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Protein

Kinesin light chain 4

Gene

Klc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
Gene namesi
Name:Klc4
Synonyms:Knsl8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1922014. Klc4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002150982 – 619Kinesin light chain 4Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei174PhosphoserineCombined sources1
Modified residuei449PhosphotyrosineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei566PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei612PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9DBS5.
MaxQBiQ9DBS5.
PaxDbiQ9DBS5.
PeptideAtlasiQ9DBS5.
PRIDEiQ9DBS5.

PTM databases

iPTMnetiQ9DBS5.
PhosphoSitePlusiQ9DBS5.
SwissPalmiQ9DBS5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000003546.
CleanExiMM_KLC4.
GenevisibleiQ9DBS5. MM.

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.By similarity

Protein-protein interaction databases

BioGridi217004. 8 interactors.
DIPiDIP-48704N.
IntActiQ9DBS5. 9 interactors.
MINTiMINT-4099881.
STRINGi10090.ENSMUSP00000003642.

Structurei

3D structure databases

ProteinModelPortaliQ9DBS5.
SMRiQ9DBS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati55 – 88TPR 1Add BLAST34
Repeati211 – 244TPR 2Add BLAST34
Repeati253 – 286TPR 3Add BLAST34
Repeati295 – 328TPR 4Add BLAST34
Repeati337 – 370TPR 5Add BLAST34
Repeati379 – 412TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 155Sequence analysisAdd BLAST91

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated
Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ9DBS5.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ9DBS5.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTKVVS QGLEALHSEH QAVLQSLSHT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
RQLRQYDEDG HGMEEKEGEA TKDSLDDLFP NEEEEDSGND LSRGQGAAAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGRD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TDHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYESQ LGPDNPNVAR TKNNLASCYL KQGKYSEAEA
410 420 430 440 450
LYKEILTCAH VQEFGSVDDD HKPIWMHAEE REEMSRSRPR DSSAPYAEYG
460 470 480 490 500
GWYKACRVSS PTVNTTLKNL GALYRRQGKL EAAETLEECA LRSRKQGTDP
510 520 530 540 550
ISQTKVAELL GEGDGRKAIQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSSMKRAAS LNYLNQPNAA
610
PLQVSRGLSA STVDLSSSS
Length:619
Mass (Da):68,613
Last modified:April 27, 2001 - v1
Checksum:iBE2D6B3CD451A7BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004774 mRNA. Translation: BAB23552.1.
AK170793 mRNA. Translation: BAE42032.1.
CCDSiCCDS28832.1.
RefSeqiNP_083367.1. NM_029091.2.
XP_006525106.1. XM_006525043.2.
XP_011244990.1. XM_011246688.2.
XP_011244991.1. XM_011246689.1.
UniGeneiMm.279599.

Genome annotation databases

EnsembliENSMUST00000003642; ENSMUSP00000003642; ENSMUSG00000003546.
GeneIDi74764.
KEGGimmu:74764.
UCSCiuc008ctj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004774 mRNA. Translation: BAB23552.1.
AK170793 mRNA. Translation: BAE42032.1.
CCDSiCCDS28832.1.
RefSeqiNP_083367.1. NM_029091.2.
XP_006525106.1. XM_006525043.2.
XP_011244990.1. XM_011246688.2.
XP_011244991.1. XM_011246689.1.
UniGeneiMm.279599.

3D structure databases

ProteinModelPortaliQ9DBS5.
SMRiQ9DBS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217004. 8 interactors.
DIPiDIP-48704N.
IntActiQ9DBS5. 9 interactors.
MINTiMINT-4099881.
STRINGi10090.ENSMUSP00000003642.

PTM databases

iPTMnetiQ9DBS5.
PhosphoSitePlusiQ9DBS5.
SwissPalmiQ9DBS5.

Proteomic databases

EPDiQ9DBS5.
MaxQBiQ9DBS5.
PaxDbiQ9DBS5.
PeptideAtlasiQ9DBS5.
PRIDEiQ9DBS5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003642; ENSMUSP00000003642; ENSMUSG00000003546.
GeneIDi74764.
KEGGimmu:74764.
UCSCiuc008ctj.1. mouse.

Organism-specific databases

CTDi89953.
MGIiMGI:1922014. Klc4.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
InParanoidiQ9DBS5.
KOiK10407.
OMAiMSKSRHR.
OrthoDBiEOG091G05DM.
PhylomeDBiQ9DBS5.
TreeFamiTF314010.

Miscellaneous databases

ChiTaRSiKlc4. mouse.
PROiQ9DBS5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003546.
CleanExiMM_KLC4.
GenevisibleiQ9DBS5. MM.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 2 hits.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 3 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLC4_MOUSE
AccessioniPrimary (citable) accession number: Q9DBS5
Secondary accession number(s): Q3TCC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.