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Protein

Transmembrane 9 superfamily member 1

Gene

Tm9sf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an essential role in autophagy.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane 9 superfamily member 1
Gene namesi
Name:Tm9sf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1921390. Tm9sf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence analysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Transmembranei412 – 43221HelicalSequence analysisAdd
BLAST
Transmembranei469 – 48921HelicalSequence analysisAdd
BLAST
Transmembranei499 – 51921HelicalSequence analysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence analysisAdd
BLAST
Transmembranei570 – 59021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 606579Transmembrane 9 superfamily member 1PRO_0000034362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9DBU0.
MaxQBiQ9DBU0.
PaxDbiQ9DBU0.
PRIDEiQ9DBU0.

PTM databases

iPTMnetiQ9DBU0.
PhosphoSiteiQ9DBU0.

Expressioni

Gene expression databases

BgeeiQ9DBU0.
CleanExiMM_TM9SF1.
ExpressionAtlasiQ9DBU0. baseline and differential.
GenevisibleiQ9DBU0. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9DBU0. 2 interactions.
MINTiMINT-4138048.
STRINGi10090.ENSMUSP00000002391.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG108585.
InParanoidiQ9DBU0.
KOiK17085.
OMAiWYKSTVI.
OrthoDBiEOG72C4ZW.
PhylomeDBiQ9DBU0.
TreeFamiTF328663.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLGYPRSW SCHCLPVLIL LLGIGHGPWV EGVTHYKPGD PVILYVNKVG
60 70 80 90 100
PYHNPQETYH YYQLPVCCPE KIRHKSLSLG EVLDGDRMAE SLYEIRFREN
110 120 130 140 150
VEKRILCHMQ LSSAQVEQLR QAIEELYYFE FVVDDLPIRG FVGYMEESGF
160 170 180 190 200
LPHSHKIGLW THLDFHLEFH GDRIIFANVS VRDVKPHSLD GLRSDELLGL
210 220 230 240 250
THTYSVRWSE TSVEHRSDRR RGDDGGFFPR TLEIHWLSII NSMVLVFLLV
260 270 280 290 300
GFVAVILMRV LRNDLARYNL DEETSSGGSS DDFDQGDNGW KIIHTDVFRF
310 320 330 340 350
PPYRGLLCAV LGVGAQFLAL GTGIIVMALL GMFNVHRHGA INSAAILLYA
360 370 380 390 400
LTCCISGYVS SHFYRQIGGE RWVWNIILTS SLFSVPFFLT WSVVNSVHWA
410 420 430 440 450
NGSTQALPAT TILLLLTVWL LVGFPLTVIG GIFGKNNASP FDAPCRTKNI
460 470 480 490 500
AREIPPQPWY KSTVIHMTVG GFLPFSAISV ELYYIFATVW GREQYTLYGI
510 520 530 540 550
LFFVFAILLS VGACISIALT YFQLSGEDYR WWWRSVLSVG STGLFIFLYS
560 570 580 590 600
VFYYARRSNM SGAVQTVEFF GYSLLTGYVF FLMLGTISFF SSLKFIRYIY

VNLKMD
Length:606
Mass (Da):68,928
Last modified:May 16, 2003 - v2
Checksum:i1DDB125FA81EC47B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti385 – 40925VPFFL…QALPA → EFLSVTQCGELSALGQRFNT GAAT in AAF98161 (Ref. 1) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269152 mRNA. Translation: AAF98161.1.
AK004754 mRNA. Translation: BAB23535.2.
AK152476 mRNA. Translation: BAE31250.1.
AK152540 mRNA. Translation: BAE31295.1.
BC007187 mRNA. Translation: AAH07187.1.
BC017617 mRNA. Translation: AAH17617.1.
CCDSiCCDS27122.1.
RefSeqiNP_083056.2. NM_028780.3.
XP_006519675.1. XM_006519612.1.
XP_006519676.1. XM_006519613.1.
XP_006519677.1. XM_006519614.2.
XP_006519678.1. XM_006519615.1.
UniGeneiMm.132857.

Genome annotation databases

EnsembliENSMUST00000002391; ENSMUSP00000002391; ENSMUSG00000002320.
ENSMUST00000120041; ENSMUSP00000112893; ENSMUSG00000002320.
ENSMUST00000121791; ENSMUSP00000112764; ENSMUSG00000002320.
ENSMUST00000122358; ENSMUSP00000113782; ENSMUSG00000002320.
GeneIDi74140.
KEGGimmu:74140.
UCSCiuc007tzs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269152 mRNA. Translation: AAF98161.1.
AK004754 mRNA. Translation: BAB23535.2.
AK152476 mRNA. Translation: BAE31250.1.
AK152540 mRNA. Translation: BAE31295.1.
BC007187 mRNA. Translation: AAH07187.1.
BC017617 mRNA. Translation: AAH17617.1.
CCDSiCCDS27122.1.
RefSeqiNP_083056.2. NM_028780.3.
XP_006519675.1. XM_006519612.1.
XP_006519676.1. XM_006519613.1.
XP_006519677.1. XM_006519614.2.
XP_006519678.1. XM_006519615.1.
UniGeneiMm.132857.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9DBU0. 2 interactions.
MINTiMINT-4138048.
STRINGi10090.ENSMUSP00000002391.

PTM databases

iPTMnetiQ9DBU0.
PhosphoSiteiQ9DBU0.

Proteomic databases

EPDiQ9DBU0.
MaxQBiQ9DBU0.
PaxDbiQ9DBU0.
PRIDEiQ9DBU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002391; ENSMUSP00000002391; ENSMUSG00000002320.
ENSMUST00000120041; ENSMUSP00000112893; ENSMUSG00000002320.
ENSMUST00000121791; ENSMUSP00000112764; ENSMUSG00000002320.
ENSMUST00000122358; ENSMUSP00000113782; ENSMUSG00000002320.
GeneIDi74140.
KEGGimmu:74140.
UCSCiuc007tzs.1. mouse.

Organism-specific databases

CTDi10548.
MGIiMGI:1921390. Tm9sf1.

Phylogenomic databases

eggNOGiKOG1277. Eukaryota.
ENOG410XSVB. LUCA.
GeneTreeiENSGT00530000062897.
HOGENOMiHOG000216680.
HOVERGENiHBG108585.
InParanoidiQ9DBU0.
KOiK17085.
OMAiWYKSTVI.
OrthoDBiEOG72C4ZW.
PhylomeDBiQ9DBU0.
TreeFamiTF328663.

Miscellaneous databases

PROiQ9DBU0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBU0.
CleanExiMM_TM9SF1.
ExpressionAtlasiQ9DBU0. baseline and differential.
GenevisibleiQ9DBU0. MM.

Family and domain databases

InterProiIPR004240. EMP70.
[Graphical view]
PANTHERiPTHR10766. PTHR10766. 1 hit.
PfamiPF02990. EMP70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of the TM9 super family of membrane spanning proteins."
    Warner S.J., Lomax M.I.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland and Salivary gland.

Entry informationi

Entry nameiTM9S1_MOUSE
AccessioniPrimary (citable) accession number: Q9DBU0
Secondary accession number(s): Q3U7S4
, Q8VD27, Q922J5, Q9ET29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 16, 2003
Last modified: July 6, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.