Source: Ensembl
  14. positive regulation of cell cycle arrest Source: Ensembl
  15. positive regulation of collagen biosynthetic process Source: Ensembl
  16. positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle Source: Ensembl
  17. positive regulation of cytokine secretion Source: Ensembl
  18. positive regulation of DNA biosynthetic process Source: Ensembl
  19. positive regulation of endothelial cell apoptotic process Source: Ensembl
  20. positive regulation of epithelial to mesenchymal transition Source: Ensembl
  21. positive regulation of extracellular matrix constituent secretion Source: Ensembl
  22. positive regulation of gene expression involved in extracellular matrix organization Source: Ensembl
  23. positive regulation of mitosis Source: Ensembl
  24. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  25. positive regulation of stress fiber assembly Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of cell cycle RGCC
Alternative name(s):
Response gene to complement 32 protein
Short name:
RGC-32
Gene namesi
Name:Rgcc
Synonyms:Rgc32
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1913464. Rgcc.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Regulator of cell cycle RGCCPRO_0000274702Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691PhosphoserineBy similarity
Modified residuei71 – 711PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei111 – 1111Phosphothreonine; by CDK1By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9DBX1.
PaxDbiQ9DBX1.
PRIDEiQ9DBX1.

PTM databases

PhosphoSiteiQ9DBX1.

Expressioni

Gene expression databases

BgeeiQ9DBX1.
CleanExiMM_1190002H23RIK.
GenevestigatoriQ9DBX1.

Interactioni

Subunit structurei

Interacts with CDK1 and PLK1 (By similarity). Interacts with SMAD3.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9DBX1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 2616Ala-richAdd
BLAST
Compositional biasi64 – 10845Ser/Thr-richAdd
BLAST

Phylogenomic databases

eggNOGiNOG39648.
GeneTreeiENSGT00390000011709.
HOGENOMiHOG000294092.
HOVERGENiHBG060999.
InParanoidiQ9DBX1.
OMAiFRYDEHL.
OrthoDBiEOG7ZGX5S.
PhylomeDBiQ9DBX1.
TreeFamiTF336312.

Family and domain databases

InterProiIPR029252. RGCC.
[Graphical view]
PfamiPF15151. RGCC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPPSAQSSP AAVAAAAPAM DSAAAADLTD VLCEFDAVLA DFASPFHERH
60 70 80 90 100
FHYEEHLERM KRRSSASVSD SSGFSDSESA DSVYRDSFTF SDEKLNSPTN
110 120 130
SSPALLPSAV TPRKAKLGDT KELEDFIADL DRTLASM
Length:137
Mass (Da):14,717
Last modified:June 1, 2001 - v1
Checksum:i01646F247F8B284A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681V → I in BAB23310. (PubMed:16141072)Curated
Sequence conflicti70 – 701D → N in BAB23310. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276981 mRNA. Translation: AAK69442.1.
AK004451 mRNA. Translation: BAB23310.1.
AK004705 mRNA. Translation: BAB23490.1.
CT010403 mRNA. Translation: CAJ18609.1.
BC049580 mRNA. Translation: AAH49580.1.
BC050935 mRNA. Translation: AAH50935.1.
CCDSiCCDS49552.1.
RefSeqiNP_079703.2. NM_025427.2.
UniGeneiMm.29811.

Genome annotation databases

EnsembliENSMUST00000022595; ENSMUSP00000022595; ENSMUSG00000022018.
GeneIDi66214.
KEGGimmu:66214.
UCSCiuc007ust.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276981 mRNA. Translation: AAK69442.1 .
AK004451 mRNA. Translation: BAB23310.1 .
AK004705 mRNA. Translation: BAB23490.1 .
CT010403 mRNA. Translation: CAJ18609.1 .
BC049580 mRNA. Translation: AAH49580.1 .
BC050935 mRNA. Translation: AAH50935.1 .
CCDSi CCDS49552.1.
RefSeqi NP_079703.2. NM_025427.2.
UniGenei Mm.29811.

3D structure databases

ProteinModelPortali Q9DBX1.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9DBX1.

Proteomic databases

MaxQBi Q9DBX1.
PaxDbi Q9DBX1.
PRIDEi Q9DBX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022595 ; ENSMUSP00000022595 ; ENSMUSG00000022018 .
GeneIDi 66214.
KEGGi mmu:66214.
UCSCi uc007ust.1. mouse.

Organism-specific databases

CTDi 28984.
MGIi MGI:1913464. Rgcc.

Phylogenomic databases

eggNOGi NOG39648.
GeneTreei ENSGT00390000011709.
HOGENOMi HOG000294092.
HOVERGENi HBG060999.
InParanoidi Q9DBX1.
OMAi FRYDEHL.
OrthoDBi EOG7ZGX5S.
PhylomeDBi Q9DBX1.
TreeFami TF336312.

Miscellaneous databases

NextBioi 320993.
PROi Q9DBX1.
SOURCEi Search...

Gene expression databases

Bgeei Q9DBX1.
CleanExi MM_1190002H23RIK.
Genevestigatori Q9DBX1.

Family and domain databases

InterProi IPR029252. RGCC.
[Graphical view ]
Pfami PF15151. RGCC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase."
    Badea T., Niculescu F., Soane L., Fosbrink M., Sorana H., Rus V., Shin M.L., Rus H.
    J. Biol. Chem. 277:502-508(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Lung.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Testis.
  5. "Response gene to complement 32 is essential for fibroblast activation in renal fibrosis."
    Li Z., Xie W.B., Escano C.S., Asico L.D., Xie Q., Jose P.A., Chen S.Y.
    J. Biol. Chem. 286:41323-41330(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SMAD3.

Entry informationi

Entry nameiRGCC_MOUSE
AccessioniPrimary (citable) accession number: Q9DBX1
Secondary accession number(s): Q9D0U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3