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Q9DBS6 (Q9DBS6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pde1b MGI 97523
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity. SAAS SAAS023174

Ontologies

Keywords
   LigandMetal-binding SAAS SAAS023088
   Molecular functionHydrolase SAAS SAAS023088
Gene Ontology (GO)
   Biological_processcAMP catabolic process

Inferred from electronic annotation. Source: Ensembl

cGMP catabolic process

Inferred from electronic annotation. Source: Ensembl

cellular response to granulocyte macrophage colony-stimulating factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to macrophage colony-stimulating factor stimulus

Inferred from electronic annotation. Source: Ensembl

locomotory behavior

Inferred from mutant phenotype PubMed 12077213PubMed 17559891. Source: MGI

monocyte differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of dopamine metabolic process

Inferred from mutant phenotype PubMed 17559891. Source: MGI

regulation of neurotransmitter levels

Inferred from mutant phenotype PubMed 17559891. Source: MGI

response to amphetamine

Inferred from mutant phenotype PubMed 17010100PubMed 17559891. Source: MGI

serotonin metabolic process

Inferred from mutant phenotype PubMed 17559891. Source: MGI

signal transduction

Inferred from mutant phenotype PubMed 12077213. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 12077213. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: Ensembl

calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Inferred from sequence orthology PubMed 7568196. Source: MGI

calmodulin-dependent cyclic-nucleotide phosphodiesterase activity

Inferred from sequence orthology PubMed 7568196. Source: MGI

cyclic-nucleotide phosphodiesterase activity

Inferred from sequence orthology PubMed 9003415. Source: MGI

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9DBS6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: FB86B38967CFD0C4

FASTA49556,598
        10         20         30         40         50         60 
MVKQLENGEV NIEELKKNLE YTASLLEAVY IDETRQILDT EDELRELRSD AVPSEVRDWL 

        70         80         90        100        110        120 
ASTFTQQTRA KGRRAEEKPK FRSIVHAVQA GIFVERMFRR TYTSVGPTYS TAVHNCLKNL 

       130        140        150        160        170        180 
DLWCFDVFSL NRAADDHALR TIVFELLTRH SLISRFKIPT VFLMSFLEAL ETGYGKYKNP 

       190        200        210        220        230        240 
YHNQIHAADV TQTVHCFLLR TGMVHCLSEI EVLAIIFAAA IHDYEHTGTT NSFHIQTKSE 

       250        260        270        280        290        300 
CAILYNDRSV LENHHISSVF RMMQDDEMNI FINLTKDEFA ELRALVIEMV LATDMSCHFQ 

       310        320        330        340        350        360 
QVKTMKTALQ QLERIDKSKA LSLLLHAADI SHPTKQWSVH SRWTKALMEE FFRQGDKEAE 

       370        380        390        400        410        420 
LGLPFSPLCD RTSTLVAQSQ IGFIDFIVEP TFSVLTDVAE KSVQPLADDD SKPKSQPSFQ 

       430        440        450        460        470        480 
WRQPSLDVDV GDPNPDVVSF RATWTKYIQE NKQKWKERAA SGITNQMSID ELSPCEEEAP 

       490 
SSPAEDEHNQ NGNLD 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB23551.1.
Tissue: Lung EMBL BAB23551.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004772 mRNA. Translation: BAB23551.1.
RefSeqNP_001272819.1. NM_001285890.1.
UniGeneMm.390792.

3D structure databases

ProteinModelPortalQ9DBS6.
SMRQ9DBS6. Positions 37-461.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000023132.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID18574.
KEGGmmu:18574.

Organism-specific databases

CTD5153.
MGIMGI:97523. Pde1b.

Phylogenomic databases

HOVERGENHBG056120.
InParanoidQ9DBS6.
KOK13755.

Gene expression databases

ArrayExpressQ9DBS6.
BgeeQ9DBS6.
GenevestigatorQ9DBS6.

Family and domain databases

Gene3D1.10.1300.10. 2 hits.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ9DBS6_MOUSE
AccessionPrimary (citable) accession number: Q9DBS6
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)