Q9DBS6 (Q9DBS6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAB23551.1

Gene names

Name:

Pde1b MGI 97523

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. SAAS SAAS023174

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS023174
Molecular function	Hydrolase SAAS SAAS023174
Gene Ontology (GO)
Biological_process	cAMP catabolic process Inferred from electronic annotation. Source: Compara cGMP catabolic process Inferred from electronic annotation. Source: Compara cellular response to granulocyte macrophage colony-stimulating factor stimulus Inferred from electronic annotation. Source: Compara cellular response to macrophage colony-stimulating factor stimulus Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from mutant phenotype PubMed 12077213PubMed 17559891. Source: MGI monocyte differentiation Inferred from electronic annotation. Source: Compara regulation of dopamine metabolic process Inferred from mutant phenotype PubMed 17559891. Source: MGI regulation of neurotransmitter levels Inferred from mutant phenotype PubMed 17559891. Source: MGI response to amphetamine Inferred from mutant phenotype PubMed 17010100PubMed 17559891. Source: MGI serotonin metabolic process Inferred from mutant phenotype PubMed 17559891. Source: MGI signal transduction Inferred from mutant phenotype PubMed 12077213. Source: MGI visual learning Inferred from mutant phenotype PubMed 12077213. Source: MGI
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	3',5'-cyclic-AMP phosphodiesterase activity Inferred from electronic annotation. Source: Compara calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Inferred from sequence orthology PubMed 7568196. Source: MGI calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Inferred from sequence orthology PubMed 7568196. Source: MGI metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9DBS6 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: FB86B38967CFD0C4	FASTA	495	56,598
	10 20 30 40 50 60 MVKQLENGEV NIEELKKNLE YTASLLEAVY IDETRQILDT EDELRELRSD AVPSEVRDWL 70 80 90 100 110 120 ASTFTQQTRA KGRRAEEKPK FRSIVHAVQA GIFVERMFRR TYTSVGPTYS TAVHNCLKNL 130 140 150 160 170 180 DLWCFDVFSL NRAADDHALR TIVFELLTRH SLISRFKIPT VFLMSFLEAL ETGYGKYKNP 190 200 210 220 230 240 YHNQIHAADV TQTVHCFLLR TGMVHCLSEI EVLAIIFAAA IHDYEHTGTT NSFHIQTKSE 250 260 270 280 290 300 CAILYNDRSV LENHHISSVF RMMQDDEMNI FINLTKDEFA ELRALVIEMV LATDMSCHFQ 310 320 330 340 350 360 QVKTMKTALQ QLERIDKSKA LSLLLHAADI SHPTKQWSVH SRWTKALMEE FFRQGDKEAE 370 380 390 400 410 420 LGLPFSPLCD RTSTLVAQSQ IGFIDFIVEP TFSVLTDVAE KSVQPLADDD SKPKSQPSFQ 430 440 450 460 470 480 WRQPSLDVDV GDPNPDVVSF RATWTKYIQE NKQKWKERAA SGITNQMSID ELSPCEEEAP 490 SSPAEDEHNQ NGNLD

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[4]	Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB23551.1. Tissue: Lung EMBL BAB23551.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK004772 mRNA. Translation: BAB23551.1.
IPI	IPI00988251.
UniGene	Mm.390792.
3D structure databases
HSSP	HSSP built from PDB template 1MKD based on UniProtKB Q08499.
ProteinModelPortal	Q9DBS6.
SMR	Q9DBS6. Positions 37-461.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023132. Q9DBS6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc007xyi.1. mouse.
Organism-specific databases
MGI	MGI:97523. Pde1b.
Phylogenomic databases
HOVERGEN	HBG056120.
InParanoid	Q9DBS6.
Gene expression databases
ArrayExpress	Q9DBS6.
Bgee	Q9DBS6.
Genevestigator	Q9DBS6.
Family and domain databases
Gene3D	1.10.1300.10. 2 hits.
InterPro	IPR003607. HD/PDEase_dom. IPR023088. PDEase. IPR002073. PDEase_catalytic_dom. IPR023174. PDEase_CS. IPR013706. PDEase_N. [Graphical view]
Pfam	PF00233. PDEase_I. 1 hit. PF08499. PDEase_I_N. 1 hit. [Graphical view]
PRINTS	PR00387. PDIESTERASE1.
SMART	SM00471. HDc. 1 hit. [Graphical view]
PROSITE	PS00126. PDEASE_I. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q9DBS6_MOUSE

Accession

Primary (citable) accession number: Q9DBS6

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)