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Q9DBU2

- NAA60_MOUSE

UniProt

Q9DBU2 - NAA60_MOUSE

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Protein
N-alpha-acetyltransferase 60
Gene
Naa60, Nat15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone acetyltransferase localized in the Golgi apparatus that mediates acetylation of free histone H4, thereby facilitating nucleosome assembly. Has a preference for free histone H4 'Lys-20'(H4K20ac), 'Lys-79'(H4K79ac) and 'Lys-91' (H4K91ac). Also displays alpha (N-terminal) acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase By similarity.

Catalytic activityi

Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. H4 histone acetyltransferase activity Source: UniProtKB
  2. peptide alpha-N-acetyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. N-terminal peptidyl-methionine acetylation Source: UniProtKB
  2. cell proliferation Source: UniProtKB
  3. chromosome segregation Source: UniProtKB
  4. histone H4 acetylation Source: UniProtKB
  5. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Chromosome partition

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 60 (EC:2.3.1.48, EC:2.3.1.88)
Alternative name(s):
N-acetyltransferase 15
NatF catalytic subunit
Gene namesi
Name:Naa60
Synonyms:Nat15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1922013. Naa60.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242N-alpha-acetyltransferase 60
PRO_0000321567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791N6-acetyllysine; by autocatalysis By similarity
Modified residuei105 – 1051N6-acetyllysine; by autocatalysis By similarity
Modified residuei109 – 1091N6-acetyllysine; by autocatalysis By similarity
Modified residuei121 – 1211N6-acetyllysine; by autocatalysis By similarity

Post-translational modificationi

Acetylated: autoacetylation is required for optimal acetyltransferase activity By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ9DBU2.

PTM databases

PhosphoSiteiQ9DBU2.

Expressioni

Gene expression databases

ArrayExpressiQ9DBU2.
BgeeiQ9DBU2.
GenevestigatoriQ9DBU2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006138.

Structurei

3D structure databases

ProteinModelPortaliQ9DBU2.
SMRiQ9DBU2. Positions 11-181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 182170N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG276305.
GeneTreeiENSGT00390000008314.
HOGENOMiHOG000280717.
HOVERGENiHBG061680.
InParanoidiQ9DBU2.
OMAiPPWTILI.
TreeFamiTF323980.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9DBU2-1 [UniParc]FASTAAdd to Basket

« Hide

MTEVVPSSAL SEVSLRLLCH DDIDTVKHLC GDWFPIEYPD SWYRDITSNK    50
KFFSLAATYR GAIVGMIVAE IKNRTKIHKE DGDILASSFS VDTQVAYILS 100
LGVVKEFRKH GIGSLLLESL KDHISTTAQD HCKAIYLHVL TTNNTAINFY 150
ENRDFRQHHY LPYYYSIRGV LKDGFTYVLY INGGHPPWTI LDYIQHLGSA 200
LANLSPCSIP HRIYRQAHSL LCSFLPWSSI STKGGIEYSR TM 242
Length:242
Mass (Da):27,507
Last modified:June 1, 2001 - v1
Checksum:iF2307B2007F13F84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004750 mRNA. Translation: BAB23531.1.
AK088736 mRNA. Translation: BAC40538.1.
BC004837 mRNA. Translation: AAH04837.1.
CCDSiCCDS37239.1.
RefSeqiNP_001277618.1. NM_001290689.1.
NP_083366.1. NM_029090.3.
XP_006522742.1. XM_006522679.1.
XP_006522743.1. XM_006522680.1.
UniGeneiMm.28403.

Genome annotation databases

EnsembliENSMUST00000006138; ENSMUSP00000006138; ENSMUSG00000005982.
ENSMUST00000115860; ENSMUSP00000111526; ENSMUSG00000005982.
ENSMUST00000150655; ENSMUSP00000135206; ENSMUSG00000005982.
GeneIDi74763.
KEGGimmu:74763.
UCSCiuc007xyw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004750 mRNA. Translation: BAB23531.1 .
AK088736 mRNA. Translation: BAC40538.1 .
BC004837 mRNA. Translation: AAH04837.1 .
CCDSi CCDS37239.1.
RefSeqi NP_001277618.1. NM_001290689.1.
NP_083366.1. NM_029090.3.
XP_006522742.1. XM_006522679.1.
XP_006522743.1. XM_006522680.1.
UniGenei Mm.28403.

3D structure databases

ProteinModelPortali Q9DBU2.
SMRi Q9DBU2. Positions 11-181.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000006138.

PTM databases

PhosphoSitei Q9DBU2.

Proteomic databases

PRIDEi Q9DBU2.

Protocols and materials databases

DNASUi 74763.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006138 ; ENSMUSP00000006138 ; ENSMUSG00000005982 .
ENSMUST00000115860 ; ENSMUSP00000111526 ; ENSMUSG00000005982 .
ENSMUST00000150655 ; ENSMUSP00000135206 ; ENSMUSG00000005982 .
GeneIDi 74763.
KEGGi mmu:74763.
UCSCi uc007xyw.1. mouse.

Organism-specific databases

CTDi 79903.
MGIi MGI:1922013. Naa60.

Phylogenomic databases

eggNOGi NOG276305.
GeneTreei ENSGT00390000008314.
HOGENOMi HOG000280717.
HOVERGENi HBG061680.
InParanoidi Q9DBU2.
OMAi PPWTILI.
TreeFami TF323980.

Miscellaneous databases

NextBioi 341584.
PROi Q9DBU2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9DBU2.
Bgeei Q9DBU2.
Genevestigatori Q9DBU2.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Lung and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiNAA60_MOUSE
AccessioniPrimary (citable) accession number: Q9DBU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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