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Protein

Transmembrane protein 43

Gene

Tmem43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane.1 Publication

GO - Molecular functioni

  • protein self-association Source: MGI

GO - Biological processi

  • nuclear membrane organization Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 43
Alternative name(s):
Protein LUMA
Gene namesi
Name:Tmem43
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921372. Tmem43.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 3130NuclearSequence analysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Topological domaini53 – 313261Perinuclear spaceSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 34511NuclearSequence analysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence analysisAdd
BLAST
Topological domaini367 – 3682Perinuclear spaceSequence analysis
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Topological domaini390 – 40011NuclearSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum lumen Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of nuclear inner membrane Source: MGI
  • nuclear inner membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 400399Transmembrane protein 43PRO_0000284499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9DBS1.
MaxQBiQ9DBS1.
PaxDbiQ9DBS1.
PeptideAtlasiQ9DBS1.
PRIDEiQ9DBS1.
TopDownProteomicsiQ9DBS1.

PTM databases

PhosphoSiteiQ9DBS1.
SwissPalmiQ9DBS1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030095.
CleanExiMM_TMEM43.
GenevisibleiQ9DBS1. MM.

Interactioni

Subunit structurei

Can form oligomers through the transmembrane domains. Interacts with EMD; the interaction retains EMD at the inner nuclear membrane. Interacts with LMNA and LMNB2. Interacts with SUN2 (By similarity).By similarity

GO - Molecular functioni

  • protein self-association Source: MGI

Protein-protein interaction databases

BioGridi216508. 1 interaction.
IntActiQ9DBS1. 3 interactions.
MINTiMINT-4128379.
STRINGi10090.ENSMUSP00000032183.

Structurei

3D structure databases

ProteinModelPortaliQ9DBS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM43 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEFK. Eukaryota.
ENOG410Z3TK. LUCA.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ9DBS1.
OMAiGDYFYHS.
OrthoDBiEOG091G0A4D.
PhylomeDBiQ9DBS1.
TreeFamiTF324718.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. DUF1625. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANYSSTSS RKEHVKVTSE PQPGFLERLS ETSGGMFVGL MTFLLSFYLI
60 70 80 90 100
FTNEGRALKT ATSLAEGLSL VVSPDSIHSV APENEGRLVH IIGALRTSKL
110 120 130 140 150
LSDPNYGVHL PAVKLRRHVE MYQWVETEES SEYTEDGQVK KETKYSYNTE
160 170 180 190 200
WRSEIVNSRN FDREIGHKNP SAMAVESFTA TAPFVQIGRF FLSAGLIDKI
210 220 230 240 250
DNFKALSLAK LEDPHVDIIR RGDFFYHSEN PKYPEVGDVR VSFSYAGLSS
260 270 280 290 300
DDPDLGPAHV VTVIARQRGD QLIPYSTKSG DTLLLLHHGD FSAEEVFRRE
310 320 330 340 350
QKSNSMKTWG LRAAGWMAMF MGLNLMTRIL YTLVDWFPVF RDLVNIGLKA
360 370 380 390 400
FAFCVATSLT LLTVAAGWLF YRPLWAALIG CLALVPIIIA RTRVPAKKLE
Length:400
Mass (Da):44,783
Last modified:June 1, 2001 - v1
Checksum:i5A9732B4214D4316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004778 mRNA. Translation: BAB23556.1.
AK151693 mRNA. Translation: BAE30617.1.
AK151766 mRNA. Translation: BAE30672.1.
AK152078 mRNA. Translation: BAE30929.1.
AK168559 mRNA. Translation: BAE40432.1.
BC024933 mRNA. Translation: AAH24933.1.
CCDSiCCDS20368.1.
RefSeqiNP_083042.1. NM_028766.2.
UniGeneiMm.38801.

Genome annotation databases

EnsembliENSMUST00000032183; ENSMUSP00000032183; ENSMUSG00000030095.
GeneIDi74122.
KEGGimmu:74122.
UCSCiuc009cyc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004778 mRNA. Translation: BAB23556.1.
AK151693 mRNA. Translation: BAE30617.1.
AK151766 mRNA. Translation: BAE30672.1.
AK152078 mRNA. Translation: BAE30929.1.
AK168559 mRNA. Translation: BAE40432.1.
BC024933 mRNA. Translation: AAH24933.1.
CCDSiCCDS20368.1.
RefSeqiNP_083042.1. NM_028766.2.
UniGeneiMm.38801.

3D structure databases

ProteinModelPortaliQ9DBS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216508. 1 interaction.
IntActiQ9DBS1. 3 interactions.
MINTiMINT-4128379.
STRINGi10090.ENSMUSP00000032183.

PTM databases

PhosphoSiteiQ9DBS1.
SwissPalmiQ9DBS1.

Proteomic databases

EPDiQ9DBS1.
MaxQBiQ9DBS1.
PaxDbiQ9DBS1.
PeptideAtlasiQ9DBS1.
PRIDEiQ9DBS1.
TopDownProteomicsiQ9DBS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032183; ENSMUSP00000032183; ENSMUSG00000030095.
GeneIDi74122.
KEGGimmu:74122.
UCSCiuc009cyc.1. mouse.

Organism-specific databases

CTDi79188.
MGIiMGI:1921372. Tmem43.

Phylogenomic databases

eggNOGiENOG410IEFK. Eukaryota.
ENOG410Z3TK. LUCA.
GeneTreeiENSGT00390000009671.
HOGENOMiHOG000008164.
HOVERGENiHBG062125.
InParanoidiQ9DBS1.
OMAiGDYFYHS.
OrthoDBiEOG091G0A4D.
PhylomeDBiQ9DBS1.
TreeFamiTF324718.

Miscellaneous databases

PROiQ9DBS1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030095.
CleanExiMM_TMEM43.
GenevisibleiQ9DBS1. MM.

Family and domain databases

InterProiIPR012430. TMEM43_fam.
[Graphical view]
PANTHERiPTHR13416. PTHR13416. 1 hit.
PfamiPF07787. DUF1625. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM43_MOUSE
AccessioniPrimary (citable) accession number: Q9DBS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.