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Protein

Serine/threonine-protein kinase RIO3

Gene

Riok3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei290 – 2901ATPBy similarity
Active sitei406 – 4061Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2659ATPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase RIO3 (EC:2.7.11.1)
Alternative name(s):
RIO kinase 3
Gene namesi
Name:Riok3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914128. Riok3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Serine/threonine-protein kinase RIO3PRO_0000213530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei125 – 1251PhosphoserineCombined sources
Modified residuei127 – 1271PhosphoserineCombined sources
Modified residuei128 – 1281PhosphoserineCombined sources
Modified residuei512 – 5121PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9DBU3.
MaxQBiQ9DBU3.
PaxDbiQ9DBU3.
PRIDEiQ9DBU3.

PTM databases

iPTMnetiQ9DBU3.
PhosphoSiteiQ9DBU3.

Expressioni

Gene expression databases

BgeeiQ9DBU3.
CleanExiMM_RIOK3.
GenevisibleiQ9DBU3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025270.

Structurei

3D structure databases

ProteinModelPortaliQ9DBU3.
SMRiQ9DBU3. Positions 234-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 519269Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.Curated

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiQ9DBU3.
KOiK08872.
OMAiLPKECAI.
OrthoDBiEOG7JT6W1.
TreeFamiTF105831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLVGVSSPE PGPAAAWGPS KCPWATPQNT VSCSLTEVMS EELAKELQLE
60 70 80 90 100
EEAAAFPEVV VAEGPFISGE NIDTSSDLML AQMLQMEFDR EYDAQLRREE
110 120 130 140 150
KKFNGDSKVS ISFENYRKVH PFEDSDSSED EVDWQDTRDD PYRPAKPIPT
160 170 180 190 200
PKKGFIGKGK DITTKHDEVV CGRKNTARME NFAPGFQVGD GIGMDLKLSN
210 220 230 240 250
HVFNALKQHA YSEERRSARL HEKKEHSTAE KAVDPKTRLL MYKMVNSGML
260 270 280 290 300
ETITGCISTG KESVVFHAYG GSLEDEKEDG KAIPTECAIK VFKTTLNEFK
310 320 330 340 350
NRDKYIKDDF RFKDRFSKLN PRKIIRMWAE KEMHNLTRMQ KAGIPCPTVV
360 370 380 390 400
LLKKHILVMS FIGHDQVPAP KLKEVKLSNE EMKDAYYQTL HLMQQLYNEC
410 420 430 440 450
TLVHADLSEY NMLWHAGKVW LIDVSQSVEP THPHGLEFLF RDCRNVSQFF
460 470 480 490 500
QKGGVTEALN ERELFNAVSG LNISADNEAD FLAEIEALEK MNEDHIQKNG
510
RKAASFLKDD GSPPVLSAD
Length:519
Mass (Da):58,704
Last modified:July 27, 2011 - v3
Checksum:i4DB90CAFA81C8AC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti141 – 1411P → T in BAB23529 (PubMed:16141072).Curated
Sequence conflicti496 – 4961I → V in AAH33271 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004748 mRNA. Translation: BAB23529.1.
AK147074 mRNA. Translation: BAE27655.1.
BC033271 mRNA. Translation: AAH33271.1.
CH466622 Genomic DNA. Translation: EDL01557.1.
CCDSiCCDS29062.1.
RefSeqiNP_077144.2. NM_024182.4.
UniGeneiMm.28551.

Genome annotation databases

EnsembliENSMUST00000025270; ENSMUSP00000025270; ENSMUSG00000024404.
GeneIDi66878.
KEGGimmu:66878.
UCSCiuc008eby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004748 mRNA. Translation: BAB23529.1.
AK147074 mRNA. Translation: BAE27655.1.
BC033271 mRNA. Translation: AAH33271.1.
CH466622 Genomic DNA. Translation: EDL01557.1.
CCDSiCCDS29062.1.
RefSeqiNP_077144.2. NM_024182.4.
UniGeneiMm.28551.

3D structure databases

ProteinModelPortaliQ9DBU3.
SMRiQ9DBU3. Positions 234-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025270.

PTM databases

iPTMnetiQ9DBU3.
PhosphoSiteiQ9DBU3.

Proteomic databases

EPDiQ9DBU3.
MaxQBiQ9DBU3.
PaxDbiQ9DBU3.
PRIDEiQ9DBU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025270; ENSMUSP00000025270; ENSMUSG00000024404.
GeneIDi66878.
KEGGimmu:66878.
UCSCiuc008eby.1. mouse.

Organism-specific databases

CTDi8780.
MGIiMGI:1914128. Riok3.

Phylogenomic databases

eggNOGiKOG2269. Eukaryota.
COG1718. LUCA.
GeneTreeiENSGT00390000004370.
HOGENOMiHOG000007623.
HOVERGENiHBG057475.
InParanoidiQ9DBU3.
KOiK08872.
OMAiLPKECAI.
OrthoDBiEOG7JT6W1.
TreeFamiTF105831.

Miscellaneous databases

NextBioi322909.
PROiQ9DBU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBU3.
CleanExiMM_RIOK3.
GenevisibleiQ9DBU3. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000687. RIO_kinase.
IPR018935. RIO_kinase_CS.
IPR017406. Ser/Thr_kinase_Rio3.
[Graphical view]
PANTHERiPTHR10593:SF22. PTHR10593:SF22. 1 hit.
PIRSFiPIRSF038146. Ser/Thr_PK_RIO3. 1 hit.
SMARTiSM00090. RIO. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01245. RIO1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion and Lung.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-127 AND SER-128, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-127; SER-128 AND SER-512, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiRIOK3_MOUSE
AccessioniPrimary (citable) accession number: Q9DBU3
Secondary accession number(s): Q3UI51, Q8CIC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.