Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acyl-coenzyme A oxidase-like protein

Gene

Acoxl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi376 – 3816FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase-like protein (EC:1.3.3.-)
Short name:
Acyl-CoA oxidase-like protein
Gene namesi
Name:Acoxl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1921371. Acoxl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 632632Acyl-coenzyme A oxidase-like proteinPRO_0000305101Add
BLAST

Proteomic databases

MaxQBiQ9DBS4.
PaxDbiQ9DBS4.
PRIDEiQ9DBS4.

PTM databases

iPTMnetiQ9DBS4.
PhosphoSiteiQ9DBS4.

Expressioni

Gene expression databases

BgeeiQ9DBS4.
CleanExiMM_ACOXL.
GenevisibleiQ9DBS4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028859.

Structurei

3D structure databases

ProteinModelPortaliQ9DBS4.
SMRiQ9DBS4. Positions 37-596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiKOG0135. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00530000062919.
HOGENOMiHOG000245077.
HOVERGENiHBG105796.
InParanoidiQ9DBS4.
OMAiMKKTHDE.
OrthoDBiEOG7NSB1S.
PhylomeDBiQ9DBS4.
TreeFamiTF354292.

Family and domain databases

InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9DBS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGWSGLFIE VPLYRLASKV CCHLRGPQGF LQRACQGVCC LPRDSRAAGI
60 70 80 90 100
MEEKRKSFIS QILILGEVLC MVDVSMSIKC GILFLLFGGA ISNLGSPEHV
110 120 130 140 150
TKWFWPLKEQ KYTGMFAMTE RGHGSNVRGI QTEATFDLDN QEFVIDMPCE
160 170 180 190 200
NAHKMYIGNA MHGNYAAVFA QLIIEGKSQG PHCFIVPIRD ENGNLYPGVT
210 220 230 240 250
AIDMMHKEGM NGVDNGILIF DKVRIPRENL LDKFGSVTPD GQYHSPIQSK
260 270 280 290 300
NARFNAILAT LTPSRLAVTF QALGAMKLGL MIAIRYSHSR RQFGPKDKEE
310 320 330 340 350
VKIIEHQMQA LRLMSHLATA LAVTFTSRHA DDILDEDIFQ GRALTNSRSL
360 370 380 390 400
QALMAGLKAY STWETVSCLQ DCRECTGGMG YMMETRISDL KCDTDVFVTF
410 420 430 440 450
EGDNVVMLQV VARELLAQYS KQHKKNLLLG VIQNWTATAG DKLRTSFLAF
460 470 480 490 500
NTDTVGCLAF LLKAVNFRER VLQRSLVSRI YYKVVTKKGD FFSAWNSCMH
510 520 530 540 550
HVTSLSLAHI HRVALEQFTT AVRQCPNRED QALLMKFCLL YGTKLVFQER
560 570 580 590 600
GWYLEHKYLT PKASMLIRAQ LLNLCESVKD DALKVISAFN IPHITIRAPK
610 620 630
TGIPNPGAAE AAYPAPMQPL VRDAARAQLA KL
Length:632
Mass (Da):70,706
Last modified:June 1, 2001 - v1
Checksum:i4BA075171EFE56E1
GO
Isoform 2 (identifier: Q9DBS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-280: Missing.

Show »
Length:352
Mass (Da):39,777
Checksum:i0D1617A2E88D37A5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 280280Missing in isoform 2. 1 PublicationVSP_028240Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004775 mRNA. Translation: BAB23553.1.
AL805950, AL844481 Genomic DNA. Translation: CAM14740.1.
AL805950, AL844481 Genomic DNA. Translation: CAM14741.1.
AL844481, AL805950 Genomic DNA. Translation: CAM24669.1.
AL844481, AL805950 Genomic DNA. Translation: CAM24670.1.
BC048717 mRNA. Translation: AAH48717.1.
CCDSiCCDS16711.1. [Q9DBS4-1]
RefSeqiNP_083041.1. NM_028765.3. [Q9DBS4-1]
XP_011238110.1. XM_011239808.1. [Q9DBS4-2]
UniGeneiMm.244835.

Genome annotation databases

EnsembliENSMUST00000028859; ENSMUSP00000028859; ENSMUSG00000027380. [Q9DBS4-1]
ENSMUST00000110344; ENSMUSP00000105973; ENSMUSG00000027380. [Q9DBS4-2]
GeneIDi74121.
KEGGimmu:74121.
UCSCiuc008mgg.2. mouse. [Q9DBS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004775 mRNA. Translation: BAB23553.1.
AL805950, AL844481 Genomic DNA. Translation: CAM14740.1.
AL805950, AL844481 Genomic DNA. Translation: CAM14741.1.
AL844481, AL805950 Genomic DNA. Translation: CAM24669.1.
AL844481, AL805950 Genomic DNA. Translation: CAM24670.1.
BC048717 mRNA. Translation: AAH48717.1.
CCDSiCCDS16711.1. [Q9DBS4-1]
RefSeqiNP_083041.1. NM_028765.3. [Q9DBS4-1]
XP_011238110.1. XM_011239808.1. [Q9DBS4-2]
UniGeneiMm.244835.

3D structure databases

ProteinModelPortaliQ9DBS4.
SMRiQ9DBS4. Positions 37-596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028859.

PTM databases

iPTMnetiQ9DBS4.
PhosphoSiteiQ9DBS4.

Proteomic databases

MaxQBiQ9DBS4.
PaxDbiQ9DBS4.
PRIDEiQ9DBS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028859; ENSMUSP00000028859; ENSMUSG00000027380. [Q9DBS4-1]
ENSMUST00000110344; ENSMUSP00000105973; ENSMUSG00000027380. [Q9DBS4-2]
GeneIDi74121.
KEGGimmu:74121.
UCSCiuc008mgg.2. mouse. [Q9DBS4-1]

Organism-specific databases

CTDi55289.
MGIiMGI:1921371. Acoxl.

Phylogenomic databases

eggNOGiKOG0135. Eukaryota.
COG1960. LUCA.
GeneTreeiENSGT00530000062919.
HOGENOMiHOG000245077.
HOVERGENiHBG105796.
InParanoidiQ9DBS4.
OMAiMKKTHDE.
OrthoDBiEOG7NSB1S.
PhylomeDBiQ9DBS4.
TreeFamiTF354292.

Miscellaneous databases

NextBioi339830.
PROiQ9DBS4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9DBS4.
CleanExiMM_ACOXL.
GenevisibleiQ9DBS4. MM.

Family and domain databases

InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung.

Entry informationi

Entry nameiACOXL_MOUSE
AccessioniPrimary (citable) accession number: Q9DBS4
Secondary accession number(s): Q80ZM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.